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    South San Francisco, CA Office Buildings for Sale

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    San Bruno, CA Brisbane, CA Colma, CA
    Fully Secured High-Tech Biotech Facility
    $48,000,000
    3.65 Acres
    Fully Secured High-Tech Biotech Facility

    560 Eccles AVE, South San Francisco, CA 94080

    2019-built facility with mission-critical labs, dedicated power backup, and secure dock access for large tractor-trailers.
    • Premier 21,552 SF high‑tech biotech facility built in 2019 on a 3.65‑acre site
    • Interior includes approx. 9,500 SF office, 4,500 SF mission‑critical lab space, and 7,000 SF warehouse/inspection zone
    • Security features include Security Level II: Lenel card reader system, 24‑hour CCTV, and fenced parking with 62 assigned spaces
    • Mission‑critical lab infrastructure includes 100% ducted exhaust (8 air changes/hour) and high‑purity reverse osmosis water systems
    • Power backup: 500 kW stand‑alone diesel generator plus dedicated UPS backup power
    Updated: May 20
    View details
    Freestanding Office Building For Sale
    $1,699,000
    3,010 SF
    Freestanding Office Building For Sale

    161 El Camino Real, South San Francisco, CA

    Freestanding office building in South San Francisco, delivered vacant.
    • Delivered vacant, ideal for owner‑users.
    • Freestanding, steel‑frame commercial building built in 2017.
    • Approximately 3,010 sq. ft. of gross building area.
    • 2,246 sq. ft. of ground‑level office space plus a 764 sq. ft. mezzanine.
    • Abundant natural light and high ceilings.
    Updated: Apr 24, 2025
    View details
    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 2 Active listings in South San Francisco, CA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 70 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Versatile Building Near Caltrain
    $1,999,999
    Versatile Building Near Caltrain

    Adaptable building suitable for office, school, medical, or residential use.

    422-426 Peninsula Ave, San Mateo, CA 94401

    View details
    San Mateo Office Building Investment
    $12,750,000
    17,398 SF
    San Mateo Office Building Investment

    Fully leased San Mateo office building with long-term tenant.

    630 N San Mateo Dr, San Mateo, CA

    View details
    San Francisco Office Building For Sale
    $3,055,000
    0.14 Acres
    San Francisco Office Building For Sale

    Office building available for purchase in San Francisco, California.

    390 Ashton Ave, San Francisco, CA

    View details
    Commercial Property on Corner Location
    $2,199,000
    7,110 SF
    Commercial Property on Corner Location

    Two-unit commercial property with high ceilings and abundant natural light.

    4-8 Persia Ave, San Francisco, CA

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    C3 Retail/Office Building
    $1,900,000
    0.21 Acres
    C3 Retail/Office Building

    C3-zoned building in San Jose with substantial space for retail, office, or mixed-use redevelopment plans.

    702 E Santa Clara ST 206, San Jose, CA 95112

    View details
    Vacant Lot in Downtown Vacaville
    $299,000
    0.14 Acres
    Vacant Lot in Downtown Vacaville

    Buildable lot with approved plans for single-story office building.

    Merchant Street, Vacaville, CA 95688

    View details
    Healdsburg Avenue Commercial Land
    $2,500,000
    3,240 SF
    Healdsburg Avenue Commercial Land

    Commercial land available on Healdsburg Avenue.

    821 829 Healdsburg Avenue, Healdsburg, CA 95448

    View details
    Commercial Land in Modesto
    $2,100,000
    Commercial Land in Modesto

    Commercial land available for sale in Stanislaus County.

    924 G Street, Modesto, CA 95356

    View details

    Off-Market Properties in South San Francisco, CA

    Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    163 Harris Ave
    OFFICE BUILDING (MULTI-STORY)
    Lot: 0.35 Acres
    Value Estimation by Request

    163 Harris Ave, South San Francisco, CA 94080-6008

    View details
    323 Miller Ave, Unit 329
    PROFESSIONAL BUILDING
    Lot: 0.18 Acres
    Value Estimation by Request
    Unit 329

    323 Miller Ave, South San Francisco, CA 94080-3725

    View details
    1405 Huntington Ave
    PROFESSIONAL BUILDING
    Lot: 0.04 Acres
    Estimated value
    $815,000

    1405 Huntington Ave, South San Francisco, CA 94080-5988

    View details
    1475 Huntington Ave
    PROFESSIONAL BUILDING
    Lot: 0.03 Acres
    Estimated value
    $1,145,000

    1475 Huntington Ave, South San Francisco, CA 94080-5990

    View details
    1475 Huntington Ave Ste, Unit 200
    PROFESSIONAL BUILDING
    1,530 SF Lot: 0.03 Acres
    Estimated value
    $530,000
    Unit 200

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    View details
    1241 Msn Rd
    OFFICE BUILDING (MULTI-STORY)
    4,561 SF Lot: 0.32 Acres
    Estimated value
    $1,545,000

    1241 Msn Rd, South San Francisco, CA 94080-1397

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    421 Grand Ave
    OFFICE BUILDING (MULTI-STORY)
    6,629 SF Lot: 0.16 Acres
    Value Estimation by Request

    421 Grand Ave, South San Francisco, CA 94080-3635

    View details
    1435 Huntington Ave
    PROFESSIONAL BUILDING
    3,224 SF Lot: 3.47 Acres
    Value Estimation by Request

    1435 Huntington Ave, South San Francisco, CA 94080-5989

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    435 Grand Ave
    OFFICE BUILDING (MULTI-STORY)
    Lot: 0.08 Acres

    435 Grand Ave, South San Francisco, CA 94080-3635

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    1587 San Mateo Ave
    OFFICE BUILDING (MULTI-STORY)
    Lot: 2.44 Acres
    Estimated value
    $610,000

    1587 San Mateo Ave, South San Francisco, CA 94080-6500

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    1435 Huntington Ave Ste, Unit 337
    PROFESSIONAL BUILDING
    1,220 SF Lot: 0.03 Acres
    Estimated value
    $1,225,000
    Unit 337

    1435 Huntington Ave Ste, South San Francisco, CA 94080-5989

    View details
    1165 El Camino Real
    OFFICE BUILDING (MULTI-STORY)
    Lot: 0.25 Acres
    Value Estimation by Request

    1165 El Camino Real, South San Francisco, CA 94080-3207

    View details
    359 El Camino Real
    OFFICE BUILDING (MULTI-STORY)
    16,550 SF Lot: 0.95 Acres
    Estimated value
    $1,385,000

    359 El Camino Real, South San Francisco, CA 94080-5923

    View details
    1265 Msn Rd
    OFFICE BUILDING (MULTI-STORY)
    Lot: 0.26 Acres
    Value Estimation by Request

    1265 Msn Rd, South San Francisco, CA 94080-1397

    View details
    1475 Huntington Ave Ste, Unit 306
    PROFESSIONAL BUILDING
    1,125 SF Lot: 0.03 Acres
    Value Estimation by Request
    Unit 306

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    View details
    800 Dubuque Ave, Unit 890
    OFFICE BUILDING (MULTI-STORY)
    112,912 SF Lot: 5.96 Acres
    Estimated value
    $2,295,000
    Unit 890

    800 Dubuque Ave, South San Francisco, CA 94080-1804

    View details
    160 Country Clb Dr
    PROFESSIONAL BUILDING
    10,814 SF Lot: 0.47 Acres
    Estimated value
    $11,130,000

    160 Country Clb Dr, South San Francisco, CA 94080-4347

    View details
    2 Tower Pl
    OFFICE BUILDING (MULTI-STORY)
    350,036 SF Lot: 2.91 Acres

    2 Tower Pl, South San Francisco, CA 94080-1826

    View details
    Airport Blvd
    OFFICE BUILDING (MULTI-STORY)
    Lot: 2.69 Acres

    Airport Blvd, South San Francisco, CA 94080

    View details
    100 Arroyo Dr
    PROFESSIONAL BUILDING
    Lot: 0.14 Acres
    Estimated value
    $1,010,000

    100 Arroyo Dr, South San Francisco, CA 94080-3194

    View details
    681 Gtwy Blvd, Unit 685
    OFFICE BUILDING (MULTI-STORY)
    126,971 SF Lot: 3.04 Acres
    Value Estimation by Request
    Unit 685

    681 Gtwy Blvd, South San Francisco, CA 94080-7015

    View details
    1115 Msn Rd
    PROFESSIONAL BUILDING
    4,663 SF Lot: 0.26 Acres
    Estimated value
    $1,800,000

    1115 Msn Rd, South San Francisco, CA 94080-1302

    View details

    South San Francisco, CA Office Buildings Investment Opportunities Market Analysis

    Explore 72 office buildings for sale in South San Francisco, CA on our real estate platform. These investment opportunities span a total of 3,010 square feet of properties for sale, with an estimated market value of $1,699,000.

    Sale prices for office properties in South San Francisco, CA start at $1,699,000, averaging $1,699,000, and reaching up to $1,699,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    List
    Map

    Top Commercial Asset Segments

    Office Units 40
    Office buildings 9
    Medical Office Space 3
    Coworking space 1

    Property Size Breakdown

    The majority of commercial real estate listings in South San Francisco fall within the 100,000+ square foot range.

    Demographics Overview

    Population 65K
    Population Growth (5Y) -3.8%
    Median Household Income $135,966
    College Educated 26.3%

    Taxes & Financing

    Tax Rate (average for all types) 1.16%
    Property Tax per SF $7.35 per sq ft
    Tax Rate vs County Average 0.02 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    Total CRE Area on Market Trend

    Average Price per SF — Retail

    Average Price per SF — Residential Income

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