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    South San Francisco, CA Office Buildings for Sale

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    High-Security Life Science Flex Facility
    Updated: Apr 25
    High-Security Life Science Flex Facility

    560 Eccles Avenue, South San Francisco, CA 94080

    $48,000,000
    21,552 sqft 3.65 AC lot
    Purpose‑built 2019 high‑tech facility on a 3.65‑acre site
    21,552 SF total with ~9,500 SF office, ~4,500 SF mission‑critical lab, and ~7,000 SF warehouse/inspection zone
    Mission‑critical lab build‑out includes 100% ducted exhaust (8 air changes/hour) and high‑purity reverse osmosis water systems
    Backup power includes a 500 kW stand‑alone diesel generator plus dedicated UPS for operational continuity
    Secured logistics with 4 interior dock‑high doors in a secure devanning area for 53‑foot tractor‑trailers
    View details
    Downtown Transit Core Office Building
    Updated: May 11
    Downtown Transit Core Office Building

    201 Baden Avenue, South San Francisco, CA 94080

    Contact for pricing
    12,164 sqft 0.30 AC lot
    Built in 1950, ±12,164 SF building on a ±13,003 SF lot at 201 Baden Ave in Downtown South San Francisco
    Downtown Transit Core (DTC) zoning on a transit‑oriented development site near the Caltrain Station
    Permitted uses include multiple‑unit/senior citizen residential and retail general sales & grocery stores
    Also permitted: business/professional/medical/dental offices, plus full service & quick service restaurants and coffee shops/cafes
    Listed price: $2,700,000 (±$222/SF)
    View details
    Mixed-Use Potential Office/Retail Building
    Mixed-Use Potential Office/Retail Building

    201 Baden Ave, South San Francisco, CA 94080

    Contact for pricing
    12,164 sqft 0.30 AC lot

    Two-frontage, two-story office and retail building with an additional usable tower and on-site parking.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Office Building
    Office Building

    267 E Harris Avenue, South San Francisco, CA 94080

    Contact for pricing
    7,480 sqft

    Office building offered for sale with 7,480 SF of space.

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 4 Active listings in South San Francisco, CA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 68 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Two-Story Office and Warehouse Campus
    Two-Story Office and Warehouse Campus

    831-839 Mitten Rd, Burlingame, CA 94010

    Contact for pricing
    540 sqft

    Two-story campus combines office space with a standalone warehouse, plus EV charging and abundant natural light.

    View details
    Versatile Building Near Caltrain
    Versatile Building Near Caltrain

    422-426 Peninsula Ave, San Mateo, CA 94401

    $1,999,999

    Adaptable building suitable for office, school, medical, or residential use.

    View details
    For-Sale Office Building
    For-Sale Office Building

    216 N San Mateo Drive, San Mateo, CA 94401

    $2,400,000

    Office building available for sale at 216 N San Mateo Drive, suited for owner-occupiers or office users.

    View details
    Office Building
    Office Building

    778 Burlway Road, Burlingame, CA 94010

    Contact for pricing
    47,902 sqft

    Office property offered for sale with approximately 47,902 SF of total space.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Buildable Office Development Lot
    Buildable Office Development Lot

    Merchant Street, Vacaville, CA 95688

    $299,000
    0.14 AC lot

    Vacaville lot with approved plans for a single-story office building, supported by significant predevelopment work.

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    Healdsburg Avenue Commercial Land
    Healdsburg Avenue Commercial Land

    821 829 Healdsburg Avenue, Healdsburg, CA 95448

    $2,500,000
    3,240 sqft

    Commercial land available on Healdsburg Avenue.

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    Commercial Land in Modesto
    Commercial Land in Modesto

    924 G Street, Modesto, CA 95356

    $2,100,000

    Commercial land available for sale in Stanislaus County.

    View details
    Commercial Lot with Business Potential
    Commercial Lot with Business Potential

    7118 Bowling Drive, Sacramento, CA 95823

    $395,000

    Commercial lot with business potential in a high-traffic area.

    View details

    Off-Market Properties in South San Francisco, CA

    Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    163 Harris Ave
    OFFICE BUILDING (MULTI-STORY)

    163 Harris Ave, South San Francisco, CA 94080-6008

    Value Estimation by Request
    0.35 AC lot
    View details
    323 Miller Ave, Unit 329
    PROFESSIONAL BUILDING

    323 Miller Ave, South San Francisco, CA 94080-3725

    Unit 329
    Value Estimation by Request
    0.18 AC lot
    View details
    1405 Huntington Ave
    PROFESSIONAL BUILDING

    1405 Huntington Ave, South San Francisco, CA 94080-5988

    $815,000
    Estimated value
    0.04 AC lot
    View details
    1475 Huntington Ave
    PROFESSIONAL BUILDING

    1475 Huntington Ave, South San Francisco, CA 94080-5990

    $1,145,000
    Estimated value
    0.03 AC lot
    View details
    1475 Huntington Ave Ste, Unit 200
    PROFESSIONAL BUILDING

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    Unit 200
    $530,000
    Estimated value
    1,530 sqft 0.03 AC lot
    View details
    1241 Msn Rd
    OFFICE BUILDING (MULTI-STORY)

    1241 Msn Rd, South San Francisco, CA 94080-1397

    $1,545,000
    Estimated value
    4,561 sqft 0.32 AC lot
    View details
    421 Grand Ave
    OFFICE BUILDING (MULTI-STORY)

    421 Grand Ave, South San Francisco, CA 94080-3635

    Value Estimation by Request
    6,629 sqft 0.16 AC lot
    View details
    1435 Huntington Ave
    PROFESSIONAL BUILDING

    1435 Huntington Ave, South San Francisco, CA 94080-5989

    Value Estimation by Request
    3,224 sqft 3.47 AC lot
    View details
    435 Grand Ave
    OFFICE BUILDING (MULTI-STORY)

    435 Grand Ave, South San Francisco, CA 94080-3635

    Value Estimation by Request
    0.08 AC lot
    View details
    1587 San Mateo Ave
    OFFICE BUILDING (MULTI-STORY)

    1587 San Mateo Ave, South San Francisco, CA 94080-6500

    $610,000
    Estimated value
    2.44 AC lot
    View details
    1435 Huntington Ave Ste, Unit 337
    PROFESSIONAL BUILDING

    1435 Huntington Ave Ste, South San Francisco, CA 94080-5989

    Unit 337
    $1,225,000
    Estimated value
    1,220 sqft 0.03 AC lot
    View details
    1165 El Camino Real
    OFFICE BUILDING (MULTI-STORY)

    1165 El Camino Real, South San Francisco, CA 94080-3207

    Value Estimation by Request
    0.25 AC lot
    View details
    359 El Camino Real
    OFFICE BUILDING (MULTI-STORY)

    359 El Camino Real, South San Francisco, CA 94080-5923

    $1,385,000
    Estimated value
    16,550 sqft 0.95 AC lot
    View details
    1265 Msn Rd
    OFFICE BUILDING (MULTI-STORY)

    1265 Msn Rd, South San Francisco, CA 94080-1397

    Value Estimation by Request
    0.26 AC lot
    View details
    1475 Huntington Ave Ste, Unit 306
    PROFESSIONAL BUILDING

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    Unit 306
    Value Estimation by Request
    1,125 sqft 0.03 AC lot
    View details
    800 Dubuque Ave, Unit 890
    OFFICE BUILDING (MULTI-STORY)

    800 Dubuque Ave, South San Francisco, CA 94080-1804

    Unit 890
    $2,295,000
    Estimated value
    112,912 sqft 5.96 AC lot
    View details
    160 Country Clb Dr
    PROFESSIONAL BUILDING

    160 Country Clb Dr, South San Francisco, CA 94080-4347

    $11,130,000
    Estimated value
    10,814 sqft 0.47 AC lot
    View details
    2 Tower Pl
    OFFICE BUILDING (MULTI-STORY)

    2 Tower Pl, South San Francisco, CA 94080-1826

    Value Estimation by Request
    350,036 sqft 2.91 AC lot
    View details
    Airport Blvd
    OFFICE BUILDING (MULTI-STORY)

    Airport Blvd, South San Francisco, CA 94080

    Value Estimation by Request
    2.69 AC lot
    View details
    100 Arroyo Dr
    PROFESSIONAL BUILDING

    100 Arroyo Dr, South San Francisco, CA 94080-3194

    $1,010,000
    Estimated value
    0.14 AC lot
    View details

    South San Francisco, CA Office Buildings Market Trends and Statistics

    Explore 72 office buildings for sale in South San Francisco, CA, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 53,360 square feet of properties for sale, with an estimated market value of $48,000,000.

    Sale prices for office properties in South San Francisco, CA average $48,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 35
    Office buildings 14
    Medical Office Space 3
    Coworking space 1

    Demographics Overview

    Population 65K
    Population Growth (5Y) -3.8%
    Median Household Income $135,966
    College Educated 26.3%

    High-Yield Neighborhoods for Investment

    Identify South San Francisco submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    94080 $48M

    Taxes & Financing

    Tax Rate (average for all types) 1.16%
    Property Tax per SF $7.35 per SF
    Tax Rate vs County Average 0.02 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in San Mateo County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in San Mateo County

    Retail

    Residential Income

    Property Size Breakdown

    The majority of commercial real estate listings in South San Francisco fall within the 100,000+ square foot range.

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