Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Back to Search
    Life Science Campus for Rent Title is generated by Realmo AI

    180 El Camino Real, South San Francisco, CA 94080

    View on Map
    Claim this Listing
    Loading data...
    Loading data...
    Loading data...
    For Lease
    Contact for pricing

    Vibrant campus with amenities near Biotech Bay Area corridor.

    Type:LifeSciences
    Property size:
    300,000 SF
    Added:
    Nov 22, 2025
    Days on Market:
    182
    Last Refresh:
    Apr 5 at 8:55 pm

    Property Features for 180 El Camino Real

    General Information

    Standard status
    Active
    Size
    300,000 SF
    Property subtype
    LifeSciences

    Spaces For Lease

    at 180 El Camino Real Contact us

    We can help!

    Listing Contact
    Gregg Domanico

    Listing agent Gregg Domanico License #00996779

    Listing office

    Listing date Nov 22, 2025

    Source Cbre

    Displayed information is deemed reliable but is not guaranteed and should be independently verified.

    All listing content including descriptions, pricing, images are the copyrighted material of Gregg Domanico

    HighLights

    • Prime location in Biotech Bay Area corridor, near SFO airport, BART, and Caltrain, with shuttle services.
    • Extensive amenities including a 15,000 SF conference center, 10,000 SF fitness club, and 10,000 SF restaurant and bar.
    • Abundant parking with approximately 1,600 life science spaces and a favorable parking ratio.
    • Sustainable design featuring a 40,000 SF solar panel array.
    • Expansive outdoor spaces including a 3‑acre central gathering space and private roof terraces.
    • On‑site convenience with a 24‑hour Safeway, Chipotle, coffee shop, and pizza restaurant.

    Overview

    Located in South San Francisco, this life science campus offers a collaborative environment designed for innovation. The property includes a 15,000 SF conference center, a 10,000 SF fitness club, and a 10,000 SF restaurant and bar. Outdoor amenities feature a 3-acre central gathering space and private roof terraces in each building. Convenience is enhanced by a 24-hour Safeway, Chipotle, a coffee shop, and a brick oven pizza restaurant located nearby. Each building provides dedicated bike storage, shower, and locker facilities. A 40,000 SF solar panel array on the parking garage supports sustainability efforts. Parking includes approximately 1,600 life science spaces, with a parking ratio of 1.7/1,000, which can increase to 2.0/1,000 with valet service. Building 1 also offers basement parking with around 100 spaces. The property is situated minutes from the San Francisco International Airport and near the Biotech Bay Area corridor, with proximity to BART and Caltrain, and shuttle services. The surrounding area includes residential developments and commercial amenities.
    Property Profile Location Intelligence

    Current Use by Public Records

    Bally Sport Gym & Fitness Center

    Suggested Use

    Real Estate Agency Law Firm Restaurant Spa & Massage Center Dental Office Hair Salon Nail Salon Building Supply Gym & Fitness Center Skin Care Clinic

    Zoning and permitted uses should be independently verified with local authorities.

    Location Insight

    • Map
    • Local Demand
    City
    South San Francisco
    County
    San Mateo
    State
    California
    Longitude
    -122.427
    Latitude
    37.6462

    Nearby Similar for Lease

    • Sponsored
      $129-$8,976/Mo
      11-1,292 SF

      CA, South San Francisco - Spaces Oyster Point

      611 Gateway Blvd, South San Francisco, CA 94080
      View Details
    • $2 SF/Yr
      2,621 SF

      Corner Office Space Available

      Prominent corner office space near transportation and shopping.
      1486 Huntington Avenue, South San Francisco, CA, 94080
      View Details
    • $1.75 SF/Yr
      5,180 SF

      Office/Warehouse Suite For Rent

      Office/warehouse suite featuring dock-high loading and ample parking.
      461-477 Littlefield Ave, S San Francisco, CA
      View Details
    • $2 SF/Yr
      36,881 SF

      South San Francisco Industrial Building

      36,881 SF industrial building with freight access and prime location.
      200 Shaw Road, South San Francisco, CA, 94080
      View Details
    • Contact for pricing
      22,365 SF

      South San Francisco Office/Lab Sublease

      Full floor office/lab space available for sublease through July 2029.
      651 Gateway Boulevard, South San Francisco, CA 94080
      View Details
    • Contact for pricing

      Prime Retail Space in California

      Exceptional retail leasing opportunity in a vibrant South San Francisco location.
      200 Airport Boulevard, South San Francisco, CA 94080
      View Details
    • Contact for pricing
      29,800 SF

      South San Francisco Industrial Building

      Freestanding industrial building with office/lab space for rent.
      250 Hillside Boulevard, South San Francisco, CA, 94080
      View Details
    • $2.00 SF/Yr
      29,470 SF

      South San Francisco Office Space

      LEED Gold certified office space with excellent transportation access.
      701 Gateway Blvd, South San Francisco, CA
      View Details
    • Contact for pricing
      10,248 SF

      Oyster Point Flex/Lab Space

      30,140 SF flex/lab space available for lease.
      333 Oyster Point Blvd, South San Francisco, CA 94080
      View Details
    • Contact for pricing
      8,711 SF

      Functional Lab/Office Space Available

      Prime location, functional lab/office space near transportation.
      600 Gateway Blvd, South San Francisco, CA 94080
      View Details
    • $2 SF/Yr
      6,000 SF

      South San Francisco Warehouse Space

      6,000 SF office warehouse with secure yard near Hwy 101.
      150 West Harris Avenue, South San Francisco, CA, 94080
      View Details
    • Contact for pricing
      30,491 SF

      South San Francisco Flex Space

      Flex space available for rent in South San Francisco.
      400 E Jamie Ct, South San Francisco, CA 94080
      View Details

    FAQs

    What type of property is this?
    Office units - Vibrant campus with amenities near Biotech Bay Area corridor.
    Where is this office units located?
    The property is located at 180 El Camino Real South San Francisco, CA.
    What are key features of this property?
    This property features: Prime location in Biotech Bay Area corridor, near SFO airport, BART, and Caltrain, with shuttle services.; Extensive amenities including a **15,000 SF conference center**, **10,000 SF fitness club**, and 10,000 SF restaurant and bar.; Abundant parking with approximately 1,600 life science spaces and a favorable parking ratio.
    (650) 577-2954
    We can help!
    Listing Contact
    Gregg Domanico
    Real Estate License ID: 00996779
    Request Owner's contact information
    Message sent successfully
    Error
    If you are the owner or broker of this property and would like to edit or remove this listing please send a message to web site administrator.
    Message sent successfully
    Error
    Email to Your Friends
    Link copied to clipboard
    Separate multiple addresses with a comma
    Message sent successfully
    Error

    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

    More about this property
    Thanks! Your message was sent.
    Error! Your message wasn't sent.
    Please enter your name
    Please enter email
    Please enter the email in the correct format
    Please enter phone
    Please enter the number in the correct format
    Please enter message
    Thank You

    You are Unsubscribed From Notifications

    Thank You for Inquiry
    180 El Camino Real, South San Francisco, CA, 94080
    letter with green check mark
    Check your email
    We sent you the
    agent's contact details. yellow underline
    Can't find it?
    Please check your junk/spam folder.
    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!