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220 S Spruce Ave, South San Francisco, CA

Office space near transportation and airport in South San Francisco.

Space Size1,694 SF
Lot Size2.08 Acres
Days on Market309

Property Features for 220 S Spruce Ave

General Information

Standard status Active
Size 1,694 SF
Lot size 2.08 Acres
Property subtype OFFICE
Lease Type Full Service

Spaces For Lease

at 220 S Spruce Ave Contact us

220 S Spruce Ave $2.25/SF/Mo

Floor
2
Size
1,694 SF
Type
OFFICE
Lease Type
FULL_SERVICE
Availability
AVAILABLE, Now
Sublease
No
- Public Transportation - <1 mile to CalTrain : San Bruno Station and Bart - Signage...
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Listing Agency: Colliers | San Mateo
Listed By: Mike Davis, SIOR
Source: Moodyscre
Added: Oct 6, 2025 Changed: Aug 8 Last Checked: Aug 9 at 11:46AM

Displayed information is deemed reliable but is not guaranteed and should be independently verified. All listing content including descriptions, pricing, images are the copyrighted material of Colliers | San Mateo

Investment Insights

Based on property information with market context.

This 1,694 square foot office space is located in South San Francisco, California. The building offers signage opportunities. It is situated less than one mile from the CalTrain San Bruno Station and BART, providing convenient public transportation access. The property is also located a short distance from the Highway 101, 280, and 380, and is approximately 5 minutes from SFO airport.

Key Highlights

  • Proximity to Public Transportation: Less than 1 mile to CalTrain (San Bruno Station) and BART.
  • Convenient Airport Access: 5 minutes to SFO.
  • Excellent Highway Access: Easy access to Highways 101, 280, and 380.

Property Analytics

Current Use

Pathology X Diagnostic ... Physician Cookrite Health Solutions (Bike/Boat/Book/etc) Store North State Environmental Waste Management Service Johanna Sandoval Physician J Sandoval LLC Corporate Office

Suggested Use

Top Pick Real Estate Agency (Bike/Boat/Book/etc) Store Acupuncture Skin Care Clinic Tattoo & Piercing Shop Tanning Salon

Score = modeled unmet demand for each use within ~1 mi (higher = bigger opportunity). Zoning and permitted uses should be independently verified with local authorities.

Lease Details

NNN (Triple Net)
Lease Type

Location Intelligence

Trade Area within ½ mile

2,181
Businesses Nearby

Market

Vacancy Rate% for Office in West region

11% 2019
14.1% 2020
15.5% 2021
17.2% 2022
19.9% 2023
21% 2024
20.8% 2025
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Frequently Asked Questions

What type of property is this?
Office units - Office space near transportation and airport in South San Francisco.
Where is this office units located?
The property is located at 220 S Spruce Ave South San Francisco, CA.
What are key features of this property?
This property features: Proximity to Public Transportation: Less than 1 mile to CalTrain (San Bruno Station) and BART.; Convenient Airport Access: **5 minutes to SFO.**; Excellent Highway Access: Easy access to Highways 101, 280, and 380.
(650) 486-2219 Call to check price and availability
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