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    San Diego, CA Office Spaces for Lease

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    Found 558 office space listings for lease in San Diego, CA, averaging $21/SF/YR. Use lease type data to compare options faster.
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    Remodeled Two-Story Office Suite
    Remodeled Two-Story Office Suite

    San Diego, CA 92110

    Midway District
    Contact for pricing

    Flexible office configuration with skylights, a kitchenette, and a private bathroom with shower.

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    San Diego Commercial Space For Lease
    San Diego Commercial Space For Lease

    17066 Goldentop Rd., San Diego, CA 92127

    Black Mountain Ranch
    Contact for pricing
    Built 2026

    Mixed-use, retail, office, and industrial spaces available for lease.

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    Office Suite with Conference Room
    Office Suite with Conference Room

    4305 University Ave, San Diego, CA 92105

    Castle
    Contact for pricing
    7–13 people  1,973 sqft

    Suite includes four private window-lined offices, a conference room, and a small kitchenette.

    Conference room  Kitchenette
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    Class A Office Building
    Class A Office Building

    9444 Balboa Ave, San Diego, CA 92123

    Class A Kearny Mesa
    Contact for pricing
    23–39 people  1 space  5,956 sqft
    Highway access + Road access

    Class A office space offered through 11/30/2026 with onsite fitness and a new amenity center.

    Conference room  Training room  Lounge area  Fitness facility
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    Class A Garden Office Building
    Class A Garden Office Building

    7777 Fay Ave, La Jolla, CA 92037

    Contact for pricing
    11–19 people  2,896 sqft  4-story  Class A garden office building

    Four-story Class A garden office building offering strong on-site building signage opportunities.

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    Sublease Office Building
    Sublease Office Building

    3579 Valley Centre Dr, San Diego, CA 92130

    Torrey Preserve
    Contact for pricing
    14–23 people  3,500 sqft

    Office building available for sublease, offering 3,500 SF of workspace at 3579 Valley Centre Dr.

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    Class A Medical Office Suite
    Class A Medical Office Suite

    8008 Frost St, San Diego, CA 92123

    Birdland
    Contact for pricing
    Multi-tenant  1,612 sqft
    Highway access

    Class A medical office suites within a multi-building healthcare campus with parking and on-site management.

    On-site professional property management
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    Office Space for Lease
    Office Space for Lease

    4755 Eastgate Mall, San Diego, CA

    Triple net (NNN) University City
    Contact for pricing
    126–211 people  1 space  31,706 sqft  2.82 acres

    Office space available for lease in San Diego, CA.

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    Class A Flex Space with Two-Story Lobbies
    Class A Flex Space with Two-Story Lobbies

    10431 Wateridge Cir, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    15,177 sqft  3-phase  2 buildings
    Highway access

    Flex office and production space with nine private offices, multiple conference rooms, and a campus parking ratio of 3 per 1,000 RSF.

    Two-story lobbies  Landscaped campus
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    Updated Office and Industrial Space
    Updated Office and Industrial Space

    9235 Activity Rd, San Diego, CA

    Triple net (NNN) Mira Mesa
    Contact for pricing
    15–25 people  3 spaces  3,788 sqft  9 acres

    Office and flexible industrial space near Miramar Road.

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    Downtown San Diego Office Space
    Downtown San Diego Office Space

    525 B St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    157–262 people  39,327 sqft

    Office space available for rent in downtown San Diego.

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    Office Building with Panoramic Bay Views
    Office Building with Panoramic Bay Views

    550 W C St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    62–104 people  15,688 sqft
    Public transit

    Office building with an enhanced lobby, gym, and fully equipped conference room, plus EV charging and 24/7 security.

    2.0/1,000 SF parking  Enhanced lobby  Dining and outdoor amenities  EV charging stations
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    Turn-Key Lab Office Suite
    Turn-Key Lab Office Suite

    5151 Shoreham Pl, San Diego, CA 92122

    Gross University City
    Contact for pricing
    2,632 sqft

    Turn-key lab grade clean room suite with private offices, open work area, and a private patio.

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    Fitness Center with Outdoor Workout Deck
    Fitness Center with Outdoor Workout Deck

    1011 Union St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    166–277 people  41,589 sqft  4-story

    For rent with 4 contiguous floors, multiple elevators, and indoor/outdoor dining plus an outdoor workout deck.

    Indoor/outdoor dining and lounge areas  Direct access to building parking  Tenant engagement services  24/7 security & on-site management office
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    Corner Office Suite
    Corner Office Suite

    5959 Mission Gorge Road, San Diego, CA 92120

    Grantville
    Contact for pricing
    Floor 2

    The second-floor suite is currently available for occupancy.

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    Murphy Canyon Road Office Space
    Murphy Canyon Road Office Space

    3934 Murphy Canyon Road, San Diego, CA

    Kearny Mesa
    Contact for pricing
    2,200 sqft

    Office space available for rent on Murphy Canyon Road.

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    Office Space with Private Offices
    Office Space with Private Offices

    2468 Historic Decatur Rd, San Diego, CA

    Loma Portal
    Contact for pricing
    5–9 people  1,435 sqft  0.93 acres

    Office space featuring private offices, reception, and conference room.

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    Sorrento Mesa Lab and Office
    Sorrento Mesa Lab and Office

    10431 Wateridge Cir, San Diego, CA

    University City
    Contact for pricing
    34,002 sqft

    Class A lab and office space in Sorrento Mesa.

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    Prime Commercial Property in San Diego
    Prime Commercial Property in San Diego

    San Diego, CA 92119

    Lake Murray
    Contact for pricing

    Exceptional commercial property with modern amenities and versatile floor plans.

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    Fitness Center with Ground Retail
    Fitness Center with Ground Retail

    1011 Union St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    166–277 people  41,652 sqft  4-story

    Fitness club space featuring 4 contiguous floors, direct parking access, and indoor/outdoor dining and lounge areas.

    4 High Speed Elevators  Indoor/outdoor dining and lounge areas  Tenant engagement services  24/7 security & on-site management office
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    Single-Story Office Building
    Single-Story Office Building

    12220 World Trade Dr, San Diego, CA 92128

    Triple net (NNN) Carmel Mountain
    Contact for pricing
    19–32 people  1 space  4,889 sqft  1-story
    Highway access

    Former headquarters facility with mezzanine space at a business park entrance near Interstate 15.

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    Office Spec Suite with Glass Entry
    Office Spec Suite with Glass Entry

    6256 Greenwich Dr, San Diego, CA 92122

    Class A University City
    Contact for pricing
    31–52 people  7,923 sqft
    Highway access

    Recently completed office spec suite features a prominent glass double-door entry plus private offices and an open work area.

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    North Park Office Space Available
    North Park Office Space Available

    3823 Ray St, San Diego, CA

    North Park
    Contact for pricing
    5–8 people  1 space  1,270 sqft  0.12 acres

    Flexible office spaces in a sought-after San Diego commercial district.

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    Flex Lab and Office Space
    Flex Lab and Office Space

    10431 Wateridge Cir, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    34,002 sqft  2 buildings
    Highway access

    Class A lab and office flex space with dedicated lab rooms, 97 workstations, and structured surface parking.

    Two-story lobbies  Building systems for research  Surface parking  Street parking
    View details
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