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    San Diego, CA Office Spaces for Lease

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    Found 558 office space listings for lease in San Diego, CA, averaging $21/SF/YR. Use lease type data to compare options faster.
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    Class A Spec Lab/Office Space
    Class A Spec Lab/Office Space

    10955 Vista Sorrento Pkwy., #150, San Diego, CA 92130

    Torrey Preserve
    Contact for pricing
    270–451 people  67,672 sqft  Built 2026

    Move-in ready lab and office space with robust infrastructure.

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    San Diego Office Space Available
    San Diego Office Space Available

    5355 Mira Sorrento Pl., San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    180–300 people  1 space  45,135 sqft  Built 2026

    Office space for rent in San Diego, CA.

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    Office Space Available For Lease
    Office Space Available For Lease

    8775 Aero Drive |, San Diego, CA 92123

    Serra Mesa
    Contact for pricing
    102–170 people  2 spaces  25,500 sqft  Built 1979

    Office space available for lease, totaling 25,500 square feet.

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    Available Office Space For Rent
    Available Office Space For Rent

    4669 Murphy Canyon Road |, San Diego, CA 92123

    Kearny Mesa
    Contact for pricing
    114–190 people  1 space  28,594 sqft  Built 1985

    3,945 square foot office space available for lease.

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    Finished Office Condominium For Rent
    Finished Office Condominium For Rent

    8710 Sherwood Ter, San Diego, CA 92154

    Otay Mesa
    Contact for pricing
    5–9 people  1,477 sqft

    Finished office condominium with private entrances and restrooms available for rent.

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    Office Space in Mercy Medical Bldg
    Office Space in Mercy Medical Bldg

    4060 4th Ave, San Diego, CA

    Hillcrest
    Contact for pricing
    1,994 sqft  0.87 acres

    Office space available for lease in San Diego, California.

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    La Jolla Office Space Available
    La Jolla Office Space Available

    San Diego, CA

    Little Italy
    Contact for pricing
    7–11 people  1,779 sqft  0.16 acres

    Office space for rent in La Jolla, California.

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    Class A Four-Story Office Building
    Class A Four-Story Office Building

    12121 Scripps Summit Dr, San Diego, CA 92131

    Miramar Ranch North
    Contact for pricing
    122–204 people  1 space  30,699 sqft

    Four-story Class A office building with panoramic views and covered parking.

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    Office Space Available For Lease
    Office Space Available For Lease

    3710 Ruffin Road |, San Diego, CA 92123

    Serra Mesa
    Contact for pricing
    80–133 people  1 space  20,060 sqft  Built 2006

    Office space available for lease, up to 20060 square feet.

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    Office Space in San Diego
    Office Space in San Diego

    3033 5th Ave, San Diego, CA

    Full service Park West
    Contact for pricing
    16–26 people  1 space  4,000 sqft  0.46 acres

    4,000 SF office space available for rent in San Diego.

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    Gaslamp Quarter Prime Office Space
    Gaslamp Quarter Prime Office Space

    343 4th Ave, San Diego, CA

    Gaslamp
    Contact for pricing
    3–5 people  775 sqft  0.71 acres

    Desirable office space in San Diego's vibrant Gaslamp Quarter.

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    Office Space For Lease
    Office Space For Lease

    5330 Napa St, San Diego, CA

    Full service Morena
    Contact for pricing
    13–22 people  1 space  3,382 sqft  0.78 acres

    Office space available for lease in San Diego, CA.

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    Flexible Office Space Available
    Flexible Office Space Available

    427 C St, San Diego, CA

    Core-Columbia
    Contact for pricing
    5–9 people  6 spaces  1,495 sqft  0.24 acres

    Office space for rent with flexible lease terms.

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    Office Building for Lease
    Office Building for Lease

    10256 Meanley Dr., San Diego, CA 92131

    Scripps Ranch
    Contact for pricing
    Built 2026

    Office building available for lease, offering flexible workspace options for professional tenants at a San Diego business address.

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    Historic Office Units
    Historic Office Units

    2366 Front St, San Diego, CA 92101

    Little Italy
    Contact for pricing
    Highway access

    Private workspaces pair period architectural character with shared amenities for professional use.

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    Carmel Valley Road Office Space
    Carmel Valley Road Office Space

    6040 Edgewood Bend Ct, San Diego, CA

    Little Italy
    Contact for pricing
    92–154 people  23,204 sqft  15.26 acres

    Office space available for lease in San Diego, California.

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    Office Space for Lease
    Office Space for Lease

    10260 Meanley Dr., San Diego, CA 92131

    Scripps Ranch
    Contact for pricing
    Built 2026

    Office space available for lease at 10260 Meanley Dr. in San Diego, suitable for a range of professional uses.

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    Office Suites with Secured Parking
    Office Suites with Secured Parking

    4901 Morena Blvd, San Diego, CA 92117

    Full service Bay Ho
    Contact for pricing
    4–6 people  1,042 sqft
    Highway access

    Office space offering 24-hour access through a secured gate and on-site fitness amenities.

    Fitness room  Basketball court  Deli  Outside picnic & social areas
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    Office Space with Private Offices
    Office Space with Private Offices

    2750 Womble Rd, San Diego, CA

    Loma Portal
    Contact for pricing
    11–18 people  2,760 sqft  2.99 acres

    Available office space featuring private offices, reception, and conference room.

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    Commercial Office Space Available
    Commercial Office Space Available

    401 B Street, San Diego, CA 92101

    Core-Columbia
    $26.40 SF/Yr
    1 space  Built 1983

    Office space for rent in San Diego, CA.

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    La Jolla Office Space Available
    La Jolla Office Space Available

    San Diego, CA

    Little Italy
    Contact for pricing
    8–14 people  6 spaces  2,150 sqft  0.42 acres

    Office space available for lease in La Jolla, California.

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    Flex Space with Private Offices
    Flex Space with Private Offices

    4901 Morena Blvd, San Diego, CA 92117

    Triple net (NNN) Bay Ho
    Contact for pricing
    1,612 sqft

    Flex space offering reception, five private offices, and warehouse area with one ground-level (GL) door.

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    Mirrored-Glass Office Units
    Mirrored-Glass Office Units

    2810 Camino Del Rio South, San Diego, CA 92108

    Mission Valley East
    Contact for pricing
    Highway access

    Landscaped common areas and access to major freeways serve this Mission Valley office property.

    Landscaped common areas
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    Miramar Flex Space Available
    Miramar Flex Space Available

    5260 Eastgate Mall, San Diego, CA

    University City
    Contact for pricing
    2,750 sqft

    Flex space in Western Miramar, close to I-805 and I-5.

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    Most Searched ZIP Codes in San Diego, CA

    • 92121
    • 92101
    • 92123
    • 92130
    • 92108
    • 92128
    • 92037
    • 92127
    • 92131
    • 92110
    • 92111
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