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    Mixed-Use

    San Diego, CA Mixed-use Properties for Lease

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    Coronado, CA National City, CA Chula Vista, CA Lemon Grove, CA La Mesa, CA Spring Valley, CA Bonita, CA Imperial Beach, CA
    8 properties
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    Renovated Live-Work Space
    Updated: Sep 7
    Renovated Live-Work Space

    4741 Point Loma, San Diego, CA 92106

    $12,000/Mo
    1,626 SF of ground‑floor commercial space in two connected areas
    1,750 square foot residence with four bedrooms, two baths, ocean views, and a private deck
    613 square feet of finished storefront plus a 263 square foot covered breezeway
    750 square feet of open flex space with a roll‑up door for alley loading
    Built 2016 with ADA‑compliant features and dedicated on‑site parking
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    Live-Work Property with Separate Commercial Building
    Updated: Sep 26
    Live-Work Property with Separate Commercial Building

    2971 Imperial Avenue, San Diego, CA 92102

    Contact for pricing
    700 sqft
    Detached residence with approximately 1,050 SF, 3 bedrooms and 2.5 bathrooms
    Separate commercial building with approximately 700 SF, fronting Imperial Avenue
    Newly built covered patio
    Gated driveway with alley access and parking for 6+ vehicles
    Remodeled residence with higher‑end finishes
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    Mixed-Use Property with Loading
    Mixed-Use Property with Loading

    8252-8280 Clairemont Mesa Boulevard, San Diego, CA 92111

    Kearny Mesa
    Contact for pricing
    Multi-tenant  2,932 sqft

    The San Diego park offers industrial and retail space, with building and monument signage available.

    Building and monument signage
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    San Diego Commercial Space Available
    San Diego Commercial Space Available

    9360-9420 Activity Rd., San Diego, CA 92126

    Mira Mesa
    Contact for pricing
    8,472 sqft  Built 2026

    Commercial space for lease in San Diego, California.

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    Mixed-Use Property with Hotel Suites
    Mixed-Use Property with Hotel Suites

    2611 Adams Avenue, San Diego, CA 92116

    Mission Valley East
    Contact for pricing
    Built 2025 / renov 2025

    Furnished lodging suites operate alongside a separately leased restaurant component.

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    Mixed-Use Property with Retail Space
    Mixed-Use Property with Retail Space

    San Diego, CA 92116

    Adams North
    Contact for pricing

    Retail space is paired with five apartments, with alley access and on-site parking.

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    San Diego Commercial Space For Lease
    San Diego Commercial Space For Lease

    17066 Goldentop Rd., San Diego, CA 92127

    Black Mountain Ranch
    Contact for pricing
    Built 2026

    Mixed-use, retail, office, and industrial spaces available for lease.

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    Gaslamp City Square Retail Space
    Gaslamp City Square Retail Space

    425-445 Island Ave, San Diego, CA

    Gaslamp
    Contact for pricing
    3,333 sqft

    Mixed-use property in the heart of San Diego's Gaslamp Quarter.

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    8 active listings match your search: Mixed-Use for lease in San Diego, CA. Based on your search, we've also compiled 46 Potential Opportunities for your consideration: 4 spaces in nearby cities and 42 properties for sale.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Mixed-Use Office and Retail Building
    Mixed-Use Office and Retail Building

    264 N Coast Hwy 101, Encinitas, CA 92024

    Contact for pricing
    1,730 sqft

    The property offers a flexible setting for office or retail occupancy.

    View details
    Mixed-Use Space with Private Office
    Mixed-Use Space with Private Office

    207-209 Third Ave, Chula Vista, CA 91910

    North Chula Vista
    Contact for pricing
    370 sqft

    An open customer-facing area is accompanied by a hand sink and separate office.

    Open retail floor/reception area  Private office  Hand sink
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    Mixed-Use Retail and Office Building
    Mixed-Use Retail and Office Building

    264-266 N Coast Hwy 101, Encinitas, CA 92024

    Contact for pricing
    1,730 sqft building

    The property combines retail and office space in one building along North Coast Highway 101.

    View details
    Retail Space in Otay Ranch
    Retail Space in Otay Ranch

    1445 Town Center Dr, Chula Vista, CA

    Hilltop
    Contact for pricing
    736 sqft

    Streetfront retail space in a new mixed-use development.

    View details

    Similar Spaces for Sale in San Diego, CA

    Consider Similar Space for Sale. We found 42 Spaces matching your search parameters.

    Mixed-Use Property with Residence
    Mixed-Use Property with Residence

    2971 Imperial Avenue, San Diego, CA 92102

    $1,080,000
    1,775 sqft 0.13 AC lot

    A detached home and separate street-facing commercial building share a gated site with alley access.

    View details
    Mixed-Use Building with Storefront
    Mixed-Use Building with Storefront

    4741 Point Loma, San Diego, CA 92107

    $2,295,000
    3,376 sqft

    Two commercial spaces occupy the lower level, with a four-bedroom residence above.

    View details
    Four-Story Mixed-Use Building
    Four-Story Mixed-Use Building

    920 Kline Street, La Jolla, CA 92037

    $5,800,000
    20,000 sqft 1.50 AC lot

    Mixed retail and office occupancy is supported by an updated elevator and private baths in many suites.

    View details
    Mixed-Use Property with Alley Access
    Mixed-Use Property with Alley Access

    1434-44 Garnet Ave, San Diego, CA 92109

    $1,695,000
    1,622 sqft 0.14 AC lot

    Retail/office space includes a detached studio and rear open area.

    View details
    Mixed-Use Building with Retail Space
    Mixed-Use Building with Retail Space

    3580 Adams Ave, San Diego, CA 92116

    $2,250,000
    3,690 sqft 0.15 AC lot

    Retail space and five apartments share the property, with alley access and on-site parking.

    View details
    Mixed-Use Building with Live-Work Layout
    Mixed-Use Building with Live-Work Layout

    3236 National Ave, San Diego, CA 92113

    $979,000
    1,730 sqft

    Commercial space occupies the lower level, with shopkeeper quarters above.

    View details
    Mixed-Use Property with Retail Frontage
    Mixed-Use Property with Retail Frontage

    3783-89 Park Blvd, San Diego, CA 92103

    $3,750,000
    7,310 sqft

    Eight residences include studios, cottages, and duplex units, with an on-site laundry room serving the property.

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    Mixed-Use Storefront Property
    Mixed-Use Storefront Property

    3275 Euclid, San Diego, CA 92105

    $900,000
    0.11 AC lot

    Corner-lot commercial property with storefront space and separate entrances.

    View details
    Retail Strip Center with Monument Signage
    Retail Strip Center with Monument Signage

    7878 CLAIREMONT MESA BLVD, San Diego, CA 92111

    Contact for pricing
    13,671 sqft

    A mix of established tenants occupies the center, with parking around the building and several entry and exit points.

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    Corner-Lot Mixed-Use Building
    Corner-Lot Mixed-Use Building

    2754 Imperial Avenue, San Diego, CA 92102

    Contact for pricing
    4,272 sqft 0.13 AC lot

    Private offices, four restrooms, a kitchenette, and on-site parking accommodate flexible commercial occupancy.

    View details
    Mixed-Use Property with Residence
    Mixed-Use Property with Residence

    4741 Point Loma Ave, San Diego, CA 92106

    Contact for pricing
    3,376 sqft

    Three-part configuration combines commercial suites with a two-level upper residence.

    View details
    Mixed-Use Development Site
    Mixed-Use Development Site

    4210 40 th Street, San Diego, CA 92105

    $1,100,000
    1,128 sqft

    CUPD-CU-2-4 zoning supports residential, commercial, and mixed-use development.

    View details
    Live-Work Space with Two Offices
    Live-Work Space with Two Offices

    2487 Kettner Blvd, San Diego, CA 92101

    $1,149,000
    1,610 sqft 0.02 AC lot

    Commercially zoned property with two kitchens, an upgraded full bath, and mixed-use flexibility for office or residential use.

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    Single-Tenant Mixed-Use Building
    Single-Tenant Mixed-Use Building

    2317 Hotel Circle South, San Diego, CA 92108

    Contact for pricing
    9,240 sqft 1.86 AC lot

    Two-story retail and office asset with CO-2-2 zoning and on-site parking.

    View details
    Freestanding Mixed-Use Lab Building
    Freestanding Mixed-Use Lab Building

    9955 Mesa Rim Rd, San Diego, CA 92121

    Contact for pricing
    15,853 sqft 5.45 AC lot

    Renovation plans include facade and landscaping upgrades, with warehouse and laboratory infrastructure already in place.

    View details
    Renovated Mixed-Use Portfolio
    Renovated Mixed-Use Portfolio

    3131-57 Adams Avenue, San Diego, CA 92116

    Contact for pricing
    7,520 sqft 0.35 AC lot

    Two adjacent properties combine apartments, retail suites, and updated residential interiors.

    View details

    San Diego, CA Mixed-use properties Lease Rates & Market Statistics

    Explore 8 Mixed-use properties for lease in San Diego, CA on Realmo, a commercial real estate exchange covering the San Diego area. The current inventory totals 15,437 square feet of properties.

    Mixed-use properties lease rates in San Diego range from $12,000/Mo at the entry level to $12,000/Mo at the top of the market, averaging $12,000/Mo. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings.

    San Diego accounts for 44% of the 18 mixed-use properties currently available across San Diego County, where nearby markets include Encinitas and Carlsbad.

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    Browse Mixed-use properties for Lease Near San Diego, CA

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    Most Searched ZIP Codes in San Diego, CA

    • 92116
    • 92102
    • 92106
    • 92110
    • 92111
    • 92126
    • 92127

    Featured San Diego Real Estate Agencies

    Realmo connects you with licensed San Diego CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Century 21 Horizon
    4134 Adams Ave., #101 San Diego, CA 92116
    Phone: (619) 280-5888
    www.century21horizon.com
    Keller Williams San Diego Metro
    3965 5th Avenue Suite 300 San Diego, CA 92103
    Phone: (619) 233-5935
    www.kwmetro.com
    Hacienda Realty
    4683 Pt. Loma Ave. San Diego, CA 92107
    Phone: (619) 417-4493
    www.haciendasd.com
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