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    San Diego, CA Mixed-use Properties for Lease

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    Coronado, CA National City, CA Chula Vista, CA
    14 listings
    Mixed-Use Corner Retail & Residential
    $4,700,000 SF/Yr
    7,600 SF
    Mixed-Use Corner Retail & Residential

    1051 Rosecrans St, San Diego, CA 92106

    Four ground-floor retail suites and four residential units on a prominent corner in Point Loma.
    • Mixed‑use property with 4 ground‑floor retail suites and 4 residential units on a prominent corner of Rosecrans St and Upshur St
    • Approximately 7,600 SF total rentable area combining retail and residential income streams
    • Currently occupied retail with tenants including Define Lagree Fitness, Compass, Rose Tattoo, and Max Fitness
    • Retail frontage along Rosecrans St, a primary corridor in Point Loma
    • WalkScore 81 (very walkable) and transitScore 30 (some transit)
    Updated: Jun 25
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    Creative East Village Office Space
    Contact for pricing
    6,000 SF
    Creative East Village Office Space

    750 11th Ave, San Diego, CA

    Unique 6,000 SF creative office space in East Village.
    • Multi‑family apartment project with 16 live/work units.
    • Street level parking for 17 vehicles.
    • Creative 6,000 +/- SF office property.
    • Suited to creative businesses.
    • Exposed elements, sealed concrete floors, sandblasted brick walls and wood truss ceilings.
    Updated: Mar 21, 2025
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    Mixed-Use Property in Banker’s Hill
    Contact for pricing
    3,106 SF
    Mixed-Use Property in Banker’s Hill

    Mixed-use property centrally located in San Diego’s Banker’s Hill.

    6th Ave & Upas St, San Diego, CA

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    Mixed-Use Property in Banker's Hill
    Contact for pricing
    2,427 SF
    Mixed-Use Property in Banker's Hill

    Mixed-use property in Banker’s Hill, centrally located and under construction.

    3366 6th Ave, San Diego, CA

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    Retail Space in Banker’s Hill
    Contact for pricing
    883 SF
    Retail Space in Banker’s Hill

    Mixed-use property in desirable Banker’s Hill neighborhood.

    3333-3343 5th Ave, San Diego, CA

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    Retail Space in Little Italy
    Contact for pricing
    644 SF
    Retail Space in Little Italy

    Retail space available in vibrant Little Italy neighborhood, San Diego.

    1900-1980 Kettner Blvd, San Diego, CA

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    Mixed-Use Property in San Diego
    Contact for pricing
    3,103 SF
    Mixed-Use Property in San Diego

    Mixed-use property offering shopping, dining, and luxury apartments.

    3725 Paseo Pl, San Diego, CA

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    Mission Blvd Retail/Office Space
    Contact for pricing
    1,090 SF
    Mission Blvd Retail/Office Space

    Retail and office spaces available in high-profile mixed-use project.

    4105-4175 Mission Blvd, San Diego, CA

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    Liberty Station Mixed-Use Community
    Contact for pricing
    350,000 SF
    Liberty Station Mixed-Use Community

    Mixed-use community with restaurants, shops, residences, and office space.

    2495 Truxtun Rd, San Diego, CA 92106

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    Gaslamp City Square Retail Space
    Contact for pricing
    3,333 SF
    Gaslamp City Square Retail Space

    Mixed-use property in the heart of San Diego's Gaslamp Quarter.

    425-445 Island Ave, San Diego, CA

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    San Diego Commercial Space For Lease
    Contact for pricing
    San Diego Commercial Space For Lease

    Mixed-use, retail, office, and industrial spaces available for lease.

    17066 Goldentop Rd, San Diego, CA 92127

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    Sorrento Valley Commercial Space Available
    $27 SF/Yr
    Sorrento Valley Commercial Space Available

    Commercial spaces for lease in Sorrento Valley, San Diego.

    11839-11855 Sorrento Valley Road, San Diego, CA 92121

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    Mixed-Use Property in Hillcrest San
    $44 SF/Yr
    Mixed-Use Property in Hillcrest San

    Mixed-use property in Hillcrest near retail, medical, and office spaces.

    3940 Fourth Avenue, San Diego, CA 92103

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    San Diego Commercial Space Available
    $2 SF/Yr
    San Diego Commercial Space Available

    Commercial space for lease in San Diego, California.

    9360-9420 Activity Rd, San Diego, CA 92126

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    Based on your search, we've compiled 64 Potential Opportunities for your consideration. Besides 14 Active listings in San Diego, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 42 Properties for Sales.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Second-Floor Creative Office Suite
    $2,195/Mo
    800 SF
    Second-Floor Creative Office Suite

    Open second-floor suite with air conditioning and golf course views, plus included internet and access to a shared conference room.

    2377 S El Camino Real, San Clemente, CA 92672

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    Mixed-Use Building in Prime Location
    $3 SF/Yr
    25,000 SF
    Mixed-Use Building in Prime Location

    Mixed-use building with ample parking in South Orange County.

    1001 Avenida Pico, San Clemente, CA 92673

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    Retail Space in Otay Ranch
    Contact for pricing
    736 SF
    Retail Space in Otay Ranch

    Streetfront retail space in a new mixed-use development.

    1445 Town Center Dr, Chula Vista, CA

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    Retail Space in Mixed-Use Project
    Contact for pricing
    1,216 SF
    Retail Space in Mixed-Use Project

    Retail space for lease in Otay Ranch master plan.

    1970 Avenida Escaya, Chula Vista, CA

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    Similar Spaces for Sale in San Diego, CA

    Consider Similar Space for Sale. We found 42 Spaces matching your search parameters.

    Mixed-Use Property Near U.S.-Mexico Border
    $4,099,000
    7,989 SF
    Mixed-Use Property Near U.S.-Mexico Border

    High-visibility, seven-unit mixed-use property in San Ysidro.

    165 W San Ysidro Blvd, San Ysidro, CA 92173

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    Mixed-Use Corner Property with Office
    $4,890,000
    3,750 SF
    Mixed-Use Corner Property with Office

    Five-unit mixed-use asset with a long-term leased office and extensively remodeled residential units, plus upgraded building systems.

    110 Maple, San Diego, CA 92103

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    Bankers Hill Mixed-Use Opportunity
    $2,849,000
    3,800 SF
    Bankers Hill Mixed-Use Opportunity

    Three-story mixed-use building in Bankers Hill with flexible zoning.

    2368 2nd AVE, San Diego, CA 92101

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    Historic Mixed-Use Property in San Diego
    $1,799,000
    0.10 Acres
    Historic Mixed-Use Property in San Diego

    Unique mixed-use property in Barrio Logan with income potential.

    2174 Logan Ave, San Diego, CA 92113

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    San Ysidro Mixed-Use Investment Opportunity
    $4,099,000
    7,989 SF
    San Ysidro Mixed-Use Investment Opportunity

    New 7-unit mixed-use property near U.S.-Mexico border.

    165 W San Ysidro Blvd, San Ysidro, CA 92173

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    Mixed-Use Trophy Property, Bankers Hill
    $4,890,000
    0.13 Acres
    Mixed-Use Trophy Property, Bankers Hill

    Rare mixed-use property in prime Bankers Hill location.

    110 Maple St, San Diego, CA 92103

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    Remodeled Office and Retail Building
    $1,189,000
    1,778 SF
    Remodeled Office and Retail Building

    Three mixed-use units with extensive upgrades, positioned for office or retail uses in Hillcrest near the 163.

    825-829 Washington St., San Diego, CA 92103

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    Live-Work Office Property
    $1,149,000
    1,610 SF
    Live-Work Office Property

    Two office spaces plus a garage flex space offer live-work conversion options in a mixed-use commercial zone.

    2487 Kettner Blvd, San Diego, CA 92101

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    Landmark Multifamily Investment Opportunity
    $4,995,000
    5,506 SF
    Landmark Multifamily Investment Opportunity

    Signature income property in prime San Diego location.

    3574 4th Ave. (-80), San Diego, CA 92103

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    Mixed-Use Property in Opportunity Zone
    $900,000
    3,450 SF
    Mixed-Use Property in Opportunity Zone

    Five-unit mixed-use property with redevelopment potential in San Diego.

    55 Ocean View Blvd, San Diego, CA 92113

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Fontana Commercial Land Lease
    $0.01 SF/Yr
    1,565 SF
    Prime Fontana Commercial Land Lease

    4.33-acre commercial land for ground lease in Fontana, CA.

    16203 Foothill Boulevard, Fontana, CA 92335

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    High Visibility Land For Lease
    Contact for pricing
    High Visibility Land For Lease

    1.41 acres at signalized intersection available for ground lease.

    1400 Willow Pass Rd, Concord, CA 94520

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    Highway 9 Development Opportunity
    Contact for pricing
    Highway 9 Development Opportunity

    32.55 acres for mixed-use development along Highway 9.

    1800 Ann Branden Blvd, Norman, OK 73069

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    Cleared Commercial Lot For Lease
    Contact for pricing
    Cleared Commercial Lot For Lease

    1.33-acre commercial lot in growing New Braunfels market.

    943 King Arthur, New Braunfels, TX 78130

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    San Diego, CA Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in San Diego, CA with 14 listings featured on our commercial real estate exchange. The current inventory includes 370,586 square feet of properties with an estimated lease value of $73 SF/Yr.

    Estimated lease rates for Mixed-use properties in San Diego, CA begin at $2 SF/Yr, with an average of $24 SF/Yr and extend to $44 SF/Yr.
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    Most Searched ZIP Codes in San Diego, CA

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