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    National City, CA Office Spaces for Lease

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    Office Building For Lease
    Updated: Jul 17
    Office Building For Lease

    502 Euclid Ave., National City, CA 91950

    Contact for pricing
    6,113 sqft
    Office building built in 2026
    For rent at 502 Euclid Ave, National City, CA
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    Three-Story Office/R&D Building
    Updated: Aug 19, 2025
    Three-Story Office/R&D Building

    401 Mile of Cars Way, National City, CA 91950

    Contact for pricing
    23,721 sqft 10.43 AC lot
    Approximately 190,000 SF three‑story office/R&D building on 10.43 acres
    60,000 SF floor plates
    Zoned MCR‑2 (mixed use commercial/residential)
    Immediately adjacent to Interstate 5; SR‑54 less than one‑half mile south
    Adjacent to the 24th Street Transit Center (trolley and bus service)
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    Renovated Medical Office Suites
    Renovated Medical Office Suites

    610 Euclid Avenue, National City, CA 91950

    Contact for pricing

    Medical suites include existing clinical improvements and electrical utilities under a Full Service Gross lease structure.

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    Flex Warehouse with Office
    Flex Warehouse with Office

    921 Coolidge Ave, National City, CA 91950

    Contact for pricing
    3,538 sqft

    Flex space with grade level access, one restroom, and a 13.5-foot clear height warehouse.

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    National City Mixed-Use Building
    National City Mixed-Use Building

    921 Coolidge Ave, National City, CA

    Contact for pricing
    3,538 sqft 0.11 AC lot

    Mixed-use building in National City with office, retail potential.

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    Medical Office Space
    Medical Office Space

    502 Euclid Ave, National City, CA 91950

    Contact for pricing
    1,746 sqft

    Medical office space adjacent to Paradise Valley Hospital with building-wide renovation underway.

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    Renovating Medical Office Suite
    Renovating Medical Office Suite

    502 Euclid Ave, National City, CA 91950

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    1,372 sqft

    Medical office space adjacent to Paradise Valley Hospital, offered with full-service gross including electrical, janitorial, and medical waste pickup.

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    Medical Office Space For Lease
    Medical Office Space For Lease

    502 Euclid Ave, National City, CA 91950

    Contact for pricing

    Medical office space available for lease.

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    Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 8 Active listings in National City, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Creative Office Suite with Private Restroom
    Creative Office Suite with Private Restroom

    221 3rd Ave, Chula Vista, CA 91910

    Contact for pricing
    620 sqft

    Creative suite with an open layout, abundant natural light, private in-suite restroom, and operable window doors for fresh air.

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    Creative Office with Boutique Flex Use
    Creative Office with Boutique Flex Use

    221 3rd Ave, Chula Vista, CA 91910

    Contact for pricing
    650 sqft

    Suite offers an open layout with natural light, high ceilings, wood-style flooring, and a private in-suite restroom.

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    Office Space Available For Rent
    Office Space Available For Rent

    5106 Federal Blvd., #201, San Diego, CA 92105

    $21 SF/Yr

    Office space available for rent in San Diego, CA.

    View details
    Office/Medical Space for Lease
    Office/Medical Space for Lease

    5106 Federal Blvd, San Diego, CA

    Contact for pricing
    1,457 sqft 0.85 AC lot

    Office and medical space with updated finishes and free parking.

    View details

    Similar Spaces for Sale in National City, CA

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    Renovated Multi-Building Office Property
    Renovated Multi-Building Office Property

    124 E 30th St, National City, CA 91950

    Contact for pricing
    18,908 sqft

    Three renovated, two-story office buildings total approximately 18,908 rentable square feet.

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    Four-Unit Mixed-Use Property
    Four-Unit Mixed-Use Property

    1343-45 Highland Avenue, National City, CA 91950

    Contact for pricing
    1,908 sqft

    Combines rear residential units with two commercial suites along a designated mixed-use corridor.

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    Four-Unit Mixed-Use Property
    Four-Unit Mixed-Use Property

    1343 45 Highland Ave, National City, CA 91950

    $895,000

    Combines rear residential units with two ground-floor commercial suites fronting Highland Avenue.

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    Warehouse Property with Secured Yard
    Warehouse Property with Secured Yard

    225 W 30th St, National City, CA 91950

    Contact for pricing
    46,454 sqft 2.29 AC lot

    Industrial-zoned warehouse property with paved, fenced outdoor storage and substantial office space.

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    National City Retail/Office Space
    National City Retail/Office Space

    801 National City Blvd, National City, CA 91950

    Contact for pricing
    4,464 sqft

    Retail and office space with dedicated parking in National City.

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    National City, CA Office Spaces Lease Rates & Market Statistics

    Browse 8 Office Spaces for lease in National City, CA on Realmo, a commercial real estate marketplace serving the National City area. The current inventory totals 40,028 square feet of properties.

    National City accounts for 1% of the 1,291 office spaces currently available across San Diego County, where nearby markets include San Diego and Carlsbad. By space type, the market includes 4 medical office space listings and 3 office units.

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