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    San Diego, CA Office Spaces for Lease

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    Found 558 office space listings for lease in San Diego, CA, averaging $21/SF/YR. Use lease type data to compare options faster.
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    San Diego Office Space Available
    San Diego Office Space Available

    9245 Sky Park Ct, San Diego, CA

    Kearny Mesa
    Contact for pricing
    5–9 people  2 spaces  1,474 sqft  2.56 acres

    Office space available for lease in San Diego, CA.

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    First-Floor Office Suite
    First-Floor Office Suite

    10935 Vista Sorrento Pkwy, San Diego, CA 92130

    Coworking Torrey Pines
    Contact for pricing
    59–99 people  14,916 sqft

    First-floor space with FF&E available, including flexible workstations, private offices, conference rooms, and multiple break areas.

    Furnished  Flexible workstations  Private offices  Conference rooms
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    San Diego Office Space Available
    San Diego Office Space Available

    17095 Via Del Campo Ct, San Diego, CA

    Rancho Bernardo
    Contact for pricing
    205–342 people  51,338 sqft  28.17 acres

    Available office space in San Diego, California.

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    Office Space with Exterior Patios
    Office Space with Exterior Patios

    6170 Cornerstone Ct E, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    13–22 people  1 space  3,313 sqft
    Highway access

    Office space features a glass-lined frontage, operable windows, and exterior patios, with convenient surface and covered parking.

    WI-FI in the common area courtyard  Operable windows and exterior patios  Reserved covered parking available
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    Second-Floor Office Suite
    Second-Floor Office Suite

    11403 West Bernardo Ct, San Diego, CA 92127

    Modified gross Rancho Bernardo
    Contact for pricing
    12–20 people  1 space  3,050 sqft

    Second-floor office suite with open work area, five private offices, and extensive window line.

    Conference room  Breakroom  Server room  Two restrooms
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    Office Suite with Combination Potential
    Office Suite with Combination Potential

    3710 Ruffin Rd, San Diego, CA 92123

    Full service Serra Mesa
    Contact for pricing
    61–103 people  1 space  15,476 sqft

    Office suite space available for lease, with option to combine Suite B with Suite A for expanded occupancy.

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    Class A Office Space Available
    Class A Office Space Available

    8889 Rio, San Diego, CA 92108

    Mission Valley East
    Contact for pricing

    Two-story, 29,639 SF office space with freeway access.

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    San Diego Office Space Available
    San Diego Office Space Available

    9373 Hazard Way, San Diego, CA

    Full service Kearny Mesa
    Contact for pricing
    6–10 people  2 spaces  1,540 sqft  0.48 acres

    Office space for rent in San Diego, 3,790 SF available.

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    Two-Story Garden Office Suites
    Two-Story Garden Office Suites

    7510-7514 Clairemont Mesa Blvd, San Diego, CA 92111

    Full service Clairemont Mesa East
    Contact for pricing
    3–5 people  5 spaces  889 sqft  2-story
    Highway access

    Two-suite office setup with reception and full HVAC, offering glass-lined space and strong freeway access for daily operations.

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    Office Suite for Lease
    Office Suite for Lease

    9605 Scranton Rd., #200, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    Built 2026

    Office suite #200 available for lease at 9605 Scranton Rd.

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    Class A Medical Office Space
    Class A Medical Office Space

    9095 Rio San Diego Dr, San Diego, CA 92108

    Mission Valley East
    Contact for pricing
    1,760 sqft
    Highway access

    Class A medical office space with renovated common areas and restrooms, plus convenient freeway and trolley access.

    Renovated common area and restrooms
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    Office Building Sublease Space
    Office Building Sublease Space

    9665 Chesapeake Dr, San Diego, CA 92123

    Kearny Mesa
    Contact for pricing
    27–46 people  6,918 sqft

    Office sublease available with flexible space ranging from 2,500 to 6,918 SF.

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    24-Hour Access Office Suites
    24-Hour Access Office Suites

    3914 Murphy Canyon Rd, San Diego, CA 92123

    Full service Kearny Mesa
    Contact for pricing
    3–5 people  1 space  779 sqft
    Highway access

    Office suites with individual suite identification, conference facilities, and ample parking in a professionally managed building.

    On-Site Deli  On-Site Fitness Room  Conference Facilities  Ample Parking Available
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    Office Suites with 24-Hour Access
    Office Suites with 24-Hour Access

    3914 Murphy Canyon Rd, San Diego, CA 92123

    Full service Kearny Mesa
    Contact for pricing
    4–7 people  1 space  1,163 sqft

    Office suites offer conference facilities, on-site deli and fitness room, plus ample parking and 24-hour access.

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    Class A Office Building with Fitness Center
    Class A Office Building with Fitness Center

    13480 Evening Creek Dr N, San Diego, CA 92128

    Class A Sabre Springs
    Contact for pricing
    19–31 people  4,759 sqft
    Public transit

    Class A office building with on-site management, EV charging, and a fitness center with shower and locker facilities.

    4.0/1,000 SF parking  Fitness center with shower and locker facilities  Outdoor meeting areas with free WiFi  EV charging stations
    View details
    Open-Layout Office Suite
    Open-Layout Office Suite

    600 B St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    31–51 people  7,764 sqft

    Office suite with an open layout and double doors off the lobby corridor.

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    Office Space for Lease
    Office Space for Lease

    17190 Bernardo Center Dr, San Diego, CA 92128

    Rancho Bernardo
    Contact for pricing
    37–63 people  9,471 sqft

    Office space is available between 14,487 and 41,092 SF for lease at 17190 Bernardo Center Dr.

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    San Diego Office Space Available
    San Diego Office Space Available

    5333 Mission Center Rd, San Diego, CA

    Mission Valley East
    Contact for pricing
    11–18 people  2,844 sqft  7.52 acres

    Office space featuring reception, offices, breakroom, and courtyard access.

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    Garden Office Courtyard Suite
    Garden Office Courtyard Suite

    10505 Sorrento Valley Rd, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    7–12 people  1 space  1,907 sqft
    Highway access

    Garden-style courtyard office space with operable windows, showers, and a common conference room.

    Monument signage  Garden style courtyard  Common area conference room  Showers
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    Two-Story Elevator Served Office Building
    Two-Story Elevator Served Office Building

    9320 Chesapeake Dr, San Diego, CA 92123

    Kearny Mesa
    Contact for pricing
    2–3 people  1 space  525 sqft  2-story
    Highway access

    Recently renovated office building with updated common areas and new restrooms, conveniently accessible to major freeways.

    3.5/1,000 SF parking
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    High-End Office Space Available
    High-End Office Space Available

    10920 Via Frontera, San Diego, CA

    Rancho Bernardo
    Contact for pricing
    14–24 people  3,685 sqft  2.62 acres

    Top floor office space with scenic views and upgraded finishes.

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    Loft-Style Office Building
    Loft-Style Office Building

    5893 Oberlin Dr, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    160–266 people  40,000 sqft

    Loft-style, two-story office space with skylights and prominent signage visibility along Mira Mesa Blvd.

    3.9/1,000 SF parking  Bike/wetsuit storage  Skylights  Prominent signage opportunities
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    Office/Medical Space Available
    Office/Medical Space Available

    10455 Pacific Center Court, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing

    Office and medical space for rent in San Diego.

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    Third-Floor Office Space with Natural Light
    Third-Floor Office Space with Natural Light

    1350 Columbia St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    11–18 people  1 space  2,752 sqft  Built 2007
    Public transit  Highway access

    Third-floor office with natural light, exposed HVAC, and concrete walls and ceilings in the MetroWork building.

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    Most Searched ZIP Codes in San Diego, CA

    • 92121
    • 92101
    • 92123
    • 92130
    • 92108
    • 92128
    • 92037
    • 92127
    • 92131
    • 92110
    • 92111
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