Monroe County, NY Mixed-use properties for Rent & Lease

Updated: Jun 2

Mixed-Use Redevelopment Property

721-751 Pittsford Victor Road, Pittsford, NY 14534

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3,500 sqft

Mixed‑use redevelopment under new ownership
Retail and office opportunities ranging from 1,800 to 3,500 SF
Exposure to Route 96
Located in Bushnell’s Basin
721‑751 Pittsford Victor Road, Pittsford, NY 14534

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Updated: Sep 25, 2025

Rochester Mixed-Use Complex for Lease

1280 Scottsville Road, Rochester, NY 14624

$9 SF/Yr

Excellent access to major highways including I‑390, I‑490, I‑590, and the NYS Thruway.
Centrally located to the City of Rochester and surrounding suburbs.
Mixed‑use complex offering office, retail, and flex spaces.
Grade level doors provide convenient access.
Signage available facing Scottsville Road, offering great visibility.

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Mixed-Use Building with Mezzanine Office

739 S Clinton Ave, Rochester, NY 14620

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6,113 sqft

Completely redeveloped in 2016 and includes private restrooms, changing rooms, and a mezzanine office with on-site free parking.

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Mixed-Use Property on Erie Canal

40 Clinton Street, Brockport, NY 14420

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Renovated mixed-use property with canal views and income potential.

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SkyView On The Ridge

Medley Centre Parkway, Rochester, NY 14622

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Mixed-use property with high visibility and competitive lease rates.

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Downtown Rochester Mixed-Use Building

65 W Broad St, Rochester, NY 14614

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Mixed-use building in Rochester's Four Corners neighborhood with modern amenities.

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Corner Location Business/Investment Opportunity

3913 Rush Mendon Rd, Mendon, NY 14506

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High-exposure corner location suitable for office, retail, or business.

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Downtown Rochester Mixed-Use Building

87 N Clinton Ave, Rochester, NY

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18,624 sqft 0.33 AC lot

Mixed-use building with office, lofts, and retail spaces.

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Loft-Style Mixed-Use Property

80 Rockwood Pl, Rochester, NY 14610

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50,000 sqft

50,000 SF mixed-use property suitable for office or retail.

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Elmgrove Crossings Commercial Space

700 Mile Crossing Blvd, Rochester, NY 14624

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Conveniently located commercial space with immediate expressway access.

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East Rochester Office/Medical/Flex Space

105 Despatch Dr, East Rochester, NY 14445

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3.00 AC lot

Class B office/medical/flex space in central Eastside location.

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Based on your search, we've compiled 94 Potential Opportunities for your consideration. Besides 11 Active listings in Monroe County, NY, we suggest exploring alternatives. Similar 83 Properties for Sales.

Similar Spaces for Sale in Monroe County, NY

Consider Similar Space for Sale. We found 83 Spaces matching your search parameters.

Mixed-Use Building with Retail Space

2322 Lyell Avenue, Gates, NY 14606

$1,349,999

8,448 sqft

Two suites combine street-level retail with second-floor office space.

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Two-Story Mixed-Use Property

495 Hudson Avenue, Rochester, NY 14605

$175,000

7,148 sqft 0.32 AC lot

Unfinished interiors, three parcels, and separate structures create a substantial redevelopment project near downtown Rochester.

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Two-Story Mixed-Use Building

1600 Lyell Ave, Rochester, NY 14606

$990,000

18,900 sqft

Fully leased retail space below is paired with five vacant upper-level suites for future occupancy.

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Renovated Mixed-Use Property

2264 Clifford Avenue, Rochester, NY 14609

$749,900

5,616 sqft

Two commercial units combine restaurant infrastructure with a flexible retail or office component.

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Mixed-Use Property with Rooftop Terrace

170-174 Griffith St, Rochester, NY 14607

$625,000

3,396 sqft

Separate entrances support distinct residential and commercial functions with flexible interior layouts.

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Two-Story Mixed-Use Property

1231 Ayrault Road, Fairport, NY 14450

$2,700,000

4,458 sqft 0.90 AC lot

Freestanding commercial building with a grocery-oriented business, apartment income, covered outdoor dining, and recent building upgrades.

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Historic Mixed-Use Building with Parking

383 Park Avenue, Rochester, NY 14607

$699,000

3,312 sqft

C-1-zoned property combines updated interiors with flexible two-level commercial space.

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Brick Mixed-Use Property

321 Driving Park Avenue, Rochester, NY 14613

$1,300,000

13,600 sqft 0.14 AC lot

Corner building combining residential apartments, commercial storefronts, storage, and recently upgraded common-area systems.

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Mixed-Use Property with Rooftop Terrace

170-174 Griffith Street, Rochester, NY 14607

$625,000

3,396 sqft 0.04 AC lot

Two separately entered components combine residential comfort with open commercial space and distinctive outdoor amenities.

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Mixed-Use Property with Rooftop Terrace

170174 Griffith Street, Rochester, NY 14607

$625,000

3,396 sqft

Two distinct spaces provide separate residential and commercial entrances beneath one roof.

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Mixed-Use Building with Laundromat

512 E Lyell Avenue, Rochester, NY 14606

$299,900

5,646 sqft 0.25 AC lot

Multifamily and commercial space occupy a brick building with a former laundromat area and billboard income component.

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Mixed-Use Building with Apartment

1541 E Main Street, Rochester, NY 14609

$134,900

3,783 sqft

Two-level property combines commercial space, residential accommodation, basement storage, a garage, and a rear yard.

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Mixed-Use Building with Apartment

606 Monroe Avenue, Rochester, NY 14607

$220,000

3,027 sqft 0.12 AC lot

Redevelopment-ready commercial space with a second-floor apartment and flexible occupancy options.

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