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    Hilton Head Island, SC Medical Office Space for Sale

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    Bluffton, SC Port Royal, SC Beaufort, SC
    7 listings
    Professional Office Condo with Income
    $769,000
    Professional Office Condo with Income

    70 Main Street, Suite 400 |, Hilton Head Island, SC 29926

    Multi-suite office condo with existing rental income in prime location.
    • Existing rental income from multiple tenants provides immediate financial benefit.
    • Flexible layout allows for owner‑occupancy while generating rental income.
    • Rare income‑producing office configuration, especially within the Main Street corridor of Hilton Head Island.
    • Prime Main Street location offers convenient access to the entire island.
    • Surrounded by a strong mix of professional services, medical offices, and upscale retail.
    Updated: Apr 1
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    Stand Alone Medical Office Building
    $1,348,000
    3,600 SF
    Stand Alone Medical Office Building

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926

    Stand-alone medical building on Hilton Head Island, ready for occupancy.
    • Stand‑alone medical building on Hilton Head Island.
    • Prime location on Main Street, north end of Hilton Head, with easy access to Highway 278.
    • Proximity to Hilton Head Hospital and surrounding professional area.
    • Ground‑floor layout with multiple exam rooms, waiting area, and private offices.
    • Plumbing in place for additional exam or treatment rooms.
    Updated: Jan 27
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    Stand Alone Medical Building
    $1,348,000
    Stand Alone Medical Building

    Stand-alone medical building on Hilton Head Island for sale.

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926

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    Two-Story Office Building on Hilton Head
    $1,950,000
    9,600 SF
    Two-Story Office Building on Hilton Head

    9,600 SF office building in prime Hilton Head location.

    5 Dunmore Court, Hilton Head Island, SC 29926

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    Hilton Head Office/Medical Space
    $375,000
    Hilton Head Office/Medical Space

    Office/Medical space for sale near Hilton Head Hospital.

    23 Main Street, Suite 303, Hilton Head Island, SC 29926

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    Medical Office Suite Near Hospital
    Contact for pricing
    750 SF
    Medical Office Suite Near Hospital

    Ground floor medical office suite near Hilton Head Hospital.

    23 Main Street, Suite 101-A, Hilton Head Island, SC 29926

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    Medical Office Suite Near Hospital
    Contact for pricing
    1,500 SF
    Medical Office Suite Near Hospital

    Ground floor medical office suite available near Hilton Head Hospital.

    23 Main Street, Suite 101-A, Hilton Head Island, SC 29926

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    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 7 Active listings in Hilton Head Island, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 24 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Leased Medical Space For Sale
    $628,148
    Leased Medical Space For Sale

    100% leased medical space with new long-term lease.

    14 Oak Forest Road, Bluffton, SC 29910

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    Office/Medical Suite Near Port Royal
    Contact for pricing
    1,484 SF
    Office/Medical Suite Near Port Royal

    1,484 SF office/medical suite for sale near Port Royal.

    1264 Ribaut Rd, Suite 302, Beaufort, SC 29902

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    Medical Office Suites For Sale
    $2,861,037
    6,808 SF
    Medical Office Suites For Sale

    Four medical office suites totaling 6808 sqft for sale.

    14 Oak Forest Rd, Bluffton, SC 29910

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    Highway Frontage Development Opportunity
    $1,250,000
    2.50 Acres
    Highway Frontage Development Opportunity

    Prime commercial land with high visibility and traffic count.

    205 Sea Island Parkway, Beaufort, SC 29907

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Beaufort Land for Sale
    $459,000
    7.32 Acres
    Beaufort Land for Sale

    7.32 acre commercial land in Beaufort, South Carolina.

    Goethe Hill Road lot: 3, Beaufort, SC 29906

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    Prime Commercial Pad Site, Hinesville
    $1,250,000
    7,000 SF
    Prime Commercial Pad Site, Hinesville

    High-visibility commercial land in Hinesville with strong growth potential.

    W Oglethorpe Highway lot: 1, Hinesville, GA 31313

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    Kingsland Commercial Lot For Sale
    $325,000
    1.85 Acres
    Kingsland Commercial Lot For Sale

    1.85-acre commercial lot off I-95 in Camden County, Georgia.

    1.85 AC Harrietts Bluff Road, Kingsland, GA 31569

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    Kingsland, GA Commercial Lot
    $250,000
    1.90 Acres
    Kingsland, GA Commercial Lot

    1.9-acre commercial lot off I-95 in up-and-coming growth corridor.

    1.9 AC Harrietts Bluff Road, Kingsland, GA 31569

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    Off-Market Properties in Hilton Head Island, SC

    Consider similar Off-Market properties in Hilton Head Island, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    35 Bill Fries Dr
    MEDICAL BUILDING
    2,330 SF Lot: 1.00 Acre
    Value Estimation by Request

    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730

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    35 Bill Fries Dr
    MEDICAL BUILDING
    1,986 SF Lot: 1.00 Acre
    Value Estimation by Request

    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730

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    845 William Hilton Pkwy
    MEDICAL BUILDING
    4,322 SF Lot: 0.96 Acres
    Estimated value
    $1,435,000

    845 William Hilton Pkwy, Hilton Head Island, SC 29928-3404

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    843 William Hilton Pkwy
    MEDICAL BUILDING
    7,471 SF Lot: 0.99 Acres
    Value Estimation by Request

    843 William Hilton Pkwy, Hilton Head Island, SC 29928-3444

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    18 Bethea Dr
    MEDICAL BUILDING
    10,984 SF Lot: 8.80 Acres
    Estimated value
    $20,900,000

    18 Bethea Dr, Hilton Head Island, SC 29926-4702

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    35 Bill Fries Dr
    MEDICAL BUILDING
    2,096 SF Lot: 1.00 Acre
    Value Estimation by Request

    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730

    View details
    460 William Hilton Pkwy
    MEDICAL BUILDING
    15,660 SF Lot: 2.58 Acres
    Estimated value
    $1,785,000

    460 William Hilton Pkwy, Hilton Head Island, SC 29926-2497

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    13 Lamotte Dr
    MEDICAL BUILDING
    3,750 SF Lot: 1.22 Acres
    Value Estimation by Request

    13 Lamotte Dr, Hilton Head Island, SC 29926-2743

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    190 Pembroke Dr
    MEDICAL BUILDING
    19,729 SF Lot: 5.46 Acres
    Value Estimation by Request

    190 Pembroke Dr, Hilton Head Island, SC 29926-2389

    View details
    9 Executive Park Rd Ste A
    MEDICAL BUILDING
    4,853 SF Lot: 0.41 Acres
    Value Estimation by Request

    9 Executive Park Rd Ste A, Hilton Head Island, SC 29928-4703

    View details
    35 Bill Fries Dr
    MEDICAL BUILDING
    2,992 SF Lot: 1.00 Acre
    Value Estimation by Request

    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730

    View details
    70 Shelter Cv Ln Ste A
    MEDICAL BUILDING
    23,077 SF Lot: 3.61 Acres
    Value Estimation by Request

    70 Shelter Cv Ln Ste A, Hilton Head Island, SC 29928-2005

    View details
    18 Hospital Ctr Blvd
    MEDICAL BUILDING
    2,016 SF Lot: 0.98 Acres
    Value Estimation by Request

    18 Hospital Ctr Blvd, Hilton Head Island, SC 29926-2733

    View details
    93 Main St
    MEDICAL BUILDING
    2,760 SF Lot: 1.05 Acres
    Value Estimation by Request

    93 Main St, Hilton Head Island, SC 29926-6613

    View details
    35 Bill Fries Dr
    MEDICAL BUILDING
    2,978 SF Lot: 1.00 Acre
    Value Estimation by Request

    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730

    View details
    3801 Main St
    MEDICAL BUILDING
    3,067 SF Lot: 0.83 Acres
    Value Estimation by Request

    3801 Main St, Hilton Head Island, SC 29926-1676

    View details
    12 Lafayette Pl
    MEDICAL BUILDING
    7,587 SF Lot: 1.08 Acres
    Value Estimation by Request

    12 Lafayette Pl, Hilton Head Island, SC 29926-2203

    View details

    Hilton Head Island, SC Medical Office Space Investment Opportunities Market Analysis

    Explore 31 medical office space for sale in Hilton Head Island, SC, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 13,200 square feet of properties for sale, with an estimated market value of $3,298,000.

    Sale prices for medical spaces in Hilton Head Island, SC start at $1,348,000, averaging $1,649,000, and reaching up to $1,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    List
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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 30
    Medical Office Space 10
    Office buildings 9
    Coworking space 1

    Demographics Overview

    Population 40K
    Population Growth (5Y) -5.0%
    Median Household Income $100,221
    College Educated 41.2%

    High-Yield Neighborhoods for Investment

    Identify Hilton Head Island submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    29926 $1.2M

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Beaufort County

    New Delisted

    Property Size Breakdown

    The majority of commercial real estate listings in Hilton Head Island fall within the 50,000 to 100,000 square foot range.

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