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    Hilton Head Island, SC Medical Office Space for Sale

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    Columbia, SC Greenville, SC Aiken, SC
    7 results
    Professional Office Condo with Income
    $769,000

    Professional Office Condo with Income

    70 Main Street, Suite 400 |, Hilton Head Island, SC 29926

    Multi-suite office condo with existing rental income in prime location.

    • Existing rental income from multiple tenants provides immediate financial benefit.
    • Flexible layout allows for owner‑occupancy while generating rental income.
    • Rare income‑producing office configuration, especially within the Main Street corridor of Hilton Head Island.
    • Prime Main Street location offers convenient access to the entire island.
    • Surrounded by a strong mix of professional services, medical offices, and upscale retail.
    Updated: Apr 1
    View details
    Hilton Head Office/Medical Space
    $375,000

    Hilton Head Office/Medical Space

    23 Main Street, Suite 303, Hilton Head Island, SC 29926

    Office/Medical space for sale near Hilton Head Hospital.

    • Prime Location: North end of Hilton Head Island, near Hilton Head Hospital, Hilton Head Plantation, and Indigo Run.
    • Ideal for Medical Use: Configured as a medical office space with multiple exam rooms.
    • Turnkey Ready: Includes reception area, waiting room, restroom, IT closet, and nurses station.
    • Ample Exam Rooms: Features 4‑5 exam rooms, some with built‑in cabinets and sinks.
    • Functional Layout: Reception area with built‑in desks, cabinets, storage, and window counters.
    Updated: Mar 5
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    Stand Alone Medical Office Building
    $1,348,000
    3,600 SF

    Stand Alone Medical Office Building

    Stand-alone medical building on Hilton Head Island, ready for occupancy.

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926
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    Stand Alone Medical Building
    $1,348,000

    Stand Alone Medical Building

    Stand-alone medical building on Hilton Head Island for sale.

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926
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    Two-Story Office Building on Hilton Head
    $1,950,000
    9,600 SF

    Two-Story Office Building on Hilton Head

    9,600 SF office building in prime Hilton Head location.

    5 Dunmore Court, Hilton Head Island, SC 29926
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    Medical Office Suite Near Hospital
    Contact for pricing
    750 SF

    Medical Office Suite Near Hospital

    Ground floor medical office suite near Hilton Head Hospital.

    23 Main Street, Suite 101-A, Hilton Head Island, SC 29926
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    Medical Office Suite Near Hospital
    Contact for pricing
    1,500 SF

    Medical Office Suite Near Hospital

    Ground floor medical office suite available near Hilton Head Hospital.

    23 Main Street, Suite 101-A, Hilton Head Island, SC 29926
    View details
    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 7 Active listings in Hilton Head Island, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 24 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Leased Medical Space For Sale
    $628,148

    Leased Medical Space For Sale

    100% leased medical space with new 5-year lease.

    14 Oak Forest Road, Bluffton, SC 29910
    View details
    Office/Medical Suite Near Port Royal
    Contact for pricing
    1,484 SF

    Office/Medical Suite Near Port Royal

    1,484 SF office/medical suite for sale near Port Royal.

    1264 Ribaut Rd, Suite 302, Beaufort, SC 29902
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    Office/Medical Suite Near Port Royal
    Contact for pricing
    3,224 SF

    Office/Medical Suite Near Port Royal

    Office/medical suite for lease near Port Royal in Beaufort, SC.

    1264 Ribaut Rd, Suite 302, Beaufort, SC 29902
    View details
    Medical Office Suites For Sale
    $2,861,037
    6,808 SF

    Medical Office Suites For Sale

    Four medical office suites totaling 6808 sqft for sale.

    14 Oak Forest Rd, Bluffton, SC 29910
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Beaufort Land for Sale
    $459,000
    7.32 Acres

    Beaufort Land for Sale

    7.32 acre commercial land in Beaufort, South Carolina.

    Goethe Hill Road lot: 3, Beaufort, SC 29906
    View details
    Prime Land Near Savannah Hospitals
    $219,000
    0.38 Acres

    Prime Land Near Savannah Hospitals

    Strategically located vacant lot near hospitals, ideal for development.

    114 E Derenne Street, Savannah, GA 31405
    View details
    Prime Commercial Pad Site, Hinesville
    $1,250,000
    1.64 Acres

    Prime Commercial Pad Site, Hinesville

    High-visibility commercial land in Hinesville with strong growth potential.

    W Oglethorpe Highway lot: 1, Hinesville, GA 31313
    View details
    Kingsland Commercial Lot For Sale
    $325,000
    1.85 Acres

    Kingsland Commercial Lot For Sale

    1.85-acre commercial lot off I-95 in Camden County, Georgia.

    1.85 AC Harrietts Bluff Road, Kingsland, GA 31569
    View details

    Explore Off-Market Properties in Hilton Head Island, SC

    Consider similar Off-Market properties in Hilton Head Island, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    35 Bill Fries Dr

    35 Bill Fries Dr

    MEDICAL BUILDING • 2,330 SF
    Value Estimation by Request
    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730
    View details
    35 Bill Fries Dr

    35 Bill Fries Dr

    MEDICAL BUILDING • 1,986 SF
    Value Estimation by Request
    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730
    View details
    845 William Hilton Pkwy

    845 William Hilton Pkwy

    MEDICAL BUILDING • 4,322 SF
    Value Estimation
    $1,435,000
    845 William Hilton Pkwy, Hilton Head Island, SC 29928-3404
    View details
    843 William Hilton Pkwy

    843 William Hilton Pkwy

    MEDICAL BUILDING • 7,471 SF
    Value Estimation by Request
    843 William Hilton Pkwy, Hilton Head Island, SC 29928-3444
    View details
    18 Bethea Dr

    18 Bethea Dr

    MEDICAL BUILDING • 10,984 SF
    Value Estimation
    $20,900,000
    18 Bethea Dr, Hilton Head Island, SC 29926-4702
    View details
    35 Bill Fries Dr

    35 Bill Fries Dr

    MEDICAL BUILDING • 2,096 SF
    Value Estimation by Request
    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730
    View details
    460 William Hilton Pkwy

    460 William Hilton Pkwy

    MEDICAL BUILDING • 15,660 SF
    Value Estimation
    $1,785,000
    460 William Hilton Pkwy, Hilton Head Island, SC 29926-2497
    View details
    13 Lamotte Dr

    13 Lamotte Dr

    MEDICAL BUILDING • 3,750 SF
    Value Estimation by Request
    13 Lamotte Dr, Hilton Head Island, SC 29926-2743
    View details
    190 Pembroke Dr

    190 Pembroke Dr

    MEDICAL BUILDING • 19,729 SF
    Value Estimation by Request
    190 Pembroke Dr, Hilton Head Island, SC 29926-2389
    View details
    9 Executive Park Rd Ste A

    9 Executive Park Rd Ste A

    MEDICAL BUILDING • 4,853 SF
    Value Estimation by Request
    9 Executive Park Rd Ste A, Hilton Head Island, SC 29928-4703
    View details
    35 Bill Fries Dr

    35 Bill Fries Dr

    MEDICAL BUILDING • 2,992 SF
    Value Estimation by Request
    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730
    View details
    70 Shelter Cv Ln Ste A

    70 Shelter Cv Ln Ste A

    MEDICAL BUILDING • 23,077 SF
    Value Estimation by Request
    70 Shelter Cv Ln Ste A, Hilton Head Island, SC 29928-2005
    View details
    18 Hospital Ctr Blvd

    18 Hospital Ctr Blvd

    MEDICAL BUILDING • 2,016 SF
    Value Estimation by Request
    18 Hospital Ctr Blvd, Hilton Head Island, SC 29926-2733
    View details
    93 Main St

    93 Main St

    MEDICAL BUILDING • 2,760 SF
    Value Estimation by Request
    93 Main St, Hilton Head Island, SC 29926-6613
    View details
    35 Bill Fries Dr

    35 Bill Fries Dr

    MEDICAL BUILDING • 2,978 SF
    Value Estimation by Request
    35 Bill Fries Dr, Hilton Head Island, SC 29926-2730
    View details
    3801 Main St

    3801 Main St

    MEDICAL BUILDING • 3,067 SF
    Value Estimation by Request
    3801 Main St, Hilton Head Island, SC 29926-1676
    View details
    12 Lafayette Pl

    12 Lafayette Pl

    MEDICAL BUILDING • 7,587 SF
    Value Estimation by Request
    12 Lafayette Pl, Hilton Head Island, SC 29926-2203
    View details

    Hilton Head Island, SC Medical Office Space Investment Opportunities Market Analysis

    Explore 31 medical office space for sale in Hilton Head Island, SC, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 13,200 square feet of properties for sale, with an estimated market value of $3,298,000.

    Sale prices for medical spaces in Hilton Head Island, SC start at $1,348,000, averaging $1,649,000, and reaching up to $1,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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