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    Sikeston, MO Commercial Real Estate for Sale

    85 results
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    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres

    Sikeston Commercial Property For Sale

    1105 S Main St, Sikeston, MO 63801

    Prime commercial location with high visibility and established business history.

    • Prime commercial location with high‑visibility at a 4‑way stoplight intersection.
    • Zoned C3 Highway Commercial, ideal for QSR or redevelopment.
    • Outstanding traffic count and accessibility.
    • Proven location with a 20+ year history.
    • Substantial 471’ highway frontage and 1.2‑acre lot size.
    Updated: Mar 3
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    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF

    Sikeston Car Wash with Expansion Potential

    531 N Main St, Sikeston, MO 63780

    Turnkey car wash with expansion potential in high-demand market.

    • Significant expansion/redevelopment potential due to additional land.
    • Turnkey operation with all new equipment, ensuring lower overhead.
    • Established monthly membership program provides recurring revenue and operational stability.
    • Excellent visibility and strong traffic exposure.
    • Complements existing carwash (MLS 26000082) capturing a broader customer base and reinforcing brand presence.
    Updated: Jan 8
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    Sikeston Commercial Property with Income
    $290,000
    4,244 SF

    Sikeston Commercial Property with Income

    Commercial building, duplex, and storage on 1.22 acres.

    101-103 Donald Fulton Dr, Sikeston, MO 63801
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    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 N Main St, Sikeston, MO 63801
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    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF

    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front St, Sikeston, MO 63801
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    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF

    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main St, Sikeston, MO 63801
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    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    Commercial property with endless business opportunities in downtown Sikeston.

    202 S Kingshighway St, Sikeston, MO 63801
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    Sikeston Warehouse with Highway Access
    $1,100,000
    24,700 SF

    Sikeston Warehouse with Highway Access

    Large warehouse with easy access to I-55 and I-57.

    300 Matthews Ln, Sikeston, MO 63801
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    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn St, Sikeston, MO 63801
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    Commercial Land on Highway 61
    $144,000
    1.01 Acres

    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove St, Sikeston, MO 63801
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    Commercial Land Ready For Development
    $199,000
    2.00 Acres

    Commercial Land Ready For Development

    Two-acre commercial lot available for development in Sikeston, Missouri.

    224 S Interstate Dr, Sikeston, MO 63801
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    Commercial Land in Retail Area
    $500,000
    1.05 Acres

    Commercial Land in Retail Area

    1.05 acres of commercial land for development in Sikeston.

    1209 Lawrence St, Sikeston, MO 63801
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    Commercial Land in Sikeston, MO
    $500,000
    1.24 Acres

    Commercial Land in Sikeston, MO

    1.24 acre commercial lot near apartments and retail.

    1201 Lawrence St, Sikeston, MO 63801
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    Sikeston Land For Sale
    $325,000
    40.61 Acres

    Sikeston Land For Sale

    40.61 acre land parcel in Sikeston, Missouri.

    Holmes Ave, Sikeston, MO 63801
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    Commercial Land in Sikeston, MO
    $195,000
    0.72 Acres

    Commercial Land in Sikeston, MO

    Vacant, level commercial lot available in Sikeston, Missouri.

    116 Hospitality Dr, Sikeston, MO 63801
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    Prime Land for Commercial Development
    $3,960,000
    88.00 Acres

    Prime Land for Commercial Development

    88 acres at I-55 and I-57, Sikeston, MO.

    Ables Rd, Sikeston, MO 63801
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    Commercial Land on South Main
    Contact for pricing

    Commercial Land on South Main

    Highly visible land parcel suitable for retail development.

    1240 S Main St, Sikeston, MO 63801
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    Sikeston Land on David Drive
    $110,000
    10.06 Acres

    Sikeston Land on David Drive

    10.06 acres suitable for business, home, or development.

    10.06 Acres David Lane-, Sikeston, MO 63801
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    Sikeston Land Ready For Development
    $110,000
    10.10 Acres

    Sikeston Land Ready For Development

    10.10 acres suitable for business, home, or subdivision.

    10.10 Acres- David Ln, Sikeston, MO 63801
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    Sikeston Industrial Warehouse For Sale
    Contact for pricing
    0.31 Acres

    Sikeston Industrial Warehouse For Sale

    Prime Missouri Warehouse, High Visibility

    1240 Main St, Sikeston, MO 63801
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    Sikeston Commercial Building - High Traffic!
    $400,000
    0.74 Acres

    Sikeston Commercial Building - High Traffic!

    7100 sq ft, Multi-Suite, High Traffic Area

    1218 Linn St, Sikeston, MO 63801
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    Sikeston Commercial Building For Sale
    $239,000

    Sikeston Commercial Building For Sale

    Prime Sikeston location, great investment opportunity.

    1637 Malone Ave, Sikeston, MO 63801
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    Sikeston Flex Space: Prime Industrial
    $460,000
    19,498 SF

    Sikeston Flex Space: Prime Industrial

    19,498 SF Flex Building, 1.8 Acres

    205 New Madrid St, Sikeston, MO 63801
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    Sikeston Commercial Property: Prime Location
    $450,000
    1.24 Acres

    Sikeston Commercial Property: Prime Location

    Historic Church & Multi-Purpose Building

    306 Kingshighway St, Sikeston, MO 63801
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    Sikeston, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 38 commercial real estate for sale in Sikeston, MO, showcased through 85 active listings on our real estate platform. These investment opportunities span a total of 8,136,137 square feet of properties for sale, with an estimated market value of $17,838,400.

    Sale prices for business properties in Sikeston, MO start at $110,000, averaging $557,450, and reaching up to $3,960,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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