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    Sikeston, MO
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    Sikeston, MO Retail Properties & Spaces for Lease

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    Charleston, MO Scott City, MO Advance, MO
    Sikeston Office Suite For Rent
    $3,625/Mo
    2,000 SF

    Sikeston Office Suite For Rent

    912 S Main Street, Sikeston, MO 63801

    Recently-built office suite with four offices, bathroom, and kitchenette.

    • High visibility location on Sikeston's busiest corridor.
    • Ready for immediate occupancy with 4 finished offices.
    • Two entrances ideal for businesses with public traffic.
    • Includes a bathroom and kitchenette with refrigerator and table/chairs.
    • Located in a recently‑built (2020) strip center.
    Updated: Sep 22, 2025
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    Professional Space Near Main Intersection
    $2,000/Mo

    Professional Space Near Main Intersection

    1226 Linn St, Suite C, Sikeston, MO 63801

    Prime location, high visibility, and flexible floor plan.

    • Prime location near the main intersection of town, offering high visibility and accessibility.
    • Flexible floor plan suitable for various business types (office, studio, showroom).
    • Ample parking for employees and visitors.
    • Eye‑catching monument signage on East Malone Avenue.
    • Convenient access to major highways for easy commuting to neighboring cities.
    Updated: Mar 5
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    Professional Space Near Main Intersection
    $1,000/Mo

    Professional Space Near Main Intersection

    Prime location, high visibility, and flexible floor plan.

    1226 Linn St, Suite D, Sikeston, MO 63801
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    New Office/Retail Center on Main
    Contact for pricing
    2,600 SF

    New Office/Retail Center on Main

    Prime location with excellent traffic and visibility.

    600 N. Main Street, Sikeston, MO 63801
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    Retail Space in Sikeston, MO
    $12 SF/Yr
    2,900 SF

    Retail Space in Sikeston, MO

    Retail space available in grocery store anchored shopping center.

    925-1077 Malone Ave, Sikeston, MO
    View details
    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 5 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 13 Properties for Sales.

    Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail Space in Charleston, MO
    $9 SF/Yr

    Retail Space in Charleston, MO

    Retail space available for lease in Charleston, Missouri.

    601 S Main Street, Charleston, MO 63834
    View details
    Retail Space in Cape Girardeau
    Contact for pricing

    Retail Space in Cape Girardeau

    Retail property for lease in Cape Girardeau, Missouri.

    250 South Silver Springs Road, Cape Girardeau, MO 63701
    View details
    Retail Space For Lease
    Contact for pricing

    Retail Space For Lease

    Retail property available for lease at 601 S Main St.

    601 S Main St, Charleston, MO 63834
    View details
    Retail Space Available For Rent
    Contact for pricing
    14,850 SF

    Retail Space Available For Rent

    Retail spaces available, ranging from 4,050 to 14,850 SqFt.

    258 Siemers Drive, Cape Girardeau, MO 63701
    View details

    Similar Spaces for Sale in Sikeston, MO

    Consider Similar Space for Sale. We found 13 Spaces matching your search parameters.

    Sikeston Commercial Property For Sale
    $699,900
    2,196 SF

    Sikeston Commercial Property For Sale

    Commercial property in Sikeston, Missouri, suitable for retail or automotive.

    1207 W Malone Avenue, Sikeston, MO 63801
    View details
    Historic Downtown Sikeston Retail Opportunity
    $275,000
    14,642 SF

    Historic Downtown Sikeston Retail Opportunity

    Two-story retail space in high-traffic downtown Sikeston.

    124 E Front Street, Sikeston, MO 63801
    View details
    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres

    Sikeston Commercial Property For Sale

    Prime commercial location with high visibility and established business history.

    1105 S Main Street, Sikeston, MO 63801
    View details
    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF

    Sikeston Car Wash with Expansion Potential

    Turnkey car wash with expansion potential in high-demand market.

    531 N Main Street, Sikeston, MO 63780
    View details
    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 & 2010 N Main Street, Sikeston, MO 63801
    View details
    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF

    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main Street, Sikeston, MO 63801
    View details
    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn Street, Sikeston, MO 63801
    View details
    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF

    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front Street, Sikeston, MO 63801
    View details
    Sikeston Commercial Building Investment Opportunity
    $979,500
    11,000 SF

    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801
    View details
    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF

    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front Street, Sikeston, MO 63801
    View details
    Sikeston Commercial Property with Income
    $290,000
    4,244 SF

    Sikeston Commercial Property with Income

    Commercial building, duplex, and storage on 1.22 acres.

    101-103 Donald Fulton Dr, Sikeston, MO 63801
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    Neighborhood Center with Established Businesses
    Contact for pricing
    7,364 SF

    Neighborhood Center with Established Businesses

    Neighborhood center with high traffic, visibility, and established businesses.

    1100 - 1105 S. Main, Sikeston, MO 63801
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    Turnkey Carwash in Sikeston, MO
    $1,250,000
    40,946 SF

    Turnkey Carwash in Sikeston, MO

    Established carwash with high traffic, visibility, and membership program.

    900 S Main, Sikeston, MO 63801
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Land in Paducah
    $2.00 SF/Yr

    Prime Commercial Land in Paducah

    8 acres of commercial real estate on Paducah's retail corridor.

    5251 Hinkleville Road, Paducah, KY 42001
    View details
    Vacant Lot in Downtown Paducah
    $1,000/Mo

    Vacant Lot in Downtown Paducah

    Vacant commercial lot for lease in downtown Paducah.

    525 Broadway, Paducah, KY 42001
    View details
    Vacant Land Near I-44
    $225,000 SF/Yr

    Vacant Land Near I-44

    10.11 acres of vacant land with I-44 visibility.

    800 S Highway, Fenton, MO 63026
    View details
    Collinsville Commercial Space For Lease
    $5,000/Mo
    5,000 SF

    Collinsville Commercial Space For Lease

    Versatile commercial space in Collinsville, available immediately.

    1902 Vandalia Street, Collinsville, IL 62234
    View details

    Sikeston, MO Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Sikeston, MO with 5 listings featured on our commercial real estate exchange. The current inventory includes 4,900 square feet of properties with an estimated lease value of $33 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Sikeston, MO begin at $12 SF/Yr, with an average of $16 SF/Yr and extend to $21 SF/Yr.
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    Most Searched ZIP Codes in Sikeston, MO

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