Charleston, MO Commercial real estate for sale

Updated: Jan 23

Updated Mixed-Use Building

506 S Main Street, Charleston, MO 63834

$350,000

4,173 sqft 0.23 AC lot

4,173‑square‑foot mixed‑use property on a 0.23‑acre lot
Commercial and residential zoning
Brick construction dating to 1900
New roof, windows, flooring, and bathrooms
Two central heating and air‑conditioning units

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Updated: Apr 10, 2025

Retail Building with Highway Frontage

1113 E. Marshall, Charleston, MO 63834

$99,900

2,121 sqft

2,121‑square‑foot existing building constructed in 1947
More than 300 feet of highway frontage
Approximately 1 mile from I‑57
Property encompasses more than 2 acres
Commercial zoning

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Office Building with Open Floor Space

2380 S. Main, Charleston, MO 63834

$79,000

1,452 sqft 0.73 AC lot

Commercially zoned property with central heating and cooling, two private offices, and additional rear work area.

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Remodeled Mixed-Use Property

506 S Main St, Charleston, MO 63834

$350,000

4,173 sqft

Commercial/residential zoning supports flexible occupancy within a substantially updated building.

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Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 4 Active listings in Charleston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 68 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Commercial Land Near Interstate Access

2338 S Acres Drive, Sikeston, MO 63801

$1,100,000

22.84 AC lot

Vacant commercial land with agricultural zoning and direct proximity to Interstate 55 access.

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Farm with Horse Facilities

2128 W 416th Road, East Prairie, MO 63845

$339,500

4.06 AC lot

Rural farm property with multiple metal outbuildings, equestrian improvements, and a residential home with practical utility space.

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Truck Terminal with Drive-In Doors

328 South Interstate Drive, Sikeston, MO 63801

Contact for pricing

9,234 sqft

Industrial facility combines office space, truck-serving work areas, and dedicated gravel parking for commercial vehicles.

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Specialty Property with Circular Driveway

2128 W 416th Road, East Prairie, MO 63845

$339,500

The property includes a circular driveway, additional parking, and electric service.

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Off-Market Properties in Charleston, MO

Consider similar Off-Market properties in Charleston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.