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    Charleston, MO Commercial Real Estate for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    6 results
    Remodeled Commercial Property in Charleston
    $350,000
    4,173 SF

    Remodeled Commercial Property in Charleston

    506 S Main Street, Charleston, MO 63834

    Turnkey commercial property with residential zoning in prime location.

    • Prime location with high visibility.
    • Turnkey, beautifully remodeled commercial property.
    • Zoned for commercial/residential use.
    • Substantial 4173 Sq Ft of space.
    • New roof, windows, flooring, and bathrooms.
    Updated: Jan 23
    View details
    Charleston, MO Commercial Land Opportunity
    $950,000
    11.04 Acres

    Charleston, MO Commercial Land Opportunity

    3,5,7,9 Charleston Plaza, Charleston, MO 63834

    11.04 acre commercial land with high visibility and access.

    • 11.04 +/- acre tract ideal for commercial development such as a truck stop, travel center, or logistics site.
    • Excellent visibility and easy on‑and‑off access from Interstate 57.
    • High‑traffic location in Charleston, Missouri, with strong growth potential.
    • Strategic location in one of Southeast Missouri’s most convenient interstate corridors.
    • Presents a tremendous opportunity for investors, developers, or business owners.
    Updated: Oct 15, 2025
    View details
    Charleston Commercial Property on Highway
    $110,000
    2,121 SF

    Charleston Commercial Property on Highway

    Commercial property with existing building and highway frontage in Charleston.

    1113 E. Marshall, Charleston, MO 63834
    View details
    Remodeled Mixed-Use Property For Sale
    $425,000
    4,173 SF

    Remodeled Mixed-Use Property For Sale

    Turnkey, remodeled mixed-use property with commercial/residential zoning.

    506 S Main Street, Charleston, MO 63834
    View details
    Retail Building on Highway 105
    $84,000
    1,452 SF

    Retail Building on Highway 105

    Retail building with great visibility and expansion potential.

    2380 S. Main, Charleston, MO 63834
    View details
    Charleston, MO Commercial Investment Opportunity
    $575,000
    2,134 SF

    Charleston, MO Commercial Investment Opportunity

    High-traffic commercial property suitable for restaurant, retail, or office use.

    11 Truman St, Charleston, MO 63834
    View details
    Based on your search, we've compiled 325 Potential Opportunities for your consideration. Besides 6 Active listings in Charleston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 315 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Commercial Building in High Traffic
    $400,000
    7,100 SF

    Commercial Building in High Traffic

    7100 sq ft commercial building in high traffic area.

    1218 Linn St, Sikeston, MO 63801
    View details
    Prime Land for Commercial Development
    $3,960,000

    Prime Land for Commercial Development

    Commercial land available at I-55 and I-57 interchange.

    Ables Road, Sikeston, MO 63801
    View details
    Mound City Warehouse For Sale
    $395,000
    39,535 SF

    Mound City Warehouse For Sale

    39,535 SF warehouse on 2.52 acres in Mound City.

    100 Ohio Ave, Mound City, IL
    View details
    Mound City Industrial Property
    $395,000
    39,535 SF

    Mound City Industrial Property

    Industrial property available for sale in Mound City, Illinois.

    100 Ohio Ave, Mound City, IL 62963
    View details

    Explore Off-Market Properties in Charleston, MO

    Consider similar Off-Market properties in Charleston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    115 Main St

    115 Main St

    OFFICE (GENERAL) • 4,453 SF
    Value Estimation by Request
    115 Main St, Charleston, MO 63834-1632
    View details
    Aly Behind 606th Helena

    Aly Behind 606th Helena

    WAREHOUSE, STORAGE • 1,571 SF
    Value Estimation by Request
    Aly Behind 606th Helena, Charleston, MO 63834
    View details
    801 Marshall St

    801 Marshall St

    OFFICE (GENERAL) • 7,032 SF
    Value Estimation by Request
    801 Marshall St, Charleston, MO 63834-1262
    View details
    204 1st St

    204 1st St

    OFFICE (GENERAL) • 1,664 SF
    Value Estimation by Request
    204 1st St, Charleston, MO 63834-1100
    View details
    105 Ctr St

    105 Ctr St

    RETAIL STORES (PERSONAL SERVICES) • 1,612 SF
    Value Estimation by Request
    105 Ctr St, Charleston, MO 63834-1602
    View details
    270 Kirkpatrick St, Unit 77

    270 Kirkpatrick St, Unit 77

    RETAIL STORES (PERSONAL SERVICES) • 1,827 SF
    Value Estimation by Request
    270 Kirkpatrick St, Charleston, MO 63834-8208
    View details
    208 Commercial St

    208 Commercial St

    OFFICE (GENERAL) • 2,150 SF
    Value Estimation by Request
    208 Commercial St, Charleston, MO 63834-1749
    View details
    201 Ctr St

    201 Ctr St

    FUNERAL HOME • 5,588 SF
    Value Estimation by Request
    201 Ctr St, Charleston, MO 63834-1604
    View details
    109 Commercial St

    109 Commercial St

    OFFICE (GENERAL) • 520 SF
    Value Estimation by Request
    109 Commercial St, Charleston, MO 63834-1728
    View details
    1009 Main St

    1009 Main St

    COMMERCIAL (GENERAL) • 0.16 Acres
    Value Estimation by Request
    1009 Main St, Charleston, MO 63834
    View details
    County Rd 215

    County Rd 215

    COMMERCIAL (GENERAL) • 0.33 Acres
    Value Estimation by Request
    County Rd 215, Charleston, MO 63834
    View details
    619 Marshall St

    619 Marshall St

    RETAIL STORES (PERSONAL SERVICES) • 4,640 SF
    Value Estimation by Request
    619 Marshall St, Charleston, MO 63834
    View details
    5th St

    5th St

    COMMERCIAL (GENERAL) • 0.73 Acres
    Value Estimation by Request
    5th St, Charleston, MO 63834
    View details
    2402 Main St

    2402 Main St

    MEDICAL BUILDING • 7,833 SF
    Value Estimation by Request
    2402 Main St, Charleston, MO 63834-8318
    View details
    810 Marshall St

    810 Marshall St

    COMMERCIAL (GENERAL) • 0.22 Acres
    Value Estimation by Request
    810 Marshall St, Charleston, MO 63834-1261
    View details
    505 Danforth St

    505 Danforth St

    PROFESSIONAL CLUBS/ASSOCIATIONS • 3,544 SF
    Value Estimation by Request
    505 Danforth St, Charleston, MO 63834-2101
    View details
    205 Main St

    205 Main St

    RETAIL STORES (PERSONAL SERVICES) • 17,660 SF
    Value Estimation by Request
    205 Main St, Charleston, MO 63834
    View details
    10 Charleston Plz

    10 Charleston Plz

    RETAIL STORES (PERSONAL SERVICES) • 3,313 SF
    Value Estimation by Request
    10 Charleston Plz, Charleston, MO 63834-4302
    View details

    Charleston, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 321 commercial real estate for sale in Charleston, MO, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 14,053 square feet of properties for sale, with an estimated market value of $1,544,000.

    Sale prices for business properties in Charleston, MO start at $84,000, averaging $308,800, and reaching up to $575,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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