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    Charleston, MO Commercial Real Estate for Sale

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    Bertrand, MO Wyatt, MO East Prairie, MO
    6 listings
    Remodeled Commercial Property in Charleston
    $350,000
    4,173 SF
    Remodeled Commercial Property in Charleston

    506 S Main Street, Charleston, MO 63834

    Turnkey commercial property with residential zoning in prime location.
    • Prime location with high visibility.
    • Turnkey, beautifully remodeled commercial property.
    • Zoned for commercial/residential use.
    • Substantial 4173 Sq Ft of space.
    • New roof, windows, flooring, and bathrooms.
    Updated: Jan 23
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    Charleston, MO Commercial Land Opportunity
    $950,000
    11.04 Acres
    Charleston, MO Commercial Land Opportunity

    3,5,7,9 Charleston Plaza, Charleston, MO 63834

    11.04 acre commercial land with high visibility and access.
    • 11.04 +/- acre tract ideal for commercial development such as a truck stop, travel center, or logistics site.
    • Excellent visibility and easy on‑and‑off access from Interstate 57.
    • High‑traffic location in Charleston, Missouri, with strong growth potential.
    • Strategic location in one of Southeast Missouri’s most convenient interstate corridors.
    • Presents a tremendous opportunity for investors, developers, or business owners.
    Updated: Oct 15, 2025
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    Remodeled Mixed-Use Property For Sale
    $425,000
    4,173 SF
    Remodeled Mixed-Use Property For Sale

    Turnkey, remodeled mixed-use property with commercial/residential zoning.

    506 S Main Street, Charleston, MO 63834

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    Retail Building on Highway 105
    $84,000
    1,452 SF
    Retail Building on Highway 105

    Retail building with great visibility and expansion potential.

    2380 S. Main, Charleston, MO 63834

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    Charleston, MO Commercial Investment Opportunity
    $575,000
    2,134 SF
    Charleston, MO Commercial Investment Opportunity

    High-traffic commercial property suitable for restaurant, retail, or office use.

    11 Truman St, Charleston, MO 63834

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    High-Frontage Retail or Office Building
    $99,900
    2,121 SF
    High-Frontage Retail or Office Building

    Commercial building on a highway-frontage site with space for retail or office redevelopment.

    1113 E. Marshall, Charleston, MO 63834

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    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 6 Active listings in Charleston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 66 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    East Prairie Commercial Building For Sale
    $185,000
    9,700 SF
    East Prairie Commercial Building For Sale

    9700 sqft commercial building in East Prairie, Missouri.

    201-203 E. Pine, East Prairie, MO 63845

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    Productive Farm in Bertrand, Missouri
    $1,100,000
    230.00 Acres
    Productive Farm in Bertrand, Missouri

    230-acre farm with income potential and expansion opportunities.

    000 County Road 429, Bertrand, MO 63823

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    RV Park with Restaurant
    $740,000
    3,876 SF
    RV Park with Restaurant

    RV park with restaurant, store, cabins, and highway frontage.

    4067 W. 404 Road, Bertrand, MO 63823

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    17-Acre Parcel Near Dogwood Community
    $260,000
    17.00 Acres
    17-Acre Parcel Near Dogwood Community

    17-acre parcel with tillable land and rental properties.

    2447 West 416th Road, East Prairie, MO 63845

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    Off-Market Properties in Charleston, MO

    Consider similar Off-Market properties in Charleston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    115 Main St
    OFFICE (GENERAL)
    4,453 SF Lot: 0.39 Acres
    Value Estimation by Request

    115 Main St, Charleston, MO 63834-1632

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    Aly Behind 606th Helena
    WAREHOUSE, STORAGE
    1,571 SF Lot: 0.10 Acres
    Value Estimation by Request

    Aly Behind 606th Helena, Charleston, MO 63834

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    801 Marshall St
    OFFICE (GENERAL)
    7,032 SF Lot: 0.33 Acres
    Value Estimation by Request

    801 Marshall St, Charleston, MO 63834-1262

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    204 1st St
    OFFICE (GENERAL)
    1,664 SF Lot: 0.10 Acres
    Value Estimation by Request

    204 1st St, Charleston, MO 63834-1100

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    105 Ctr St
    RETAIL STORES (PERSONAL SERVICES)
    1,612 SF Lot: 0.04 Acres
    Value Estimation by Request

    105 Ctr St, Charleston, MO 63834-1602

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    270 Kirkpatrick St, Unit 77
    RETAIL STORES (PERSONAL SERVICES)
    1,827 SF Lot: 0.29 Acres
    Value Estimation by Request
    Unit 77

    270 Kirkpatrick St, Charleston, MO 63834-8208

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    208 Commercial St
    OFFICE (GENERAL)
    2,150 SF Lot: 0.16 Acres
    Value Estimation by Request

    208 Commercial St, Charleston, MO 63834-1749

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    201 Ctr St
    FUNERAL HOME
    5,588 SF Lot: 0.63 Acres
    Value Estimation by Request

    201 Ctr St, Charleston, MO 63834-1604

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    109 Commercial St
    OFFICE (GENERAL)
    520 SF Lot: 0.02 Acres
    Value Estimation by Request

    109 Commercial St, Charleston, MO 63834-1728

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    1009 Main St
    COMMERCIAL (GENERAL)
    Lot: 0.16 Acres
    Value Estimation by Request

    1009 Main St, Charleston, MO 63834

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    County Rd 215
    COMMERCIAL (GENERAL)
    Lot: 0.33 Acres
    Value Estimation by Request

    County Rd 215, Charleston, MO 63834

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    619 Marshall St
    RETAIL STORES (PERSONAL SERVICES)
    4,640 SF Lot: 0.21 Acres
    Value Estimation by Request

    619 Marshall St, Charleston, MO 63834

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    5th St
    COMMERCIAL (GENERAL)
    Lot: 0.73 Acres
    Value Estimation by Request

    5th St, Charleston, MO 63834

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    2402 Main St
    MEDICAL BUILDING
    7,833 SF Lot: 1.51 Acres
    Value Estimation by Request

    2402 Main St, Charleston, MO 63834-8318

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    810 Marshall St
    COMMERCIAL (GENERAL)
    Lot: 0.22 Acres
    Value Estimation by Request

    810 Marshall St, Charleston, MO 63834-1261

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    505 Danforth St
    PROFESSIONAL CLUBS/ASSOCIATIONS
    3,544 SF Lot: 0.37 Acres
    Value Estimation by Request

    505 Danforth St, Charleston, MO 63834-2101

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    205 Main St
    RETAIL STORES (PERSONAL SERVICES)
    17,660 SF
    Value Estimation by Request

    205 Main St, Charleston, MO 63834

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    10 Charleston Plz
    RETAIL STORES (PERSONAL SERVICES)
    3,313 SF Lot: 1.17 Acres
    Value Estimation by Request

    10 Charleston Plz, Charleston, MO 63834-4302

    View details

    Charleston, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in Charleston, MO, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 14,053 square feet of properties for sale, with an estimated market value of $1,533,900.

    Sale prices for business properties in Charleston, MO start at $84,000, averaging $306,780, and reaching up to $575,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 5,218
    Population Growth (5Y) -22.6%
    Median Household Income $45,658
    College Educated 13.5%

    High-Yield Neighborhoods for Investment

    Identify Charleston submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63834 $415.7K

    Taxes & Financing

    Average Loan-to-Value 65.0%

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