Charleston, MO Commercial real estate for sale

Updated: Jan 23

Updated Mixed-Use Building

506 S Main Street, Charleston, MO 63834

$350,000

4,173 sqft 0.23 AC lot

4,173‑square‑foot mixed‑use property on a 0.23‑acre lot
Commercial and residential zoning
Brick construction dating to 1900
New roof, windows, flooring, and bathrooms
Two central heating and air‑conditioning units

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Updated: Oct 15, 2025

Interstate-Access Commercial Land

3,5,7,9 Charleston Plaza, Charleston, MO 63834

$950,000

11.04 AC lot

Approximately 11.04 acres of commercial land
Located just off Interstate 57
Situated in Charleston, Missouri, within Mississippi County
Address: 3,5,7,9 Charleston Plaza, Charleston, MO 63834

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Retail Building with Highway Frontage

1113 E. Marshall, Charleston, MO 63834

$99,900

2,121 sqft

Existing commercial structure offers renovation flexibility for retail or office use.

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Warehouse with 14-Foot Doors

2751 E Marshall St, Charleston, MO 63834

Contact for pricing

3,000 sqft

Functional warehouse shop with four 14' doors, on-site parking, and convenient access to Interstate 57.

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Office Building with Open Floor Space

2380 S. Main, Charleston, MO 63834

$84,000

1,452 sqft 0.73 AC lot

Commercially zoned property with central heating and cooling, two private offices, and additional rear work area.

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Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 5 Active listings in Charleston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Restaurant Building with Storage

115 East Pine Street, East Prairie, MO 63845

$300,000

1,600 sqft 0.31 AC lot

Commercially zoned restaurant property includes equipment, storage buildings, parking, and a generator.

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Brick Flex Building with Loading

201-203 E. Pine, East Prairie, MO 63845

$185,000

9,700 sqft 0.44 AC lot

Commercial zoning and a corner-lot layout accommodate office, retail, and delivery-oriented configurations.

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Agricultural Land for Subdivision

615 David Lane, Miner, MO 63801

$150,000

20.16 AC lot

Two agricultural-zoned lots totaling 20.16 acres in Miner, MO, suitable for residential or business development.

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Gated Flex and Workshop Property

299 County Highway 539, Miner, MO 63801

Contact for pricing

7,800 sqft 2.72 AC lot

Gated property with a 2.72-acre yard, 2,160-square-foot office, and 7,800-square-foot workshop plus barn/open storage.

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Off-Market Properties in Charleston, MO

Consider similar Off-Market properties in Charleston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.