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    Sikeston, MO

    Sikeston, MO Commercial Real Estate for Lease

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    East Prairie, MO Charleston, MO New Madrid, MO Dexter, MO Scott City, MO
    12 properties
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    Tunnel Car Wash Property
    Updated: Aug 27
    Tunnel Car Wash Property

    900 S Main Street, Sikeston, MO 63801

    $4,800/Mo
    0.94 AC lot
    Operating tunnel car wash
    0.94 acres
    Built in 2016
    Brick construction
    Metal roof
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    Finished Office Suite with Kitchenette
    Updated: Jul 12
    Finished Office Suite with Kitchenette

    912 S Main Street, Sikeston, MO 63801

    $3,625/Mo
    Four finished offices within a 2020‑built strip center
    Bathroom and kitchenette with free‑standing refrigerator, table, and chairs
    Two entrances support regular public access
    Forced‑air heating and central air
    Parking lot with accessible approach and ramp
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    Office Units with Basement
    Office Units with Basement

    202 S Kingshighway Street, Sikeston, MO 63801

    $4,500/Mo
    0.34 AC lot

    Two-level layout includes open work areas, private offices, conference space, restrooms, and convenient parking access.

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    Warehouse with Dock Doors
    Warehouse with Dock Doors

    300 Matthews Lane Front, Sikeston, MO 63801

    $5,000/Mo
    20,000 sqft

    Functional warehouse space with concrete flooring, loading access, and two restrooms.

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    Warehouse with Dock Access
    Warehouse with Dock Access

    300 Matthews Lane, Sikeston, MO 63801

    $5,000/Mo
    1.20 AC lot

    Warehouse space offers concrete flooring, loading infrastructure, and overhead access for commercial operations.

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    New Retail/Office Space Available
    New Retail/Office Space Available

    E-600 N Main Street, Sikeston, MO 63801

    $1,950/Mo
    1,300 sqft

    Prime location with high traffic and ample parking.

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    Flexible Office Suite
    Flexible Office Suite

    1226 Linn Street Suite C, Sikeston, MO 63801

    $1,500/Mo

    Adaptable layout supports office, studio, or showroom operations.

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    Trucking Terminal with Drive-In Doors
    Trucking Terminal with Drive-In Doors

    328 South Interstate Drive, Sikeston, MO 63801

    $3,999/Mo
    9,234 sqft

    Trucking terminal with offices, shop/warehouse space, gravel off-street parking, and two overhead drive-in doors.

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    Neighborhood Shopping Center
    Neighborhood Shopping Center

    1103-1102 S Main Street, Sikeston, MO 63801

    $3,682/Mo

    Center features multiple entrances, off-street parking, and established Tractor Supply and Ruler Foods businesses.

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    Neighborhood Shopping Center
    Neighborhood Shopping Center

    1105-1102 S Main St, Sikeston, MO 63801

    $2,214/Mo

    The center includes Tractor Supply and Ruler Foods businesses, off-street parking, and multiple entrances.

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    Warehouse with Truck Drop Lot
    Warehouse with Truck Drop Lot

    103 South Acres Drive, Sikeston, MO 63801

    Contact for pricing
    210,000 sqft

    Large warehouse facility with dock access, elevated clear heights, truck staging, and direct proximity to two interstate routes.

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    Retail Space in Sikeston, MO
    Retail Space in Sikeston, MO

    925-1077 Malone Ave, Sikeston, MO

    Contact for pricing
    2,900 sqft 8.68 AC lot

    Retail space available in grocery store anchored shopping center.

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    Based on your search, we've compiled 51 Potential Opportunities for your consideration. Besides 12 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 35 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Warehouse Shop with Truck Access
    Warehouse Shop with Truck Access

    2751 E Marshall St, Charleston, MO 63834

    $5,000/Mo
    3,000 sqft

    Functional shop space provides truck-friendly access and loading capability for transportation-oriented operations.

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    Versatile Showroom, Office, and Shop
    Versatile Showroom, Office, and Shop

    229 Airport Rd, Scott City, MO 63780

    $12,000/Mo
    8,516 sqft

    8,516 SF building with high visibility and multiple drive-throughs.

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    Charleston Retail or Office Space
    Charleston Retail or Office Space

    114 W Commercial, Charleston, MO 63834

    $6 SF/Yr
    3,028 sqft

    Retail or office space with excellent visibility and parking.

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    Fenced Commercial Land
    Fenced Commercial Land

    3141 E Outer Rd, Scott City, MO 63780

    Contact for pricing

    Fenced, graveled commercial land with city utilities and build-to-suit flexibility.

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    Similar Spaces for Sale in Sikeston, MO

    Consider Similar Space for Sale. We found 35 Spaces matching your search parameters.

    Two-Building Religious Facility Campus
    Two-Building Religious Facility Campus

    951 S Kingshighway, Sikeston, MO 63801

    $1,600,000
    19,813 sqft 5.10 AC lot

    Two substantial buildings provide auditorium, classrooms, offices, multipurpose space, kitchens, storage, and community-oriented gathering areas.

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    Historic Two-Story Storefront
    Historic Two-Story Storefront

    124 E Front St, Sikeston, MO 63801

    $275,000
    14,642 sqft

    Downtown commercial building with leased ground-floor space and an unfinished upper level.

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    Historic Two-Story Storefront
    Historic Two-Story Storefront

    124 E Front Street, Sikeston, MO 63801

    $275,000
    14,642 sqft 0.22 AC lot

    Brick commercial building with leased ground-floor space and an open upper level.

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    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

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    Flex Building with Storage Units
    Flex Building with Storage Units

    330 State Highway H, Sikeston, MO 63801

    $799,000
    2.99 AC lot

    Metal flex facility combining warehouse, office, and rear storage components with interstate access.

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    Multi-Tenant Shopping Center
    Multi-Tenant Shopping Center

    908 S Kingshighway Street, Sikeston, MO 63801

    $1,200,000
    24,984 sqft

    Two tracts contain a commercial center with multiple storefronts and an established tenant base.

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    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $399,000
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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    Freestanding Restaurant Building
    Freestanding Restaurant Building

    1103 S Main Street, Sikeston, MO 63801

    $1,200,000
    1.24 AC lot

    The vacant site includes a brick structure with water available.

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    Church and Community Campus
    Church and Community Campus

    951 S Kingshighway, Sikeston, MO 63801

    $1,600,000
    5.10 AC lot

    Two substantial buildings provide auditorium, classrooms, offices, meeting areas, kitchens, gymnasium, storage, and multipurpose space.

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    Flex Space with Additional Acre Lot
    Flex Space with Additional Acre Lot

    20079 Us Highway 61, Sikeston, MO 63801

    $140,000
    2,238 sqft

    Versatile flex building with strong visibility and easy access, plus an additional one-acre lot for expansion and storage.

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    Warehouse with Dual-Unit Flexibility
    Warehouse with Dual-Unit Flexibility

    300 Matthews Lane, Sikeston, MO 63801

    $1,100,000
    1.20 AC lot

    Metal-sided warehouse offering loading access, office space, and a separate shop area.

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    Corner-Lot Office Building
    Corner-Lot Office Building

    202 S Kingshighway Street, Sikeston, MO 63801

    $185,000
    0.34 AC lot

    Two-level layout includes reception, offices, open work areas, conference space, restrooms, kitchen break room, storage, and elevator access.

    View details

    Sikeston, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Sikeston, MO with 12 listings featured on our commercial real estate exchange. The current inventory includes 243,434 square feet of properties with an estimated lease value of $26.20.

    Estimated lease rates for Commercial real estate in Sikeston, MO begin at $3 SF/Yr, with an average of $8.73 SF/Yr and extend to $18 SF/Yr.
    Sikeston, MO CRE market trends — vacancy, lease rates and price per SF, updated monthly
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