Sikeston, MO Commercial Real Estate for Lease

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Charleston, MO Scott City, MO

14 properties

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Updated: May 11

Remodeled Office Suite with Private Rooms

210 S Kingshighway Suite 100, Sikeston, MO 63801

$546/Mo

Approximately 800 SF open space plus 2 smaller rooms that could be used for a private office and/or storage
Entire building has been recently remodeled with new flooring, paint, electrical, and lighting
Central air and forced‑air heating
Public water source
Common area adjoins the space, suitable for a waiting room or receptionist

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Updated: May 11

Remodeled Office Suite with Private Bath

210 S Kingshighway Suite 200, Sikeston, MO 63801

$658/Mo

Approximately 1,000 SF of open space with 1 private office and a separate bath
Entire building has been recently remodeled with new flooring, paint, electrical, and lighting
Brick construction with forced‑air heating and central air
Public water source
Common area adjoins the space for use as a waiting room or receptionist area

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Remodeled Office Suite

210 S Kingshighway Suite 300, Sikeston, MO 63801

$790/Mo

Recently remodeled office suite offers an open work area plus a private office and two storage rooms.

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New Retail/Office Space Available

E-600 N Main Street, Sikeston, MO 63801

$1,950/Mo

1,300 sqft

Prime location with high traffic and ample parking.

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Corner Lot Office Building

202 S Kingshighway Street, Sikeston, MO 63801

$4,500/Mo

Leasable office building with main-level reception, offices, restrooms, and basement space accessible by stairs or elevator.

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Multi-Office Retail-Front Suite

912 S Main Street, Sikeston, MO 63801

$3,625/Mo

Recently built strip-center suite offers four offices, a kitchenette, and two entrances for businesses serving the public.

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Remodeled Private Office Suite

210 S Kingshighway Suite 600, Sikeston, MO 63801

$305/Mo

Single private office suite in a fully remodeled building, well suited for professional services or an entrepreneur.

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Trucking Terminal with Drive-In Doors

328 South Interstate Drive, Sikeston, MO 63801

$5.75 SF/Yr

9,234 sqft

Trucking terminal with offices, shop/warehouse space, gravel off-street parking, and two overhead drive-in doors.

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Two-Unit Flex Warehouse Facility

300 Matthews Lane, Sikeston, MO 63801

$5,000/Mo

Two separate warehouse units are available, including a dock-equipped front space and a back unit with offices and shop area.

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Heated and Cooled Warehouse Suite

1107 School Street #B, Sikeston, MO 63801

$1,000/Mo

1,500 sqft

Warehouse suite with a 30-by-50 open layout, 14-foot overhead door, bathroom, and secure gated, fully fenced access.

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Heavy Industrial Flex Building

410 W Malone Ave, Sikeston, MO 63801

$8 SF/Yr

7,000 sqft

Flex space with a basement and heavy industrial zoning, suitable for office, distribution, or manufacturing uses.

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Flexible Office Suite with Parking

C-1226 Linn St, Sikeston, MO 63801

$1,500/Mo

Modern office suite with flexible floor plan and ample parking, positioned near a main town intersection for easy access.

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Medical Office Space Sublease

1124 N Main Street, Sikeston, MO 63801

$16.50 SF/Yr

2,631 sqft

2,631 SF medical office space available for sublease.

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Retail Space in Sikeston, MO

925-1077 Malone Ave, Sikeston, MO

$12 SF/Yr

2,900 sqft

Retail space available in grocery store anchored shopping center.

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Based on your search, we've compiled 45 Potential Opportunities for your consideration. Besides 14 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 27 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Retail Building with Drive-Through Window

5 S Kingshighway, Cape Girardeau, MO 63703

$8,707/Mo

3,483 sqft

Drive-through retail building with off-street paved parking on C2-zoned land, adjacent to major retailers.

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Turn-Key Office Suite

450 Siemers Drive, Cape Girardeau, MO 63701

$5,642/Mo

6,770 sqft

Turn-key office suite in a business park with highway and interstate frontage for strong day-to-day customer visibility.

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Charleston Retail or Office Space

114 W Commercial St, Charleston, MO 63834

$6.50 SF/Yr

3,028 sqft

Retail or office space with excellent visibility and parking.

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Retail Space For Lease

601 S Main St, Charleston, MO 63834

Contact for pricing

Retail property available for lease at 601 S Main St.

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Similar Spaces for Sale in Sikeston, MO

Consider Similar Space for Sale. We found 27 Spaces matching your search parameters.

Historic Two-Story Downtown Retail Building

124 E Front Street, Sikeston, MO 63801

$275,000

14,642 sqft 0.22 AC lot

Two-story retail building built in 1915 with high ceilings and ground-floor leased space.

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Sikeston Commercial Building Investment Opportunity

808 E Wakefield Ave, Sikeston, MO 63801

$979,500

11,000 sqft

High-visibility commercial building with income and upside potential.

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Flex-Industrial Headquarters Facility

205 S New Madrid St, Sikeston, MO 63801

$449,500

19,498 sqft 1.00 AC lot

Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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Prime Land I-55 Exit 69

2338 South Acres Drive, Sikeston, MO 63801

$1,200,000

994,910 sqft 22.84 AC lot

High-traffic vacant land suitable for retail or restaurant development.

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Remodeled Professional Office Building

210 S Kingshighway Street, Sikeston, MO 63801

$775,000

1.67 AC lot

Remodeled office building with multiple entrances, parking on three sides, and new life-safety systems.

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Vacant Land Off Interstate Exit

2338 S Acres Drive, Sikeston, MO 63801

$1,200,000

22.84 AC lot

Vacant ground totaling 22+ acres in Agricultural zoning, positioned just off an I-55 north exit for high-exposure development.

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Commercial Land Site

109 Stallcup Drive, Sikeston, MO 63801

$400,000

114,562 sqft 2.50 AC lot

Over 2.5 acres available near major retail and hospitality along US 60 and 61.

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Shadow-Anchored NNN Shopping Center

1209-1215 S Main St, Sikeston, MO 63801

$3,750,000

49,173 sqft

Multi-tenant NNN shopping center anchored by nearby Walmart and Lowe’s, with retailers including Harbor Freight, CATO, and Hibbett Sports.

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Retail and Office Buildings with Drive-Through

1018 Linn Street, Sikeston, MO 63801

$550,000

4.20 AC lot

Two Morton buildings offer an office setup and a larger shop with multiple drive-through and walk-through doors on irrigated acreage.

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Downtown Office Building with Parking

202 S Kingshighway Street, Sikeston, MO 63801

$279,000

0.34 AC lot

Corner lot office building includes a receptionist area, multiple offices, and basement level with elevator access.

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Sikeston, MO Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Sikeston, MO with 14 listings featured on our commercial real estate exchange. The current inventory includes 24,565 square feet of properties with an estimated lease value of $68.25 SF/Yr.

Estimated lease rates for Commercial real estate in Sikeston, MO begin at $5.75 SF/Yr, with an average of $11.38 SF/Yr and extend to $18 SF/Yr.

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