Sikeston, MO Office Spaces for Rent & Lease

Updated: Jul 12

Office Units with Basement

202 S Kingshighway Street, Sikeston, MO 63801

$4,500/Mo

0.34 AC lot

7,638‑square‑foot office property on a 0.34‑acre corner lot
15 parking spaces, including 2 handicap spaces
Main level includes reception, open cubicle area, 2 offices, and 2 restrooms
Basement offers kitchen break room, conference or office room, storage, and open workspace
Accessible elevator and front‑entry ramp

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Updated: Sep 23, 2025

Finished Office Suite with Kitchenette

912 S Main Street, Sikeston, MO 63801

$3,625/Mo

Four finished offices within a 2020‑built strip center
Bathroom and kitchenette with free‑standing refrigerator, table, and chairs
Two entrances support regular public access
Forced‑air heating and central air
Parking lot with accessible approach and ramp

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New Retail/Office Space Available

E-600 N Main Street, Sikeston, MO 63801

$1,950/Mo

1,300 sqft

Prime location with high traffic and ample parking.

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Flexible Office Suite

1226 Linn Street Suite C, Sikeston, MO 63801

$1,500/Mo

Adaptable layout supports office, studio, or showroom operations.

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Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 4 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Retail Suite with Pylon Signage

3065 William St Unit 202, Cape Girardeau, MO 63703

$1,285/Mo

976 sqft

Flexible commercial suite with on-site signage and access to nearby retail, office, hospitality, and dining uses.

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Office Units with Highway Frontage

450 Siemers Drive, Cape Girardeau, MO 63701

$5,642/Mo

6,770 sqft

Office space includes central air, multiple heating systems, driveway parking, and public water and sewer service.

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Versatile Showroom, Office, and Shop

229 Airport Rd, Scott City, MO 63780

$12,000/Mo

8,516 sqft

8,516 SF building with high visibility and multiple drive-throughs.

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Charleston Retail or Office Space

114 W Commercial, Charleston, MO 63834

$6 SF/Yr

3,028 sqft

Retail or office space with excellent visibility and parking.

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Similar Spaces for Sale in Sikeston, MO

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Sikeston Commercial Building Investment Opportunity

808 E Wakefield Ave, Sikeston, MO 63801

$979,500

11,000 sqft

High-visibility commercial building with income and upside potential.

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Flex Building with Storage Units

330 State Highway H, Sikeston, MO 63801

$799,000

2.99 AC lot

Metal flex facility combining warehouse, office, and rear storage components with interstate access.

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Flex-Industrial Headquarters Facility

205 S New Madrid St, Sikeston, MO 63801

$449,500

19,498 sqft 1.00 AC lot

Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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Corner-Lot Office Building

202 S Kingshighway Street, Sikeston, MO 63801

$185,000

0.34 AC lot

Two-level layout includes reception, offices, open work areas, conference space, restrooms, kitchen break room, storage, and elevator access.

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Historic Two-Story Storefront

112 Front Street, Sikeston, MO 63801

$190,000

0.11 AC lot

Brick construction, public water, and central air serve this downtown commercial property.

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Remodeled Office Building

210 S Kingshighway Street, Sikeston, MO 63801

$775,000

1.67 AC lot

Remodeled brick office property with multiple entrances, updated building systems, and basement space.

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Sikeston, MO Office Spaces Lease Rates & Market Statistics

Explore 4 Office Spaces for lease in Sikeston, MO on Realmo, a commercial real estate exchange covering the Sikeston area. The current inventory totals 1,300 square feet of properties.

Asking lease rates for Office Spaces in Sikeston start at $18 SF/Yr, average $18 SF/Yr, and reach $18 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $18 SF/Yr is 27% below the Missouri state average of $24.65 SF/Yr.

Sikeston accounts for 80% of the 5 office spaces currently available across Scott County, where a nearby market includes Scott City.