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    Sikeston, MO Office Spaces for Lease

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    Charleston, MO Scott City, MO
    Downtown Office Building with Elevator
    Updated: Feb 5
    Downtown Office Building with Elevator

    202 S Kingshighway Street, Sikeston, MO 63801

    $4,500/Mo
    7,638 SF gross building area in a downtown Sikeston office building
    Corner lot with 15 parking spaces, including 2 handicap spaces
    Elevator and stairs provide basement access from the back entrance
    Main level includes receptionist area, open space with cubicles, 2 offices, and 2 restrooms
    Basement level includes kitchen break room, 2 restrooms, conference room or office, storage, and open cubicle space
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    Multi-Office Retail-Front Suite
    Updated: Sep 23, 2025
    Multi-Office Retail-Front Suite

    912 S Main Street, Sikeston, MO 63801

    $3,625/Mo
    Offices suite in a recently built strip center; year built 2020
    Suite includes 4 finished offices, plus a bathroom and kitchenette
    Kitchenette includes a free‑standing refrigerator, with table/chairs provided
    Two entrances for convenient access for entities with public traffic
    Central air and forced‑air heating; flat rubber roof; block and concrete construction
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    New Retail/Office Space Available
    New Retail/Office Space Available

    E-600 N Main Street, Sikeston, MO 63801

    $1,950/Mo
    1,300 sqft

    Prime location with high traffic and ample parking.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Medical Office Space Sublease
    Medical Office Space Sublease

    1124 N Main Street, Sikeston, MO 63801

    $16.50 SF/Yr
    2,631 sqft

    2,631 SF medical office space available for sublease.

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    Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 4 Active listings in Sikeston, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Suite with High Visibility
    Office Suite with High Visibility

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft

    Turnkey office suite in a business park with central air, forced-air gas heat, and driveway parking.

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    Versatile Showroom, Office, and Shop
    Versatile Showroom, Office, and Shop

    229 Airport Rd, Scott City, MO 63780

    $12,000/Mo
    8,516 sqft

    8,516 SF building with high visibility and multiple drive-throughs.

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    Heated Flex Warehouse with Office
    Heated Flex Warehouse with Office

    823 S Kingshighway, Cape Girardeau, MO 63703

    $3,334/Mo
    5,516 sqft

    Heated warehouse space combines a cooled office, private bathroom, and multiple loading options.

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    Charleston Retail or Office Space
    Charleston Retail or Office Space

    114 W Commercial St, Charleston, MO 63834

    $6.50 SF/Yr
    3,028 sqft

    Retail or office space with excellent visibility and parking.

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    Similar Spaces for Sale in Sikeston, MO

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

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    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $449,500
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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    Remodeled Professional Office Building
    Remodeled Professional Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot

    Remodeled office building with multiple entrances, parking on three sides, and new life-safety systems.

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    Office Building on Corner Lot
    Office Building on Corner Lot

    202 S Kingshighway Street, Sikeston, MO 63801

    $279,000
    0.34 AC lot

    Office building with elevator and ramp access, 15 parking spaces, and central air on a corner lot.

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    Commercial Building in High Traffic
    Commercial Building in High Traffic

    1218 Linn St, Sikeston, MO 63801

    $400,000
    7,100 sqft 0.74 AC lot

    7100 sq ft commercial building in high traffic area.

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    Office Building with Flexible Suite Layout
    Office Building with Flexible Suite Layout

    713 Tanner, Sikeston, MO 63801

    $250,000

    Commercial zoned office building offering a flexible layout for a single suite or up to four office suites.

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    Remodeled Office Building with Basement
    Remodeled Office Building with Basement

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000

    Updated office property offers flexible single-tenant or multi-tenant configuration with multiple entrances and parking around the building.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft 2.43 AC lot

    2.43 acres for office development with build-to-suit opportunity.

    View details
    Office Units with Modern Build-Out
    Office Units with Modern Build-Out

    1902 Vandalia Street, Collinsville, IL 62234

    $5,000/Mo

    Recently built office space with private offices, an open bullpen, and an accessible ramp approach for entry.

    View details
    Corner Office Unit
    Corner Office Unit

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    C4 zoning allows commercial, medical, and residential uses at this accessible corner property.

    View details
    Commercial Land with Build-to-Suit Potential
    Commercial Land with Build-to-Suit Potential

    2914&2920 E 22nd Street, Joplin, MO 64804

    $20 SF/Yr
    5,000 sqft

    C-1-zoned land supports a customizable commercial building concept with potential for C-3 zoning.

    View details

    Sikeston, MO Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Sikeston, MO with 4 listings featured on our commercial real estate exchange. The current inventory includes 3,931 square feet of properties with an estimated lease value of $34.50 SF/Yr.

    Estimated lease rates for Office Spaces in Sikeston, MO begin at $16.50 SF/Yr, with an average of $17.25 SF/Yr and extend to $18 SF/Yr.
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