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    Sikeston, MO

    Sikeston, MO Commercial Real Estate for Sale

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    35 properties
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    Historic Two-Story Storefront
    Updated: Feb 25
    Historic Two-Story Storefront

    124 E Front Street, Sikeston, MO 63801

    $275,000
    14,642 sqft 0.22 AC lot
    14,642‑square‑foot commercial building on a 0.22‑acre parcel
    Two‑story brick building constructed in 1915
    Two existing leases occupy the ground floor
    Open upper level available for future buildout or occupancy
    High ceilings and a flat roof
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    Flex Building with Storage Units
    Updated: Aug 26
    Flex Building with Storage Units

    330 State Highway H, Sikeston, MO 63801

    $799,000
    2.99 AC lot
    17,000‑square‑foot metal building on approximately 2.99 acres
    Approximately 12,000 square feet of insulated warehouse space
    Approximately 5,000 square feet of office area with 7 offices, a kitchen, and 4 bathrooms
    3‑phase electrical service, floor drains, newer HVAC, and newer water heater
    Four 14‑foot bay doors support warehouse access and deliveries
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    Freestanding Restaurant Building
    Freestanding Restaurant Building

    1103 S Main Street, Sikeston, MO 63801

    $1,200,000
    1.24 AC lot

    The vacant site includes a brick structure with water available.

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    Two-Building Religious Facility Campus
    Two-Building Religious Facility Campus

    951 S Kingshighway, Sikeston, MO 63801

    $1,600,000
    19,813 sqft 5.10 AC lot

    Two substantial buildings provide auditorium, classrooms, offices, multipurpose space, kitchens, storage, and community-oriented gathering areas.

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    Church and Community Campus
    Church and Community Campus

    951 S Kingshighway, Sikeston, MO 63801

    $1,600,000
    5.10 AC lot

    Two substantial buildings provide auditorium, classrooms, offices, meeting areas, kitchens, gymnasium, storage, and multipurpose space.

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    Warehouse with Dual-Unit Flexibility
    Warehouse with Dual-Unit Flexibility

    300 Matthews Lane, Sikeston, MO 63801

    $1,100,000
    1.20 AC lot

    Metal-sided warehouse offering loading access, office space, and a separate shop area.

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    Corner-Lot Office Building
    Corner-Lot Office Building

    202 S Kingshighway Street, Sikeston, MO 63801

    $185,000
    0.34 AC lot

    Two-level layout includes reception, offices, open work areas, conference space, restrooms, kitchen break room, storage, and elevator access.

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    Historic Two-Story Storefront
    Historic Two-Story Storefront

    124 E Front St, Sikeston, MO 63801

    $275,000
    14,642 sqft

    Downtown commercial building with leased ground-floor space and an unfinished upper level.

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    Historic Two-Story Storefront
    Historic Two-Story Storefront

    112 Front Street, Sikeston, MO 63801

    $190,000
    0.11 AC lot

    Brick construction, public water, and central air serve this downtown commercial property.

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    Commercial Land Near Interstate Access
    Commercial Land Near Interstate Access

    2338 S Acres Drive, Sikeston, MO 63801

    $1,100,000
    22.84 AC lot

    Vacant commercial land with agricultural zoning and direct proximity to Interstate 55 access.

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    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

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    Remodeled Office Building
    Remodeled Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot

    Remodeled brick office property with multiple entrances, updated building systems, and basement space.

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    35-Unit Self Storage Facility
    35-Unit Self Storage Facility

    2008 & 2010 N Main Street, Sikeston, MO 63801

    $499,000
    1.30 AC lot

    Self-storage property with leased commercial space and durable concrete construction.

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    Multi-Tenant Shopping Center
    Multi-Tenant Shopping Center

    908 S Kingshighway Street, Sikeston, MO 63801

    $1,200,000
    24,984 sqft

    Two tracts contain a commercial center with multiple storefronts and an established tenant base.

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    Commercial Land with Highway Frontage
    Commercial Land with Highway Frontage

    103 Grove Estates, Sikeston, MO 63801

    $144,000
    1.01 AC lot

    C-1 zoning and public utilities support neighborhood-serving retail, office, medical, and professional uses.

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    Metal-Sided Gas Station Property
    Metal-Sided Gas Station Property

    133 W Malone Avenue, Sikeston, MO 63801

    $299,000
    0.22 AC lot

    Metal-sided commercial property with documented gas station operations through 2022.

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    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $399,000
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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    Commercial Land Parcel
    Commercial Land Parcel

    1168 Stallcup Drive, Sikeston, MO 63801

    $450,000
    2.93 AC lot

    Commercial-zoned land positioned near major retailers, restaurants, and nearby hotels.

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    Flex Space with Additional Acre Lot
    Flex Space with Additional Acre Lot

    20079 Us Highway 61, Sikeston, MO 63801

    $140,000
    2,238 sqft

    Versatile flex building with strong visibility and easy access, plus an additional one-acre lot for expansion and storage.

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    Commercial Land Parcel
    Commercial Land Parcel

    109 Stallcup Drive, Sikeston, MO 63801

    $400,000
    2.63 AC lot

    Commercial-zoned land positioned near retail, hotels, restaurants, and shopping services.

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    Multi-Building Warehouse Property
    Multi-Building Warehouse Property

    109 Lakeside Dr, Sikeston, MO 63801

    $450,000
    18,000 sqft 2.29 AC lot

    Four separate structures create a flexible footprint for warehouse and distribution operations.

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    Drive-Through Restaurant Property
    Drive-Through Restaurant Property

    1105 S Main Street, Sikeston, MO 63801

    $650,000
    1.28 AC lot

    Existing restaurant building with highway frontage, signalized intersection access, and C3 Highway Commercial zoning.

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    Vacant Commercial Land
    Vacant Commercial Land

    2338 S Acres St, Sikeston, MO 63801

    $1,100,000
    22.00 AC lot

    Vacant ground property totaling over 22 acres positioned just off I-55 North Exit 69, offering drive-by exposure.

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    Mixed-Use Property with Duplex
    Mixed-Use Property with Duplex

    101-103 Donald Fulton Dr, Sikeston, MO 63801

    $290,000
    4,244 sqft 1.22 AC lot

    C-3-zoned property combines a commercial building, two residential units, storage space, and concrete parking.

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    Sikeston, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Sikeston, MO, showcased through 35 active listings on our real estate platform. These investment opportunities span a total of 358,296 square feet of properties for sale, with an estimated market value of $18,689,750.

    Sale prices for business properties in Sikeston, MO start at $90,000, averaging $602,895, and reaching up to $1,600,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    Sikeston, MO CRE market trends — vacancy, lease rates and price per SF, updated monthly
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    Demographics Overview

    Population 22K
    Population Growth (5Y) -3.7%
    Median Household Income $55,945
    College Educated 31.9%

    High-Yield Neighborhoods for Investment

    Identify Sikeston submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63801 $570.5K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Total CRE Inventory on Market (SF)

    Property Size Breakdown

    The majority of commercial real estate listings in Sikeston fall within the 25,000 to 50,000 square foot range.

    How Realmo verifies these figures

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