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    Sikeston, MO Commercial Real Estate for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    29 results
    Remodeled Commercial Building in Sikeston
    $775,000
    1.67 Acres

    Remodeled Commercial Building in Sikeston

    210 S Kingshighway Street, Sikeston, MO 63801

    Remodeled commercial building suitable for single or multiple tenants.

    • Completely remodeled building ideal for single or multiple professional/service‑related tenants.
    • New fire alarm and sprinkler system for enhanced safety.
    • Parking on 3 sides of the building.
    • Large basement accessible by elevator or stairs, suitable for storage or additional offices.
    • Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.
    Updated: Feb 26
    View details
    Historic Downtown Sikeston Retail Opportunity
    $275,000
    14,642 SF

    Historic Downtown Sikeston Retail Opportunity

    124 E Front Street, Sikeston, MO 63801

    Two-story retail space in high-traffic downtown Sikeston.

    • Prime downtown location with high visibility and foot traffic.
    • Value‑add opportunity with a blank canvas upstairs for customization.
    • Existing leases on the ground floor provide immediate income.
    • Historic building (built in 1915) with unique character.
    • Close proximity to retail, professional services, and restaurants.
    Updated: Feb 25
    View details
    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres

    Sikeston Commercial Property For Sale

    Prime commercial location with high visibility and established business history.

    1105 S Main Street, Sikeston, MO 63801
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    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF

    Sikeston Car Wash with Expansion Potential

    Turnkey car wash with expansion potential in high-demand market.

    531 N Main Street, Sikeston, MO 63780
    View details
    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    Commercial property with endless business opportunities in downtown Sikeston.

    202 S Kingshighway Street, Sikeston, MO 63801
    View details
    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 & 2010 N Main Street, Sikeston, MO 63801
    View details
    Sikeston Industrial Warehouse on 8+ Acres
    $350,000
    10,000 SF

    Sikeston Industrial Warehouse on 8+ Acres

    Industrial warehouse with I-55 frontage, ideal for logistics or distribution.

    608b State Highway H, Sikeston, MO 63801
    View details
    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF

    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main Street, Sikeston, MO 63801
    View details
    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn Street, Sikeston, MO 63801
    View details
    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF

    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front Street, Sikeston, MO 63801
    View details
    Sikeston Warehouse with Highway Access
    $1,100,000
    24,700 SF

    Sikeston Warehouse with Highway Access

    Large warehouse with easy access to I-55 and I-57.

    300 Matthews Lane, Sikeston, MO 63801
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    Commercial Land in Sikeston, MO
    $400,000
    2.63 Acres

    Commercial Land in Sikeston, MO

    2.63 acres in booming retail and hospitality area.

    109 Stallcup Drive, Sikeston, MO 63801
    View details
    Sikeston Commercial Building Investment Opportunity
    $979,500
    11,000 SF

    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801
    View details
    Commercial Land on Highway 61
    $144,000
    1.01 Acres

    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove Estates, Sikeston, MO 63801
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    Commercial Land in Retail Area
    $500,000
    1.05 Acres

    Commercial Land in Retail Area

    1.05 acres of commercial land for development in Sikeston.

    1209 Lawrence, Sikeston, MO 63801
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    Commercial Land in Sikeston, MO
    $500,000
    1.24 Acres

    Commercial Land in Sikeston, MO

    1.24 acre commercial lot near apartments and retail.

    1201 Lawrence, Sikeston, MO 63801
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    Commercial Land Ready For Development
    $199,000
    2.00 Acres

    Commercial Land Ready For Development

    Two-acre commercial lot available for development in Sikeston, Missouri.

    224 S Interstate Drive, Sikeston, MO 63801
    View details
    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF

    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front Street, Sikeston, MO 63801
    View details
    Sikeston Commercial Property with Income
    $290,000
    4,244 SF

    Sikeston Commercial Property with Income

    Commercial building, duplex, and storage on 1.22 acres.

    101-103 Donald Fulton Dr, Sikeston, MO 63801
    View details
    Neighborhood Center with Established Businesses
    Contact for pricing
    7,364 SF

    Neighborhood Center with Established Businesses

    Neighborhood center with high traffic, visibility, and established businesses.

    1100 - 1105 S. Main, Sikeston, MO 63801
    View details
    Commercial Land in Sikeston, MO
    $195,000
    0.72 Acres

    Commercial Land in Sikeston, MO

    Vacant, level commercial lot available in Sikeston, Missouri.

    116 Hospitality Drive, Sikeston, MO 63801
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    Prime Land for Commercial Development
    $3,960,000
    88.00 Acres

    Prime Land for Commercial Development

    88 acres at I-55 and I-57, Sikeston, MO.

    0 Ables Road, Sikeston, MO 63801
    View details
    Commercial Building in High Traffic
    $400,000
    7,100 SF

    Commercial Building in High Traffic

    7100 sq ft commercial building in high traffic area.

    1218 Linn St, Sikeston, MO 63801
    View details
    Turnkey Carwash in Sikeston, MO
    $1,250,000
    40,946 SF

    Turnkey Carwash in Sikeston, MO

    Established carwash with high traffic, visibility, and membership program.

    900 S Main, Sikeston, MO 63801
    View details

    Sikeston, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 29 commercial real estate for sale in Sikeston, MO, showcased through 29 active listings on our real estate platform. These investment opportunities span a total of 7,352,492 square feet of properties for sale, with an estimated market value of $15,571,000.

    Sale prices for business properties in Sikeston, MO start at $144,000, averaging $648,791, and reaching up to $3,960,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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