Advertise
    Sikeston, MO

    Sikeston, MO Commercial Real Estate for Sale

    Notify Me
    List
    Map
    Miner, MO Bertrand, MO East Prairie, MO Charleston, MO Benton, MO Essex, MO Oran, MO Bloomfield, MO
    27 properties
    Sort:
    Historic Two-Story Downtown Retail Building
    Updated: Feb 25
    Historic Two-Story Downtown Retail Building

    124 E Front Street, Sikeston, MO 63801

    $275,000
    14,642 sqft 0.22 AC lot
    2‑story downtown Sikeston building originally built in 1915
    Historic brick construction with high ceilings
    Ground floor includes two existing leases
    Flat roof with forced‑air heating and central air cooling (electric)
    Utilities: natural gas available; public water and public sewer
    View details
    Remodeled Professional Office Building
    Updated: Feb 27
    Remodeled Professional Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot
    Completely remodeled large commercial building (brick) built in 1964
    HVAC includes forced air heating and central air cooling
    Remodel scope included wiring, lights, electrical panels, bathrooms, and floors
    New fire alarm and sprinkler system
    Roof is about 75% new; parking lot resurfaced
    View details
    Vacant Land Off Interstate Exit
    Vacant Land Off Interstate Exit

    2338 S Acres Drive, Sikeston, MO 63801

    $1,200,000
    22.84 AC lot

    Vacant ground totaling 22+ acres in Agricultural zoning, positioned just off an I-55 north exit for high-exposure development.

    View details
    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

    View details
    Retail and Office Buildings with Drive-Through
    Retail and Office Buildings with Drive-Through

    1018 Linn Street, Sikeston, MO 63801

    $550,000
    4.20 AC lot

    Two Morton buildings offer an office setup and a larger shop with multiple drive-through and walk-through doors on irrigated acreage.

    View details
    Downtown Office Building with Parking
    Downtown Office Building with Parking

    202 S Kingshighway Street, Sikeston, MO 63801

    $279,000
    0.34 AC lot

    Corner lot office building includes a receptionist area, multiple offices, and basement level with elevator access.

    View details
    Commercial Land Parcel
    Commercial Land Parcel

    109 Stallcup Drive, Sikeston, MO 63801

    $400,000
    2.63 AC lot

    Over 2.5-acre commercial lot near Wal-Mart and US 60/61.

    View details
    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $449,500
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

    View details
    Commercial Development Land Parcel
    Commercial Development Land Parcel

    224 S Interstate Drive, Sikeston, MO 63801

    $199,000
    2.00 AC lot

    A 2-acre commercial lot in Sikeston, MO, available for a build-to-suit development under commercial zoning.

    View details
    Industrial Warehouse with I-55 Access
    Industrial Warehouse with I-55 Access

    608B State Highway H, Sikeston, MO 63801

    $350,000
    8.80 AC lot

    Industrial warehouse on 8.8 acres with multiple overhead doors and direct I-55 frontage.

    View details
    Prime Land I-55 Exit 69
    Prime Land I-55 Exit 69

    2338 South Acres Drive, Sikeston, MO 63801

    $1,200,000
    994,910 sqft 22.84 AC lot

    High-traffic vacant land suitable for retail or restaurant development.

    View details
    Commercial Development Land Site
    Commercial Development Land Site

    103 Grove Estates, Sikeston, MO 63801

    $144,000
    1.01 AC lot

    Commercially zoned tract with Highway 61 frontage for office, medical, and professional services near Sikeston residential areas.

    View details
    Vacant Commercial Land Lot
    Vacant Commercial Land Lot

    116 Hospitality Drive, Sikeston, MO 63801

    $195,000
    0.72 AC lot

    Vacant, level commercial-zoned lot outside the flood plain, suitable for a future development footprint.

    View details
    Commercial Land Site
    Commercial Land Site

    109 Stallcup Drive, Sikeston, MO 63801

    $400,000
    114,562 sqft 2.50 AC lot

    Over 2.5 acres available near major retail and hospitality along US 60 and 61.

    View details
    Flexible Office Building
    Flexible Office Building

    713 Tanner, Sikeston, MO 63801

    $250,000

    Well-maintained office building configured as one suite or up to four suites with multiple private entrances and parking.

    View details
    Former Restaurant with Commercial Kitchen
    Former Restaurant with Commercial Kitchen

    1212 Linn, Sikeston, MO 63801

    $425,000

    Former restaurant includes a spacious dining area, commercial kitchen infrastructure, and ample parking for new concepts.

    View details
    Shadow-Anchored NNN Shopping Center
    Shadow-Anchored NNN Shopping Center

    1209-1215 S Main St, Sikeston, MO 63801

    $3,750,000
    49,173 sqft

    Multi-tenant NNN shopping center anchored by nearby Walmart and Lowe’s, with retailers including Harbor Freight, CATO, and Hibbett Sports.

    View details
    Commercial Property with Storage and Duplex
    Commercial Property with Storage and Duplex

    101-103 Donald Fulton Dr, Sikeston, MO 63801

    $290,000
    4,244 sqft 1.22 AC lot

    Large commercial building and a separately fenced duplex with storage building and concrete parking.

    View details
    Historic Downtown Mixed-Use Opportunity
    Historic Downtown Mixed-Use Opportunity

    124 E Front Street, Sikeston, MO 63801

    $299,000
    14,642 sqft 0.22 AC lot

    Two-story historic building in downtown Sikeston with modern potential.

    View details
    Commercial Building in High Traffic
    Commercial Building in High Traffic

    1218 Linn St, Sikeston, MO 63801

    $400,000
    7,100 sqft 0.74 AC lot

    7100 sq ft commercial building in high traffic area.

    View details
    Sikeston Warehouse with Truck Parking
    Sikeston Warehouse with Truck Parking

    103 South Acres Drive, Sikeston, MO 63801

    Contact for pricing
    210,000 sqft

    210,000 SF warehouse near I-55 and I-57.

    View details
    Sikeston Commercial Land Available
    Sikeston Commercial Land Available

    1240 S Main Street, Sikeston, MO 63801

    Contact for pricing

    Commercial land available in Sikeston, Missouri.

    View details
    Sikeston Commercial Property for Sale
    Sikeston Commercial Property for Sale

    1330 South Main Street, Sikeston, MO 63801

    Contact for pricing

    Commercial property available in Sikeston, Missouri.

    View details
    Prime Land for Commercial Development
    Prime Land for Commercial Development

    Ables Road, Sikeston, MO 63801

    $3,960,000

    Commercial land available at I-55 and I-57 interchange.

    View details

    Sikeston, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Sikeston, MO, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 1,229,771 square feet of properties for sale, with an estimated market value of $8,043,000.

    Sale prices for business properties in Sikeston, MO start at $275,000, averaging $893,666, and reaching up to $3,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    List
    Map

    Demographics Overview

    Population 22K
    Population Growth (5Y) -3.7%
    Median Household Income $55,945
    College Educated 31.9%

    High-Yield Neighborhoods for Investment

    Identify Sikeston submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63801 $626.7K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Total CRE Inventory on Market (SF)

    Property Size Breakdown

    The majority of commercial real estate listings in Sikeston fall within the 25,000 to 50,000 square foot range.

    Need Help?

    Reach out if you need assistance with Realmo tools or have questions about your listings

    Contact Us

    Browse Commercial real estate for Sale Near Sikeston, MO

    Popular Searches in Sikeston, MO

    Popular Categories

    Most Searched ZIP Codes in Sikeston, MO

    • 63801

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!