Sikeston, MO Commercial Real Estate for Sale

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41 properties

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Updated: Feb 25

Two-Story Historic Retail Building

124 E Front Street, Sikeston, MO 63801

$275,000

14,642 sqft 0.22 AC lot

Two leases on the ground floor
Upstairs described as a blank canvas for future buildout
Built in 1915 in a historic brick, two‑story structure
Forced‑air heating and electric central air cooling
Flat roof with public water and public sewer

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Updated: Aug 26

Flex Building with Storage Units

330 State Highway H, Sikeston, MO 63801

$799,000

2.99 AC lot

17,000‑square‑foot metal building on approximately 2.99 acres
Approximately 12,000 square feet of insulated warehouse space
Approximately 5,000 square feet of office area with 7 offices, a kitchen, and 4 bathrooms
3‑phase electrical service, floor drains, newer HVAC, and newer water heater
Four 14‑foot bay doors support warehouse access and deliveries

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Remodeled Professional Office Building

210 S Kingshighway Street, Sikeston, MO 63801

$775,000

1.67 AC lot

Remodeled office building with multiple entrances, parking on three sides, and new life-safety systems.

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Historic Two-Story Storefront

124 E Front St, Sikeston, MO 63801

$275,000

14,642 sqft

Downtown commercial building with leased ground-floor space and an unfinished upper level.

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Historic Two-Story Storefront

112 Front Street, Sikeston, MO 63801

$190,000

0.11 AC lot

Brick construction, public water, and central air serve this downtown commercial property.

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35-Unit Self Storage Facility

2008 & 2010 N Main Street, Sikeston, MO 63801

$549,000

1.30 AC lot

Self-storage property with leased commercial space and durable concrete construction.

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Vacant Land Off Interstate Exit

2338 S Acres Drive, Sikeston, MO 63801

$1,200,000

22.84 AC lot

Vacant ground totaling 22+ acres in Agricultural zoning, positioned just off an I-55 north exit for high-exposure development.

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Sikeston Commercial Building Investment Opportunity

808 E Wakefield Ave, Sikeston, MO 63801

$979,500

11,000 sqft

High-visibility commercial building with income and upside potential.

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Commercial Land Parcel

1168 Stallcup Drive, Sikeston, MO 63801

$450,000

2.93 AC lot

Commercially zoned land parcel of 2.93 acres near major retailers and national hotel options.

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Warehouse with Dual-Unit Flexibility

300 Matthews Lane, Sikeston, MO 63801

$1,100,000

1.20 AC lot

Metal-sided warehouse offering loading access, office space, and a separate shop area.

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Flex-Industrial Headquarters Facility

205 S New Madrid St, Sikeston, MO 63801

$449,500

19,498 sqft 1.00 AC lot

Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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Metal-Sided Gas Station Property

133 W Malone Avenue, Sikeston, MO 63801

$299,000

0.22 AC lot

Metal-sided commercial property with documented gas station operations through 2022.

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Corner-Lot Office Building

202 S Kingshighway Street, Sikeston, MO 63801

$279,000

0.34 AC lot

Two-level layout includes reception, offices, open work areas, conference space, restrooms, kitchen break room, storage, and elevator access.

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Flex Space with Additional Acre Lot

20079 Us Highway 61, Sikeston, MO 63801

$165,000

2,238 sqft

Versatile flex building with strong visibility and easy access, plus an additional one-acre lot for expansion and storage.

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Commercial Land Parcel

109 Stallcup Drive, Sikeston, MO 63801

$400,000

2.63 AC lot

Over 2.5-acre commercial lot near Wal-Mart and US 60/61.

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Commercial Development Land Parcel

224 S Interstate Drive, Sikeston, MO 63801

$199,000

2.00 AC lot

A 2-acre commercial lot in Sikeston, MO, available for a build-to-suit development under commercial zoning.

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Vacant Commercial Land

2338 S Acres St, Sikeston, MO 63801

$1,200,000

22.00 AC lot

Vacant ground property totaling over 22 acres positioned just off I-55 North Exit 69, offering drive-by exposure.

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Commercial Development Land Site

103 Grove Estates, Sikeston, MO 63801

$144,000

1.01 AC lot

Commercially zoned tract with Highway 61 frontage for office, medical, and professional services near Sikeston residential areas.

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Shadow-Anchored NNN Shopping Center

1209-1215 S Main St, Sikeston, MO 63801

Contact for pricing

49,173 sqft

Multi-tenant NNN shopping center anchored by nearby Walmart and Lowe’s, with retailers including Harbor Freight, CATO, and Hibbett Sports.

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Flexible Multi-Suite Office Building

713 Tanner, Sikeston, MO 63801

$250,000

Commercially zoned office property with private entrances, natural light, and adaptable space for professional operations.

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Truck Terminal with Drive-In Doors

328 South Interstate Drive, Sikeston, MO 63801

Contact for pricing

9,234 sqft

Industrial facility combines office space, truck-serving work areas, and dedicated gravel parking for commercial vehicles.

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Drive-Through Restaurant Property

1105 S Main Street, Sikeston, MO 63801

$650,000

1.28 AC lot

Existing restaurant building with highway frontage, signalized intersection access, and C3 Highway Commercial zoning.

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Days Inn & Suites Hotel

220 S Interstate Dr, Sikeston, MO 63801

Contact for pricing

40,148 sqft 10.50 AC lot

Hospitality property with renovated interiors, event facilities, dining areas, a pool, and fitness room.

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Conventional Restaurant Property

1212 Linn, Sikeston, MO 63801

$425,000

Former restaurant with dining space, commercial kitchen infrastructure, and on-site parking.

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Sikeston, MO Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Sikeston, MO, showcased through 41 active listings on our real estate platform. These investment opportunities span a total of 592,619 square feet of properties for sale, with an estimated market value of $15,132,250.

Sale prices for business properties in Sikeston, MO start at $90,000, averaging $540,437, and reaching up to $1,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 22K

Population Growth (5Y) -3.7%

Median Household Income $55,945

College Educated 31.9%

High-Yield Neighborhoods for Investment

Identify Sikeston submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
63801	$521.8K

Taxes & Financing

Average Loan-to-Value 65.0%

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in Scott County

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Property Size Breakdown

The majority of commercial real estate listings in Sikeston fall within the 25,000 to 50,000 square foot range.

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