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    Sikeston, MO Office Spaces for Sale

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    Flex Building with Storage Units
    Updated: Aug 26
    Flex Building with Storage Units

    330 State Highway H, Sikeston, MO 63801

    $799,000
    2.99 AC lot
    17,000‑square‑foot metal building on approximately 2.99 acres
    Approximately 12,000 square feet of insulated warehouse space
    Approximately 5,000 square feet of office area with 7 offices, a kitchen, and 4 bathrooms
    3‑phase electrical service, floor drains, newer HVAC, and newer water heater
    Four 14‑foot bay doors support warehouse access and deliveries
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    Remodeled Professional Office Building
    Updated: Feb 27
    Remodeled Professional Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot
    Completely remodeled large commercial building (brick) built in 1964
    HVAC includes forced air heating and central air cooling
    Remodel scope included wiring, lights, electrical panels, bathrooms, and floors
    New fire alarm and sprinkler system
    Roof is about 75% new; parking lot resurfaced
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    Historic Two-Story Storefront
    Historic Two-Story Storefront

    112 Front Street, Sikeston, MO 63801

    $190,000
    0.11 AC lot

    Brick construction, public water, and central air serve this downtown commercial property.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

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    Corner-Lot Office Building
    Corner-Lot Office Building

    202 S Kingshighway Street, Sikeston, MO 63801

    $279,000
    0.34 AC lot

    Two-level layout includes reception, offices, open work areas, conference space, restrooms, kitchen break room, storage, and elevator access.

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    Flexible Multi-Suite Office Building
    Flexible Multi-Suite Office Building

    713 Tanner, Sikeston, MO 63801

    $250,000

    Commercially zoned office property with private entrances, natural light, and adaptable space for professional operations.

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    Flex-Industrial Headquarters Facility
    Flex-Industrial Headquarters Facility

    205 S New Madrid St, Sikeston, MO 63801

    $449,500
    19,498 sqft 1.00 AC lot

    Multi-parcel flex facility combining office infrastructure with a full-length drive-through warehouse for operations and distribution.

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    Multi-Office Building
    Multi-Office Building

    201 S New Madrid Street, Sikeston, MO 63801

    Contact for pricing

    Professional office property with reception, private workrooms, conference space, kitchenette, and file storage.

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    Church Facility with Open Floor Plan
    Church Facility with Open Floor Plan

    416 Greer Ave, Sikeston, MO 63801

    Contact for pricing

    Multi-room building near US 60 Business Highway with flexible interior areas.

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    Based on your search, we've compiled 79 Potential Opportunities for your consideration. Besides 9 Active listings in Sikeston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 63 Off-Market properties to explore as potential leads, plus 3 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Multi-Building Auto Shop Property
    Multi-Building Auto Shop Property

    120 W Business US Highway 60, Dexter, MO 63841

    $435,000
    4,500 sqft 0.86 AC lot

    Commercial automotive property with repair, office, and wash-bay improvements along Business Highway 60.

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    Retail Building with Highway Frontage
    Retail Building with Highway Frontage

    1113 E. Marshall, Charleston, MO 63834

    $99,900
    2,121 sqft

    Existing commercial structure offers renovation flexibility for retail or office use.

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    Office Building with Open Floor Space
    Office Building with Open Floor Space

    2380 S. Main, Charleston, MO 63834

    $84,000
    1,452 sqft 0.73 AC lot

    Commercially zoned property with central heating and cooling, two private offices, and additional rear work area.

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    Flex Space With Insulated Shop
    Flex Space With Insulated Shop

    1115 HWY. 114, Dexter, MO 63841

    Contact for pricing

    Combined office and shop improvements support varied commercial operations on a fenced acreage parcel.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Development Land Site
    Commercial Development Land Site

    103 Grove Estates, Sikeston, MO 63801

    $144,000
    1.01 AC lot

    Commercially zoned tract with Highway 61 frontage for office, medical, and professional services near Sikeston residential areas.

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    Commercial Development Land Parcel
    Commercial Development Land Parcel

    224 S Interstate Drive, Sikeston, MO 63801

    $199,000
    2.00 AC lot

    A 2-acre commercial lot in Sikeston, MO, available for a build-to-suit development under commercial zoning.

    View details
    Renovated Office Building
    Renovated Office Building

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $239,900
    2,937 sqft 0.25 AC lot

    Brick commercial property with central air, public utilities, and open-lot parking near downtown activity.

    View details

    Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    816 Linn St
    OFFICE BUILDING

    816 Linn St, Sikeston, MO 63801-2241

    Value Estimation by Request
    2,135 sqft 0.29 AC lot
    View details
    101 Plz Dr
    OFFICE BUILDING

    101 Plz Dr, Sikeston, MO 63801-5136

    Value Estimation by Request
    957 sqft 0.26 AC lot
    View details
    613 Greer Ave
    MEDICAL BUILDING

    613 Greer Ave, Sikeston, MO 63801

    Value Estimation by Request
    3,468 sqft 0.30 AC lot
    View details
    330 State Hwy H H
    OFFICE BUILDING

    330 State Hwy H H, Sikeston, MO 63801-5349

    Value Estimation by Request
    10,400 sqft 3.00 AC lot
    View details
    228 Interstate Dr
    OFFICE BUILDING

    228 Interstate Dr, Sikeston, MO 63801-8621

    Value Estimation by Request
    468 sqft 0.60 AC lot
    View details
    2830 Brewer Dr
    OFFICE BUILDING

    2830 Brewer Dr, Sikeston, MO 63801

    Value Estimation by Request
    640 sqft 1.60 AC lot
    View details
    101 Kennedy Dr
    OFFICE BUILDING

    101 Kennedy Dr, Sikeston, MO 63801-5126

    Value Estimation by Request
    2,726 sqft 0.56 AC lot
    View details
    215 Stoddard St
    OFFICE BUILDING

    215 Stoddard St, Sikeston, MO 63801-4124

    Value Estimation by Request
    3,212 sqft 0.32 AC lot
    View details
    102 Smith Ave
    OFFICE BUILDING

    102 Smith Ave, Sikeston, MO 63801-5240

    Value Estimation by Request
    6,660 sqft 0.48 AC lot
    View details
    Sikeston, MO 63801
    OFFICE BUILDING

    Sikeston, MO 63801

    Value Estimation by Request
    2,160 sqft 2.72 AC lot
    View details
    301 Malone Ave
    OFFICE BUILDING

    301 Malone Ave, Sikeston, MO 63801-2827

    Value Estimation by Request
    3,058 sqft 0.21 AC lot
    View details
    217 Kingshighway St
    OFFICE BUILDING

    217 Kingshighway St, Sikeston, MO 63801-2963

    Value Estimation by Request
    3,525 sqft 0.50 AC lot
    View details
    301 New Madrid St
    OFFICE BUILDING

    301 New Madrid St, Sikeston, MO 63801-1971

    Value Estimation by Request
    4,722 sqft 0.85 AC lot
    View details
    Interstate S Dr
    OFFICE BUILDING

    Interstate S Dr, Sikeston, MO 63801

    Value Estimation by Request
    5,040 sqft 4.27 AC lot
    View details
    310 Ctr St
    OFFICE BUILDING

    310 Ctr St, Sikeston, MO 63801-4231

    $460,000
    Estimated value
    9,154 sqft 0.52 AC lot
    View details

    Sikeston, MO Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in Sikeston, MO, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 30,498 square feet of properties for sale, with an estimated market value of $3,722,000.

    Sale prices for office spaces in Sikeston, MO start at $190,000, averaging $531,714, and reaching up to $979,500 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 12
    Office buildings 7
    Creative space 1
    Medical Office Space 1

    Demographics Overview

    Population 22K
    Population Growth (5Y) -3.7%
    Median Household Income $55,945
    College Educated 31.9%

    High-Yield Neighborhoods for Investment

    Identify Sikeston submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63801 $531.7K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in Scott County

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