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    Sikeston, MO Office Properties & Spaces for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    Remodeled Commercial Building in Sikeston
    $775,000
    1.67 Acres

    Remodeled Commercial Building in Sikeston

    210 S Kingshighway Street, Sikeston, MO 63801

    Remodeled commercial building suitable for single or multiple tenants.

    • Completely remodeled building ideal for single or multiple professional/service‑related tenants.
    • New fire alarm and sprinkler system for enhanced safety.
    • Parking on 3 sides of the building.
    • Large basement accessible by elevator or stairs, suitable for storage or additional offices.
    • Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.
    Updated: Feb 26
    View details
    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    202 S Kingshighway Street, Sikeston, MO 63801

    Commercial property with endless business opportunities in downtown Sikeston.

    • Large 7,638 sq ft building suitable for diverse business opportunities.
    • Prime downtown Sikeston location on a corner lot.
    • Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
    • Functional layout with reception area, open workspace, private offices, conference room, and break room.
    • Equipped with both stairs and an elevator for basement access.
    Updated: Dec 10, 2025
    View details
    Sikeston Commercial Building Investment Opportunity
    $979,500
    11,000 SF

    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801
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    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF

    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front Street, Sikeston, MO 63801
    View details
    Commercial Building in High Traffic
    $400,000
    7,100 SF

    Commercial Building in High Traffic

    7100 sq ft commercial building in high traffic area.

    1218 Linn St, Sikeston, MO 63801
    View details
    Based on your search, we've compiled 155 Potential Opportunities for your consideration. Besides 5 Active listings in Sikeston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 142 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Charleston Commercial Property on Highway
    $110,000
    2,121 SF

    Charleston Commercial Property on Highway

    Commercial property with existing building and highway frontage in Charleston.

    1113 E. Marshall, Charleston, MO 63834
    View details
    Cape Girardeau Medical Office Building
    $270,000
    2,546 SF

    Cape Girardeau Medical Office Building

    2,546 SF medical office building in a thriving complex.

    62 Doctors Park, Cape Girardeau, MO 63703
    View details
    Prime Commercial Space on Mount Auburn
    Contact for pricing
    1,660 SF

    Prime Commercial Space on Mount Auburn

    Versatile commercial space with parking and high visibility.

    326 S. Mount Auburn, Cape Girardeau, MO 63703
    View details
    Charleston, MO Commercial Investment Opportunity
    $575,000
    2,134 SF

    Charleston, MO Commercial Investment Opportunity

    High-traffic commercial property suitable for restaurant, retail, or office use.

    11 Truman St, Charleston, MO 63834
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land in Dexter, MO
    $2,000,000
    2.96 Acres

    Commercial Land in Dexter, MO

    Commercial property suitable for business, subdivision possible.

    0 W Bus Hwy 60, Dexter, MO 63841
    View details
    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
    View details
    Commercial Property on Highway 25
    $109,000
    7,000 SF

    Commercial Property on Highway 25

    7000 sq ft commercial property on 1 acre lot.

    2770 N Douglass, Malden, MO 63863
    View details
    Union City Building Lots
    Contact for pricing

    Union City Building Lots

    Land for sale in Union City, Tennessee.

    604 Miles Avenue N (Lot 5), Union City, TN 38261
    View details

    Explore Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    816 Linn St

    816 Linn St

    OFFICE BUILDING • 2,135 SF
    Value Estimation by Request
    816 Linn St, Sikeston, MO 63801-2241
    View details
    101 Plz Dr

    101 Plz Dr

    OFFICE BUILDING • 957 SF
    Value Estimation by Request
    101 Plz Dr, Sikeston, MO 63801-5136
    View details
    613 Greer Ave

    613 Greer Ave

    MEDICAL BUILDING • 3,468 SF
    Value Estimation by Request
    613 Greer Ave, Sikeston, MO 63801
    View details
    330 State Hwy H H

    330 State Hwy H H

    OFFICE BUILDING • 10,400 SF
    Value Estimation by Request
    330 State Hwy H H, Sikeston, MO 63801-5349
    View details
    228 Interstate Dr

    228 Interstate Dr

    OFFICE BUILDING • 468 SF
    Value Estimation by Request
    228 Interstate Dr, Sikeston, MO 63801-8621
    View details
    2830 Brewer Dr

    2830 Brewer Dr

    OFFICE BUILDING • 640 SF
    Value Estimation by Request
    2830 Brewer Dr, Sikeston, MO 63801
    View details
    101 Kennedy Dr

    101 Kennedy Dr

    OFFICE BUILDING • 2,726 SF
    Value Estimation by Request
    101 Kennedy Dr, Sikeston, MO 63801-5126
    View details
    215 Stoddard St

    215 Stoddard St

    OFFICE BUILDING • 3,212 SF
    Value Estimation by Request
    215 Stoddard St, Sikeston, MO 63801-4124
    View details
    102 Smith Ave

    102 Smith Ave

    OFFICE BUILDING • 6,660 SF
    Value Estimation by Request
    102 Smith Ave, Sikeston, MO 63801-5240
    View details
    Sikeston, MO 63801

    Sikeston, MO 63801

    OFFICE BUILDING • 2,160 SF
    Value Estimation by Request
    Sikeston, MO 63801
    View details
    301 Malone Ave

    301 Malone Ave

    OFFICE BUILDING • 3,058 SF
    Value Estimation by Request
    301 Malone Ave, Sikeston, MO 63801-2827
    View details
    217 Kingshighway St

    217 Kingshighway St

    OFFICE BUILDING • 3,525 SF
    Value Estimation by Request
    217 Kingshighway St, Sikeston, MO 63801-2963
    View details
    301 New Madrid St

    301 New Madrid St

    OFFICE BUILDING • 4,722 SF
    Value Estimation by Request
    301 New Madrid St, Sikeston, MO 63801-1971
    View details
    Interstate S Dr

    Interstate S Dr

    OFFICE BUILDING • 5,040 SF
    Value Estimation by Request
    Interstate S Dr, Sikeston, MO 63801
    View details
    310 Ctr St

    310 Ctr St

    OFFICE BUILDING • 9,154 SF
    Value Estimation by Request
    310 Ctr St, Sikeston, MO 63801-4231
    View details
    201 New Madrid St

    201 New Madrid St

    OFFICE BUILDING • 2,706 SF
    Value Estimation by Request
    201 New Madrid St, Sikeston, MO 63801-2953
    View details
    1901 Malone Ave

    1901 Malone Ave

    OFFICE BUILDING • 1,804 SF
    Value Estimation by Request
    1901 Malone Ave, Sikeston, MO 63801-3631
    View details
    801 Main St

    801 Main St

    OFFICE BUILDING • 5,560 SF
    Value Estimation by Request
    801 Main St, Sikeston, MO 63801-5806
    View details
    104 Lillian Dr

    104 Lillian Dr

    OFFICE BUILDING • 10,250 SF
    Value Estimation by Request
    104 Lillian Dr, Sikeston, MO 63801-2203
    View details

    Sikeston, MO Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 147 office properties & spaces for sale in Sikeston, MO, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 585,719 square feet of properties for sale, with an estimated market value of $5,114,000.

    Sale prices for office spaces in Sikeston, MO start at $279,000, averaging $568,222, and reaching up to $775,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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