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    Sikeston, MO Office Spaces for Sale

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    Miner, MO Bertrand, MO East Prairie, MO
    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF
    Downtown Sikeston Commercial Office Building

    202 S Kingshighway Street, Sikeston, MO 63801

    Commercial property with endless business opportunities in downtown Sikeston.
    • Large 7,638 sq ft building suitable for diverse business opportunities.
    • Prime downtown Sikeston location on a corner lot.
    • Includes 15 parking spaces with handicap accessibility (2 spaces and ramp).
    • Functional layout with reception area, open workspace, private offices, conference room, and break room.
    • Equipped with both stairs and an elevator for basement access.
    Updated: Dec 10, 2025
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    Remodeled Commercial Building in Sikeston
    $775,000
    1.67 Acres
    Remodeled Commercial Building in Sikeston

    210 S Kingshighway Street, Sikeston, MO 63801

    Remodeled commercial building suitable for single or multiple tenants.
    • Completely remodeled building ideal for single or multiple professional/service‑related tenants.
    • New fire alarm and sprinkler system for enhanced safety.
    • Parking on 3 sides of the building.
    • Large basement accessible by elevator or stairs, suitable for storage or additional offices.
    • Remodel includes new wiring, lights, electrical panels, bathrooms, and floors.
    Updated: Feb 26
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    Sikeston Commercial Building Investment Opportunity
    $979,500
    11,000 SF
    Sikeston Commercial Building Investment Opportunity

    High-visibility commercial building with income and upside potential.

    808 E Wakefield Ave, Sikeston, MO 63801

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    Historic Downtown Mixed-Use Opportunity
    $299,000
    14,642 SF
    Historic Downtown Mixed-Use Opportunity

    Two-story historic building in downtown Sikeston with modern potential.

    124 E Front Street, Sikeston, MO 63801

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    Commercial Building in High Traffic
    $400,000
    7,100 SF
    Commercial Building in High Traffic

    7100 sq ft commercial building in high traffic area.

    1218 Linn St, Sikeston, MO 63801

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 5 Active listings in Sikeston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Dexter, MO Mixed-Use Opportunity
    $199,900
    0.96 Acres
    Dexter, MO Mixed-Use Opportunity

    Versatile building near school, suitable for various commercial purposes.

    405 S 1 Mile Road, Dexter, MO 63841

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    Office and Storage Investment Opportunity
    $695,000
    3,700 SF
    Office and Storage Investment Opportunity

    Income-producing property with office building and storage units in Dexter.

    2102 N Outer Rd, Dexter, MO 63841

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    Charleston, MO Commercial Investment Opportunity
    $575,000
    2,134 SF
    Charleston, MO Commercial Investment Opportunity

    High-traffic commercial property suitable for restaurant, retail, or office use.

    11 Truman St, Charleston, MO 63834

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    High-Frontage Retail or Office Building
    $99,900
    2,121 SF
    High-Frontage Retail or Office Building

    Commercial building on a highway-frontage site with space for retail or office redevelopment.

    1113 E. Marshall, Charleston, MO 63834

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on Highway 61
    $144,000
    1.01 Acres
    Commercial Land on Highway 61

    Commercial land on high-traffic route near Sikeston Industrial Park.

    103 Grove Estates, Sikeston, MO 63801

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    Commercial Land in Sikeston, MO
    $195,000
    0.72 Acres
    Commercial Land in Sikeston, MO

    Vacant, level commercial lot available in Sikeston, Missouri.

    116 Hospitality Drive, Sikeston, MO 63801

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    Commercial Land Ready For Development
    $199,000
    2.00 Acres
    Commercial Land Ready For Development

    Two-acre commercial lot available for development in Sikeston, Missouri.

    224 S Interstate Drive, Sikeston, MO 63801

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    Commercial Land in Dexter, MO
    $2,000,000
    2.96 Acres
    Commercial Land in Dexter, MO

    Commercial property suitable for business, subdivision possible.

    0 W Bus Hwy 60, Dexter, MO 63841

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    Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    816 Linn St
    OFFICE BUILDING
    2,135 SF Lot: 0.29 Acres
    Value Estimation by Request

    816 Linn St, Sikeston, MO 63801-2241

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    101 Plz Dr
    OFFICE BUILDING
    957 SF Lot: 0.26 Acres
    Value Estimation by Request

    101 Plz Dr, Sikeston, MO 63801-5136

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    613 Greer Ave
    MEDICAL BUILDING
    3,468 SF Lot: 0.30 Acres
    Value Estimation by Request

    613 Greer Ave, Sikeston, MO 63801

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    330 State Hwy H H
    OFFICE BUILDING
    10,400 SF Lot: 3.00 Acres
    Value Estimation by Request

    330 State Hwy H H, Sikeston, MO 63801-5349

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    228 Interstate Dr
    OFFICE BUILDING
    468 SF Lot: 0.60 Acres
    Value Estimation by Request

    228 Interstate Dr, Sikeston, MO 63801-8621

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    2830 Brewer Dr
    OFFICE BUILDING
    640 SF Lot: 1.60 Acres
    Value Estimation by Request

    2830 Brewer Dr, Sikeston, MO 63801

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    101 Kennedy Dr
    OFFICE BUILDING
    2,726 SF Lot: 0.56 Acres
    Value Estimation by Request

    101 Kennedy Dr, Sikeston, MO 63801-5126

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    215 Stoddard St
    OFFICE BUILDING
    3,212 SF Lot: 0.32 Acres
    Value Estimation by Request

    215 Stoddard St, Sikeston, MO 63801-4124

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    102 Smith Ave
    OFFICE BUILDING
    6,660 SF Lot: 0.48 Acres
    Value Estimation by Request

    102 Smith Ave, Sikeston, MO 63801-5240

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    Sikeston, MO 63801
    OFFICE BUILDING
    2,160 SF Lot: 2.72 Acres
    Value Estimation by Request

    Sikeston, MO 63801

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    301 Malone Ave
    OFFICE BUILDING
    3,058 SF Lot: 0.21 Acres
    Value Estimation by Request

    301 Malone Ave, Sikeston, MO 63801-2827

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    217 Kingshighway St
    OFFICE BUILDING
    3,525 SF Lot: 0.50 Acres
    Value Estimation by Request

    217 Kingshighway St, Sikeston, MO 63801-2963

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    301 New Madrid St
    OFFICE BUILDING
    4,722 SF Lot: 0.85 Acres
    Value Estimation by Request

    301 New Madrid St, Sikeston, MO 63801-1971

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    Interstate S Dr
    OFFICE BUILDING
    5,040 SF Lot: 4.27 Acres
    Value Estimation by Request

    Interstate S Dr, Sikeston, MO 63801

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    310 Ctr St
    OFFICE BUILDING
    9,154 SF Lot: 0.52 Acres
    Value Estimation by Request

    310 Ctr St, Sikeston, MO 63801-4231

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    201 New Madrid St
    OFFICE BUILDING
    2,706 SF Lot: 0.13 Acres
    Value Estimation by Request

    201 New Madrid St, Sikeston, MO 63801-2953

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    1901 Malone Ave
    OFFICE BUILDING
    1,804 SF Lot: 0.21 Acres
    Value Estimation by Request

    1901 Malone Ave, Sikeston, MO 63801-3631

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    801 Main St
    OFFICE BUILDING
    5,560 SF Lot: 0.20 Acres
    Value Estimation by Request

    801 Main St, Sikeston, MO 63801-5806

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    104 Lillian Dr
    OFFICE BUILDING
    10,250 SF Lot: 1.14 Acres
    Value Estimation by Request

    104 Lillian Dr, Sikeston, MO 63801-2203

    View details

    Sikeston, MO Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in Sikeston, MO, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 37,015 square feet of properties for sale, with an estimated market value of $1,957,500.

    Sale prices for office spaces in Sikeston, MO start at $279,000, averaging $489,375, and reaching up to $979,500 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Office Units 12
    Office buildings 4
    Medical Office Space 3

    Demographics Overview

    Population 22K
    Population Growth (5Y) -3.7%
    Median Household Income $55,945
    College Educated 31.9%

    High-Yield Neighborhoods for Investment

    Identify Sikeston submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63801 $546.5K

    Taxes & Financing

    Average Loan-to-Value 65.0%

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