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    Sikeston, MO Office Buildings for Sale

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    Miner, MO Bertrand, MO East Prairie, MO Charleston, MO Benton, MO Essex, MO Oran, MO Bloomfield, MO
    Remodeled Professional Office Building
    Updated: Feb 27
    Remodeled Professional Office Building

    210 S Kingshighway Street, Sikeston, MO 63801

    $775,000
    1.67 AC lot
    Completely remodeled large commercial building (brick) built in 1964
    HVAC includes forced air heating and central air cooling
    Remodel scope included wiring, lights, electrical panels, bathrooms, and floors
    New fire alarm and sprinkler system
    Roof is about 75% new; parking lot resurfaced
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    Downtown Office Building with Parking
    Updated: Dec 10, 2025
    Downtown Office Building with Parking

    202 S Kingshighway Street, Sikeston, MO 63801

    $279,000
    0.34 AC lot
    Commercial building in downtown Sikeston at 202 S Kingshighway with 7,638 sq ft of gross building area
    Corner lot with 15 parking places, including 2 handicap spaces, plus front and back handicap ramp access
    Main level includes receptionist area, open office/cubicle space, 2 separate offices, and 2 restrooms
    Basement accessed by stairs and elevator, offering break room/kitchen area, 2 restrooms, conference/office, storage, and additional open cubicle space
    Central air and forced‑air electric heating; appliances include refrigerator and vented exhaust fan, plus water heater
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    Flexible Office Building
    Flexible Office Building

    713 Tanner, Sikeston, MO 63801

    $250,000

    Well-maintained office building configured as one suite or up to four suites with multiple private entrances and parking.

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    Sikeston Commercial Building Investment Opportunity
    Sikeston Commercial Building Investment Opportunity

    808 E Wakefield Ave, Sikeston, MO 63801

    $979,500
    11,000 sqft

    High-visibility commercial building with income and upside potential.

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    Commercial Building in High Traffic
    Commercial Building in High Traffic

    1218 Linn St, Sikeston, MO 63801

    $400,000
    7,100 sqft 0.74 AC lot

    7100 sq ft commercial building in high traffic area.

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 5 Active listings in Sikeston, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Two-Level Office Building For Sale
    Two-Level Office Building For Sale

    10 Doctors Park, Cape Girardeau, MO 63703

    $815,000
    9,857 sqft 0.44 AC lot

    9,857 SF office building with multiple offices and restrooms.

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    Versatile Retail/Office Building
    Versatile Retail/Office Building

    2357 Rust Avenue, Cape Girardeau, MO 63703

    $199,900
    0.57 AC lot

    Clean 1,800 sq ft commercial building with adaptable interior and parking, offered for sale.

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    Commercial Building with Highway Frontage
    Commercial Building with Highway Frontage

    1113 E. Marshall, Charleston, MO 63834

    $99,900
    2,121 sqft

    Commercial building ready for renovation, featuring 300+ feet of highway frontage and 2+ acres for additional commercial use.

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    Retail Building with Office Back Area
    Retail Building with Office Back Area

    2380 S. Main, Charleston, MO 63834

    $84,000
    1,452 sqft 0.73 AC lot

    Retail building offers two offices, open floor space, and a half bath, with a large lot for expansion.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Development Land Site
    Commercial Development Land Site

    103 Grove Estates, Sikeston, MO 63801

    $144,000
    1.01 AC lot

    Commercially zoned tract with Highway 61 frontage for office, medical, and professional services near Sikeston residential areas.

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    Renovated Downtown Office and Retail Building
    Renovated Downtown Office and Retail Building

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $239,900
    2,937 sqft 0.25 AC lot

    Renovated commercial building on a high-traffic downtown corridor, offering flexible space for offices or storefront services.

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    Level Commercial Development Lot
    Level Commercial Development Lot

    2549 New Holt Road, Paducah, KY 42001

    $265,000
    1.17 AC lot

    1.17+/- acre level lot with a recorded plat showing approximately 3,675+/- SF buildable area.

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    B-1 Commercial Development Land
    B-1 Commercial Development Land

    3671 James Sanders Blvd., Paducah, KY 42001

    $385,000
    1.37 AC lot

    B-1 commercial land with utilities in the City, positioned near a high-visibility corner for flexible development options.

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    Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    816 Linn St
    OFFICE BUILDING

    816 Linn St, Sikeston, MO 63801-2241

    Value Estimation by Request
    2,135 sqft 0.29 AC lot
    View details
    101 Plz Dr
    OFFICE BUILDING

    101 Plz Dr, Sikeston, MO 63801-5136

    Value Estimation by Request
    957 sqft 0.26 AC lot
    View details
    330 State Hwy H H
    OFFICE BUILDING

    330 State Hwy H H, Sikeston, MO 63801-5349

    Value Estimation by Request
    10,400 sqft 3.00 AC lot
    View details
    228 Interstate Dr
    OFFICE BUILDING

    228 Interstate Dr, Sikeston, MO 63801-8621

    Value Estimation by Request
    468 sqft 0.60 AC lot
    View details
    2830 Brewer Dr
    OFFICE BUILDING

    2830 Brewer Dr, Sikeston, MO 63801

    Value Estimation by Request
    640 sqft 1.60 AC lot
    View details
    101 Kennedy Dr
    OFFICE BUILDING

    101 Kennedy Dr, Sikeston, MO 63801-5126

    Value Estimation by Request
    2,726 sqft 0.56 AC lot
    View details
    215 Stoddard St
    OFFICE BUILDING

    215 Stoddard St, Sikeston, MO 63801-4124

    Value Estimation by Request
    3,212 sqft 0.32 AC lot
    View details
    102 Smith Ave
    OFFICE BUILDING

    102 Smith Ave, Sikeston, MO 63801-5240

    Value Estimation by Request
    6,660 sqft 0.48 AC lot
    View details
    Sikeston, MO 63801
    OFFICE BUILDING

    Sikeston, MO 63801

    Value Estimation by Request
    2,160 sqft 2.72 AC lot
    View details
    301 Malone Ave
    OFFICE BUILDING

    301 Malone Ave, Sikeston, MO 63801-2827

    Value Estimation by Request
    3,058 sqft 0.21 AC lot
    View details
    217 Kingshighway St
    OFFICE BUILDING

    217 Kingshighway St, Sikeston, MO 63801-2963

    Value Estimation by Request
    3,525 sqft 0.50 AC lot
    View details
    301 New Madrid St
    OFFICE BUILDING

    301 New Madrid St, Sikeston, MO 63801-1971

    Value Estimation by Request
    4,722 sqft 0.85 AC lot
    View details
    Interstate S Dr
    OFFICE BUILDING

    Interstate S Dr, Sikeston, MO 63801

    Value Estimation by Request
    5,040 sqft 4.27 AC lot
    View details
    310 Ctr St
    OFFICE BUILDING

    310 Ctr St, Sikeston, MO 63801-4231

    Value Estimation by Request
    9,154 sqft 0.52 AC lot
    View details
    201 New Madrid St
    OFFICE BUILDING

    201 New Madrid St, Sikeston, MO 63801-2953

    Value Estimation by Request
    2,706 sqft 0.13 AC lot
    View details
    1901 Malone Ave
    OFFICE BUILDING

    1901 Malone Ave, Sikeston, MO 63801-3631

    Value Estimation by Request
    1,804 sqft 0.21 AC lot
    View details
    801 Main St
    OFFICE BUILDING

    801 Main St, Sikeston, MO 63801-5806

    Value Estimation by Request
    5,560 sqft 0.20 AC lot
    View details
    104 Lillian Dr
    OFFICE BUILDING

    104 Lillian Dr, Sikeston, MO 63801-2203

    Value Estimation by Request
    10,250 sqft 1.14 AC lot
    View details
    105 Kathleen St
    OFFICE BUILDING

    105 Kathleen St, Sikeston, MO 63801-2941

    Value Estimation by Request
    1,008 sqft 0.20 AC lot
    View details

    Sikeston, MO Office Buildings Market Trends and Statistics

    Explore 72 office buildings for sale in Sikeston, MO, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 18,100 square feet of properties for sale, with an estimated market value of $1,379,500.

    Sale prices for office properties in Sikeston, MO start at $400,000, averaging $689,750, and reaching up to $979,500 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 16
    Office buildings 6
    Medical Office Space 3

    Demographics Overview

    Population 22K
    Population Growth (5Y) -3.7%
    Median Household Income $55,945
    College Educated 31.9%

    High-Yield Neighborhoods for Investment

    Identify Sikeston submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63801 $536.7K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Total CRE Inventory on Market (SF)

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