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    Seneca, SC Commercial Real Estate for Sale

    93 results
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    Seneca Retail/Warehouse Opportunity
    $1,800,000
    1.01 Acres

    Seneca Retail/Warehouse Opportunity

    518 N 1 St, Seneca, SC 29678

    All brick/concrete building with existing tenants and expansion potential.

    • High‑traffic location in a growing area of Seneca, SC.
    • All brick/concrete building construction.
    • Existing tenants occupy approximately 8000 sqft, providing immediate income.
    • Over 7000 sqft available for new tenant or owner‑occupancy.
    • Warehouse‑style construction with 16‑foot ceilings.
    Updated: Jan 7
    View details
    Turn-Key Restaurant Franchise Opportunity
    $1,500,000
    0.78 Acres

    Turn-Key Restaurant Franchise Opportunity

    1053 By Pass 123 Byp, Seneca, SC 29678

    Profitable Moe's Southwest Grill franchise with real estate for sale.

    • Turn‑key, cash‑flowing Moe's Southwest Grill franchise with associated real estate.
    • Built in 2020, substantially below replacement cost.
    • Located on the busiest highway in Seneca, SC with approximately 35,000 daily vehicles.
    • Limited fast casual restaurant competition in the direct market.
    • #1 for catering in the Upstate region (Greenville‑Spartanburg‑Anderson).
    Updated: Oct 11, 2025
    View details
    Commercial Property on Radio Station Rd
    $250,000
    0.63 Acres

    Commercial Property on Radio Station Rd

    Commercial property with road frontage, suitable for business location.

    11081 N Radio Station Rd, Seneca, SC 29678
    View details
    Seneca Commercial Buildings For Sale
    $450,000
    1.02 Acres

    Seneca Commercial Buildings For Sale

    Two industrial buildings with flexible space and manufacturing potential.

    306 Byp Unit Building B And, Seneca, SC 29678
    View details
    Seneca Commercial Property with Expansion Potential
    $687,500
    3.95 Acres

    Seneca Commercial Property with Expansion Potential

    High-visibility commercial property ideal for storage, sales, or service center.

    298 Worth St, Seneca, SC 29678
    View details
    Studio Condo Near Clemson Campus
    $270,000

    Studio Condo Near Clemson Campus

    Studio condo near Clemson University with rental management options.

    13500 Clemson Blvd, Seneca, SC 29678
    View details
    Affordable Townhome Near Clemson University
    $152,500

    Affordable Townhome Near Clemson University

    Townhome near Clemson University, ideal for rental or affordable living.

    1034 Ridgeview Ln, Seneca, SC 29678
    View details
    Seneca Office Building - High Traffic Area
    $250,000
    0.78 Acres

    Seneca Office Building - High Traffic Area

    Prime Seneca location, high visibility, multiple uses.

    108 Keowee School Rd, Seneca, SC 29672
    View details
    Seneca Commercial Land - 33.9 Acres
    $1,577,000
    33.90 Acres

    Seneca Commercial Land - 33.9 Acres

    Prime Seneca acreage, development potential.

    Unit 31.66 ac 31.54 Acres Frontage Rd, Seneca, SC 29678
    View details
    Seneca Office Building For Sale
    $499,950
    0.15 Acres

    Seneca Office Building For Sale

    Modern Office Space, Turn-Key Ready

    8 Accountants Cir, Seneca, SC 29678
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    Seneca Commercial Land Opportunity
    $325,000
    8.04 Acres

    Seneca Commercial Land Opportunity

    8 Acres, Highway Frontage, Three Parcels

    000000 Wells Hwy, Seneca, SC 29678
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    Seneca Commercial Land - 1.8 Acres
    $790,000
    1.80 Acres

    Seneca Commercial Land - 1.8 Acres

    High-traffic location, unrestricted, near major retailers.

    1.8 Acres Rochester Hwy, Seneca, SC 29672
    View details
    Downtown Seneca Office Space
    Contact for pricing
    0.11 Acres

    Downtown Seneca Office Space

    Prime Seneca location, flexible office suites.

    108 North 1St St, Seneca, SC 29678
    View details
    Seneca Industrial Building - Great Location!
    $349,900
    0.50 Acres

    Seneca Industrial Building - Great Location!

    Versatile 4218 sq ft building, ideal for retail or light industrial use.

    310 North 2Nd St, Seneca, SC 29678
    View details
    Seneca Commercial Land - 77 Acres
    $3,833,000
    78.90 Acres

    Seneca Commercial Land - 77 Acres

    Prime Seneca acreage, city limits, development potential.

    Unit Keowee I 76.66 Acres Frontage Rd And Knollwood Dr Rd, Seneca, SC 29678
    View details
    Seneca Commercial Land - Highway 123
    $1,050,000
    1.45 Acres

    Seneca Commercial Land - Highway 123

    High-traffic location, build-to-suit option available.

    994 Us 123 Hwy, Seneca, SC 29678
    View details
    Seneca Commercial Land - Prime Location
    $325,000
    1.29 Acres

    Seneca Commercial Land - Prime Location

    1.29 Acres, High Visibility, Zoned GC

    911 North 1St St, Seneca, SC 29678
    View details
    Historic Seneca Mill Property
    $169,000
    1.30 Acres

    Historic Seneca Mill Property

    Prime 1.3-acre Mill Site, Seneca, SC

    00 Hwy 24 Hwy, Seneca, SC 29678
    View details
    Lake Keowee Commercial Land
    $2,250,000
    45.00 Acres

    Lake Keowee Commercial Land

    45 Acres, Seneca, SC - Investment Opportunity

    Unit Keowee I 45+/- Acres Knollwood Dr, Seneca, SC 29678
    View details
    Seneca Medical Office Building
    $2,283,233
    6,227 SF

    Seneca Medical Office Building

    High-yield, single-tenant medical office

    10110 Clemson Blvd, Seneca, SC 29672
    View details
    Luxury Condo Hotel Near Campus
    $292,110

    Luxury Condo Hotel Near Campus

    Studio condo in luxury hotel with rental management options.

    13500 Clemson Blvd, Seneca, SC 29678
    View details
    Medical Office NNN Investment
    $2,283,233
    6,227 SF

    Medical Office NNN Investment

    Single tenant medical office building with long-term lease.

    10110 Clemson Blvd, Seneca, SC 29672
    View details
    Retail Property on Main Corridor
    $1,000,000
    7,250 SF

    Retail Property on Main Corridor

    Retail property with excellent visibility and heavy traffic.

    1592 Sandifer Blvd, Seneca, SC 29678
    View details
    Two Warehouses Near Clemson
    $490,000
    9,650 SF

    Two Warehouses Near Clemson

    Two warehouse buildings totaling 9,650 SF on one acre.

    306 By Pass 123, Seneca, SC 29678
    View details

    Seneca, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 1073 commercial real estate investment opportunities in Seneca, SC with 93 listings featured on our commercial real estate marketplace. The current inventory includes 74,866,862 square feet of properties with an estimated value of $282,918,684.

    Estimated prices for commercial real estate in Seneca, SC begin at $30,000, with an average of $909,706 and extend to $24,940,000.

    In Seneca, SC, current investment values show:

    • Retail properties positioned at $737,678
    • Individual retail properties measuring $535,666
    • Land assessed at $685,585
    • Office Properties & Spaces calculated at $1,520,174
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    Browse Commercial real estate for Sale Near Seneca, SC

    Popular Searches in Seneca, SC

    Most Searched ZIP Codes in Seneca, SC

    • 29678
    • 29672

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