Sign Up Successful!
You now have access to more from Realmo!
    For Sale
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Property Types
    • Retail
    • Office
    • Residential Income
    • Restaurants
    • Industrial
    • Mixed-Use
    • Hospitality
    • Health Care
    • Sports & Entertainment
    • Land
    • Agricultural
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Sikeston, MO Commercial Real Estate for Sale

    85 results
    List
    Map
    Sikeston Commercial Property with Duplex
    $320,000
    4,244 SF

    Sikeston Commercial Property with Duplex

    101-103 Donald Fulton Dr, Sikeston, MO 63801

    Commercial building, duplex, and storage on a large lot.

    • Large 3124 sq ft commercial building suitable for various businesses.
    • Income‑generating duplex with both sides currently rented.
    • Additional 900 sq ft storage building.
    • Concrete parking area.
    • Property is enclosed by a 6' chain link fence with two sliding gates.
    Updated: Jan 20
    View details
    Sikeston Fourplex with Income Potential
    $360,000
    0.26 Acres

    Sikeston Fourplex with Income Potential

    416 Lake St, Sikeston, MO 63801

    Fourplex in Sikeston, MO with long-term tenants and income potential.

    • Four‑plex townhouse ideal for investment portfolio or new investors.
    • New roof installed December 2025.
    • Unit 718 fully renovated in January 2026.
    • Three long‑term tenants already in place.
    • Coin‑operated washer/dryer provides additional income.
    Updated: Jan 9
    View details
    Sikeston Car Wash with Expansion Potential
    $1,000,000
    40,511 SF

    Sikeston Car Wash with Expansion Potential

    Turnkey car wash with expansion potential in high-demand market.

    531 N Main St, Sikeston, MO 63780
    View details
    Sikeston Carwash with High Visibility
    $1,250,000
    40,946 SF

    Sikeston Carwash with High Visibility

    Turnkey carwash with high traffic, visibility, and recurring revenue.

    900 S Main St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property For Sale
    $650,000
    1.28 Acres

    Sikeston Commercial Property For Sale

    Prime commercial location with high visibility and established business history.

    1105 S Main St, Sikeston, MO 63801
    View details
    Historical Building in Downtown Sikeston
    $269,000
    6,321 SF

    Historical Building in Downtown Sikeston

    Two-story historic building in downtown Sikeston, ideal for investors.

    112 Front St, Sikeston, MO 63801
    View details
    Historic Downtown Sikeston Retail Opportunity
    $299,000
    14,642 SF

    Historic Downtown Sikeston Retail Opportunity

    Two-story retail space in historic downtown Sikeston, Missouri.

    124 E Front St, Sikeston, MO 63801
    View details
    Sikeston Retail Property For Sale
    $550,000
    1,150 SF

    Sikeston Retail Property For Sale

    Established family-owned business with high visibility for over 30 years.

    1018 Linn St, Sikeston, MO 63801
    View details
    Downtown Sikeston Commercial Office Building
    $279,000
    4,273 SF

    Downtown Sikeston Commercial Office Building

    Commercial property with endless business opportunities in downtown Sikeston.

    202 S Kingshighway St, Sikeston, MO 63801
    View details
    Sikeston Warehouse with Highway Access
    $1,100,000
    24,700 SF

    Sikeston Warehouse with Highway Access

    Large warehouse with easy access to I-55 and I-57.

    300 Matthews Ln, Sikeston, MO 63801
    View details
    Sikeston Commercial Property For Sale
    $600,000
    1.30 Acres

    Sikeston Commercial Property For Sale

    Income-producing property with commercial spaces and storage units.

    2008 N Main St, Sikeston, MO 63801
    View details
    Sikeston Commercial Building - High Traffic!
    $400,000
    0.74 Acres

    Sikeston Commercial Building - High Traffic!

    7100 sq ft, Multi-Suite, High Traffic Area

    1218 Linn St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property - 5 Acres
    $485,000
    5.00 Acres

    Sikeston Commercial Property - 5 Acres

    Prime 5-acre commercial lot, versatile building.

    714 State Highway H, Sikeston, MO 63801
    View details
    Sikeston Commercial Property: Prime Location
    $450,000
    1.24 Acres

    Sikeston Commercial Property: Prime Location

    Historic Church & Multi-Purpose Building

    306 Kingshighway St, Sikeston, MO 63801
    View details
    Sikeston Commercial Property - High Income Potential
    $565,000
    1.28 Acres

    Sikeston Commercial Property - High Income Potential

    Versatile Commercial Building w/ Apartment & Billboard Income

    475 Western Dr, Sikeston, MO 63801
    View details
    Sikeston Commercial Building For Sale
    $239,000

    Sikeston Commercial Building For Sale

    Prime Sikeston location, great investment opportunity.

    1637 Malone Ave, Sikeston, MO 63801
    View details
    Sikeston Commercial Building - Huge Potential
    $460,000
    1.80 Acres

    Sikeston Commercial Building - Huge Potential

    Versatile facility, ample parking, leaseback option.

    205 New Madrid St, Sikeston, MO 63801
    View details
    Sikeston Industrial Warehouse For Sale
    Contact for pricing
    0.31 Acres

    Sikeston Industrial Warehouse For Sale

    Prime Missouri Warehouse, High Visibility

    1240 Main St, Sikeston, MO 63801
    View details
    Sikeston Flex Space: Prime Industrial
    $460,000
    19,498 SF

    Sikeston Flex Space: Prime Industrial

    19,498 SF Flex Building, 1.8 Acres

    205 New Madrid St, Sikeston, MO 63801
    View details

    Explore Off-Market Properties in Sikeston, MO

    Consider similar Off-Market properties in Sikeston, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    116 Hospitality Dr

    116 Hospitality Dr

    Commercial real estate • 0.72 Acres
    Value Estimation by Request
    116 Hospitality Dr, Sikeston, MO 63801
    View details
    714 State Highway H

    714 State Highway H

    Commercial real estate • 5.00 Acres
    Value Estimation by Request
    714 State Highway H, Sikeston, MO 63801
    View details
    102 Kingshighway St

    102 Kingshighway St

    Restaurants • 23,450 SF
    Value Estimation by Request
    102 Kingshighway St, Sikeston, MO 63801
    View details
    802 Wakefield Ave

    802 Wakefield Ave

    Multifamily properties • 1.89 Acres
    Value Estimation by Request
    802 Wakefield Ave, Sikeston, MO 63801
    View details

    Sikeston, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 753 commercial real estate investment opportunities in Sikeston, MO with 85 listings featured on our commercial real estate marketplace. The current inventory includes 34,338,116 square feet of properties with an estimated value of $88,013,400.

    Estimated prices for commercial real estate in Sikeston, MO begin at $42,500, with an average of $500,076 and extend to $3,960,000.

    In Sikeston, MO, current investment values show:

    • Other commercial real estate positioned at $607,920
    • Land measuring $211,906
    • Residential land & home lots assessed at $60,967
    • Retail properties calculated at $554,695
    List
    Map

    Browse Commercial real estate for Sale Near Sikeston, MO

    Popular Searches in Sikeston, MO

    Most Searched ZIP Codes in Sikeston, MO

    • 63801
    • 65501

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.