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    Hillsboro, MO Commercial Real Estate for Sale

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    Cedar Hill, MO De Soto, MO Dittmer, MO
    14 results
    Hillsboro Land Near City Hall
    $426,900
    2,772 SF

    Hillsboro Land Near City Hall

    114 Main Street, Hillsboro, MO 63050

    Versatile half-acre lot in prime Hillsboro location.

    • Prime location across from City Hall and one block from the courthouse.
    • Versatile property ideal for professional offices (attorneys, consultants, etc.).
    • Spacious half‑acre lot allows for future expansion or new construction.
    • High visibility and easy access in a bustling downtown area.
    • Recently updated with a functional kitchen area.
    Updated: Nov 11, 2025
    View details
    Hillsboro Mixed-Use Redevelopment Opportunity
    $450,000
    6,090 SF

    Hillsboro Mixed-Use Redevelopment Opportunity

    9637 Old State Route 21, Hillsboro, MO 63050

    Versatile 6-acre property with highway frontage and redevelopment potential.

    • Prime highway frontage on 6 acres offering outstanding visibility and accessibility.
    • Versatile property with four buildings suitable for redevelopment or continued hospitality use.
    • Existing infrastructure includes a restaurant, four hotel rooms, a three‑bedroom residence, and a large outbuilding.
    • Many upgrades completed in 2018.
    • Much of the existing equipment remains in good condition.
    Updated: Feb 16
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    Hillsboro Church with Conversion Potential
    $1,750,000
    5.00 Acres

    Hillsboro Church with Conversion Potential

    Church building on 5 acres, suitable for office conversion.

    4770 State Road B, Hillsboro, MO 63050
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    Commercial Land on Corner Lot
    $350,000
    0.98 Acres

    Commercial Land on Corner Lot

    Corner lot with high visibility near highways in Hillsboro, MO.

    10865 Business 21, Hillsboro, MO 63050
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    Acreage for Recreational or Residential Use
    $770,000
    45.29 Acres

    Acreage for Recreational or Residential Use

    45+ acres suitable for residential, recreational, or development.

    Hillsboro, MO 63050
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    Land in Hillsboro, Missouri
    Contact for pricing
    0.21 Acres

    Land in Hillsboro, Missouri

    Land for sale in Hillsboro, Missouri.

    1 Grant Court, Hillsboro, MO 63050
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    Land in Hillsboro, Missouri
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    0.26 Acres

    Land in Hillsboro, Missouri

    Land available in Hillsboro, Missouri.

    9688 Jackson Drive, Hillsboro, MO 63050
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    Hillsboro, MO Land For Sale
    Contact for pricing
    0.21 Acres

    Hillsboro, MO Land For Sale

    0.21 acre agricultural land for sale in Hillsboro, MO.

    5615 Katys Way, Hillsboro, MO 63050
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    Land in Hillsboro, Missouri
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    0.20 Acres

    Land in Hillsboro, Missouri

    Land for sale in Hillsboro, Missouri.

    9704 Gettysburg Drive, Hillsboro, MO 63050
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    Hillsboro Retail with Highway Frontage
    $299,000
    0.27 Acres

    Hillsboro Retail with Highway Frontage

    Retail property in Hillsboro with highway frontage and recent updates.

    10550 Business 21, Hillsboro, MO 63050
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    Hillsboro Land For Sale
    $1,750,000

    Hillsboro Land For Sale

    Land available in Jefferson County, Missouri.

    4770 State Road B, Hillsboro, MO 63050
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    Hillsboro Retail Property for Sale
    $2,200,000
    9,641 SF

    Hillsboro Retail Property for Sale

    9,641 SF retail property available in Hillsboro, Missouri.

    10333 Business 21, Hillsboro, MO
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    Commercial Land For Sale
    $1,200,000
    43.25 Acres

    Commercial Land For Sale

    43 Acres zoned CC2 with high visibility and frontage.

    8719 Old State Route 21, Hillsboro, MO 63050
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    Commercial Property Near City Hall
    $426,900
    2,772 SF

    Commercial Property Near City Hall

    Updated commercial property with large lot near government buildings.

    114 Main St, Hillsboro, MO 63050
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    Based on your search, we've compiled 231 Potential Opportunities for your consideration. Besides 14 Active listings in Hillsboro, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 213 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Versatile Flex Office/Warehouse Property
    $875,000
    10,000 SF

    Versatile Flex Office/Warehouse Property

    Two-story office/warehouse near I-55, suitable for diverse businesses.

    622 Collins Drive, Festus, MO 63028
    View details
    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF

    Historic Mixed-Use Commercial Property

    Unique 4,095 SF commercial property in downtown De Soto.

    400 N 3rd Street, De Soto, MO 63020
    View details
    De Soto Retail Business Opportunity
    $850,000
    15,500 SF

    De Soto Retail Business Opportunity

    Own a business and a piece of history!

    400 S Main Street, De Soto, MO 63020
    View details
    53 Acres Near Festus
    $2,000,000
    53.80 Acres

    53 Acres Near Festus

    53 acres of land with frontage on Hwy A.

    2351 Buck Creek Road, Festus, MO 63028
    View details

    Off-Market Properties in Hillsboro, MO

    Consider similar Off-Market properties in Hillsboro, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    10308 Business 21

    10308 Business 21

    RETAIL STORES (PERSONAL SERVICES) • 1,254 SF
    Value Estimation by Request
    10308 Business 21, Hillsboro, MO 63050-3583
    View details
    7683 Hillsboro House Spgs Rd

    7683 Hillsboro House Spgs Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 7,312 SF
    Value Estimation by Request
    7683 Hillsboro House Spgs Rd, Hillsboro, MO 63050-1802
    View details
    304 Locust St

    304 Locust St

    OFFICE (GENERAL) • 0.25 Acres
    Value Estimation by Request
    304 Locust St, Hillsboro, MO 63050-4346
    View details
    10510 Business 21

    10510 Business 21

    AUTO REPAIR, GARAGE • 2,946 SF
    Value Estimation by Request
    10510 Business 21, Hillsboro, MO 63050-5901
    View details
    535 Elm St

    535 Elm St

    OFFICE (GENERAL) • 980 SF
    Value Estimation by Request
    535 Elm St, Hillsboro, MO 63050-4322
    View details
    10770 Business 21

    10770 Business 21

    OFFICE (GENERAL) • 1,708 SF
    Value Estimation by Request
    10770 Business 21, Hillsboro, MO 63050-5075
    View details
    10410 Business 21

    10410 Business 21

    NURSERY, GREENHOUSE, FLORIST • 1,427 SF
    Value Estimation by Request
    10410 Business 21, Hillsboro, MO 63050-5709
    View details
    3812 State Rd Z Z

    3812 State Rd Z Z

    CONVENIENCE STORE (W/FUEL PUMP) • 6,188 SF
    Value Estimation by Request
    3812 State Rd Z Z, Hillsboro, MO 63050-3715
    View details
    301 Cedarview Ct

    301 Cedarview Ct

    GARDEN APT, COURT APT (5+ UNITS) • 87,744 SF
    Value Estimation
    $6,220,000
    301 Cedarview Ct, Hillsboro, MO 63050-3562
    View details
    638 1st St

    638 1st St

    OFFICE (GENERAL) • 960 SF
    Value Estimation by Request
    638 1st St, Hillsboro, MO 63050-4306
    View details

    Hillsboro, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 227 commercial real estate for sale in Hillsboro, MO, showcased through 14 active listings on our real estate platform. These investment opportunities span a total of 21,275 square feet of properties for sale, with an estimated market value of $3,503,800.

    Sale prices for business properties in Hillsboro, MO start at $426,900, averaging $875,950, and reaching up to $2,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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