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    Hillsboro, MO
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    Hillsboro, MO Commercial Real Estate for Sale

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    Dittmer, MO Cedar Hill, MO De Soto, MO
    14 listings
    Renovated Professional Office Building
    $329,900
    2,536 SF
    Renovated Professional Office Building

    535 Elm Street, Hillsboro, MO 63050

    Move-in ready office with ADA accessibility, updated systems, and versatile space for professional and medical-related services.
    • Completely renovated professional office building with move‑in ready interior
    • Recent updates include new flooring, fresh paint, updated lighting, and kitchenette cabinetry
    • Major systems refreshed: newer roof and newer HVAC system within the last several years
    • Additional backup power with a generator
    • ADA accessible with abundant parking in a parking lot
    Updated: Jun 22
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    Hillsboro Land Near City Hall
    $426,900
    2,772 SF
    Hillsboro Land Near City Hall

    114 Main Street, Hillsboro, MO 63050

    Versatile half-acre lot in prime Hillsboro location.
    • Prime location across from City Hall and one block from the courthouse.
    • Versatile property ideal for professional offices (attorneys, consultants, etc.).
    • Spacious half‑acre lot allows for future expansion or new construction.
    • High visibility and easy access in a bustling downtown area.
    • Recently updated with a functional kitchen area.
    Updated: Nov 11, 2025
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    Hillsboro Church with Conversion Potential
    $1,750,000
    5.00 Acres
    Hillsboro Church with Conversion Potential

    Church building on 5 acres, suitable for office conversion.

    4770 State Road B, Hillsboro, MO 63050

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    Mixed-Use Hospitality Property
    $425,000
    6,090 SF
    Mixed-Use Hospitality Property

    Multi-building property with former restaurant, guest rooms, and a residence, supported by public water and separate electric meters.

    9637 Old State Route 21, Hillsboro, MO 63050

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    Commercial Land on Corner Lot
    $350,000
    0.98 Acres
    Commercial Land on Corner Lot

    Corner lot with high visibility near highways in Hillsboro, MO.

    10865 Business 21, Hillsboro, MO 63050

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    Commercial Land with Utilities On-Site
    $1,150,000
    2.40 Acres
    Commercial Land with Utilities On-Site

    2.4-acre development site with 200 feet of frontage and fire hydrant/utilities already in place for added planning flexibility.

    101 Hi Crest St, Hillsboro, MO 63050

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    Hillsboro Retail Property for Sale
    $2,200,000
    9,641 SF
    Hillsboro Retail Property for Sale

    9,641 SF retail property available in Hillsboro, Missouri.

    10333 Business 21, Hillsboro, MO

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    Land in Hillsboro, Missouri
    Contact for pricing
    0.26 Acres
    Land in Hillsboro, Missouri

    Land available in Hillsboro, Missouri.

    9688 Jackson Drive, Hillsboro, MO 63050

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    Hillsboro Retail with Highway Frontage
    $299,000
    0.27 Acres
    Hillsboro Retail with Highway Frontage

    Retail property in Hillsboro with highway frontage and recent updates.

    10550 Business 21, Hillsboro, MO 63050

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    Hillsboro Land For Sale
    $1,750,000
    Hillsboro Land For Sale

    Land available in Jefferson County, Missouri.

    4770 State Road B, Hillsboro, MO 63050

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    Land For Sale, Hillsboro, MO
    Contact for pricing
    0.20 Acres
    Land For Sale, Hillsboro, MO

    Land available in Hillsboro, Missouri.

    9704 Gettysburg Drive, Hillsboro, MO 63050

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    Corner Commercial Development Land
    Contact for pricing
    0.79 Acres
    Corner Commercial Development Land

    Multi-lot C2 land at a high-traffic corner with all utilities available to support retail and service uses.

    905 Peach Tree Plaza Dr, Hillsboro, MO 63050

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    Commercial Land For Sale
    $1,200,000
    43.25 Acres
    Commercial Land For Sale

    43 Acres zoned CC2 with high visibility and frontage.

    8719 Old State Route 21, Hillsboro, MO 63050

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    Commercial Property Near City Hall
    $426,900
    2,772 SF
    Commercial Property Near City Hall

    Updated commercial property with large lot near government buildings.

    114 Main St, Hillsboro, MO 63050

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    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 14 Active listings in Hillsboro, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 58 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF
    Historic Mixed-Use Commercial Property

    Unique 4,095 SF commercial property in downtown De Soto.

    400 N 3rd Street, De Soto, MO 63020

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    De Soto Mixed-Use Opportunity
    $420,000
    5,000 SF
    De Soto Mixed-Use Opportunity

    Mixed-use property on Main Street with retail and residential potential.

    120 N Main Street, De Soto, MO 63020

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    Festus Land with Builder Potential
    $150,300
    10.02 Acres
    Festus Land with Builder Potential

    10.02 acre lot perfect for countryside living near St. Louis.

    22 Hematite Farms Rd, Festus, MO 63028

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    53 Acres Near Festus
    $2,000,000
    53.80 Acres
    53 Acres Near Festus

    53 acres of land with frontage on Hwy A.

    2351 Buck Creek Road, Festus, MO 63028

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    Off-Market Properties in Hillsboro, MO

    Consider similar Off-Market properties in Hillsboro, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    10308 Business 21
    RETAIL STORES (PERSONAL SERVICES)
    1,254 SF Lot: 0.79 Acres
    Value Estimation by Request

    10308 Business 21, Hillsboro, MO 63050-3583

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    7683 Hillsboro House Spgs Rd
    OFFICE/RESIDENTIAL (MIXED USE)
    7,312 SF Lot: 22.79 Acres
    Value Estimation by Request

    7683 Hillsboro House Spgs Rd, Hillsboro, MO 63050-1802

    View details
    304 Locust St
    OFFICE (GENERAL)
    Lot: 0.25 Acres
    Value Estimation by Request

    304 Locust St, Hillsboro, MO 63050-4346

    View details
    10510 Business 21
    AUTO REPAIR, GARAGE
    2,946 SF Lot: 0.34 Acres
    Value Estimation by Request

    10510 Business 21, Hillsboro, MO 63050-5901

    View details
    535 Elm St
    OFFICE (GENERAL)
    980 SF Lot: 1.41 Acres

    535 Elm St, Hillsboro, MO 63050-4322

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    10770 Business 21
    OFFICE (GENERAL)
    1,708 SF Lot: 0.30 Acres
    Value Estimation by Request

    10770 Business 21, Hillsboro, MO 63050-5075

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    10410 Business 21
    NURSERY, GREENHOUSE, FLORIST
    1,427 SF Lot: 1.12 Acres
    Value Estimation by Request

    10410 Business 21, Hillsboro, MO 63050-5709

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    3812 State Rd Z Z
    CONVENIENCE STORE (W/FUEL PUMP)
    6,188 SF Lot: 1.53 Acres
    Value Estimation by Request

    3812 State Rd Z Z, Hillsboro, MO 63050-3715

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    301 Cedarview Ct
    GARDEN APT, COURT APT (5+ UNITS)
    87,744 SF Lot: 7.92 Acres
    Estimated value
    $6,220,000

    301 Cedarview Ct, Hillsboro, MO 63050-3562

    View details
    638 1st St
    OFFICE (GENERAL)
    960 SF Lot: 0.42 Acres
    Value Estimation by Request

    638 1st St, Hillsboro, MO 63050-4306

    View details

    Hillsboro, MO Commercial Real Estate Market Trends and Statistics

    Explore 72 commercial real estate for sale in Hillsboro, MO, showcased through 14 active listings on our real estate platform. These investment opportunities span a total of 23,811 square feet of properties for sale, with an estimated market value of $3,808,700.

    Sale prices for business properties in Hillsboro, MO start at $329,900, averaging $761,740, and reaching up to $2,200,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 18K
    Population Growth (5Y) +10.9%
    Median Household Income $79,462
    College Educated 26.8%

    High-Yield Neighborhoods for Investment

    Identify Hillsboro submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63050 $571K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Jefferson County

    New Delisted

    Total CRE Inventory on Market (SF)

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