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    Seneca, SC Retail Properties & Spaces for Lease

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    6 properties
    Flex Space with Showroom
    Updated: Aug 15
    Flex Space with Showroom

    879 By Pass 123 Highway Includes 710 Seneca Dr, Seneca, SC 29678

    $2,000/Mo
    3,264 sqft
    Two buildings provide 4,704 SF of combined commercial space
    1,440 SF building includes showroom, office, break room, and two bathrooms
    3,264 SF Service/Garage Industrial building supports service‑oriented use
    169 feet of road frontage along US By Pass 123
    Located at the traffic light intersection of Mountain View Drive and Seneca Drive
    View details
    Service Garage with Storage Loft
    Updated: Nov 27, 2025
    Service Garage with Storage Loft

    710 Seneca Drive, Seneca, SC 29678

    $2,000/Mo
    3,264 sqft
    3,264‑square‑foot service garage
    Office, parts room, and storage loft
    Roll‑up doors for vehicle access
    Building requires improvements
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    Retail Storefront in Shopping Center
    Retail Storefront in Shopping Center

    1640 Sandifer Boulevard, Seneca, SC 29678

    Contact for pricing
    2,550 sqft

    Storefront suite in a signalized shopping center entrance with about 130 feet of frontage on Sandifer Blvd.

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    Retail Redevelopment Site
    Retail Redevelopment Site

    1637 Sandifer Blvd, Seneca, SC 29678

    Contact for pricing
    1.83 AC lot

    Freestanding retail site with full access along Sandifer Blvd and cross access to Stop-A-Minit.

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    Retail Suite with Showroom
    Retail Suite with Showroom

    10139 Clemson Boulevard #B, Seneca, SC 29678

    $1,950/Mo
    3,400 sqft

    A large open showroom area is complemented by private offices, closets, a side entrance, and a bathroom with shower.

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    Open-Plan Retail Space
    Open-Plan Retail Space

    1526 Blue Ridge Boulevard, Seneca, SC 29672

    $1,500/Mo
    1,900 sqft

    A rear roll-up door and two restrooms support flexible use of the open interior.

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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 6 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 10 Properties for Sales.

    Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Finished Coffee Shop Space
    Finished Coffee Shop Space

    382 College Avenue Basement Space, Clemson, SC 29631

    $2,800/Mo
    2,100 sqft

    Lower-level commercial space beneath The Fizz Boutique with Kieth St. access.

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    Retail Space with Porches
    Retail Space with Porches

    112 W Main Street #103, Walhalla, SC 29691

    $850/Mo

    The main-level space can support either office or retail use.

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    Main-Level Retail Space
    Main-Level Retail Space

    112 W Main Street #101, Walhalla, SC 29691

    $1,250/Mo

    An open interior is complemented by outdoor seating areas and parking on site.

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    Mixed-Use Property Near Clemson Campus
    Mixed-Use Property Near Clemson Campus

    111 Earle Street, Clemson, SC 29631

    Contact for pricing

    Mixed-use property with residential and retail components near Clemson University.

    View details

    Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Dual-Storefront Restaurant Property
    Dual-Storefront Restaurant Property

    124 And 118 N Townville Street Ye Ole Restaurant, Seneca, SC 29678

    $799,000
    5,772 sqft

    Two storefront spaces provide restaurant, confectionery, and banquet-room functionality for food and event operations.

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    Downtown Retail Building with Two Units
    Downtown Retail Building with Two Units

    319 Main Street, Seneca, SC 29678

    $1,500,000
    5,500 sqft 0.24 AC lot

    Two fully heated and air-conditioned retail units with private entrances and restrooms, plus street-to-street rear access.

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    Two-Story Storefront Property
    Two-Story Storefront Property

    110 E N 1st Street, Seneca, SC 29678

    $429,943
    5,000 sqft

    Downtown setting near shops, restaurants, and community events.

    View details
    Updated Self-Service Car Wash
    Updated Self-Service Car Wash

    1469 Blue Ridge Boulevard 1471 Blue Ridge Blvd, Seneca, SC 29672

    $895,000
    0.58 AC lot

    Automotive property with a customer waiting office, support buildings, and covered maintenance storage across a commercial site.

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    Brick Flex Building
    Brick Flex Building

    518 W N 1st Street, Seneca, SC 29678

    $1,695,000
    1.01 AC lot

    All-brick and concrete flex property with existing tenants and additional space for occupancy or leasing.

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    Downtown Mixed-Use Commercial Building
    Downtown Mixed-Use Commercial Building

    110 E North 1st St, Seneca, SC 29678

    $429,943
    5,000 sqft

    Two-level commercial building with a prominent street-front location and 2,500 sq ft per floor for flexible uses.

    View details
    Commercial Land with Existing Structure
    Commercial Land with Existing Structure

    298 By Pass 123, Seneca, SC 29678

    $650,000

    An existing commercial building and a surveyed tract front the Bypass 123 corridor in Seneca.

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    Corner Commercial Land with Building
    Corner Commercial Land with Building

    10732 Clemson Boulevard, Seneca, SC 29672

    $550,000

    Corner commercial land includes an existing brick building with open-shell interiors and access from Clemson Boulevard.

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    NNN Bank Building
    NNN Bank Building

    1313 Sandifer Boulevard, Seneca, SC 29678

    Contact for pricing

    For sale NNN bank building with corporate ABS structure in Seneca, SC.

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    Land Near Clemson University
    Land Near Clemson University

    Union Station Dr, Seneca, SC 29678

    Contact for pricing
    6.54 AC lot

    Land available near Clemson University, close to lakes.

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    Seneca, SC Retail properties & Spaces Lease Rates & Market Statistics

    Explore 6 Retail properties & Spaces for lease in Seneca, SC on Realmo, a commercial real estate exchange covering the Seneca area. The current inventory totals 14,378 square feet of properties.

    Asking lease rates for Retail properties & Spaces in Seneca start at $6.88 SF/Yr, average $7.76 SF/Yr, and reach $9.47 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $7.76 SF/Yr, the local average runs 69% below South Carolina's state average of $24.64 SF/Yr.

    Seneca accounts for 60% of the 10 retail properties & spaces currently available across Oconee County, where nearby markets include Walhalla and Fair Play.

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    Most Searched ZIP Codes in Seneca, SC

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    Featured Seneca Real Estate Agencies

    Realmo connects you with licensed Seneca CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Seneca
    455 Highway 123 Suite A Seneca, SC 29678
    Phone: (864) 482-2700
    bc5797.yourkwoffice.com
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