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Florence, SC Office Properties & Spaces for Sale

8 results
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Florence Office Building For Sale
$1,500,000
7,517 SF

Florence Office Building For Sale

1706 2Nd Loop Rd, Florence, SC 29501

Office building with 7,517 square feet of space in Florence.

  • Handicap access: accessible approach with ramp.
  • Features office(s) and reception area.
  • Kitchen facility available.
  • Private restrooms.
  • Central heating and central air.
Last Update: Oct 24
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Pamplico Highway Commercial Opportunity
$229,900
0.80 Acres

Pamplico Highway Commercial Opportunity

1424 Pamplico Hwy, Florence, SC 29505

Commercial lot on heavily traveled Pamplico Highway with multiple driveways.

  • High‑traffic location on Pamplico Highway
  • Four driveways providing easy access
  • Suitable for retail or commercial development
  • Existing house usable as an office
  • Road frontage
Last Update: Aug 14
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Historic Downtown Florence Medical Office
$1,350,000
12,411 SF

Historic Downtown Florence Medical Office

12,411 SF Medical Office Building, $1.35M
329 Irby St, Florence, SC 29501
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Florence Office Building - $285K
$285,000
1,829 SF

Florence Office Building - $285K

1,829 SF Office, High Traffic Area
2400 2Nd Loop Rd, Florence, SC 29501
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Medical Office Building Near MUSC
$2,200,000
7,950 SF

Medical Office Building Near MUSC

Medical office building near MUSC campus with ample parking.
1929 Mountain Laurel Ct, Florence, SC 29505
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Historic Mixed-Use Building in Florence
$3,000,000
13 SF

Historic Mixed-Use Building in Florence

16,000 sq ft historic building in Downtown Florence for sale.
248 W Evans St Florence, Florence, SC 29501
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Downtown Florence Business Technology Center
$12,000,000
119,567 SF

Downtown Florence Business Technology Center

Office building in downtown Florence with investment and value-add potential.
187 E Evans St, Florence, SC 29506
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McLeod Physician Associates For Sale
$1,384,320
2,666 SF

McLeod Physician Associates For Sale

2,666 SF medical office in Florence, SC for sale.
1540 American Dr, Florence, SC 29505
View details
Based on your search, we've compiled 461 Potential Opportunities for your consideration. Besides 8 Active listings in Florence, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 446 Off-Market properties to explore as potential leads, plus 3 Land Listings that present a potential for development.

Explore Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Veterinary Facility on Highway 76
$440,000
13,000 SF

Veterinary Facility on Highway 76

Spacious veterinary facility with medical office and boarding kennel.
2608 Highway 76 E, Marion, SC 29571
View details
Marion Commercial Property with Garages
$449,000
Pending

Marion Commercial Property with Garages

Versatile commercial property with office, garages, and fenced yard.
2152 Senator Gasque Hwy, Marion, SC 29571
View details
Hartsville Commercial Office For Sale
$265,000
3,258 SF

Hartsville Commercial Office For Sale

Commercial office space available in Hartsville, South Carolina.
640 S 4Th St, Hartsville, SC 29550
View details
Hartsville Office Building For Sale
$1,200,000
5,000 SF

Hartsville Office Building For Sale

Prime Hartsville location, 5,000 sq ft office.
146 Cargill Way, Hartsville, SC 29550
View details

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Florence Commercial Land For Sale
$49,900
0.17 Acres

Florence Commercial Land For Sale

Versatile B-6 zoned property with commercial and redevelopment potential.
720 S Barringer St, Florence, SC 29506
View details
Florence Commercial Lot For Sale
$1,500,000
4.02 Acres

Florence Commercial Lot For Sale

4.02 acre mixed-use lot with high visibility in Florence, SC.
1714 2Nd Loop Rd, Florence, SC 29501
View details
Commercial Lot on Darlington Street
$31,000
0.19 Acres

Commercial Lot on Darlington Street

Commercial lot with frontage on East Darlington Street, Florence, SC.
East Darlington St, Florence, SC 29506
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Explore Off-Market Properties in Florence, SC

Consider similar Off-Market properties in Florence, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

1092 Church St

1092 Church St

Flex space
Value Estimation by Request
1092 Church St, Florence, SC 29506
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650 Pamplico Hwy

650 Pamplico Hwy

Medical offices • 2,500 SF
Value Estimation by Request
650 Pamplico Hwy, Florence, SC 29505
View details
211 Pamplico Hwy

211 Pamplico Hwy

Office Properties & Spaces • 9,600 SF
Value Estimation by Request
211 Pamplico Hwy, Florence, SC 29505
View details
102 Sebrell St

102 Sebrell St

Office Properties & Spaces • 1,000 SF
Value Estimation by Request
102 Sebrell St, Florence, SC 29505
View details
1947 Hoffmeyer Rd

1947 Hoffmeyer Rd

Medical offices
Value Estimation by Request
1947 Hoffmeyer Rd, Florence, SC 29501
View details
400 Evans St

400 Evans St

Office Properties & Spaces • 2,400 SF
Value Estimation by Request
400 Evans St, Florence, SC 29501
View details
1800 2Nd Loop Rd

1800 2Nd Loop Rd

Office Properties & Spaces • 7,900 SF
Value Estimation by Request
1800 2Nd Loop Rd, Florence, SC 29501
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609 2Nd Loop Rd

609 2Nd Loop Rd

Medical offices • 3,600 SF
Value Estimation by Request
609 2Nd Loop Rd, Florence, SC 29505
View details
1224 Broughton Blvd

1224 Broughton Blvd

Flex space • 1,250 SF
Value Estimation by Request
1224 Broughton Blvd, Florence, SC 29501
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215 3rd Loop Rd

215 3rd Loop Rd

OFFICE BUILDING • 10,709 SF
Value Estimation by Request
215 3rd Loop Rd, Florence, SC 29505-4717
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151 Evans St

151 Evans St

OFFICE BUILDING • 14,829 SF
Value Estimation by Request
151 Evans St, Florence, SC 29501-3425
View details
1714 Gregg Ave

1714 Gregg Ave

MEDICAL BUILDING • 4,969 SF
Value Estimation by Request
1714 Gregg Ave, Florence, SC 29501-4120
View details
2200 Irby St

2200 Irby St

MEDICAL BUILDING • 5,996 SF
Value Estimation
$3,130,000
2200 Irby St, Florence, SC 29505-3423
View details
142 Dargan St

142 Dargan St

OFFICE BUILDING • 6,255 SF
Value Estimation by Request
142 Dargan St, Florence, SC 29506-2500
View details
255 Warley St

255 Warley St

OFFICE BUILDING • 3,590 SF
Value Estimation by Request
255 Warley St, Florence, SC 29501-4444
View details
520 Palmetto St

520 Palmetto St

OFFICE BUILDING • 1,897 SF
Value Estimation
$275,000
520 Palmetto St, Florence, SC 29501-4428
View details

Florence, SC Office Properties & Spaces Investment Opportunities Market Analysis

Explore 453 office properties & spaces for sale in Florence, SC, showcased through 8 active listings on our real estate platform. These investment opportunities span a total of 14,475,028 square feet of properties for sale, with an estimated market value of $127,209,900.

Prices for office spaces in Florence, SC start at $50,000, averaging $655,721, and reaching up to $15,640,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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