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    Spartanburg, SC Office Spaces for Lease

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    Boiling Springs, SC Roebuck, SC Wellford, SC
    54 results
    Premier Medical Office Space Available
    $20 SF/Yr
    7,039 SF
    Premier Medical Office Space Available

    1650 Skylyn Drive, Spartanburg, SC 29307

    Class A medical office space in Spartanburg's prime location.
    • Premier Class A medical office space, strategically located on the Mary Black campus, unique to the Spartanburg market.
    • On‑site wellness amenity suite featuring a fitness gym, swimming pool, and smoothie bar exclusively for building tenants.
    • Lower NNN fees than comparable properties.
    • Direct access to the Drayton Mills Trail and proximity to the vibrant Drayton Mills mixed‑use development.
    • Abundant parking.
    Updated: Mar 7
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    Spartanburg Storefront Retail/Office Space
    $15 SF/Yr
    2,046 SF
    Spartanburg Storefront Retail/Office Space

    512 E Main St, Spartanburg, SC 29302

    Renovated 2,046 SF retail/office space in downtown Spartanburg.
    • High‑visibility location in Spartanburg's thriving downtown district with strong traffic count (±28,400 VPD).
    • Recently renovated ±2,046 SF storefront retail/office space suitable for a variety of uses.
    • Charming historic details, including exposed brick and tin ceilings.
    • Proximity to a diverse mix of businesses and restaurants.
    • Located in an area experiencing significant growth with ongoing developments (Project Core, Mary Black Trail extension, Fifth Third Park, Spartanburgers Stadium).
    Updated: Nov 21, 2025
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    6,000 SF Flex Building I-85
    Contact for pricing
    6,000 SF
    6,000 SF Flex Building I-85

    Flex building with lay-down yard fronting I-85.

    50 Fairview Church Rd, Spartanburg, SC 29303

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    Move-in Ready Furnished Office Space
    $20 SF/Yr
    Move-in Ready Furnished Office Space

    Recently renovated, fully furnished office building in a prime location.

    792 John B White Sr Boulevard, Spartanburg, SC 29306

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    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF
    Historic Mill Office Space Available

    Creative office space in a vibrant mixed-use community.

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

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    Premier Office Suite For Rent
    $700/Mo
    425 SF
    Premier Office Suite For Rent

    Executive office suite in a premier location with ample natural light.

    1451 E Main St, Spartanburg, SC

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    Spartanburg Office Space Available
    $25 SF/Yr
    444 SF
    Spartanburg Office Space Available

    Office space available for rent in Spartanburg, South Carolina.

    324 E Saint John St, Spartanburg, SC

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    Renovated Office Space Available
    $20 SF/Yr
    1,500 SF
    Renovated Office Space Available

    Newly renovated office space in a high-visibility location.

    901 S Pine St, Spartanburg, SC

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    Westside Office Building For Rent
    $12 SF/Yr
    5,000 SF
    Westside Office Building For Rent

    5,000 sq ft office building in westside location.

    1220 John B White Sr Blvd, Spartanburg, SC

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    Downtown Spartanburg Retail/Office Space
    $23 SF/Yr
    1,525 SF
    Downtown Spartanburg Retail/Office Space

    Retail or office space with high visibility in downtown.

    178-182 E Main St, Spartanburg, SC

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    Spartanburg Office Space for Lease
    $16 SF/Yr
    1,200 SF
    Spartanburg Office Space for Lease

    Office space available near downtown Spartanburg with on-site parking.

    301 N Pine St, Spartanburg, SC

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    Spartanburg Flex Building For Lease
    Contact for pricing
    6,800 SF
    Spartanburg Flex Building For Lease

    Flex building with office and outdoor storage in Spartanburg.

    440 Southport Commerce Blvd, Spartanburg, SC 29306

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    Downtown Spartanburg Office Space
    $16 SF/Yr
    1,395 SF
    Downtown Spartanburg Office Space

    Office space in downtown Spartanburg with professional finishes.

    275 E Henry St, Spartanburg, SC

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    Class A Office Suite
    $23 SF/Yr
    2,268 SF
    Class A Office Suite

    Available office suite in Spartanburg's Point West Office Complex.

    775 Spartan Blvd, Spartanburg, SC

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    Westside Office/Medical Space Available
    $16 SF/Yr
    5,461 SF
    Westside Office/Medical Space Available

    5461± sq ft office/medical space for rent.

    225 E Blackstock Rd, Spartanburg, SC

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    Office Suites in Spartanburg
    $18 SF/Yr
    1,218 SF
    Office Suites in Spartanburg

    Office suites available in Spartanburg near downtown and amenities.

    900 S Pine St, Spartanburg, SC

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    Office Space for Lease
    $2,500/Mo
    1,927 SF
    Office Space for Lease

    1,927 SF office space available for lease.

    517 E St John St, Spartanburg, SC

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    Downtown Office Space for Rent
    $23 SF/Yr
    2,500 SF
    Downtown Office Space for Rent

    Prime office space in Spartanburg's revitalized Central Business District.

    101 W Saint John St, Spartanburg, SC

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    Spartanburg Office Space Available
    $11 SF/Yr
    4,000 SF
    Spartanburg Office Space Available

    4,000 sq. ft. office space for rent.

    170 Camelot Dr, Spartanburg, SC

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    Class A Office Space
    $21 SF/Yr
    2,963 SF
    Class A Office Space

    Professional office space on Spartanburg's Westside with high visibility.

    1460 John B White Sr Blvd, Spartanburg, SC

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    Southport Road Retail Opportunity
    Contact for pricing
    2,456 SF
    Southport Road Retail Opportunity

    2,456+/- SF building with excellent visibility and ample parking.

    2190 Southport Rd, Spartanburg, SC 29306

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    Spartanburg Office Space Available
    $15 SF/Yr
    2,122 SF
    Spartanburg Office Space Available

    Office space available for lease in Spartanburg, South Carolina.

    5020 N Blackstock Rd, Spartanburg, SC

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    Spartanburg Flex Space For Lease
    $15 SF/Yr
    4,000 SF
    Spartanburg Flex Space For Lease

    Flex space featuring office and warehouse areas, near I-26.

    3211 Reidville Rd, Spartanburg, SC

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    Office Space Near I-26
    Contact for pricing
    3,600 SF
    Office Space Near I-26

    3,600+/- SF office space with laydown yard near I-26.

    208 Oak Forest Rd, Spartanburg, SC 29301

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    Spartanburg, SC Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Spartanburg, SC with 54 listings featured on our commercial real estate exchange. The current inventory includes 169,606 square feet of properties with an estimated lease value of $772 /Mo.

    Estimated lease rates for Office Spaces in Spartanburg, SC begin at $10 SF/Yr, with an average of $19 SF/Yr and extend to $69 SF/Yr.
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    Most Searched ZIP Codes in Spartanburg, SC

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