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Spartanburg, SC Office Spaces for Lease

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28 properties
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Renovated Furnished Office Units
Updated: Jun 21
Renovated Furnished Office Units

792 John B White Sr Boulevard, Spartanburg, SC 29306

$2,808/Mo
0.56 AC lot
1,230‑square‑foot furnished office property
Recently renovated with updated lighting, LVP, carpet, and contemporary finishes
Flexible office layout with central heating and central air
0.56‑acre site with parking lot and porch
Access to Interstate 26 and Interstate 85
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Modern Medical Office Space
Updated: Sep 4
Modern Medical Office Space

391 Serpentine Drive, Spartanburg, SC 29303

$1,156/Mo
4,387 sqft
Two available suites: 4,387 SF on the 1st floor and 3,956 SF on the 3rd floor
2nd‑floor surgery room with exhaust system already in place
Adjacent to Spartanburg Regional Medical Hospital
Approximately one mile to I‑585 via Hwy 9
232 on‑site parking spaces, including 29 covered spaces
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Industrial Flex Space with Two Buildings
Industrial Flex Space with Two Buildings

113 Ian Ct, Spartanburg, SC 29306

$12,500/Mo
12,500 sqft 1.95 AC lot

Two-building property combines office areas with warehouse space for flexible business operations.

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Flex Space with Conditioned Warehouse
Flex Space with Conditioned Warehouse

1095 Southport Rd, Spartanburg, SC 29306

$8 SF/Yr
24,000 sqft

Industrial property combining office accommodation with conditioned warehouse and manufacturing space.

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Spartanburg Storefront Retail/Office Space
Spartanburg Storefront Retail/Office Space

512 E Main St, Spartanburg, SC 29302

$15 SF/Yr
2,046 sqft

Renovated 2,046 SF retail/office space in downtown Spartanburg.

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Office Units with Dual Frontage
Office Units with Dual Frontage

846 WO Ezell Blvd, Spartanburg, SC 29301

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3,120 sqft

B4-zoned commercial space near downtown with exposure along two public streets.

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Historic Office Building for Rent
Historic Office Building for Rent

571 East Main Street, Spartanburg, SC 29302

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4,688 sqft 0.48 AC lot

Renovated historic building with multiple rooms, suited for professional office use, with street parking available.

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Class A Office Suite
Class A Office Suite

149B West Main Street, Spartanburg, SC 29306

$30 SF/Yr

Class A suite with private offices and flexible configuration, featuring top-floor views in downtown Morgan Square.

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Historic Spartanburg Mixed-Use Retail Space
Historic Spartanburg Mixed-Use Retail Space

174 E Main St, Spartanburg, SC 29306

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4,709 sqft

Retail space available in historic mixed-use building in downtown Spartanburg.

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Office Suite with Testing Facility
Office Suite with Testing Facility

105 Corporate Dr, Spartanburg, SC 29303

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1,350 sqft

Move-in-ready office suite with testing facility and a floor plan that can be modified to fit your operation.

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Office Suite on Main Street
Office Suite on Main Street

1948 E Main St, Spartanburg, SC 29307

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Office space on the East Main Street corridor with on-site parking for customers and employees.

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Westside Office/Medical Space Available
Westside Office/Medical Space Available

225 E Blackstock Rd, Spartanburg, SC

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5,461 sqft 0.94 AC lot

5461± sq ft office/medical space for rent.

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Mixed-Use Building with Outdoor Area
Mixed-Use Building with Outdoor Area

500 W Main St, Spartanburg, SC 29301

Contact for pricing
10,992 sqft

Built in 1916 and renovated 2023–2024, featuring retail, restaurant, office, and entertainment space plus large rear outdoor area.

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Renovated Historic Mixed-Use Building
Renovated Historic Mixed-Use Building

500 W Main St, Spartanburg, SC 29301

Contact for pricing
4,388 sqft

Historic building renovated 2023–2024 with retail, restaurant, office, and entertainment space plus ample parking.

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Renovated Office Building with Parking
Renovated Office Building with Parking

500 W Main St, Spartanburg, SC 29301

Contact for pricing
5,061 sqft

Office component in a mixed-use building renovated 2023–2024 with ample parking and multiple ingress/egress options.

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Three-Level Professional Office Building
Three-Level Professional Office Building

291 S. Pine Street, Spartanburg, SC 29301

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Professional office building with three levels, multiple conference rooms, outdoor patio, and on-site parking for 38 vehicles.

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Spartanburg Office Space For Rent
Spartanburg Office Space For Rent

135 West Main Street, Spartanburg, SC

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1,700 sqft 0.08 AC lot

Office space available for rent in Spartanburg, SC.

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Office Suites in Spartanburg
Office Suites in Spartanburg

900 S Pine St, Spartanburg, SC

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1,218 sqft 0.68 AC lot

Office suites available in Spartanburg near downtown and amenities.

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Spartanburg Office Space For Rent
Spartanburg Office Space For Rent

2375 E Main St, Spartanburg, SC

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120 sqft 2.28 AC lot

Office space available for lease in Spartanburg, South Carolina.

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Spartanburg Office Space for Lease
Spartanburg Office Space for Lease

301 N Pine St, Spartanburg, SC

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1,200 sqft 0.35 AC lot

Office space available near downtown Spartanburg with on-site parking.

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Mixed-Use Building in Opportunity Zone
Mixed-Use Building in Opportunity Zone

500 W Main St, Spartanburg, SC

Contact for pricing
1,683 sqft 7.26 AC lot

Retail, restaurant, office, and entertainment spaces for lease.

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Subdividable Two-Story Office Building
Subdividable Two-Story Office Building

201 Henry Pl, Spartanburg, SC 29306

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9,240 sqft 0.68 AC lot

Two-story office building with approximately 4,600 sq. ft. per level and flexible subdivision into four units.

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Class A Office Space
Class A Office Space

1460 John B White Sr Blvd, Spartanburg, SC

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2,963 sqft 3.65 AC lot

Professional office space on Spartanburg's Westside with high visibility.

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Spartanburg Office Space For Lease
Spartanburg Office Space For Lease

2500 Winchester Pl, Spartanburg, SC

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1,200 sqft 1.55 AC lot

1,200 SF office space in busy Westside location.

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Spartanburg, SC Office Spaces Lease Rates & Market Statistics

Explore 28 Office Spaces for lease in Spartanburg, SC on Realmo, a commercial real estate exchange covering the Spartanburg area. The current inventory totals 105,826 square feet of properties — an average of ~3,800 SF per listing.

Office Spaces lease rates in Spartanburg range from $8 SF/Yr at the entry level to $30 SF/Yr at the top of the market, averaging $16.25 SF/Yr. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $16.25 SF/Yr is 33% below the South Carolina state average of $24.29 SF/Yr.

Spartanburg accounts for 78% of the 36 office spaces currently available across Spartanburg County, where nearby markets include Boiling Springs and Duncan. By space type, the market includes 24 office units and 4 office buildings.

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