Advertise
    Hilton Head, SC
    Office

    Hilton Head, SC Office Spaces for Lease

    Notify Me
    List
    Map
    Bluffton, SC Bluffton, GA Port Royal, SC Beaufort, SC Cross, SC Ridgeland, SC Hardeeville, SC Tybee Island, GA
    14 properties
    Sort:
    Multiple Office Solutions at SC, Hilton Head - Office Park Road. Contact us today to book a tour!
    View details
    Office Unit with Rear Warehouse
    Updated: Jun 10
    Office Unit with Rear Warehouse

    1 Mathews Drive, Hilton Head Island, SC 29926

    $18 SF/Yr
    1.97 AC lot
    1,500 square feet of finished office space
    Rear warehouse area included with the office unit
    Commercial zoning on a 1.97‑acre property
    Sublease with 2 years remaining on the lease
    Extension may be available with landlord approval
    View details
    Renovated Office Building
    Updated: Oct 21, 2025
    Renovated Office Building

    38 New Orleans Road, Hilton Head Island, SC 29928

    $18 SF/Yr
    0.41 AC lot
    Over 5,200 square feet of office space
    Four bathrooms per floor
    Recently renovated office building
    Exposure to New Orleans Road and William Hilton Parkway
    0.41‑acre site with on‑site parking
    View details
    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Light Industrial Flex Suites
    Light Industrial Flex Suites

    12 Cardinal Rd, Hilton Head Island, SC 29926

    $2,100/Mo
    5,090 sqft

    Two leaseable flex units include warehouse and office space with roll-up and drive-in doors plus dock access and a shared yard.

    View details
    Office Space with High-End Finishes
    Office Space with High-End Finishes

    386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC 29926

    $3,000/Mo
    2,175 sqft

    Office space featuring high-end finishes in a desirable location.

    View details
    Conditioned Flex Space
    Conditioned Flex Space

    136 Beach City Rd, Hilton Head Island, SC 29926

    Contact for pricing
    1,663 sqft

    Climate-controlled office, showroom, and warehouse areas provide a flexible commercial configuration with an on-site restroom.

    View details
    Medical Building on Hilton Head
    Medical Building on Hilton Head

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926

    $17 SF/Yr

    Stand-alone medical building for lease on Hilton Head Island.

    View details
    Class A Office Suites Available
    Class A Office Suites Available

    2 Park Lane, Hilton Head Island, SC 29928

    $18 SF/Yr

    Functional office spaces in updated building with covered parking.

    View details
    Renovated First-Floor Office Suite
    Renovated First-Floor Office Suite

    8 Lafayette Pl, Hilton Head Island, SC 29926

    Contact for pricing
    3,025 sqft

    Recently updated workspace with reception, private offices, conference room, kitchenette, and lobby access.

    View details
    Functional Office Spaces For Rent
    Functional Office Spaces For Rent

    2 Park Rd, Hilton Head Island, SC

    Contact for pricing
    1,792 sqft 1.82 AC lot

    Updated building with covered parking and a great location.

    View details
    Office Suite with Reception and Conference Room
    Office Suite with Reception and Conference Room

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    4,920 sqft

    Office suite ready for occupancy with reception, multiple offices, and a conference room in a mid-island Shelter Cove location.

    View details
    Office Suite with Reception
    Office Suite with Reception

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    7,268 sqft

    Office suite features a reception area, multiple offices, and flexible open work or meeting space.

    View details
    Medical Suites in Hilton Head
    Medical Suites in Hilton Head

    25 Hospital Center Blvd, Hilton Head Island, SC 29926

    Contact for pricing
    2,424 sqft

    Medical office suites for lease in prestigious medical complex.

    View details
    Ground-Floor Medical Office Suite
    Ground-Floor Medical Office Suite

    23 Main St, Hilton Head Island, SC 29926

    Contact for pricing
    750 sqft

    Ground-floor medical office suite in a high-profile building with ample on-site parking.

    View details
    Based on your search, we've compiled 50 Potential Opportunities for your consideration. Besides 14 Active listings in Hilton Head, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 32 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Newly Built Office Unit
    Newly Built Office Unit

    B-33 Marshellen Drive, Beaufort, SC 29902

    $3,350/Mo
    1,685 sqft

    Newly constructed office space supports medical and professional users with shared parking in a business park setting.

    View details
    Office Suite in Business Park
    Office Suite in Business Park

    33 Marshellen Drive, Beaufort, SC 29902

    $3,350/Mo
    0.08 AC lot

    Commercially zoned office space with shared parking and flexibility for medical or professional occupancy.

    View details
    Single-Story Retail Office Medical Building
    Single-Story Retail Office Medical Building

    128 Bluffton Rd, Bluffton, SC 29910

    Contact for pricing
    2,730 sqft

    Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

    View details
    New Flex Space For Lease
    New Flex Space For Lease

    5 Kitties Landing Dr, Bluffton, SC

    Contact for pricing
    3,360 sqft 1.42 AC lot

    New construction flex space suitable for office, retail, or warehouse.

    View details

    Similar Spaces for Sale in Hilton Head, SC

    Consider Similar Space for Sale. We found 32 Spaces matching your search parameters.

    Two-Story Office Building with Elevator
    Two-Story Office Building with Elevator

    1044 William Hilton Pkwy, Hilton Head Island, SC 29928

    $2,200,000
    10,017 sqft

    Flexible layout with private offices, training areas, storage, and kitchenette or breakroom spaces.

    View details
    Leased Professional Office Building
    Leased Professional Office Building

    1544 Fording Island Road, Hilton Head Island, SC 29926

    $1,399,000
    4,258 sqft

    Professional office improvements support an existing law firm tenancy with annual lease escalations.

    View details
    Flex Space with Expansion Capacity
    Flex Space with Expansion Capacity

    50 Capital Drive, Hilton Head Island, SC 29926

    $1,599,000
    4,000 sqft 1.50 AC lot

    Light Industrial property combining office, warehouse, storage units, and additional buildable capacity.

    View details
    Two-Story Office Building
    Two-Story Office Building

    2-578 William Hilton Pkwy, Hilton Head Island, SC 29926

    $999,000
    2,322 sqft

    Flexible commercial building suited to professional office or select retail uses.

    View details
    Stand Alone Medical Office Building
    Stand Alone Medical Office Building

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926

    $1,348,000
    3,600 sqft

    Stand-alone medical building on Hilton Head Island, ready for occupancy.

    View details
    Remodeled Two-Level Wellness Property
    Remodeled Two-Level Wellness Property

    16 Shelter Cove Lane, Hilton Head Island, SC 29928

    $1,999,000

    Updated standalone commercial space offers two floors and access to office, retail, medical, and professional business uses.

    View details
    Five-Building Office Campus
    Five-Building Office Campus

    1000 Main Street, Hilton Head Island, SC 29926

    $5,800,000

    Five-building office campus with professional suites and established on-site management.

    View details
    Medical Office Suite Near Hospital
    Medical Office Suite Near Hospital

    23 Main Street, Suite 101-A, Hilton Head Island, SC 29926

    Contact for pricing
    750 sqft

    Ground floor medical office suite near Hilton Head Hospital.

    View details
    Office Suite Available for Lease
    Office Suite Available for Lease

    11 Marina Side Drive, Suite A, Hilton Head Island, SC 29928

    Contact for pricing
    1,250 sqft

    General office space in a newer building, ready for occupancy.

    View details
    Waterfront Executive Office Suite
    Waterfront Executive Office Suite

    19 Shelter Cove Lane, Hilton Head Island, SC 29928

    $399,000
    0.01 AC lot

    Remodeled, furnished office suite with private offices, kitchen, and full bathroom.

    View details

    Hilton Head, SC Office Spaces Lease Rates & Market Statistics

    Browse 14 Office Spaces for lease in Hilton Head, SC on Realmo, a commercial real estate marketplace serving the Hilton Head area. The current inventory totals 31,339 square feet of properties — an average of ~2,250 SF per listing.

    Asking lease rates for Office Spaces in Hilton Head start at $4.95 SF/Yr, average $15.42 SF/Yr, and reach $18 SF/Yr at the top of the market. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $15.42 SF/Yr, the local average runs 36% below South Carolina's state average of $24.23 SF/Yr.

    Hilton Head accounts for 21% of the 66 office spaces currently available across Beaufort County, where nearby markets include Beaufort and Hilton Head Island. By space type, the market includes 10 office units and 3 medical office space listings.

    List
    Map

    Browse Office Spaces for Lease Near Hilton Head, SC

    Popular Searches in Hilton Head, SC

    Most Searched ZIP Codes in Hilton Head, SC

    • 29926
    • 29928

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!