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    Hilton Head, SC Office Spaces for Lease

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    Bluffton, SC Beaufort, SC Port Royal, SC Ridgeland, SC Hardeeville, SC Tybee Island, GA
    Found 12 office space listings for lease in Hilton Head, SC, averaging $15/SF/YR. Use lease type data to compare options faster.
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    Flexible Workspace Solutions at SC, Hilton Head - Office Park Road. Contact us today to book a tour!
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    Office Unit with Rear Warehouse
    Updated: Jun 10
    Office Unit with Rear Warehouse

    1 Mathews Drive, Hilton Head Island, SC 29926

    $18 SF/Yr
    1.97 AC lot
    1,500 square feet of finished office space
    Rear warehouse area included with the office unit
    Commercial zoning on a 1.97‑acre property
    Sublease with 2 years remaining on the lease
    Extension may be available with landlord approval
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    Light Industrial Flex Suites
    Updated: Jul 24
    Light Industrial Flex Suites

    12 Cardinal Rd, Hilton Head Island, SC 29926

    $2,100/Mo
    5,090 sqft
    12 Cardinal Road offers mid‑island light industrial flex space with Units A and B available for lease.
    Unit A includes 2,990 SF of warehouse, office, and mezzanine space with roll‑up doors, shared loading dock, drive‑in door, and full HVAC.
    Unit B includes 2,100 SF of warehouse and office space with a drive‑in door and shared dock access.
    Both units have 3‑phase power and can be leased together for a combined total of 5,090 SF.
    Each suite features loading access with roll‑up doors and a shared fenced yard.
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    Office Space with High-End Finishes
    Office Space with High-End Finishes

    386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC 29926

    $3,000/Mo
    8–14 people  1 space  2,175 sqft  Built 1986

    Office space featuring high-end finishes in a desirable location.

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    Conditioned Flex Space
    Conditioned Flex Space

    136 Beach City Rd, Hilton Head Island, SC 29926

    Triple net (NNN)
    Contact for pricing
    1,663 sqft

    Climate-controlled office, showroom, and warehouse areas provide a flexible commercial configuration with an on-site restroom.

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    Medical Suites in Hilton Head
    Medical Suites in Hilton Head

    25 Hospital Center Blvd, Hilton Head Island, SC 29926

    Triple net (NNN)
    Contact for pricing
    2,424 sqft

    Medical office suites for lease in prestigious medical complex.

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    Class A Office Suites Available
    Class A Office Suites Available

    2 Park Lane, Hilton Head Island, SC 29928

    $19 SF/Yr
    2 spaces

    Functional office spaces in updated building with covered parking.

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    Renovated First-Floor Office Suite
    Renovated First-Floor Office Suite

    8 Lafayette Pl, Hilton Head Island, SC 29926

    Triple net (NNN) Class A
    Contact for pricing
    12–20 people  1 space  3,025 sqft  Floor 1
    6 private offices  1 meeting room  Highway access + Road access

    Recently updated workspace with reception, private offices, conference room, kitchenette, and lobby access.

    Monument signage  Split HVAC system  Kitchenette  Common restrooms
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    Functional Office Spaces For Rent
    Functional Office Spaces For Rent

    2 Park Rd, Hilton Head Island, SC

    Triple net (NNN)
    Contact for pricing
    7–11 people  3 spaces  1,792 sqft  1.82 acres

    Updated building with covered parking and a great location.

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    Office Suite with Reception and Conference Room
    Office Suite with Reception and Conference Room

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    19–32 people  4,920 sqft  Multi-tenant

    Office suite ready for occupancy with reception, multiple offices, and a conference room in a mid-island Shelter Cove location.

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    Office Suite with Reception
    Office Suite with Reception

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    29–48 people  7,268 sqft  Multi-tenant

    Office suite features a reception area, multiple offices, and flexible open work or meeting space.

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    Ground-Floor Medical Office Suite
    Ground-Floor Medical Office Suite

    23 Main St, Hilton Head Island, SC 29926

    Triple net (NNN)
    Contact for pricing
    750 sqft

    Ground-floor medical office suite in a high-profile building with ample on-site parking.

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    12 active listings match your search: Office for lease in Hilton Head, SC. Based on your search, we've also compiled 34 Potential Opportunities for your consideration: 4 spaces in nearby cities and 30 properties for sale.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Private Second-Floor Office Suite
    Private Second-Floor Office Suite

    1613 Paris Avenue, Port Royal, SC 29935

    $600/Mo
    1 space  160 sqft  Built 2001  Floor 2
    Road access

    Utilities are included, with WiFi provided separately.

    Dedicated building parking  Shared restroom
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    Office Suite with Conference Room
    Office Suite with Conference Room

    1001 Paris Avenue, Port Royal, SC 29935

    $2,841/Mo
    6 private offices  1 meeting room

    Flexible layout includes multiple office areas, a restroom, break room, and printer room.

    Restroom  Break room  Printer room  Connected to GG's Restaurant
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    Single-Story Retail Office Medical Building
    Single-Story Retail Office Medical Building

    128 Bluffton Rd, Bluffton, SC 29910

    Triple net (NNN)
    Contact for pricing
    2,730 sqft

    Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

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    New Flex Space For Lease
    New Flex Space For Lease

    5 Kitties Landing Dr, Bluffton, SC

    Triple net (NNN)
    Contact for pricing
    3,360 sqft

    New construction flex space suitable for office, retail, or warehouse.

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    Similar Spaces for Sale in Hilton Head, SC

    Consider Similar Space for Sale. We found 30 Spaces matching your search parameters.

    Leased Professional Office Building
    Leased Professional Office Building

    1544 Fording Island Road, Hilton Head Island, SC 29926

    $1,399,000
    4,258 sqft

    Professional office improvements support an existing law firm tenancy with annual lease escalations.

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    Flex Space with Expansion Capacity
    Flex Space with Expansion Capacity

    50 Capital Drive, Hilton Head Island, SC 29926

    $1,599,000
    4,000 sqft 1.50 AC lot

    Light Industrial property combining office, warehouse, storage units, and additional buildable capacity.

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    Two-Story Office Building
    Two-Story Office Building

    578 William Hilton Parkway #2, Hilton Head Island, SC 29928

    $999,000
    2,322 sqft

    The building offers a professional layout with potential for retail use.

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    Medical Office Suites
    Medical Office Suites

    23 Main Street, Suite 101, Hilton Head Island, SC 29926

    $499,000
    1,500 sqft

    Ground-floor space is divided into two suites, with one currently leased and the other vacant.

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    Two-Story Office Building
    Two-Story Office Building

    2-578 William Hilton Pkwy, Hilton Head Island, SC 29926

    $999,000
    2,322 sqft

    Flexible commercial building suited to professional office or select retail uses.

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    Stand Alone Medical Office Building
    Stand Alone Medical Office Building

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926

    $1,348,000
    3,600 sqft

    Stand-alone medical building on Hilton Head Island, ready for occupancy.

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    Flex Space with Rear Warehouse
    Flex Space with Rear Warehouse

    1 Mathews Drive, Hilton Head Island, SC 29926

    Contact for pricing
    1,500 sqft

    A finished office component is paired with an additional warehouse area.

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    Remodeled Two-Level Wellness Property
    Remodeled Two-Level Wellness Property

    16 Shelter Cove Lane, Hilton Head Island, SC 29928

    $1,999,000

    Updated standalone commercial space offers two floors and access to office, retail, medical, and professional business uses.

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    Five-Building Office Campus
    Five-Building Office Campus

    1000 Main Street, Hilton Head Island, SC 29926

    $5,800,000

    Five-building office campus with professional suites and established on-site management.

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    Medical Office Suite Near Hospital
    Medical Office Suite Near Hospital

    23 Main Street, Suite 101-A, Hilton Head Island, SC 29926

    Contact for pricing
    750 sqft

    Ground floor medical office suite near Hilton Head Hospital.

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    Office Suite Available for Lease
    Office Suite Available for Lease

    11 Marina Side Drive, Suite A, Hilton Head Island, SC 29928

    Contact for pricing
    1,250 sqft

    General office space in a newer building, ready for occupancy.

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    Class A Office Space Available
    Class A Office Space Available

    8 Lafayette Pl, Hilton Head Island, SC 29926

    Contact for pricing
    10,189 sqft

    First floor office space in Hilton Head Island, South Carolina.

    View details

    Hilton Head, SC Office Spaces Lease Rates & Market Statistics

    Browse 12 Office Spaces for lease in Hilton Head, SC on Realmo, a commercial real estate marketplace serving the Hilton Head area. The current inventory totals 31,339 square feet of properties — an average of ~2,600 SF per listing.

    Asking lease rates for Office Spaces in Hilton Head start at $4.95 SF/Yr, average $14.62 SF/Yr, and reach $19 SF/Yr at the top of the market. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $14.62 SF/Yr, the local average runs 42% below South Carolina's state average of $25.07 SF/Yr.

    Hilton Head accounts for 20% of the 59 office spaces currently available across Beaufort County, where nearby markets include Beaufort and Hilton Head Island.

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