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    Beaufort County, SC Office Spaces for Lease

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    Single-Story Retail Office Medical Building
    Single-Story Retail Office Medical Building

    128 Bluffton Rd, Bluffton, SC 29910

    Contact for pricing
    2,730 sqft

    Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

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    Single-Story Medical Office Retail
    Single-Story Medical Office Retail

    128 Bluffton Rd, Bluffton, SC 29910

    Contact for pricing
    2,655 sqft

    Pre-leasing single-story retail and office building planned for delivery in Fall 2026.

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    Customizable Office Unit
    Customizable Office Unit

    B-960 Ribaut Rd, Beaufort, SC 29902

    $30 SF/Yr
    3,200 sqft

    Build-out can be tailored to tenant specifications, with upgraded electrical, mechanical, and plumbing systems.

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    Office Suite with Reception and Conference Room
    Office Suite with Reception and Conference Room

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    4,920 sqft

    Office suite ready for occupancy with reception, multiple offices, and a conference room in a mid-island Shelter Cove location.

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    Office Suite with Reception
    Office Suite with Reception

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    7,268 sqft

    Office suite features a reception area, multiple offices, and flexible open work or meeting space.

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    New Flex Space For Lease
    New Flex Space For Lease

    5 Kitties Landing Dr, Bluffton, SC

    Contact for pricing
    3,360 sqft 1.42 AC lot

    New construction flex space suitable for office, retail, or warehouse.

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    Class A Office Medical Building
    Class A Office Medical Building

    5 Buck Island Rd, Bluffton, SC 29910

    Contact for pricing
    17,525 sqft

    Class A office and medical building with floor-to-ceiling windows and an interior elevator at a highway intersection.

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    Ground-Floor Medical Office Suite
    Ground-Floor Medical Office Suite

    23 Main St, Hilton Head Island, SC 29926

    Contact for pricing
    750 sqft

    Ground-floor medical office suite in a high-profile building with ample on-site parking.

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    Office Space with Balcony Access
    Office Space with Balcony Access

    19 Market, Beaufort, SC

    Contact for pricing
    1,350 sqft 0.05 AC lot

    Office space featuring multiple balconies, private bathroom, and concrete flooring.

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    Class A Office Space
    Class A Office Space

    New Riverside Vlg Wy, Bluffton, SC 29910

    Contact for pricing

    Office space in mixed-use center with retail and residential.

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    Downtown Beaufort Office Space Available
    Downtown Beaufort Office Space Available

    1121 Boundary St, Beaufort, SC 29902

    Contact for pricing
    3,729 sqft

    Office space for rent in downtown Beaufort, South Carolina.

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    Based on your search, we've compiled 123 Potential Opportunities for your consideration. Besides 61 Active listings in Beaufort County, SC, we suggest exploring alternatives. Consider Similar 62 Spaces for Sales.

    Similar Spaces for Sale in Beaufort County, SC

    Consider Similar Space for Sale. We found 62 Spaces matching your search parameters.

    Flex Space with Expansion Capacity
    Flex Space with Expansion Capacity

    50 Capital Drive, Hilton Head Island, SC 29926

    $1,599,000
    4,000 sqft 1.50 AC lot

    Light Industrial property combining office, warehouse, storage units, and additional buildable capacity.

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    Two-Story Office Building with Elevator
    Two-Story Office Building with Elevator

    1044 William Hilton Pkwy, Hilton Head Island, SC 29928

    $2,200,000
    10,017 sqft

    Flexible layout with private offices, training areas, storage, and kitchenette or breakroom spaces.

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    Office-Showroom Warehouse Building
    Office-Showroom Warehouse Building

    29 Kitties Landing Road, Bluffton, SC 29910

    $2,475,000
    10,000 sqft 1.00 AC lot

    Metal-frame office, showroom, and warehouse building with four roll-up doors and full HVAC on about one acre.

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    Leased Professional Office Building
    Leased Professional Office Building

    1544 Fording Island Road, Hilton Head Island, SC 29926

    $1,399,000
    4,258 sqft

    Professional office improvements support an existing law firm tenancy with annual lease escalations.

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    Two-Story Office Building
    Two-Story Office Building

    2-578 William Hilton Pkwy, Hilton Head Island, SC 29926

    $999,000
    2,322 sqft

    Flexible commercial building suited to professional office or select retail uses.

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    Waterfront Mixed-Use Building
    Waterfront Mixed-Use Building

    916 Bay Street, Beaufort, SC 29902

    $5,250,000
    16,692 sqft

    Four-story concrete property with commercial zoning, rooftop expansion capacity, elevator service, and covered gated parking.

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    Stand Alone Medical Office Building
    Stand Alone Medical Office Building

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926

    $1,348,000
    3,600 sqft

    Stand-alone medical building on Hilton Head Island, ready for occupancy.

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    Custom Office Building
    Custom Office Building

    10 Bruin Rd, Bluffton, SC 29910

    $850,000
    1,400 sqft

    Stand-alone property with custom woodwork, parking, and signage opportunities in the Neighborhood Core Historic District.

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    Built-Out Medical Office Space
    Built-Out Medical Office Space

    53 Persimmons Street STE 105, Bluffton, SC 29910

    Contact for pricing
    3,445 sqft

    Existing medical-office improvements support healthcare and professional occupancy, subject to the current lease and landlord approval.

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    Renovated Office Unit
    Renovated Office Unit

    29 Plantation Park Drive, Bluffton, SC 29910

    Contact for pricing
    1,300 sqft

    Three private offices, a reception area, conference room, restroom, and kitchenette create a practical multi-room layout.

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    Remodeled Two-Level Wellness Property
    Remodeled Two-Level Wellness Property

    16 Shelter Cove Lane, Hilton Head Island, SC 29928

    $1,999,000

    Updated standalone commercial space offers two floors and access to office, retail, medical, and professional business uses.

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    Leased Medical Office Space
    Leased Medical Office Space

    53 Persimmons Street, Bluffton, SC 29910

    $1,395,000

    A long-term medical tenant occupies the property under a lease with annual rent increases.

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    Highway 278 Frontage Office Building
    Highway 278 Frontage Office Building

    5 Buck Island Rd, Bluffton, SC 29910

    Contact for pricing
    8,800 sqft

    Class A office/medical building on Highway 278 in Bluffton.

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