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    Beaufort County, SC Office Spaces for Lease

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    Single-Story Retail Office Medical Building
    Single-Story Retail Office Medical Building

    128 Bluffton Rd, Bluffton, SC 29910

    Contact for pricing
    2,730 sqft

    Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

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    Single-Story Medical Office Retail
    Single-Story Medical Office Retail

    128 Bluffton Rd, Bluffton, SC 29910

    Contact for pricing
    2,655 sqft

    Pre-leasing single-story retail and office building planned for delivery in Fall 2026.

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    Office Suite with Reception and Conference Room
    Office Suite with Reception and Conference Room

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    4,920 sqft

    Office suite ready for occupancy with reception, multiple offices, and a conference room in a mid-island Shelter Cove location.

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    Mixed Commercial Space Available
    Mixed Commercial Space Available

    46 Old Wild Horse Road, Hilton Head Island, SC 29926

    Contact for pricing
    1,500 sqft

    1,500 sq. ft. space ideal for retail, office, or storage.

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    Office Suite with Reception
    Office Suite with Reception

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing
    7,268 sqft

    Office suite features a reception area, multiple offices, and flexible open work or meeting space.

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    New Flex Space For Lease
    New Flex Space For Lease

    5 Kitties Landing Dr, Bluffton, SC

    Contact for pricing
    3,360 sqft 1.42 AC lot

    New construction flex space suitable for office, retail, or warehouse.

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    Medical Office Suites
    Medical Office Suites

    25 Hospital Center Blvd, Hilton Head Island, SC 29926

    Contact for pricing
    2,774 sqft

    Three-story medical pavilion offers multiple suite layouts for lease, connected by breezeway to Hilton Head Hospital.

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    Class A Office Medical Building
    Class A Office Medical Building

    5 Buck Island Rd, Bluffton, SC 29910

    Contact for pricing
    17,525 sqft

    Class A office and medical building with floor-to-ceiling windows and an interior elevator at a highway intersection.

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    Ground-Floor Medical Office Suite
    Ground-Floor Medical Office Suite

    23 Main St, Hilton Head Island, SC 29926

    Contact for pricing
    750 sqft

    Ground-floor medical office suite in a high-profile building with ample on-site parking.

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    Office Space with Balcony Access
    Office Space with Balcony Access

    19 Market, Beaufort, SC

    Contact for pricing
    1,350 sqft 0.05 AC lot

    Office space featuring multiple balconies, private bathroom, and concrete flooring.

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    Class A Office Space
    Class A Office Space

    New Riverside Vlg Wy, Bluffton, SC 29910

    Contact for pricing

    Office space in mixed-use center with retail and residential.

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    Shelter Cove Office Space Available
    Shelter Cove Office Space Available

    23B Shelter Cove Ln, Hilton Head Island, SC 29928

    Contact for pricing

    Office suites available in prime Shelter Cove location.

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    Downtown Beaufort Office Space Available
    Downtown Beaufort Office Space Available

    1121 Boundary St, Beaufort, SC 29902

    Contact for pricing

    Office space for rent in downtown Beaufort, South Carolina.

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    Office Space on Sea Island
    Office Space on Sea Island

    189 Sea Island Pkwy, Beaufort, SC 29907

    Contact for pricing

    Office space for lease on Lady’s Island, SC.

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    Class A Office Space Available
    Class A Office Space Available

    1 Carecore Dr, Bluffton, SC 29910

    Contact for pricing

    LEED Certified office space for lease in Buckwalter Place.

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    Based on your search, we've compiled 135 Potential Opportunities for your consideration. Besides 63 Active listings in Beaufort County, SC, we suggest exploring alternatives. Consider Similar 72 Spaces for Sales.

    Similar Spaces for Sale in Beaufort County, SC

    Consider Similar Space for Sale. We found 72 Spaces matching your search parameters.

    Two-Story Office Building with Elevator
    Two-Story Office Building with Elevator

    1044 William Hilton Pkwy, Hilton Head Island, SC 29928

    $2,200,000
    10,017 sqft

    Flexible layout with private offices, training areas, storage, and kitchenette or breakroom spaces.

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    Office-Showroom Warehouse Building
    Office-Showroom Warehouse Building

    29 Kitties Landing Road, Bluffton, SC 29910

    $2,475,000
    10,000 sqft 1.00 AC lot

    Metal-frame office, showroom, and warehouse building with four roll-up doors and full HVAC on about one acre.

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    Leased Professional Office Building
    Leased Professional Office Building

    1544 Fording Island Road, Hilton Head Island, SC 29926

    $1,399,000
    4,258 sqft

    Professional office improvements support an existing law firm tenancy with annual lease escalations.

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    Ground-Floor Office Unit
    Ground-Floor Office Unit

    386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC 29926

    $450,000
    2,175 sqft

    Two-level office unit with reception, conference, and storage areas, plus additional finished space upstairs.

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    Stand Alone Medical Office Building
    Stand Alone Medical Office Building

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926

    $1,348,000
    3,600 sqft

    Stand-alone medical building on Hilton Head Island, ready for occupancy.

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    Live-Work Bungalow with Central Air
    Live-Work Bungalow with Central Air

    1890 Trask Parkway, Seabrook, SC 29940

    $399,000
    0.47 AC lot

    Nearly half-acre live-work bungalow on US 21, zoned Rural Community Center with central air and public water.

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    Marsh-Front Live-Work Building
    Marsh-Front Live-Work Building

    Saint Helena Island, SC 29920

    $425,000
    0.32 AC lot

    Marsh-front commercial live-work building on Highway 21 with zoning T4VC, public water, septic, and ample parking.

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    Mixed-Use Property with Trail Frontage
    Mixed-Use Property with Trail Frontage

    12 Neil Road, Beaufort, SC 29906

    $2,495,000
    2.69 AC lot

    Two existing structures combine live/work space with a modular building and access from established roads.

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    Second-Floor Office Condo
    Second-Floor Office Condo

    52 New Orleans Rd, Hilton Head Island, SC 29928

    Contact for pricing
    2,588 sqft

    Second-floor office condo with elevator access and reception, seven offices, and a conference room.

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