Sign Up Successful!
You now have access to more from Realmo!
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Office
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Cape Girardeau County, MO Office Properties & Spaces for Lease

    6 results
    List
    Map
    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Dr, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
    View details
    Retail/Office Space in Jackson, MO
    $1,200 / Mo
    1,305 SF

    Retail/Office Space in Jackson, MO

    220 E Monroe St, Jackson, MO 63755

    1300 SF suite suitable for office, retail, or service business.

    • Prime downtown corner location with high traffic count
    • 1,300 SF suite suitable for office, retail, or service business
    • Large off‑street paved parking
    • Excellent signage
    • Immediate occupancy possible
    Updated: Oct 16, 2025
    View details
    Cape Girardeau Office Space Available
    Pending
    $5,500 / Mo
    7,000 SF

    Cape Girardeau Office Space Available

    Well-maintained commercial property with ample space in a convenient location.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    Renovated commercial space with high visibility in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
    View details
    HubCo Coworking Office Space
    $36 SF/Yr
    8,200 SF

    HubCo Coworking Office Space

    Modern Cape Girardeau Office Suites

    1427 Thomas Dr, Cape Girardeau, MO 63701
    View details
    West Park Mall Medical Office Space
    Contact for pricing
    79,122 SF

    West Park Mall Medical Office Space

    Missouri medical office suites for lease

    3049 William St, Cape Girardeau, MO 63703
    View details
    Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 6 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 10 Properties for Sales.

    Explore Similar Spaces for Sale in Cape Girardeau County, MO

    Consider Similar Space for Sale. We found 10 Spaces in Nearby Locations matching your search parameters.

    Versatile Commercial Building Near I-55
    Pending
    $570,000
    3,096 SF

    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755
    View details
    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Property in Missouri
    $295,000
    2,920 SF

    Versatile Commercial Property in Missouri

    Adaptable commercial space with retail, office, and warehouse capabilities.

    225 Clark Ave, Cape Girardeau, MO 63701
    View details
    Furnished Mixed-Use Professional Building
    $299,999
    3,210 SF

    Furnished Mixed-Use Professional Building

    Two-level, fully furnished office building in Jackson, Missouri.

    902 E Jackson Blvd, Jackson, MO 63755
    View details
    Mixed-Use Property in Jackson, MO
    $569,000
    2,304 SF

    Mixed-Use Property in Jackson, MO

    Commercial property with shop, office, and storage on 3.3 acres.

    6065 State Hwy W, Jackson, MO 63755
    View details
    Renovated Downtown Commercial Property
    $550,000
    4,548 SF

    Renovated Downtown Commercial Property

    Versatile, renovated 11-bedroom property in downtown Cape Girardeau, Missouri.

    224 N Frederick St, Cape Girardeau, MO 63701
    View details
    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
    View details
    Prime Cape Girardeau Office Building
    $899,900
    13,694 SF

    Prime Cape Girardeau Office Building

    13,694 SF Executive Office Space

    18 Main St, Cape Girardeau, MO 63701
    View details

    Cape Girardeau County, MO Office Properties & Spaces Leasing Opportunities Market Analysis

    Explore Office Properties & Spaces leasing options in Cape Girardeau County, MO with 16 listings featured on our commercial real estate exchange. The current inventory includes 1,141,794,720 square feet of properties with an estimated lease value of $76 SF/Yr.

    Estimated lease rates for Office Properties & Spaces in Cape Girardeau County, MO begin at $9 SF/Yr, with an average of $15 SF/Yr and extend to $36 SF/Yr.
    List
    Map

    Office Properties & Spaces by market

    Browse Office Properties & Spaces for Lease Near Cape Girardeau, MO

    Popular Categories

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.