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    Cape Girardeau County, MO Office Spaces for Sale

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    Kansas City, MO Louis, MO Saint Louis, MO
    27 results
    Versatile Commercial Building Near I-55
    $569,900
    3,096 SF
    Versatile Commercial Building Near I-55

    5598 Us Highway 61 North, Jackson, MO 63755

    High-traffic location, built in 2017, suitable for diverse businesses.
    • High‑traffic location with highway/interstate frontage.
    • Built in 2017 with maintenance‑free exterior and roof.
    • Originally designed as a restaurant with a full commercial kitchen and seating for 90.
    • County with no zoning restrictions allows for diverse business opportunities.
    • Open floor plan and ample parking.
    Updated: Apr 13
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    Furnished Mixed-Use Professional Building
    $184,900
    3,210 SF
    Furnished Mixed-Use Professional Building

    902 E Jackson Boulevard, Jackson, MO 63755

    Two-level, fully furnished office building in Jackson, Missouri.
    • Fully furnished, move‑in ready professional office building suitable for various businesses.
    • Opportunity to own your workspace and generate income by leasing the second level.
    • Excellent visibility on E. Jackson Blvd., providing easy client access.
    • Two levels: Main level with reception, 4 offices, 2 conference rooms; Lower level with separate entrance, reception, 4 offices, breakroom.
    • Strategic investment: Own instead of rent, offset mortgage with lease income, expand later, or lease both levels.
    Updated: May 18
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    Updated Office Building For Sale
    $350,000
    4,000 SF
    Updated Office Building For Sale

    Well-maintained office building with high visibility and ample parking.

    824 Independence Street, Cape Girardeau, MO 63703

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    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF
    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701

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    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF
    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF
    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701

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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF
    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701

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    Leased Office Building For Sale
    $500,000
    7,140 SF
    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701

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    Mixed-Use Building in Jackson, MO
    $325,000
    2,665 SF
    Mixed-Use Building in Jackson, MO

    Mixed-use property with income potential in Jackson, Missouri.

    1502 W Jackson Boulevard, Jackson, MO 63755

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    Two-Level Office Building For Sale
    $815,000
    9,857 SF
    Two-Level Office Building For Sale

    9,857 SF office building with multiple offices and restrooms.

    10 Doctors Park, Cape Girardeau, MO 63703

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    Downtown Office Building For Sale
    $899,900
    13,694 SF
    Downtown Office Building For Sale

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701

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    Cape Girardeau Medical Office Building
    $270,000
    2,546 SF
    Cape Girardeau Medical Office Building

    2,546 SF medical office building in a thriving complex.

    62 Doctors Park, Cape Girardeau, MO 63703

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    Renovated Commercial Building on Sprigg
    $239,900
    2,937 SF
    Renovated Commercial Building on Sprigg

    Renovated commercial space with high visibility and income potential.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Historic Bar and Office Space
    $499,900
    4,630 SF
    Historic Bar and Office Space

    Downtown Cape Girardeau property featured in the movie Gone Girl.

    117 Themis Street, Cape Girardeau, MO 63701

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    Retail/Office Space Near I-55
    Contact for pricing
    5.13 Acres
    Retail/Office Space Near I-55

    Prime location near I-55 and West Park Mall.

    3065 William, Cape Girardeau, MO 63703

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    Downtown Cape Girardeau Office/Flex Space
    Contact for pricing
    5,225 SF
    Downtown Cape Girardeau Office/Flex Space

    5,225 SF office/flex space in downtown Cape Girardeau.

    122 S. Spanish St., Cape Girardeau, MO 63701

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    Professional Office Complex For Sale
    Contact for pricing
    6.78 Acres
    Professional Office Complex For Sale

    Professional office complex with parking near I-55, hotels, restaurants.

    240-276 S. Mount Auburn Road, Cape Girardeau, MO 63703

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    Cape Girardeau Commercial Space Available
    Contact for pricing
    1,250 SF
    Cape Girardeau Commercial Space Available

    Flexible commercial space for office, retail, or service businesses.

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703

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    Prime Commercial Space on Mount Auburn
    Contact for pricing
    1,660 SF
    Prime Commercial Space on Mount Auburn

    Versatile commercial space with parking and high visibility.

    326 S. Mount Auburn, Cape Girardeau, MO 63703

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    Prime Location Office Suites
    Contact for pricing
    1,348 SF
    Prime Location Office Suites

    Excellent visibility office suites near I-55 and Highway 74.

    440 S. Mount Auburn Road, Cape Girardeau, MO 63703

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    Warehouse Space in Central Cape
    Contact for pricing
    50,000 SF
    Warehouse Space in Central Cape

    Up to 50,000 SF available with flexible space sizes.

    334 N. Broadview, Cape Girardeau, MO 63701

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    High Traffic Retail/Office Space
    Contact for pricing
    1,450 SF
    High Traffic Retail/Office Space

    Neighborhood center with high visibility and excellent tenant mix.

    2500 - 2536 William, Cape Girardeau, MO 63703

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    Commercial Land in Central Location
    Contact for pricing
    1.20 Acres
    Commercial Land in Central Location

    1.2 acres suitable for retail or office development.

    1749 Independence, Cape Girardeau, MO 63701

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    Versatile Commercial Building on 1.9 Acres
    $2,900,000
    13,458 SF
    Versatile Commercial Building on 1.9 Acres

    All-brick commercial building with abundant parking and multiple use opportunities.

    1429 N Mount Auburn Road, Cape Girardeau, MO 63701

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    Cape Girardeau County, MO Office Spaces Investment Opportunities Market Analysis

    Explore 30 office spaces for sale in Cape Girardeau County, MO, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 99,944 square feet of properties for sale, with an estimated market value of $10,083,300.

    Sale prices for office spaces in Cape Girardeau County, MO start at $184,900, averaging $593,135, and reaching up to $2,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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