Cape Girardeau County, MO Commercial Real Estate for Sale

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Turn-Key Bar and Grill Business
Updated: Jun 19
Turn-Key Bar and Grill Business

201 State Street E, Delta, MO 63744

$149,900
1,303 sqft · 0.19 AC lot
Turn‑key JAX Bar & Grill business with appliances including refrigerator, freezer, and ice maker
Metal siding building built in 2017 with approx. 1,303 finished SF
Includes approx. $19,000 of equipment and fixtures (excluding pool table, juke box, and ATM)
Heating: natural gas; cooling listed as multi units
Located at the crossroads of Hwy 25, Hwy N, and Hwy EE in Delta, MO
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201 State Street E, Delta, MO 63744

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Versatile Commercial Building Near I-55
Updated: Jun 26
Versatile Commercial Building Near I-55

5598 Us Highway 61 North, Jackson, MO 63755

$549,900
3,096 sqft · 0.64 AC lot
High‑traffic location with highway/interstate frontage.
Built in 2017 with maintenance‑free exterior and roof.
Originally designed as a restaurant with a full commercial kitchen and seating for 90.
County with no zoning restrictions allows for diverse business opportunities.
Open floor plan and ample parking.
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Warehouse with Showroom and Shop Space
Warehouse with Showroom and Shop Space

3082 County Road 620, Cape Girardeau, MO 63701

$700,000
7,200 sqft · 1.37 AC lot

Purchase a 7,200 SF warehouse with dedicated showroom, shop area, and framed upstairs space for flexible business or storage needs.

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Turnkey Sports Bar & Restaurant
Turnkey Sports Bar & Restaurant

26 N Main Street, Cape Girardeau, MO 63701

$795,000
5,921 sqft · 0.20 AC lot

For sale sports bar and restaurant business with a commercial kitchen, gaming equipment, and multiple big-screen TVs.

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Renovated Mid-Century Office Building
Renovated Mid-Century Office Building

429 N Broadview Street, Cape Girardeau, MO 63701

$1,690,000
15,831 sqft · 1.37 AC lot

Renovated 1960s office building with event space, overhead doors, and gated rear parking for flexible operations.

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Fully Furnished Two-Level Office Building
Fully Furnished Two-Level Office Building

902 E Jackson Boulevard, Jackson, MO 63755

$269,900
3,210 sqft · 0.30 AC lot

Turnkey professional office building with separate entrances and furnished suites across two levels for owner use or leasing.

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Renovated Downtown Office and Retail Building
Renovated Downtown Office and Retail Building

230 N Sprigg Street, Cape Girardeau, MO 63701

$239,900
2,937 sqft · 0.25 AC lot

Renovated commercial building on a high-traffic downtown corridor, offering flexible space for offices or storefront services.

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Fully Operational Car Wash Facility
Fully Operational Car Wash Facility

1004 William Street, Cape Girardeau, MO 63703

$119,900
600 sqft · 0.51 AC lot

Fully operational car wash with recently updated equipment and multiple payment options for convenient customer transactions.

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Residential Income Property with Shop
Residential Income Property with Shop

241 County Road 226, Cape Girardeau, MO 63701

$999,900
4,000 sqft · 5.00 AC lot

An all-brick home on 5 acres with a heated three-bay shop and an above-shop apartment for flexible living or rental income.

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Warehouse with Multiple Overhead Doors
Warehouse with Multiple Overhead Doors

6065 State Highway W, Jackson, MO 63755

$499,900
3.03 AC lot

3,800-sf shop with office, covered workspace, and overhead doors plus additional storage areas on over 3 acres.

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Automotive Repair and Retail Building
Automotive Repair and Retail Building

246 W Deerwood Drive, Jackson, MO 63755

$895,000
0.95 AC lot

Commercially zoned building with automotive repair and retail use, including offices, reception, and extensive parking.

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Downtown Restaurant Building with Patio
Downtown Restaurant Building with Patio

20 N Spanish Street, Cape Girardeau, MO 63701

$825,000
0.17 AC lot

Well-configured restaurant space with separate dining areas, bar, and a covered patio for expanded guest seating.

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Well-Kept Commercial Building with Parking
Well-Kept Commercial Building with Parking

2357 Rust Avenue, Cape Girardeau, MO 63703

$199,900
0.57 AC lot

Versatile 1,800-square-foot commercial building with easy access and ample parking in Cape Girardeau, Missouri.

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Ambulatory Surgery Center Investment Opportunity
Ambulatory Surgery Center Investment Opportunity

3241 Percy Drive, Cape Girardeau, MO 63701

$8,050,000
13,650 sqft · 2.71 AC lot

Single-tenant surgery center near St. Francis Medical Center for sale.

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Updated Office Building For Sale
Updated Office Building For Sale

824 Independence Street, Cape Girardeau, MO 63703

$350,000
0.42 AC lot

Well-maintained office building with high visibility and ample parking.

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Turn-Key Farmer's Market Restaurant
Turn-Key Farmer's Market Restaurant

4053 State Highway E, Oak Ridge, MO 63769

$200,000
0.20 AC lot

Fully operational, turn-key business with updated commercial kitchen equipment, including an outdoor smoker and pizza oven.

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Commercial Development Lot
Commercial Development Lot

367 S Broadview Street, Cape Girardeau, MO 63703

$629,000
3.00 AC lot

Commercially zoned 3-acre lot suited for future development in an area with ongoing and nearby new development.

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Mixed-Use Property with Event Venue
Mixed-Use Property with Event Venue

4940 County Road 532, Jackson, MO 63755

$795,000
7.44 AC lot

Rustic residence plus treehouse-style event venue and bar/kitchen, offering flexible uses on a private drive.

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Flex Space with Riverfront Access
Flex Space with Riverfront Access

308 N Main Street, Cape Girardeau, MO 63701

$475,000
0.50 AC lot

Flexible riverfront building with multiple overhead doors, loading dock, and parking on both sides for varied commercial uses.

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Commercial Land Parcel
Commercial Land Parcel

502 N Silver Springs Road, Cape Girardeau, MO 63701

$229,000
1.18 AC lot

Zoned Commercial 1.18-acre parcel on N Silver Springs Road in Cape Girardeau, Missouri.

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Downtown Commercial Development Lot
Downtown Commercial Development Lot

N Main Street, Cape Girardeau, MO 63701

$450,000
1.04 AC lot

Commercial-zoned downtown lot abutting a casino property line, suited for a range of retail and commercial concepts.

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Two-Level Office Building For Sale
Two-Level Office Building For Sale

10 Doctors Park, Cape Girardeau, MO 63703

$815,000
9,857 sqft · 0.44 AC lot

9,857 SF office building with multiple offices and restrooms.

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Former Butcher Shop and Facility
Former Butcher Shop and Facility

3006 State Highway FF, Jackson, MO 63755

$800,000
14,104 sqft · 4.27 AC lot

14,104 SF flex/manufacturing space in Jackson, Missouri.

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Equipped Shop Property Near Jackson
Equipped Shop Property Near Jackson

7276 State Highway 72, Jackson, MO 63755

$299,900
5,262 sqft · 1.00 AC lot

Fully equipped shop on 1 acre near Missouri Route 72.

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Cape Girardeau County, MO Commercial Real Estate Market Trends and Statistics

Explore 95 commercial real estate for sale in Cape Girardeau County, MO, showcased through 95 active listings on our real estate platform. These investment opportunities span a total of 2,133,416 square feet of properties for sale, with an estimated market value of $32,332,800.

Sale prices for business properties in Cape Girardeau County, MO start at $69,000, averaging $923,794, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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