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    Cape Girardeau County, MO Commercial Real Estate for Sale

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    Restaurant Building with Highway Frontage
    Updated: Jul 22
    Restaurant Building with Highway Frontage

    5598 Us Highway 61 N, Jackson, MO 63755

    $549,900
    3,096 sqft 0.64 AC lot
    3,096 square feet on 0.64 acres
    Built in 2017 with metal siding and a metal roof
    Restaurant layout designed for seating up to 90 guests
    Prepared for commercial kitchen installation
    Highway and interstate frontage at 5598 US Highway 61 N
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    Single-Tenant Medical Center
    Updated: Sep 14
    Single-Tenant Medical Center

    3241 Percy Drive, Cape Girardeau, MO 63701

    $8,050,000
    13,650 sqft 2.71 AC lot
    13,650 sq. ft. ambulatory surgery center on 2.708 acres
    Single‑tenant medical facility built in 2002
    Directly across from St. Francis Medical Center
    Two years remaining on current lease with 2% annual rental increases
    New state‑of‑the‑art HVAC system
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    Renovated Office Building
    Renovated Office Building

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $239,900
    2,937 sqft 0.25 AC lot

    Brick commercial property with central air, public utilities, and open-lot parking near downtown activity.

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    Renovated Mid-Century Office Building
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    $1,690,000
    10,000 sqft

    Updated office building with multiple private offices, conference rooms, and an event space with bar and projection screen.

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    Renovated Mid-Century Office Building
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    $1,690,000
    1.37 AC lot

    Updated workspace includes private offices, meeting rooms, shared work areas, and an event room with bar and projection screen.

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    Restaurant Property
    Restaurant Property

    1830 E Jackson Boulevard, Jackson, MO 63755

    $1,500,000
    1.14 AC lot

    The restaurant is operating while its building and real estate are offered for sale.

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    Flex Space with Showroom
    Flex Space with Showroom

    3082 County Road 620, Cape Girardeau, MO 63701

    $650,000
    1.37 AC lot

    Versatile commercial facility combining customer-facing space, industrial work areas, and unfinished expansion capacity.

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    Restaurant Building with Open Layout
    Restaurant Building with Open Layout

    5598 Us Highway 61 North, Jackson, MO 63755

    $549,900
    3,096 sqft

    Highway-fronted building built in 2017 with restaurant-oriented infrastructure and flexible commercial configuration.

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    Restaurant Building with Banquet Space
    Restaurant Building with Banquet Space

    20 N Spanish Street, Cape Girardeau, MO 63701

    $799,000
    0.17 AC lot

    Versatile restaurant layout includes dining, banquet, bar, kitchen, and covered patio areas in downtown Cape Girardeau.

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    Equipped Sports Bar Property
    Equipped Sports Bar Property

    26 N Main Street, Cape Girardeau, MO 63701

    $795,000
    0.20 AC lot

    Sale includes the building, bar business, commercial kitchen, and entertainment equipment.

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    Retail Building with Drive-Through
    Retail Building with Drive-Through

    5 S Kingshighway, Cape Girardeau, MO 63703

    $1,650,000
    3,483 sqft 0.80 AC lot

    The C2-zoned site includes paved off-street parking and a drive-through window.

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    Corner Bar and Pub Building
    Corner Bar and Pub Building

    632 Broadway Street, Cape Girardeau, MO 63701

    $1,200,000
    0.36 AC lot

    Renovated kitchen, patio, and accessible exterior restrooms support food-and-beverage operations.

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    Furnished Two-Level Office Building
    Furnished Two-Level Office Building

    902 E Jackson Boulevard, Jackson, MO 63755

    $229,000
    0.30 AC lot

    Flexible professional property with furnished offices, conference rooms, and a separately accessed second level.

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    Two-Level Office Building For Sale
    Two-Level Office Building For Sale

    10 Doctors Park, Cape Girardeau, MO 63703

    $815,000
    9,857 sqft 0.44 AC lot

    9,857 SF office building with multiple offices and restrooms.

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    Brick Flex Space with Warehouse
    Brick Flex Space with Warehouse

    333 N Main Street, Cape Girardeau, MO 63701

    $425,000
    0.25 AC lot

    Brick commercial property combining warehouse capacity and finished offices in a downtown Cape Girardeau setting.

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    Corner Conventional Restaurant Property
    Corner Conventional Restaurant Property

    45 S Kingshighway, Cape Girardeau, MO 63703

    $2,500,000
    0.85 AC lot

    Established restaurant property with highway and interstate frontage, public water, and an on-site parking lot.

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    13,694 SF Single-Level Office Building
    13,694 SF Single-Level Office Building

    18 N Main St, Cape Girardeau, MO 63701

    $899,900
    13,674 sqft

    Single-level office building suitable for various uses and businesses.

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    Renovated Live-Work Space
    Renovated Live-Work Space

    210 Wilson Street, Delta, MO 63744

    $129,900
    0.21 AC lot

    Flexible commercial layout combines showroom, private rooms, kitchen, multipurpose area, and potential on-site living quarters.

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    Downtown Office Building For Sale
    Downtown Office Building For Sale

    18 N. Main, Cape Girardeau, MO 63701

    $899,900
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    118-Unit Self-Storage Facility
    118-Unit Self-Storage Facility

    687 S Old Orchard Road, Jackson, MO 63755

    $975,000
    2.65 AC lot

    Recently built storage property with varied unit sizes and electric forced-air heating.

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    Office Building With Garage Warehouse
    Office Building With Garage Warehouse

    1605 Old Cape Rd, Jackson, MO 63755

    $1,000,000
    5.50 AC lot

    Updated office improvements combine private work areas, meeting space, support rooms, and covered outdoor gathering space.

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    Historic Office Condominium Units
    Historic Office Condominium Units

    937 Broadway Street, Cape Girardeau, MO 63701

    $99,000
    4,300 sqft

    Multiple commercial condominium suites in a brick downtown building with central air, public water, and public sewer.

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    Flex Warehouse with Overhead Doors
    Flex Warehouse with Overhead Doors

    6065 State Highway W, Jackson, MO 63755

    $499,900
    3,800 sqft 3.30 AC lot

    Flex warehouse on 3.3 acres with finished office space, multiple overhead doors, and covered carport/storage structures.

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    Restaurant with Pizza Oven
    Restaurant with Pizza Oven

    4053 State Highway E, Oak Ridge, MO 63769

    $200,000
    0.20 AC lot

    Restaurant property with upgraded kitchen equipment, outdoor smoker, and dedicated pizza oven.

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    Cape Girardeau County, MO Commercial Real Estate Market Trends and Statistics

    Explore 107 commercial real estate for sale in Cape Girardeau County, MO, showcased through 107 active listings on our real estate platform. These investment opportunities span a total of 372,123 square feet of properties for sale, with an estimated market value of $54,763,750.

    Sale prices for business properties in Cape Girardeau County, MO start at $60,000, averaging $740,050, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Realmo connects you with licensed Cape Girardeau County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: 15733358111
    www.capeareahomes.com
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