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    Cape Girardeau County, MO Commercial Real Estate for Sale

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    Kansas City, MO Louis, MO Saint Louis, MO
    88 results
    Versatile Commercial Building Near I-55
    $569,900
    3,096 SF

    Versatile Commercial Building Near I-55

    5598 Us Highway 61 North, Jackson, MO 63755

    High-traffic location, built in 2017, suitable for diverse businesses.

    • High‑traffic location with highway/interstate frontage.
    • Built in 2017 with maintenance‑free exterior and roof.
    • Originally designed as a restaurant with a full commercial kitchen and seating for 90.
    • County with no zoning restrictions allows for diverse business opportunities.
    • Open floor plan and ample parking.
    Updated: Apr 13
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    Unique Mixed-Use Property with Treehouse
    $850,000
    7.44 Acres

    Unique Mixed-Use Property with Treehouse

    4940 County Road 532, Jackson, MO 63755

    Exceptional property with residence, treehouse, and income-producing potential.

    • Unique 2,500+ sq. ft. "Treehouse" building with commercial‑style kitchen, bar, and large deck offering significant income‑generating potential.
    • Main house features rustic design elements including wood beams, vaulted pinewood ceilings, and a stone wood‑burning fireplace.
    • Fully finished walk‑out basement with family room, bedroom, bonus rooms, and bathroom.
    • Property includes an existing shop and footings for a 40 x 50 shop.
    • Energy‑efficient wood‑burning stove heats the entire home.
    Updated: Apr 28
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    Furnished Mixed-Use Professional Building
    $184,900
    3,210 SF

    Furnished Mixed-Use Professional Building

    Two-level, fully furnished office building in Jackson, Missouri.

    902 E Jackson Boulevard, Jackson, MO 63755
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    Mixed-Use Building in Prime Location
    $895,000
    7,000 SF

    Mixed-Use Building in Prime Location

    Turn-key mixed-use building in a high-traffic Jackson location.

    246 W Deerwood Drive, Jackson, MO 63755
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    Updated Office Building For Sale
    $350,000
    4,000 SF

    Updated Office Building For Sale

    Well-maintained office building with high visibility and ample parking.

    824 Independence Street, Cape Girardeau, MO 63703
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    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701
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    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
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    Versatile Commercial Space in Cape Girardeau
    $825,000
    0.17 Acres

    Versatile Commercial Space in Cape Girardeau

    Well-designed commercial space with banquet, dining, and bar areas.

    20 N Spanish Street, Cape Girardeau, MO 63701
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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
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    Versatile Commercial Building in Missouri
    $199,900
    0.57 Acres

    Versatile Commercial Building in Missouri

    Adaptable 1800 sq ft commercial building in Cape Girardeau.

    2357 Rust Avenue, Cape Girardeau, MO 63703
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    Historic Landmark in Downtown Jackson
    $669,000
    10,000 SF

    Historic Landmark in Downtown Jackson

    Landmark building with potential for various commercial uses.

    101 W Main Street, Jackson, MO 63755
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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701
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    Turn-Key Restaurant Business Opportunity
    $200,000
    2,760 SF

    Turn-Key Restaurant Business Opportunity

    Fully operational restaurant, ready for new owner in Oak Ridge.

    4053 State Highway E, Oak Ridge, MO 63769
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    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701
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    Mixed-Use Building in Jackson, MO
    $325,000
    2,665 SF

    Mixed-Use Building in Jackson, MO

    Mixed-use property with income potential in Jackson, Missouri.

    1502 W Jackson Boulevard, Jackson, MO 63755
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    Renovated 11-Bedroom Income Property
    $450,000
    4,548 SF

    Renovated 11-Bedroom Income Property

    Versatile, renovated 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick Street, Cape Girardeau, MO 63701
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    Industrial Warehouse on 3.9 Acres
    $489,900
    3.90 Acres

    Industrial Warehouse on 3.9 Acres

    Industrial warehouse for sale in Cape Girardeau, Missouri.

    840 S Kingshighway, Cape Girardeau, MO 63703
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    Downtown Cape Girardeau Commercial Lot
    $450,000
    1.04 Acres

    Downtown Cape Girardeau Commercial Lot

    Prime commercial lot near casino, ideal for development.

    0 N Main Street, Cape Girardeau, MO 63701
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    Commercial Lot in High Growth Area
    $629,000
    3.00 Acres

    Commercial Lot in High Growth Area

    3-acre commercial lot in a high-growth area.

    367 S Broadview Street, Cape Girardeau, MO 63703
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    Broadway Commercial Opportunity
    $1,200,000
    0.36 Acres

    Broadway Commercial Opportunity

    Commercial property on Broadway with high visibility and accessibility.

    632 Broadway Street, Cape Girardeau, MO 63701
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    Cape Girardeau Mixed-Use Property
    $1,125,000
    4,000 SF

    Cape Girardeau Mixed-Use Property

    Mixed-use property with shop and residential rental income.

    241 County Road 226, Cape Girardeau, MO 63701
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    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF

    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Drive, Cape Girardeau, MO 63701
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    Wedding Venue with Living Quarters
    $584,900
    8.72 Acres

    Wedding Venue with Living Quarters

    Successful wedding venue with living quarters on over 8 acres.

    1082 County Road 349, Jackson, MO 63755
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    Retail Property in High Visibility Location
    $375,000
    0.67 Acres

    Retail Property in High Visibility Location

    Two-level retail space with 16 parking spots in Jackson, MO.

    1336 Clover Drive, Jackson, MO 63755
    View details

    Cape Girardeau County, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 2368 commercial real estate for sale in Cape Girardeau County, MO, showcased through 88 active listings on our real estate platform. These investment opportunities span a total of 201,857 square feet of properties for sale, with an estimated market value of $28,485,200.

    Sale prices for business properties in Cape Girardeau County, MO start at $69,000, averaging $863,187, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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