Cape Girardeau County, MO Commercial Real Estate for Sale

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Turnkey Bar and Grill
Updated: Jun 19
Turnkey Bar and Grill

201 E State St, Delta, MO

$149,900
1,303 sqft
Turnkey JAX Bar & Grill operating business with 22 years of establishment
Located at the crossroads of Hwy 25, Hwy N, and Hwy EE in Delta, MO with high traffic count
Approx. 1,303 finished SF bar and grill building, approx. 9 years old
Includes approx. $19,000 of equipment and fixtures (pool table, juke box, and ATM excluded)
Owner retiring—business transfer available for a new owner
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201 E State St, Delta, MO

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Former Restaurant Building with Parking
Updated: Jul 22
Former Restaurant Building with Parking

5598 Us Highway 61 N, Jackson, MO 63755

$549,900
3,096 sqft 0.64 AC lot
Metal‑sided commercial building built in 2017 with a metal roof
Central air plus forced‑air and electric heating
Parking available via a driveway and includes ample on‑site parking
Public water and public sewer; cable available
Originally set up for a restaurant with seating for 90 guests and space for a commercial kitchen
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Historic Duplex with Two-Story Portico
Historic Duplex with Two-Story Portico

325 N Sprigg Street, Cape Girardeau, MO 63701

$425,000
6,027 sqft 0.66 AC lot

Historic brick duplex on a 0.657-acre lot built in 1915, featuring a two-story portico and a detached carriage house apartment conversion.

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Office Building with Road Frontage
Office Building with Road Frontage

230 N Sprigg Street, Cape Girardeau, MO 63701

$239,900
2,937 sqft 0.25 AC lot

Renovated brick office building with central air, flat roof, and road frontage on N Sprigg St.

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Retail Space with Drive-Through
Retail Space with Drive-Through

5 S Kingshighway, Cape Girardeau, MO 63703

$1,650,000
3,483 sqft 0.80 AC lot

C2-zoned commercial property with paved parking, a drive-through window, and established retail neighbors.

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Restaurant Building with Covered Patio
Restaurant Building with Covered Patio

20 N Spanish Street, Cape Girardeau, MO 63701

$799,000
0.17 AC lot

Restaurant space configured for main dining, banquet service, and a dedicated bar, with a covered patio seating area.

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Sports Bar with Commercial Kitchen
Sports Bar with Commercial Kitchen

26 N Main Street, Cape Girardeau, MO 63701

$795,000
0.20 AC lot

Fully equipped sports bar with a commercial kitchen and gaming amenities, built with fiber cement and served by public water.

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Brick Flex Building With Office Space
Brick Flex Building With Office Space

333 N Main Street, Cape Girardeau, MO 63701

$425,000
0.25 AC lot

Mixed-use configuration pairs finished offices with substantial warehouse functionality near downtown Cape Girardeau.

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Multi-Entrances Office Building
Multi-Entrances Office Building

1404 Old Cape Road, Jackson, MO 63755

$1,200,000
8,700 sqft 1.09 AC lot

Double-corner office building features multiple separate entrances, ample parking, and flexible upper- and lower-level layouts.

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Ambulatory Surgery Center Investment Opportunity
Ambulatory Surgery Center Investment Opportunity

3241 Percy Drive, Cape Girardeau, MO 63701

$8,050,000
13,650 sqft 2.71 AC lot

Single-tenant surgery center near St. Francis Medical Center for sale.

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Commercial Kitchen with Outdoor Smoker
Commercial Kitchen with Outdoor Smoker

4053 State Highway E, Oak Ridge, MO 63769

$200,000
0.20 AC lot

Updated commercial kitchen with new appliances, plus a Smokin' Brothers outdoor smoker and pizza oven for food prep operations.

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Self-Storage Facility with 118 Units
Self-Storage Facility with 118 Units

687 S Old Orchard Rd, Jackson, MO 63755

$1,100,000
4,200 sqft 2.65 AC lot

Income-producing self-storage facility with 118 units totaling about 4,200 square feet on 2.65 acres.

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Four-Unit Medical Office Condos
Four-Unit Medical Office Condos

937 Broadway Street, Cape Girardeau, MO 63701

$99,000
4,300 sqft

Historic brick medical office condominiums with public water and public sewer and centralized building utilities.

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Turn-Key Bar & Grill
Turn-Key Bar & Grill

201 State Street E, Delta, MO 63744

$149,900
0.19 AC lot

Bar & grill business and building offered turnkey, about 9 years new, with included equipment and fixtures.

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Two-Level Office Building For Sale
Two-Level Office Building For Sale

10 Doctors Park, Cape Girardeau, MO 63703

$815,000
9,857 sqft 0.44 AC lot

9,857 SF office building with multiple offices and restrooms.

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Commercial Development Lot
Commercial Development Lot

367 S Broadview Street, Cape Girardeau, MO 63703

$629,000
3.00 AC lot

Commercially zoned 3-acre lot suited for future development in an area with ongoing and nearby new development.

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Brick Office Building with Central Air
Brick Office Building with Central Air

824 Independence Street, Cape Girardeau, MO 63703

$350,000
0.42 AC lot

Well maintained brick office building with forced-air heating and central air, plus ample on-site parking.

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Equipped Shop Property Near Jackson
Equipped Shop Property Near Jackson

7276 State Highway 72, Jackson, MO 63755

$299,900
5,262 sqft 1.00 AC lot

Fully equipped shop on 1 acre near Missouri Route 72.

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Commercial Land
Commercial Land

1980 Golden Eagle Court, Cape Girardeau, MO 63701

$395,000
2.39 AC lot

Commercial land with public water available and flexibility for several business-oriented uses.

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Downtown Office Building For Sale
Downtown Office Building For Sale

18 N. Main, Cape Girardeau, MO 63701

$899,900
13,694 sqft

13,694 SF office building in historic downtown Cape Girardeau.

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Downtown Commercial Development Lot
Downtown Commercial Development Lot

N Main Street, Cape Girardeau, MO 63701

$450,000
1.04 AC lot

Zoned Commercial lot on N Main Street, adjacent to the casino, positioned within busy downtown surroundings.

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Commercial Land Parcel
Commercial Land Parcel

502 N Silver Springs Road, Cape Girardeau, MO 63701

$229,000
1.18 AC lot

Commercially zoned land parcel totaling 1.18 acres in Cape Girardeau, Missouri.

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Flex Warehouse with Overhead Doors
Flex Warehouse with Overhead Doors

6065 State Highway W, Jackson, MO 63755

$499,900
3,800 sqft 3.30 AC lot

Flex warehouse on 3.3 acres with finished office space, multiple overhead doors, and covered carport/storage structures.

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Flex Space With Attached Warehouse
Flex Space With Attached Warehouse

225 Clark Avenue, Cape Girardeau, MO 63701

$250,000
0.19 AC lot

Open front area supports showroom, office, or client reception uses.

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Cape Girardeau County, MO Commercial Real Estate Market Trends and Statistics

Explore 107 commercial real estate for sale in Cape Girardeau County, MO, showcased through 107 active listings on our real estate platform. These investment opportunities span a total of 344,037 square feet of properties for sale, with an estimated market value of $55,906,690.

Sale prices for business properties in Cape Girardeau County, MO start at $35,000, averaging $901,720, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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