Cape Girardeau County, MO Retail Properties & Spaces for Lease

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Updated: Dec 31, 2025

Retail Storefront with Delivery Entrance

2931 E Jackson Boulevard, Jackson, MO 63755

$1,440/Mo

1,220 sq ft retail space with signage location on Jackson Blvd in a retail center building
Minimum 3‑year lease; potential to expand into an adjacent, identical unit
Central air conditioning with electric heat (varies by unit) and flat roof
Includes a bathroom, plenty of parking, and a delivery entrance at the back of the building
Landlord provides trash and lot maintenance; public water and cable available

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Updated: Jun 24

Retail Building with Drive-Through Window

5 S Kingshighway, Cape Girardeau, MO 63703

$8,707/Mo

3,483 sqft

3,483 SF drive‑through retail building on C2‑zoned land
Located on 0.80 acres in a high‑traffic, highly visible area
Off‑street paved parking included
Drive‑through window for retail or restaurant operations
Adjacent to major retailers including Walgreens, Tractor Supply, and Schnucks Market

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Versatile Commercial Space on Kingshighway

500 N Kingshighway St, Cape Girardeau, MO 63701

$3,650/Mo

3,500 sqft

3,500 SF commercial property suitable for retail, office, or service.

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Mixed-Use Commercial Space Available

2117 Broadway St. Suite B, Cape Girardeau, MO 63701

$1,900/Mo

2,400 sqft

Versatile storefront and warehouse space in downtown Cape Girardeau.

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Retail and Office Storefront

211 Merriwether St, Cape Girardeau, MO 63703

$1,000/Mo

1,300 sqft

Flexible 1,300 SF storefront layout with retail frontage and included office spaces, suited for mixed-use operations.

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New Development Retail Space Available

2510 Veterans Memorial Drive, Cape Girardeau, MO 63701

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10,000 sqft

Prime lease space with high visibility and build-out allowance.

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Prime Retail/Office Space Available

3465 William, Cape Girardeau, MO 63703

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2,300 sqft

New 2,300 SF space ideal for retail or office.

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Restaurant-Ready Office/Retail Suite

820 N Sprigg St, Cape Girardeau, MO 63701

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3,000 sqft

Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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Retail Storefront with Office Space

221 Merriwether Street, Cape Girardeau, MO 63703

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1,275 sqft

Downtown retail storefront with office space for rent.

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Regional Shopping Center Near I-55

155-157 Siemers Dr, Cape Girardeau, MO

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9,400 sqft

Regional shopping center with easy access to Interstate 55.

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Retail Space Near St. Francis

3049 Williams St, Cape Girardeau, MO

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3,154 sqft

Retail space available across from St. Francis Medical Center.

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Retail Space Near West Park

3036-3048 William St, Cape Girardeau, MO

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4,970 sqft

Retail space in regional shopping hub with high visibility.

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Retail Space Near West Park

240-250 S Silver Springs Rd, Cape Girardeau, MO

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1,595 sqft

Retail space available in regional shopping hub near West Park.

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Based on your search, we've compiled 38 Potential Opportunities for your consideration. Besides 13 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 21 Properties for Sales.

Similar Spaces for Sale in Cape Girardeau County, MO

Consider Similar Space for Sale. We found 21 Spaces matching your search parameters.

Renovated Downtown Office and Retail Building

230 N Sprigg Street, Cape Girardeau, MO 63701

$239,900

2,937 sqft 0.25 AC lot

Renovated commercial building on a high-traffic downtown corridor, offering flexible space for offices or storefront services.

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Automotive Repair and Retail Building

246 W Deerwood Drive, Jackson, MO 63755

$895,000

0.95 AC lot

Commercially zoned building with automotive repair and retail use, including offices, reception, and extensive parking.

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Versatile Retail/Office Building

2357 Rust Avenue, Cape Girardeau, MO 63703

$199,900

0.57 AC lot

Clean 1,800 sq ft commercial building with adaptable interior and parking, offered for sale.

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Warehouse with Showroom and Shop

3082 County Road 620, Cape Girardeau, MO 63701

$700,000

7,200 sqft

Versatile warehouse with finished showroom, shop space, and framed upstairs area in Cape Girardeau.

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Versatile Commercial Space in Downtown

20 N Spanish Street, Cape Girardeau, MO 63701

$825,000

7,396 sqft

7,396 SF commercial building with multiple dining areas.

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Broadway Commercial Opportunity For Sale

632 Broadway Street, Cape Girardeau, MO 63701

$1,200,000

3,600 sqft

Commercial property with renovated kitchen, patio, and high visibility.

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Equipped Shop Property Near Jackson

7276 State Highway 72, Jackson, MO 63755

$299,900

5,262 sqft 1.00 AC lot

Fully equipped shop on 1 acre near Missouri Route 72.

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Freestanding Restaurant in Growing Community

421 E Jackson Blvd, Jackson, MO

$867,000

3,000 sqft 0.93 AC lot

Freestanding restaurant with drive-through in a high-traffic location.

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Prime Retail Space in Cape

731 Broadway St, Cape Girardeau, MO 63701

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4,500 sqft

4,500 SF retail space in historic downtown Cape Girardeau.

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High Traffic Retail/Office Space

2500 - 2536 William, Cape Girardeau, MO 63703

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1,450 sqft 4.45 AC lot

Neighborhood center with high visibility and excellent tenant mix.

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Prime Commercial Space on Mount Auburn

326 S. Mount Auburn, Cape Girardeau, MO 63703

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1,660 sqft

Versatile commercial space with parking and high visibility.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Ground Lease Commercial Land

5251 Hinkleville Road, Paducah, KY 42001

Contact for pricing

Eight-acre commercial pad with multiple ingress/egress options and utilities ready for development on a major I-24 corridor.

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Downtown Food Truck Land Lot

525 Broadway, Paducah, KY 42001

$1,000/Mo

Vacant lot on Broadway with zoning for food trucks and an electricity/building willingness from the owner.

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Vacant Commercial Land with I-44 Access

800 S Highway, Fenton, MO 63026

$225,000/Mo

Vacant acreage on I-44 with visibility and access, positioned near restaurants, hotels, and the Amazon warehouse area.

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Class A Office Suite with Bullpen

1902 Vandalia Street, Collinsville, IL 62234

$5,000/Mo

Recently built office space with private offices, bullpen, and modern amenities for professional teams.

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Cape Girardeau County, MO Retail properties & Spaces Market Trends and Statistics

Explore Retail properties & Spaces leasing options in Cape Girardeau County, MO with 13 listings featured on our commercial real estate exchange. The current inventory includes 10,683 square feet of properties with an estimated lease value of $61.24 SF/Yr.

Estimated lease rates for Retail properties & Spaces in Cape Girardeau County, MO begin at $9.23 SF/Yr, with an average of $15.31 SF/Yr and extend to $30 SF/Yr.

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