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    Cape Girardeau County, MO Retail Properties & Spaces for Lease

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    Saint Louis, MO Kansas City, MO Springfield, MO
    22 results
    Renovated Commercial Space For Lease
    $2,500/Mo
    2,937 SF
    Renovated Commercial Space For Lease

    230 N Sprigg Street, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.
    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Flexible Restaurant/Retail/Office Suite
    $18 SF/Yr
    3,000 SF
    Flexible Restaurant/Retail/Office Suite

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

    Versatile suites with existing restaurant infrastructure, positioned across from Towers Hall for high student traffic.
    • 3,000 SF commercial lease space with flexible use for restaurant, retail, or office
    • Located directly across from Towers Hall at Southeast Missouri State University
    • Former restaurant space with existing commercial restaurant infrastructure
    • Situated in an established multi‑tenant retail strip with two existing restaurant tenants operating in the center
    • High exposure along N Sprigg Street with convenient access and parking
    Updated: Jun 2
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    Retail Space in High Traffic Area
    $1,440/Mo
    Retail Space in High Traffic Area

    Retail space in Jackson, MO with high visibility.

    2931 E Jackson Boulevard, Jackson, MO 63755

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    Historic Art Deco Landmark Space
    $2,900/Mo
    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701

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    Retail Space For Rent
    $2,024/Mo
    Retail Space For Rent

    Retail space available for lease in Cape Girardeau, Missouri.

    155 Siemers Drive, Cape Girardeau, MO 63701

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    New Development Retail Space Available
    Contact for pricing
    10,000 SF
    New Development Retail Space Available

    Prime lease space with high visibility and build-out allowance.

    2510 Veterans Memorial Drive, Cape Girardeau, MO 63701

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    Prime Retail/Office Space Available
    Contact for pricing
    2,300 SF
    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William, Cape Girardeau, MO 63703

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    Retail Space in Cape Girardeau
    Contact for pricing
    Retail Space in Cape Girardeau

    Retail space available for lease in Cape Girardeau, Missouri.

    3049 William Street, Cape Girardeau, MO 63703

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    Retail Space For Rent
    $4 SF/Yr
    Retail Space For Rent

    Retail space available for lease in Cape Girardeau, Missouri.

    3047 William Street, Cape Girardeau, MO 63701

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    Retail Space Available For Rent
    Contact for pricing
    Retail Space Available For Rent

    Retail space for rent in Cape Girardeau, Missouri.

    3036 William St, Cape Girardeau, MO 63701

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    Retail Space in Cape Girardeau
    Contact for pricing
    Retail Space in Cape Girardeau

    Retail property for lease in Cape Girardeau, Missouri.

    250 South Silver Springs Road, Cape Girardeau, MO 63701

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    Versatile Commercial Space on Kingshighway
    Contact for pricing
    3,500 SF
    Versatile Commercial Space on Kingshighway

    3,500 SF commercial property suitable for retail, office, or service.

    500 N Kingshighway St, Cape Girardeau, MO 63701

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    Retail Storefront with Office Space
    Contact for pricing
    1,275 SF
    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether Street, Cape Girardeau, MO 63703

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    Retail Space in High-Traffic Location
    $1,440/Mo
    1,220 SF
    Retail Space in High-Traffic Location

    Retail space with signage, parking, and delivery entrance available for lease.

    2931 E Jackson Blvd, Jackson, MO 63755

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    Retail Space in Cape Girardeau
    $12 SF/Yr
    2,937 SF
    Retail Space in Cape Girardeau

    Retail space available for rent in Cape Girardeau, Missouri.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Retail Space Near St. Francis
    Contact for pricing
    3,154 SF
    Retail Space Near St. Francis

    Retail space available across from St. Francis Medical Center.

    3049 Williams St, Cape Girardeau, MO

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    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF
    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO

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    Commercial Space For Lease
    Contact for pricing
    Commercial Space For Lease

    Commercial space available for lease at 3049 William St.

    3049 William St, Cape Girardeau, MO 63703

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    Retail Space Near West Park
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    4,970 SF
    Retail Space Near West Park

    Retail space in regional shopping hub with high visibility.

    3036-3048 William St, Cape Girardeau, MO

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    Retail Space Near West Park
    Contact for pricing
    1,595 SF
    Retail Space Near West Park

    Retail space available in regional shopping hub near West Park.

    240-250 S Silver Springs Rd, Cape Girardeau, MO

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    Retail Space Available For Rent
    Contact for pricing
    4,970 SF
    Retail Space Available For Rent

    Retail space available, offering 4,970 square feet.

    3036 William Street, Cape Girardeau, MO 63701

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    Commercial Space For Lease
    Contact for pricing
    Commercial Space For Lease

    Commercial space available for lease in Cape Girardeau, Missouri.

    155 Siemers Dr, Cape Girardeau, MO 63701

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    Based on your search, we've compiled 48 Potential Opportunities for your consideration. Besides 22 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 26 Properties for Sales.

    Similar Spaces for Sale in Cape Girardeau County, MO

    Consider Similar Space for Sale. We found 26 Spaces matching your search parameters.

    Versatile Commercial Building Near I-55
    $569,900
    3,096 SF
    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755

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    Mixed-Use Building in Prime Location
    $895,000
    7,000 SF
    Mixed-Use Building in Prime Location

    Turn-key mixed-use building in a high-traffic Jackson location.

    246 W Deerwood Drive, Jackson, MO 63755

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    Cape Girardeau County, MO Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Cape Girardeau County, MO with 22 listings featured on our commercial real estate exchange. The current inventory includes 10,094 square feet of properties with an estimated lease value of $54 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Cape Girardeau County, MO begin at $10 SF/Yr, with an average of $13 SF/Yr and extend to $18 SF/Yr.
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