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    Cape Girardeau County, MO Retail Properties & Spaces for Lease

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    Saint Louis, MO Louis, MO Kansas City, MO
    18 results
    Renovated Commercial Space For Lease
    $2,500/Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg Street, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
    View details
    Historic Art Deco Landmark Space
    $2,900/Mo

    Historic Art Deco Landmark Space

    824 Broadway St, Cape Girardeau, MO 63701

    Restored historic building in downtown Cape Girardeau's commercial district.

    • Prime downtown Broadway location in a revitalized historic landmark
    • Restored Art Deco architectural character with preserved marquee elements
    • High‑traffic location with excellent frontage and visibility
    • Flexible floor plans suitable for retail, office, or service providers
    • Strong walkability and proximity to shops, restaurants, and city amenities
    Updated: Mar 5
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    Retail Space in High Traffic Area
    $1,440/Mo

    Retail Space in High Traffic Area

    Retail space in Jackson, MO with high visibility.

    2931 E Jackson Boulevard, Jackson, MO 63755
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    New Development Retail Space Available
    Contact for pricing
    10,000 SF

    New Development Retail Space Available

    Prime lease space with high visibility and build-out allowance.

    2510 Veterans Memorial Drive, Cape Girardeau, MO 63701
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    Prime Retail/Office Space Available
    Contact for pricing
    2,300 SF

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William, Cape Girardeau, MO 63703
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    Retail Storefront with Office Space
    Contact for pricing
    1,275 SF

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether Street, Cape Girardeau, MO 63703
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    Retail Space in High-Traffic Location
    $1,440/Mo
    1,220 SF

    Retail Space in High-Traffic Location

    Retail space with signage, parking, and delivery entrance available for lease.

    2931 E Jackson Blvd, Jackson, MO 63755
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    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO
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    Retail Space in Cape Girardeau
    $12 SF/Yr
    2,937 SF

    Retail Space in Cape Girardeau

    Retail space available for rent in Cape Girardeau, Missouri.

    230 N Sprigg Street, Cape Girardeau, MO 63701
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    Retail Space Near St. Francis
    Contact for pricing
    3,154 SF

    Retail Space Near St. Francis

    Retail space available across from St. Francis Medical Center.

    3049 Williams St, Cape Girardeau, MO
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    Commercial Space For Lease
    Contact for pricing

    Commercial Space For Lease

    Commercial space available for lease at 3049 William St.

    3049 William St, Cape Girardeau, MO 63703
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    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF

    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO
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    Retail Space Near West Park
    Contact for pricing
    7,908 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with easy Interstate access.

    3047 William St, Cape Girardeau, MO
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    Retail Space Near West Park
    Contact for pricing
    4,970 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with high visibility.

    3036-3048 William St, Cape Girardeau, MO
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    Retail Space Near West Park
    Contact for pricing
    1,595 SF

    Retail Space Near West Park

    Retail space available in regional shopping hub near West Park.

    240-250 S Silver Springs Rd, Cape Girardeau, MO
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    Retail Space Available For Rent
    Contact for pricing
    14,850 SF

    Retail Space Available For Rent

    Retail spaces available, ranging from 4,050 to 14,850 SqFt.

    258 Siemers Drive, Cape Girardeau, MO 63701
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    Retail Space Available For Rent
    Contact for pricing
    4,970 SF

    Retail Space Available For Rent

    Retail space available, offering 4,970 square feet.

    3036 William Street, Cape Girardeau, MO 63701
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    Commercial Space For Lease
    Contact for pricing

    Commercial Space For Lease

    Commercial space available for lease in Cape Girardeau, Missouri.

    155 Siemers Dr, Cape Girardeau, MO 63701
    View details
    Based on your search, we've compiled 40 Potential Opportunities for your consideration. Besides 18 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 22 Properties for Sales.

    Explore Similar Spaces for Sale in Cape Girardeau County, MO

    Consider Similar Space for Sale. We found 22 Spaces matching your search parameters.

    Versatile Commercial Building Near I-55
    $569,900
    3,096 SF

    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755
    View details
    Mixed-Use Building in Prime Location
    $895,000
    7,000 SF

    Mixed-Use Building in Prime Location

    Turn-key mixed-use building in a high-traffic Jackson location.

    246 W Deerwood Drive, Jackson, MO 63755
    View details
    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701
    View details
    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
    View details
    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Building in Missouri
    $199,900
    0.57 Acres

    Versatile Commercial Building in Missouri

    Adaptable 1800 sq ft commercial building in Cape Girardeau.

    2357 Rust Avenue, Cape Girardeau, MO 63703
    View details

    Cape Girardeau County, MO Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Cape Girardeau County, MO with 18 listings featured on our commercial real estate exchange. The current inventory includes 1,770,055,325 square feet of properties with an estimated lease value of $22 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Cape Girardeau County, MO begin at $0.50 SF/Yr, with an average of $7 SF/Yr and extend to $12 SF/Yr.
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    Browse Retail properties & Spaces for Lease Near Cape Girardeau, MO

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