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    Cape Girardeau County, MO Commercial Real Estate for Lease

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    Renovated Office Building with Central Air
    Updated: Jul 11
    Renovated Office Building with Central Air

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft 0.25 AC lot
    Approximately 2,937 SF renovated office space
    0.252‑acre lot with road frontage on N Sprigg St
    Brand‑new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and newly tuckpointed
    Brick building with forced‑air heating and central air (electric cooling)
    Parking lot with open parking
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    Office Suite with High Visibility
    Updated: Nov 14, 2025
    Office Suite with High Visibility

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    Turnkey office suite in Cape Girardeau, MO at 450 Siemers Drive
    High visibility and Hwy/Interstate frontage location in a business park setting
    Central air with forced‑air natural gas heating plus solar heating
    Public water and public sewer, with cable available
    Built in 1991
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    Second-Floor Office Suite
    Second-Floor Office Suite

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo

    Updated second-floor suite with seven private offices, open work area, and secure 24/7 badge access.

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    Retail Building with Drive-Through Window
    Retail Building with Drive-Through Window

    5 S Kingshighway, Cape Girardeau, MO 63703

    $8,707/Mo
    3,483 sqft 0.80 AC lot

    Drive-through retail building with off-street paved parking on C2-zoned land, adjacent to major retailers.

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    Flexible Office Unit
    Flexible Office Unit

    1469 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,128/Mo

    Commercial space with a private bathroom and owner-approved build-to-suit options.

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    Retail Space with Salon Layout
    Retail Space with Salon Layout

    1461 N Kingshighway Street, Cape Girardeau, MO 63701

    $2,255/Mo
    0.80 AC lot

    Adaptable commercial suite with reception space, multiple stations, shampoo bowls, and in-unit bathroom facilities.

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    Specialty Commercial Space
    Specialty Commercial Space

    401 S West End Boulevard, Cape Girardeau, MO 63703

    $1,250/Mo

    Specialty property available for lease at 401 S West End Boulevard in Cape Girardeau, MO 63703.

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    Office Suite with Private Offices
    Office Suite with Private Offices

    1020 N. Kingshighway, Suite C, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible commercial suite with reception, work areas, natural light, parking, and signage options for office or service-oriented use.

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    Flexible Restaurant/Retail/Office Suite
    Flexible Restaurant/Retail/Office Suite

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

    $18 SF/Yr
    3,000 sqft

    Versatile suites with existing restaurant infrastructure, positioned across from Towers Hall for high student traffic.

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    Salon-Ready Retail Space
    Salon-Ready Retail Space

    1461 N Kingshighway Street, Cape Girardeau, MO 63701

    $2,255/Mo
    1,640 sqft

    Former salon layout with reception, multiple stations, shampoo bowls, laundry hookups, and an in-unit bathroom.

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    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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    Retail and Office Storefront
    Retail and Office Storefront

    211 Merriwether St, Cape Girardeau, MO 63703

    $1,000/Mo
    1,300 sqft

    Flexible 1,300 SF storefront layout with retail frontage and included office spaces, suited for mixed-use operations.

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    Ground-Floor Office Suite
    Ground-Floor Office Suite

    3065 William Street #109, Cape Girardeau, MO 63703

    $7,075/Mo
    4,273 sqft

    Ground-floor suite offers 4,273 SF with great parking and signage; utilities are included except voice and data.

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    Downtown Office Building For Lease
    Downtown Office Building For Lease

    18 N. Main, Cape Girardeau, MO 63701

    $8,558/Mo
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    Downtown Retail Lease Space
    Downtown Retail Lease Space

    731 Broadway Street, Cape Girardeau, MO 63701

    $3,000/Mo
    4,500 sqft

    Versatile 4,500 SF retail suite with full fire sprinkler coverage and multiple restrooms.

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    Retail Suite with Parking
    Retail Suite with Parking

    2500 William St, Cape Girardeau, MO 63703

    $1,650/Mo
    1,400 sqft

    Suite 2534 offers 1,400 SF in a tenant-mixed center with off-street parking and signage opportunities.

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    Flex Warehouse with Office
    Flex Warehouse with Office

    2285 Sacajawea Lane, Cape Girardeau, MO 63701

    $3,250/Mo
    4,576 sqft

    Flex facility features heated warehouse/shop space, office buildout, mezzanine, and four drive-in overhead doors.

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    Mixed-Use Commercial Space Available
    Mixed-Use Commercial Space Available

    2117 Broadway St. Suite B, Cape Girardeau, MO 63701

    $1,900/Mo
    2,400 sqft

    Versatile storefront and warehouse space in downtown Cape Girardeau.

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    Retail Space Near Interstate Exit
    Retail Space Near Interstate Exit

    102-3465 William St, Cape Girardeau, MO 63703

    $4,791/Mo
    2,300 sqft

    Commercial lease space with a customizable layout for multiple uses near Route K.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo per office
    275 sqft

    Centrally located office space with modern finishes and included amenities.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo per office
    279 sqft

    Centrally located office space with modern finishes and included amenities.

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    New White Box Retail Suite
    New White Box Retail Suite

    440 S Mount Auburn Road #102, Cape Girardeau, MO 63703

    $2,466/Mo
    1,184 sqft

    Finished commercial space with off-street parking near hotels, offices, and retail outlets.

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    Office Units with Storage
    Office Units with Storage

    5841 State Highway K, Cape Girardeau, MO 63701

    $1,400/Mo
    1,440 sqft

    Office space includes a dedicated storage area and is currently undergoing remodeling.

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    Cape Girardeau County, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Cape Girardeau County, MO with 60 listings featured on our commercial real estate exchange. The current inventory includes 203,917 square feet of properties with an estimated lease value of $370.85.

    Estimated lease rates for Commercial real estate in Cape Girardeau County, MO begin at $6 SF/Yr, with an average of $13.24 SF/Yr and extend to $30 SF/Yr.
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