Advertise
    Missouri

    Cape Girardeau County, MO Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Saint Louis, MO Kansas City, MO Springfield, MO Joplin, MO Saint Charles, MO Chesterfield, MO Cape Girardeau, MO St Joseph, MO
    50 properties
    Sort:
    Renovated Downtown Storefront Property
    Updated: Jul 11
    Renovated Downtown Storefront Property

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft 0.25 AC lot
    2937 square feet of renovated commercial space
    Renovations include A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and tuckpointing
    Brick construction with a flat roof
    Forced‑air heating and central air with electric cooling
    Open parking lot and road frontage on N Sprigg Street
    View details
    Office Units with Highway Frontage
    Updated: Nov 14, 2025
    Office Units with Highway Frontage

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    6,770 square feet of office space
    Built in 1991
    Business park setting with highway and interstate frontage
    Central air conditioning with electric, natural gas, and forced‑air heating
    Driveway parking available
    View details
    Office Unit with Garage
    Office Unit with Garage

    1000 Kingsway Drive, Cape Girardeau, MO 63701

    $2,348/Mo
    0.63 AC lot

    The lease is structured as NNN, with terms to be negotiated.

    View details
    Retail Building with Drive-Through Window
    Retail Building with Drive-Through Window

    5 S Kingshighway, Cape Girardeau, MO 63703

    $8,707/Mo
    3,483 sqft 0.80 AC lot

    Drive-through retail building with off-street paved parking on C2-zoned land, adjacent to major retailers.

    View details
    Office Unit with Garage
    Office Unit with Garage

    1000 Kingsway Drive, Cape Girardeau, MO 63701

    $1,885/Mo
    0.63 AC lot

    The lease is structured as NNN, with terms to be negotiated.

    View details
    Updated Office Suite
    Updated Office Suite

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo
    2.70 AC lot

    Second-floor workspace offers private offices, open collaboration space, a kitchenette, and secure badge access.

    View details
    Flexible Office Unit
    Flexible Office Unit

    1469 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,128/Mo

    Adaptable commercial unit with private bathroom and expansion potential for office or service uses.

    View details
    Sprinklered Storefront Space
    Sprinklered Storefront Space

    731 Broadway St, Cape Girardeau, MO 63701

    $3,000/Mo
    4,500 sqft

    Flexible commercial layout with full sprinkler protection and multiple restrooms.

    View details
    Retail Space with Salon Layout
    Retail Space with Salon Layout

    1461 N Kingshighway Street, Cape Girardeau, MO 63701

    $2,255/Mo
    0.80 AC lot

    Adaptable commercial suite with reception space, multiple stations, shampoo bowls, and in-unit bathroom facilities.

    View details
    Specialty Commercial Space
    Specialty Commercial Space

    401 S West End Boulevard, Cape Girardeau, MO 63703

    $1,250/Mo
    0.15 AC lot

    Specialty property available for lease at 401 S West End Boulevard in Cape Girardeau, MO 63703.

    View details
    Restaurant-Ready Office/Retail Suite
    Restaurant-Ready Office/Retail Suite

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

    $18 SF/Yr
    3,000 sqft

    Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

    View details
    Office Unit with Private Offices
    Office Unit with Private Offices

    C-1020 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible suite layout includes reception, open workspace, break room, and private restroom.

    View details
    Retail Suite with Pylon Signage
    Retail Suite with Pylon Signage

    3065 William St Unit 202, Cape Girardeau, MO 63703

    $1,285/Mo
    976 sqft

    Flexible commercial suite with on-site signage and access to nearby retail, office, hospitality, and dining uses.

    View details
    Office Suite with Private Offices
    Office Suite with Private Offices

    1020 N. Kingshighway, Suite C, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible commercial suite with reception, work areas, natural light, parking, and signage options for office or service-oriented use.

    View details
    Retail Suite
    Retail Suite

    2500 William St, Cape Girardeau, MO 63703

    $1,650/Mo
    1,400 sqft

    A 1,400-square-foot space offers off-street parking and signage opportunities within a multi-tenant center.

    View details
    Office/Flex Space with Dock Access
    Office/Flex Space with Dock Access

    122 S Spanish St, Cape Girardeau, MO 63703

    $2,250/Mo
    5,225 sqft

    Open commercial space supports warehouse, distribution, storage, shipping, or light manufacturing uses with city approval.

    View details
    Retail Space with Garage
    Retail Space with Garage

    1-1000 Kingsway Dr, Cape Girardeau, MO 63701

    $1,885/Mo
    1,740 sqft

    Updated commercial interior with parking and a garage, offered on negotiated NNN lease terms.

    View details
    Executive Office Suite
    Executive Office Suite

    2a-301 Broadway St, Cape Girardeau, MO 63701

    $5,633/Mo
    2,600 sqft

    Second-floor workspace with private offices, reception, breakroom, and two restrooms.

    View details
    Storefront Retail Space
    Storefront Retail Space

    1606 Independence St, Cape Girardeau, MO 63703

    $975/Mo
    875 sqft

    Flexible commercial suite with an open layout, natural light, storefront exposure, and a private restroom.

    View details
    Corner Executive Office Unit
    Corner Executive Office Unit

    301 Broadway St, Cape Girardeau, MO 63701

    $2,708/Mo
    2,600 sqft

    Second-floor corner suite with private offices, reception, breakroom, and two restrooms.

    View details
    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

    View details
    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

    View details
    Downtown Office Building For Lease
    Downtown Office Building For Lease

    18 N. Main, Cape Girardeau, MO 63701

    $8,558/Mo
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

    View details
    Retail Space with Glass Frontage
    Retail Space with Glass Frontage

    119-2136 William St, Cape Girardeau, MO 63703

    $4,375/Mo
    7,000 sqft

    Open-format space with a rear overhead door and prominent signage opportunities within a shopping center setting.

    View details

    Cape Girardeau County, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Cape Girardeau County, MO with 50 listings featured on our commercial real estate exchange. The current inventory includes 153,525 square feet of properties with an estimated lease value of $307.16.

    Estimated lease rates for Commercial real estate in Cape Girardeau County, MO begin at $5.17 SF/Yr, with an average of $13.35 SF/Yr and extend to $30 SF/Yr.
    List
    Map

    Commercial real estate by market

    Browse Commercial real estate for Lease Near Cape Girardeau, MO

    Popular Searches in Cape Girardeau

    Popular Categories

    Featured Cape Girardeau County Real Estate Agencies

    Realmo connects you with licensed Cape Girardeau County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: 15733358111
    www.capeareahomes.com
    Why this one?
    Saved
    Reason not saved — we won't ask again

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!