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    Cape Girardeau County, MO Commercial Real Estate for Lease

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    31 properties
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    Turn-Key Office Suite
    Updated: Nov 14, 2025
    Turn-Key Office Suite

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft · $10 SF/Yr
    Office suite with business park frontage on Hwy/Interstate
    Built in 1991
    Heating: forced air with natural gas and solar (heating)
    Cooling: central air and electric
    Utilities: cable available
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    Renovated Office and Storefront Building
    Updated: Jul 1, 2025
    Renovated Office and Storefront Building

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft · $10 SF/Yr
    Massive brick building (approx. 3,000 sq ft) with renovated space
    Road frontage on N Sprigg St in a downtown, high‑traffic area
    BRAND NEW A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and newly tuckpointed exterior
    Forced air heating with central air and electric cooling
    Public utilities: public water and public sewer
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    Retail Storefront with Signage Access
    Retail Storefront with Signage Access

    2931 E Jackson Boulevard, Jackson, MO 63755

    $1,440/Mo

    A 1,220 sq ft storefront in a retail center with a dedicated bathroom, parking, and back-of-building delivery access.

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    Retail Building with Drive-Through Window
    Retail Building with Drive-Through Window

    5 S Kingshighway, Cape Girardeau, MO 63703

    $8,707/Mo
    3,483 sqft · $30 SF/Yr

    Drive-through retail building with off-street paved parking on C2-zoned land, adjacent to major retailers.

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    Mixed-Use Commercial Space Available
    Mixed-Use Commercial Space Available

    2117 Broadway St. Suite B, Cape Girardeau, MO 63701

    $1,900/Mo
    2,400 sqft · $9 SF/Yr

    Versatile storefront and warehouse space in downtown Cape Girardeau.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo
    275 sqft · $37 SF/Yr

    Centrally located office space with modern finishes and included amenities.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo
    279 sqft · $36 SF/Yr

    Centrally located office space with modern finishes and included amenities.

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    Flex Space with Off-Street Parking
    Flex Space with Off-Street Parking

    213 Clark Street, Cape Girardeau, MO 63701

    $1,500/Mo

    Flexible 1,172 SF flex space in an M-1 district, suited for day care, office, or professional service use.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft · $24 SF/Yr

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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    Cape Girardeau Warehouse Space Available
    Cape Girardeau Warehouse Space Available

    45 N Broadview St - Middle, Cape Girardeau, MO 63701

    $3,000/Mo
    5,100 sqft · $7 SF/Yr

    Versatile warehouse space with high ceilings and ample parking.

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    Versatile Warehouse Space Available
    Versatile Warehouse Space Available

    45 N Broadview St - Front, Cape Girardeau, MO 63701

    $6,000/Mo
    9,600 sqft · $7 SF/Yr

    9600 sf warehouse with high ceilings, shared loading dock.

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    Retail and Office Storefront
    Retail and Office Storefront

    211 Merriwether St, Cape Girardeau, MO 63703

    $1,000/Mo
    1,300 sqft · $9 SF/Yr

    Flexible 1,300 SF storefront layout with retail frontage and included office spaces, suited for mixed-use operations.

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    Office Space for Lease
    Office Space for Lease

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo

    Office space available for lease at 2027 Broadway Street in Cape Girardeau.

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    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft · $12 SF/Yr

    3,500 SF commercial property suitable for retail, office, or service.

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    Historic Art Deco Landmark Space
    Historic Art Deco Landmark Space

    824 Broadway St, Cape Girardeau, MO 63701

    $2,900/Mo

    Restored historic building in downtown Cape Girardeau's commercial district.

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    Downtown Office Building For Lease
    Downtown Office Building For Lease

    18 N. Main, Cape Girardeau, MO 63701

    $8,558/Mo
    13,694 sqft · $7 SF/Yr

    13,694 SF office building in historic downtown Cape Girardeau.

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    Professional Office Building For Rent
    Professional Office Building For Rent

    720 Forest Ave, Cape Girardeau, MO 63701

    $1,100/Mo
    1,218 sqft · $10 SF/Yr

    1,218 SF professional office building in good location.

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    Spacious Office Space in Jackson
    Spacious Office Space in Jackson

    1600 S Hope St, Jackson, MO 63755

    $5,096/Mo
    4,368 sqft · $14 SF/Yr

    4,368 SF office space with ample parking in Jackson.

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    New Development Retail Space Available
    New Development Retail Space Available

    2510 Veterans Memorial Drive, Cape Girardeau, MO 63701

    Contact for pricing
    10,000 sqft

    Prime lease space with high visibility and build-out allowance.

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    Prime Retail/Office Space Available
    Prime Retail/Office Space Available

    3465 William, Cape Girardeau, MO 63703

    Contact for pricing
    2,300 sqft

    New 2,300 SF space ideal for retail or office.

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    Retail Storefront with Office Space
    Retail Storefront with Office Space

    221 Merriwether Street, Cape Girardeau, MO 63703

    Contact for pricing
    1,275 sqft

    Downtown retail storefront with office space for rent.

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    Warehouse with Drive-In Dock
    Warehouse with Drive-In Dock

    211 N Spring Avenue C, Cape Girardeau, MO 63701

    $6 SF/Yr
    13,875 sqft · $6,937/Mo

    13,875 SF warehouse with office and drive-in dock.

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    Restaurant-Ready Office/Retail Suite
    Restaurant-Ready Office/Retail Suite

    820 N Sprigg St, Cape Girardeau, MO 63701

    Contact for pricing
    3,000 sqft

    Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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    Retail Space in Cape Girardeau
    Retail Space in Cape Girardeau

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft · $10 SF/Yr

    Retail space available for rent in Cape Girardeau, Missouri.

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    Cape Girardeau County, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Cape Girardeau County, MO with 31 listings featured on our commercial real estate exchange. The current inventory includes 71,906 square feet of properties with an estimated lease value of $263 SF/Yr.

    Estimated lease rates for Commercial real estate in Cape Girardeau County, MO begin at $6 SF/Yr, with an average of $15 SF/Yr and extend to $37 SF/Yr.
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