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    South Portland, ME Office Spaces for Lease

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    Portland, ME Cape Elizabeth, ME Scarborough, ME
    29 results
    Class A Medical Building Space
    $25 SF/Yr
    3,099 SF
    Class A Medical Building Space

    100 Foden Road, South Portland, ME 4106

    Class A medical building with convenient highway access and ample parking.
    • Convenient location with direct access to Maine Turnpike, I‑95, and I‑295
    • High‑capacity surface parking lot with 260 spaces
    • Class A, 3‑story medical building
    • Building & Monument Signage Opportunities available
    • Campus‑like setting
    Updated: May 26
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    Versatile Office or Retail Space
    $2,000/Mo
    1,000 SF
    Versatile Office or Retail Space

    851 Sawyer St, South Portland, ME 4106

    1,000± SF space ideal for various business types.
    • Versatile 1,000± SF space suitable for office, retail, medical, or service businesses.
    • Convenient location along Route 77.
    • Dedicated off‑street parking.
    • Lease rate of $2,000/month MG (includes heat, water, & sewer).
    • Available immediately.
    Updated: May 5
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    Class A Office Sublease Available
    $15 SF/Yr
    7,599 SF
    Class A Office Sublease Available

    7,599±SF Class A office space for sublease in South Portland.

    500 Southborough Dr, South Portland, ME

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    South Portland Office Space Available
    $17 SF/Yr
    6,321 SF
    South Portland Office Space Available

    Office space for lease near Maine Mall and Portland Jetport.

    311 Darling Ave, South Portland, ME

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    Class A Office/Medical Building
    $13 SF/Yr
    4,646 SF
    Class A Office/Medical Building

    Class A office/medical building with suites available for lease.

    175 Running Hill Road, South Portland, ME

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    Class-A Office Suite For Lease
    $16 SF/Yr
    5,121 SF
    Class-A Office Suite For Lease

    Full-floor office suite in South Portland's Maine Mall area.

    30 Long Creek Dr, South Portland, ME

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    Industrial Facility with Modern Office
    Contact for pricing
    10,654 SF
    Industrial Facility with Modern Office

    Well-maintained industrial and office space near I-95 and Jetport.

    76 Darling Ave, South Portland, ME 4106

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    Class A Office Space Available
    Contact for pricing
    1,323 SF
    Class A Office Space Available

    Class A office building with ample parking and professional landscaping.

    778 Main Street, South Portland, ME 4106

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    Updated Medical Spa Space Available
    $20 SF/Yr
    4,200 SF
    Updated Medical Spa Space Available

    Recently updated medical spa, salon, or medical space for lease.

    198 Maine Mall Rd, South Portland, ME 4106

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    South Portland Office Space Available
    $10 SF/Yr
    1,812 SF
    South Portland Office Space Available

    Office space for lease in landmark South Portland building.

    100 Brickhill Avenue, South Portland, ME

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    Corner Office Suite For Rent
    $13 SF/Yr
    4,040 SF
    Corner Office Suite For Rent

    4,040± SF office suite with ample free parking.

    202 Gannett Dr, South Portland, ME

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    Class A Office Suite Available
    $13 SF/Yr
    3,765 SF
    Class A Office Suite Available

    3,765 SF office suite for lease in South Portland.

    82 Running Hill Road, South Portland, ME 4106

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    South Portland Office Space Available
    $13 SF/Yr
    2,500 SF
    South Portland Office Space Available

    2,500± SF office space for lease in South Portland.

    141 Main St, South Portland, ME

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    South Portland Warehouse and Office
    $10 SF/Yr
    31,360 SF
    South Portland Warehouse and Office

    Warehouse and office space for lease in South Portland.

    1 Madison Street, South Portland, ME 4101

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    Class A Office Space Available
    $15 SF/Yr
    8,532 SF
    Class A Office Space Available

    Premier office park with modern finishes and convenient location.

    600 Southborough Dr, South Portland, ME 4106

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    South Portland Office Space Available
    $14 SF/Yr
    11,162 SF
    South Portland Office Space Available

    Office space for lease in South Portland with ample parking.

    600 Sable Oaks Dr, South Portland, ME 4106

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    Class A Office Space Available
    $15 SF/Yr
    36,703 SF
    Class A Office Space Available

    Class A office space for lease near major transportation routes.

    179 John Roberts Rd, South Portland, ME 4106

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    Retail/Office Space Near Maine Mall
    $24 SF/Yr
    1,700 SF
    Retail/Office Space Near Maine Mall

    1,700± SF retail/office space with convenient highway access.

    209 Western Ave, South Portland, ME 4106

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    Office
    $26 SF/Yr
    15,250 SF
    Office

    Medical Office Space · 15,250 SF

    244 Western Ave, South Portland, ME 4106

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    South Portland Warehouse and Office
    $10 SF/Yr
    31,630 SF
    South Portland Warehouse and Office

    Warehouse and office space for lease in South Portland.

    1 Madison St, South Portland, ME 4106

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    Suburban Office Park Sublease Opportunity
    $9 SF/Yr
    16,912 SF
    Suburban Office Park Sublease Opportunity

    Office space for sublease in premier suburban office park.

    78 Atlantic Pl, South Portland, ME 4106

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    South Portland Office Space Available
    $17 SF/Yr
    6,321 SF
    South Portland Office Space Available

    Office suites for lease in premier suburban office park.

    311 Darling Ave, South Portland, ME 4106

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    Office Space Near Portland Jetport
    $15 SF/Yr
    Office Space Near Portland Jetport

    Office space for rent near the Portland Jetport.

    179 John Roberts Rd, South Portland, ME 4106

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    South Portland Office Space Available
    $14 SF/Yr
    11,162 SF
    South Portland Office Space Available

    Office space for rent in South Portland with ample parking.

    600 Sable Oaks Dr, South Portland, ME 4106

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    South Portland, ME Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in South Portland, ME with 29 listings featured on our commercial real estate exchange. The current inventory includes 337,468 square feet of properties with an estimated lease value of $380 /Mo.

    Estimated lease rates for Office Spaces in South Portland, ME begin at $9 SF/Yr, with an average of $15 SF/Yr and extend to $26 SF/Yr.
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    Most Searched ZIP Codes in South Portland, ME

    • 04106
    • 04101

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