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    South Portland, ME Office Spaces for Lease

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    Portland, ME Cape Elizabeth, ME Scarborough, ME Westbrook, ME Falmouth, ME Gorham, ME Saco, ME Yarmouth, ME
    20 properties
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    Class A Medical Building Space
    Updated: May 26
    Class A Medical Building Space

    100 Foden Road, South Portland, ME 04106

    $25 SF/Yr
    3,099 sqft
    Convenient location with direct access to Maine Turnpike, I‑95, and I‑295
    High‑capacity surface parking lot with 260 spaces
    Class A, 3‑story medical building
    Building & Monument Signage Opportunities available
    Campus‑like setting
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    Versatile Office or Retail Space
    Updated: May 5
    Versatile Office or Retail Space

    851 Sawyer St, South Portland, ME 04106

    $2,000/Mo
    1,000 sqft
    Versatile 1,000± SF space suitable for office, retail, medical, or service businesses.
    Convenient location along Route 77.
    Dedicated off‑street parking.
    Lease rate of $2,000/month MG (includes heat, water, & sewer).
    Available immediately.
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    Class A Office/Medical Building
    Class A Office/Medical Building

    175 Running Hill Road, South Portland, ME

    $13.50 SF/Yr
    4,646 sqft

    Class A office/medical building with suites available for lease.

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    Updated Medical Spa Space Available
    Updated Medical Spa Space Available

    198 Maine Mall Rd, South Portland, ME 04106

    $20 SF/Yr
    4,200 sqft

    Recently updated medical spa, salon, or medical space for lease.

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    Class A Office Suite Available
    Class A Office Suite Available

    82 Running Hill Road, South Portland, ME 04106

    Contact for pricing
    3,765 sqft

    3,765 SF office suite for lease in South Portland.

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    South Portland Office Space Available
    South Portland Office Space Available

    100 Brickhill Avenue, South Portland, ME

    $10 SF/Yr
    1,812 sqft

    Office space for lease in landmark South Portland building.

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    Class A Office Sublease Available
    Class A Office Sublease Available

    500 Southborough Dr, South Portland, ME

    $15 SF/Yr
    7,599 sqft

    7,599±SF Class A office space for sublease in South Portland.

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    Retail/Office Space Near Maine Mall
    Retail/Office Space Near Maine Mall

    209 Western Ave, South Portland, ME 04106

    $24.95 SF/Yr
    1,700 sqft

    1,700± SF retail/office space with convenient highway access.

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    Office Space for Lease
    Office Space for Lease

    10 Q St, South Portland, ME 04106

    Contact for pricing

    Office space available for rent at 10 Q St in South Portland, suitable for professional uses.

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    South Portland Office Space Available
    South Portland Office Space Available

    141 Main St, South Portland, ME

    $13 SF/Yr
    2,500 sqft

    2,500± SF office space for lease in South Portland.

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    South Portland Warehouse and Office
    South Portland Warehouse and Office

    1 Madison Street, South Portland, ME 04101

    $10 SF/Yr
    31,360 sqft

    Warehouse and office space for lease in South Portland.

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    Class A Office Space Available
    Class A Office Space Available

    600 Southborough Dr, South Portland, ME 04106

    $15 SF/Yr
    8,532 sqft

    Premier office park with modern finishes and convenient location.

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    South Portland Warehouse and Office
    South Portland Warehouse and Office

    1 Madison St, South Portland, ME 04106

    $10 SF/Yr
    31,630 sqft

    Warehouse and office space for lease in South Portland.

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    Suburban Office Park Sublease Opportunity
    Suburban Office Park Sublease Opportunity

    78 Atlantic Pl, South Portland, ME 04106

    $9.50 SF/Yr
    16,912 sqft

    Office space for sublease in premier suburban office park.

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    South Portland Office Space Available
    South Portland Office Space Available

    311 Darling Ave, South Portland, ME 04106

    $17 SF/Yr
    6,321 sqft

    Office suites for lease in premier suburban office park.

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    Office Space Near Portland Jetport
    Office Space Near Portland Jetport

    179 John Roberts Rd, South Portland, ME 04106

    $15 SF/Yr

    Office space for rent near the Portland Jetport.

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    South Portland Class A Office
    South Portland Class A Office

    75 John Roberts Rd, South Portland, ME 04106

    $15.95 SF/Yr
    8,114 sqft

    Class A office and flex space in South Portland for lease.

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    South Portland Office Space Available
    South Portland Office Space Available

    600 Sable Oaks Dr, South Portland, ME 04106

    $14.50 SF/Yr
    11,162 sqft

    Office space for rent in South Portland with ample parking.

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    Renovated Office Space Available
    Renovated Office Space Available

    1 Runway Road, South Portland, ME 04106

    $7.50 SF/Yr
    14,400 sqft

    Fully renovated office space for lease in South Portland.

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    Class A Office Space
    Class A Office Space

    707 Sable Oaks Dr, South Portland, ME 04106

    $21 SF/Yr

    Premier office spaces in South Portland, Maine.

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    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 20 Active listings in South Portland, ME, we suggest exploring alternatives. Similar 7 Properties for Sales.

    Similar Spaces for Sale in South Portland, ME

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Multi-Office Office Building
    Multi-Office Office Building

    762 Main Street, South Portland, ME 04106

    $719,900
    2,736 sqft 0.22 AC lot

    Office building offering multiple private offices and conference rooms across two levels.

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    Mixed-Use Office and Apartment
    Mixed-Use Office and Apartment

    854 Broadway, South Portland, ME 04106

    $550,000
    4,370 sqft 0.23 AC lot

    Multi-tenant office layout plus a one-bedroom apartment, with a detached leased garage and dry basement storage.

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    Mixed-Use Office and Apartment
    Mixed-Use Office and Apartment

    854 Broadway, South Portland, ME 04106

    $550,000
    0.23 AC lot

    Mixed-use building with multiple office suites, shared bathroom access, and a 1-bedroom apartment with two egresses.

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    Professional Condo Near Maine Mall
    Professional Condo Near Maine Mall

    25B Long Creek Drive, South Portland, ME 04106

    $890,000
    4,530 sqft

    Office space ideal for medical, dental, wellness, or clinical services.

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    South Portland, ME Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in South Portland, ME with 20 listings featured on our commercial real estate exchange. The current inventory includes 154,987 square feet of properties with an estimated lease value of $244.90 SF/Yr.

    Estimated lease rates for Office Spaces in South Portland, ME begin at $7.50 SF/Yr, with an average of $15.31 SF/Yr and extend to $25 SF/Yr.
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    Most Searched ZIP Codes in South Portland, ME

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    • 04101

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