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    South Portland, ME Office Properties & Spaces for Lease

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    Portland, ME Bangor, ME Lewiston, ME
    31 results
    Office Space in John Roberts
    $15 SF/Yr
    10,000 SF

    Office Space in John Roberts

    9 Donald B Dean Dr, South Portland, ME

    Class A office space available for rent in South Portland.

    • Class A office space.
    • 10,000± SF available or subdividable.
    • In close proximity to the Maine Mall & I‑295.
    • Prominent building with great visibility.
    • Located in John Roberts Office Park.
    Updated: Nov 10, 2025
    View details
    Class A Office/Medical Building
    $13 SF/Yr
    4,646 SF

    Class A Office/Medical Building

    175 Running Hill Road, South Portland, ME

    Class A office/medical building with suites available for lease.

    • Class A office/medical building with suites available, ranging from 4,646 to 8,542± SF.
    • Central location with easy access to Maine Turnpike/I‑95 and I‑295.
    • Conveniently located near Portland International Jetport, hotels, and restaurants.
    • Professionally managed property situated on 13.09± acres.
    • Ample paved parking available.
    Updated: Jul 29, 2025
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    Class-A Office Suite For Lease
    $16 SF/Yr
    5,121 SF

    Class-A Office Suite For Lease

    Full-floor office suite in South Portland's Maine Mall area.

    30 Long Creek Dr, South Portland, ME
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    South Portland Office Space Available
    $16 SF/Yr
    6,321 SF

    South Portland Office Space Available

    Office space for lease near Maine Mall and Portland Jetport.

    311 Darling Ave, South Portland, ME
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    Class A Office Space Available
    Contact for pricing
    1,323 SF

    Class A Office Space Available

    Class A office building with ample parking and professional landscaping.

    778 Main Street, South Portland, ME 4106
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    South Portland Retail/Office Opportunity
    Contact for pricing
    11,890 SF

    South Portland Retail/Office Opportunity

    Modern, adaptable space in high-traffic Maine Mall area.

    264 Gorham Rd, South Portland, ME
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    Updated Medical Spa Space Available
    $20 SF/Yr
    4,200 SF

    Updated Medical Spa Space Available

    Recently updated medical spa, salon, or medical space for lease.

    198 Maine Mall Rd, South Portland, ME 4106
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    Class A Office Sublease Available
    $15 SF/Yr
    7,599 SF

    Class A Office Sublease Available

    7,599±SF Class A office space for sublease in South Portland.

    500 Southborough Dr, South Portland, ME
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    Industrial Facility with Modern Office
    Contact for pricing
    10,654 SF

    Industrial Facility with Modern Office

    Well-maintained industrial and office space near I-95 and Jetport.

    76 Darling Ave, South Portland, ME 4106
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    South Portland Office Space Available
    Contact for pricing
    2,601 SF

    South Portland Office Space Available

    Class A office space for lease near I-95 and I-295.

    324 Cummings Rd, South Portland, ME
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    Corner Office Suite For Rent
    $14 SF/Yr
    4,040 SF

    Corner Office Suite For Rent

    4,040± SF office suite with ample free parking.

    202 Gannett Dr, South Portland, ME
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    Class A Office Suite Available
    $13 SF/Yr
    3,765 SF

    Class A Office Suite Available

    3,765 SF office suite for lease in South Portland.

    82 Running Hill Road, South Portland, ME 4106
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    South Portland Office Space Available
    $10 SF/Yr
    1,812 SF

    South Portland Office Space Available

    Office space for lease in landmark South Portland building.

    100 Brickhill Avenue, South Portland, ME
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    South Portland Office Space Available
    $13 SF/Yr
    2,500 SF

    South Portland Office Space Available

    2,500± SF office space for lease in South Portland.

    141 Main St, South Portland, ME
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    South Portland Warehouse and Office
    $10 SF/Yr
    31,360 SF

    South Portland Warehouse and Office

    Warehouse and office space for lease in South Portland.

    1 Madison Street, South Portland, ME 4101
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    South Portland Office Space Available
    $14 SF/Yr
    11,162 SF

    South Portland Office Space Available

    Office space for lease in South Portland with ample parking.

    600 Sable Oaks Dr, South Portland, ME 4106
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    Class A Office Space Available
    $15 SF/Yr
    36,703 SF

    Class A Office Space Available

    Class A office space for lease near major transportation routes.

    179 John Roberts Rd, South Portland, ME 4106
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    Class A Office Space Available
    Contact for pricing
    8,532 SF

    Class A Office Space Available

    Premier office park with modern finishes and convenient location.

    600 Southborough Dr, South Portland, ME 4106
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    Office
    Contact for pricing
    15,250 SF

    Office

    Medical Office Space · 15,250 SF

    244 Western Ave, South Portland, ME 4106
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    Retail/Office Space Near Maine Mall
    Contact for pricing
    1,700 SF

    Retail/Office Space Near Maine Mall

    1,700± SF retail/office space with convenient highway access.

    209 Western Ave, South Portland, ME 4106
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    South Portland Warehouse and Office
    Contact for pricing
    31,630 SF

    South Portland Warehouse and Office

    Warehouse and office space for lease in South Portland.

    1 Madison St, South Portland, ME 4106
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    Suburban Office Park Sublease Opportunity
    Contact for pricing
    16,912 SF

    Suburban Office Park Sublease Opportunity

    Office space for sublease in premier suburban office park.

    78 Atlantic Pl, South Portland, ME 4106
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    Office Space Near Portland Jetport
    Contact for pricing

    Office Space Near Portland Jetport

    Office space for rent near the Portland Jetport.

    179 John Roberts Rd, South Portland, ME 4106
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    South Portland Office Space Available
    Contact for pricing
    6,321 SF

    South Portland Office Space Available

    Office suites for lease in premier suburban office park.

    311 Darling Ave, South Portland, ME 4106
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    South Portland, ME Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in South Portland, ME with 31 listings featured on our commercial real estate exchange. The current inventory includes 1,850,080,320 square feet of properties with an estimated lease value of $29 SF/Yr.

    Estimated lease rates for Office properties & Spaces in South Portland, ME begin at $14 SF/Yr, with an average of $14 SF/Yr and extend to $15 SF/Yr.
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    Browse Office properties & Spaces for Lease Near South Portland, ME

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    Most Searched ZIP Codes in South Portland, ME

    • 04106
    • 04101

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