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    South Portland, ME Commercial Real Estate for Sale

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    Portland, ME Lewiston, ME Bangor, ME
    11 results
    Mixed-Use Property in South Portland
    $560,000
    0.23 Acres

    Mixed-Use Property in South Portland

    854 Broadway, South Portland, ME 04106

    Mixed-use property with office spaces and apartment in South Portland.

    • Mixed‑use property in a highly visible location on a popular commuter street.
    • Immaculate 1‑bedroom apartment on the 3rd floor featuring 2 egresses, cherry cabinets, and granite counters.
    • Two first‑floor office spaces with separate entries and beautiful hardwood floors.
    • Four individual offices on the second floor.
    • Detached 1‑car garage leased year‑round.
    Updated: Apr 15
    View details
    Mixed-Use Property on Broadway
    $560,000
    4,370 SF

    Mixed-Use Property on Broadway

    854 Broadway, South Portland, ME 04106

    Highly visible mixed-use property in South Portland, Maine.

    • Mixed‑use property in a highly visible location on a popular commuter street.
    • Immaculate 1‑bedroom apartment on the 3rd floor with cherry cabinets and granite counters.
    • Two first‑floor office spaces with separate entries and hardwood floors.
    • Four individual offices on the second floor.
    • Detached 1‑car garage leased year‑round.
    Updated: Oct 30, 2025
    View details
    South Portland Medical Investment Opportunity
    $4,327,286
    7,424 SF

    South Portland Medical Investment Opportunity

    Long-term NNN investment with a strong healthcare tenant.

    254 Western Ave, South Portland, ME
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    Retail Building Near Maine Mall
    $4,950,000
    20,700 SF

    Retail Building Near Maine Mall

    20,700 SF retail building on 2 acres for sale.

    130 Western Avenue, South Portland, ME
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    Professional Condo Near Maine Mall
    $925,000
    4,530 SF

    Professional Condo Near Maine Mall

    Office space ideal for medical, dental, wellness, or clinical services.

    25B Long Creek Drive, South Portland, ME 4106
    View details
    Retail Space with Main Street Frontage
    $2,500,000
    12,694 SF

    Retail Space with Main Street Frontage

    Retail property for rent with high visibility and large yard.

    172 Main St, South Portland, ME
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    Medical Outpatient Portfolio For Sale
    $1,154,664
    4,952 SF

    Medical Outpatient Portfolio For Sale

    Two-property medical portfolio fully leased to Straine Dental Management.

    25 Long Creek Drive, South Portland, ME 4106
    View details
    Sable Oaks Development Opportunity
    $1,995,000
    4.99 Acres

    Sable Oaks Development Opportunity

    4.99 acre commercial development site in South Portland, Maine.

    505 Sable Oaks Dr, South Portland, ME 4106
    View details
    Office Space Near Maine Mall
    $3,800,000
    2,495 SF

    Office Space Near Maine Mall

    2,495 SF mixed-use/office space near Maine Mall.

    244 Western Ave, South Portland, ME 4106
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    South Portland Commercial Land Opportunity
    Contact for pricing
    25,000 SF

    South Portland Commercial Land Opportunity

    4.14 acre commercial land parcel in South Portland, Maine.

    305 Cummings Rd, South Portland, ME
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    Medical Office Space For Sale
    $3,800,000
    19,188 SF

    Medical Office Space For Sale

    19,188 SF medical office space on 2.61 acres.

    244 Western Ave, South Portland, ME 4106
    View details
    Based on your search, we've compiled 782 Potential Opportunities for your consideration. Besides 11 Active listings in South Portland, ME, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 767 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Development Site Near Rock Row
    $450,000
    0.70 Acres

    Development Site Near Rock Row

    30,388 SF development site near Rock Row and I-95.

    25 Holm Ave, Portland, ME
    View details
    Mixed-Use Building on Congress Street
    $1,400,000

    Mixed-Use Building on Congress Street

    Mixed-use building with market and apartment near downtown Portland.

    947 Congress St, Portland, ME 4102
    View details
    Undeveloped Land Parcel For Sale
    $3,350,000
    13.50 Acres

    Undeveloped Land Parcel For Sale

    Undeveloped land with frontage on Mussey Road and I-295.

    114 Mussey Road, Scarborough, ME
    View details
    Scarborough Office Building For Sale
    $7,950,000
    38,784 SF

    Scarborough Office Building For Sale

    38,784 square foot office building in Scarborough, Maine.

    482 Payne Road, Scarborough, ME 4074
    View details

    Off-Market Properties in South Portland, ME

    Consider similar Off-Market properties in South Portland, ME. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    13 Ocean St

    13 Ocean St

    OFFICE BUILDING • 3,729 SF
    Value Estimation
    $725,000
    13 Ocean St, South Portland, ME 04106-2888
    View details
    77 1st St

    77 1st St

    VACANT COMMERCIAL LAND • 0.10 Acres
    Value Estimation
    $980,000
    77 1st St, South Portland, ME 04106-3712
    View details
    225 Waterman Dr

    225 Waterman Dr

    DEPARTMENT STORE • 4,040 SF
    Value Estimation
    $1,100,000
    225 Waterman Dr, South Portland, ME 04106-3634
    View details
    57 1st St

    57 1st St

    VACANT COMMERCIAL LAND • 0.13 Acres
    Value Estimation
    $830,000
    57 1st St, South Portland, ME 04106-3712
    View details
    2108 Broadway, Unit C

    2108 Broadway, Unit C

    COMMERCIAL CONDOMINUIM • 1,568 SF
    Value Estimation by Request
    2108 Broadway, South Portland, ME 04106-3360
    View details
    130 Sunset Ave

    130 Sunset Ave

    CHARITABLE ORGANIZATION • 0.12 Acres
    Value Estimation by Request
    130 Sunset Ave, South Portland, ME 04106-6125
    View details
    128 Sunset Ave

    128 Sunset Ave

    CHARITABLE ORGANIZATION • 0.12 Acres
    Value Estimation
    $510,000
    128 Sunset Ave, South Portland, ME 04106-6125
    View details
    127 Sunset Ave

    127 Sunset Ave

    CHARITABLE ORGANIZATION • 0.13 Acres
    Value Estimation by Request
    127 Sunset Ave, South Portland, ME 04106-6126
    View details
    324 Gannett Dr

    324 Gannett Dr

    OFFICE BUILDING • 26,118 SF
    Value Estimation
    $4,540,000
    324 Gannett Dr, South Portland, ME 04106-3270
    View details
    43 1st St

    43 1st St

    VACANT COMMERCIAL LAND • 0.21 Acres
    Value Estimation
    $1,055,000
    43 1st St, South Portland, ME 04106-3712
    View details
    73 1st St

    73 1st St

    VACANT COMMERCIAL LAND • 0.12 Acres
    Value Estimation
    $750,000
    73 1st St, South Portland, ME 04106-3712
    View details
    120 Thadeus St Ste, Unit 6

    120 Thadeus St Ste, Unit 6

    COMMERCIAL CONDOMINUIM • 1,680 SF
    Value Estimation by Request
    120 Thadeus St Ste, South Portland, ME 04106-6245
    View details
    120 Thadeus St Ste, Unit 5

    120 Thadeus St Ste, Unit 5

    COMMERCIAL CONDOMINUIM • 1,680 SF
    Value Estimation by Request
    120 Thadeus St Ste, South Portland, ME 04106-6245
    View details

    South Portland, ME Commercial Real Estate Investment Opportunities Market Analysis

    Explore 778 commercial real estate for sale in South Portland, ME, showcased through 11 active listings on our real estate platform. These investment opportunities span a total of 76,353 square feet of properties for sale, with an estimated market value of $22,016,950.

    Sale prices for business properties in South Portland, ME start at $560,000, averaging $2,752,118, and reaching up to $4,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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