Advertise
    South Portland, ME
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    South Portland, ME Office Units for Lease

    Notify Me
    List
    Map
    Portland, ME Cape Elizabeth, ME Scarborough, ME
    22 listings
    Versatile Office or Retail Space
    $2,000/Mo
    1,000 SF
    Versatile Office or Retail Space

    851 Sawyer St, South Portland, ME 4106

    1,000± SF space ideal for various business types.
    • Versatile 1,000± SF space suitable for office, retail, medical, or service businesses.
    • Convenient location along Route 77.
    • Dedicated off‑street parking.
    • Lease rate of $2,000/month MG (includes heat, water, & sewer).
    • Available immediately.
    Updated: May 5
    View details
    Class A Office Sublease Available
    $15 SF/Yr
    7,599 SF
    Class A Office Sublease Available

    500 Southborough Dr, South Portland, ME

    7,599±SF Class A office space for sublease in South Portland.
    • Class A office suite with 7,599±SF of space.
    • Located in SouthBorough Office Park, a premier office park in Maine.
    • Immediate access to I‑295 and Maine Turnpike Exit 44.
    • Recently renovated lobby entrances and restrooms.
    • Modern brick and glass facades with first‑class interior finishes.
    Updated: Nov 24, 2025
    View details
    South Portland Office Space Available
    $17 SF/Yr
    6,321 SF
    South Portland Office Space Available

    Office space for lease near Maine Mall and Portland Jetport.

    311 Darling Ave, South Portland, ME

    View details
    Class-A Office Suite For Lease
    $16 SF/Yr
    5,121 SF
    Class-A Office Suite For Lease

    Full-floor office suite in South Portland's Maine Mall area.

    30 Long Creek Dr, South Portland, ME

    View details
    South Portland Office Space Available
    $10 SF/Yr
    1,812 SF
    South Portland Office Space Available

    Office space for lease in landmark South Portland building.

    100 Brickhill Avenue, South Portland, ME

    View details
    Corner Office Suite For Rent
    $13 SF/Yr
    4,040 SF
    Corner Office Suite For Rent

    4,040± SF office suite with ample free parking.

    202 Gannett Dr, South Portland, ME

    View details
    Class A Office Suite Available
    $13 SF/Yr
    3,765 SF
    Class A Office Suite Available

    3,765 SF office suite for lease in South Portland.

    82 Running Hill Road, South Portland, ME 4106

    View details
    Industrial Facility with Modern Office
    Contact for pricing
    10,654 SF
    Industrial Facility with Modern Office

    Well-maintained industrial and office space near I-95 and Jetport.

    76 Darling Ave, South Portland, ME 4106

    View details
    South Portland Office Space Available
    $13 SF/Yr
    2,500 SF
    South Portland Office Space Available

    2,500± SF office space for lease in South Portland.

    141 Main St, South Portland, ME

    View details
    South Portland Warehouse and Office
    $10 SF/Yr
    31,360 SF
    South Portland Warehouse and Office

    Warehouse and office space for lease in South Portland.

    1 Madison Street, South Portland, ME 4101

    View details
    Class A Office Space Available
    $15 SF/Yr
    36,703 SF
    Class A Office Space Available

    Class A office space for lease near major transportation routes.

    179 John Roberts Rd, South Portland, ME 4106

    View details
    Class A Office Space Available
    $15 SF/Yr
    8,532 SF
    Class A Office Space Available

    Premier office park with modern finishes and convenient location.

    600 Southborough Dr, South Portland, ME 4106

    View details
    South Portland Office Space Available
    $14 SF/Yr
    11,162 SF
    South Portland Office Space Available

    Office space for lease in South Portland with ample parking.

    600 Sable Oaks Dr, South Portland, ME 4106

    View details
    Retail/Office Space Near Maine Mall
    $24 SF/Yr
    1,700 SF
    Retail/Office Space Near Maine Mall

    1,700± SF retail/office space with convenient highway access.

    209 Western Ave, South Portland, ME 4106

    View details
    South Portland Warehouse and Office
    $10 SF/Yr
    31,630 SF
    South Portland Warehouse and Office

    Warehouse and office space for lease in South Portland.

    1 Madison St, South Portland, ME 4106

    View details
    Suburban Office Park Sublease Opportunity
    $9 SF/Yr
    16,912 SF
    Suburban Office Park Sublease Opportunity

    Office space for sublease in premier suburban office park.

    78 Atlantic Pl, South Portland, ME 4106

    View details
    South Portland Office Space Available
    $17 SF/Yr
    6,321 SF
    South Portland Office Space Available

    Office suites for lease in premier suburban office park.

    311 Darling Ave, South Portland, ME 4106

    View details
    Office Space Near Portland Jetport
    $15 SF/Yr
    Office Space Near Portland Jetport

    Office space for rent near the Portland Jetport.

    179 John Roberts Rd, South Portland, ME 4106

    View details
    South Portland Office Space Available
    $14 SF/Yr
    11,162 SF
    South Portland Office Space Available

    Office space for rent in South Portland with ample parking.

    600 Sable Oaks Dr, South Portland, ME 4106

    View details
    South Portland Class A Office
    $15 SF/Yr
    8,114 SF
    South Portland Class A Office

    Class A office and flex space in South Portland for lease.

    75 John Roberts Rd, South Portland, ME 4106

    View details
    Class A Office Space Available
    $15 SF/Yr
    8,532 SF
    Class A Office Space Available

    Class A office space for lease in South Portland, Maine.

    600 Southborough Dr, South Portland, ME 4106

    View details
    Class A Office in Park
    $23 SF/Yr
    4,334 SF
    Class A Office in Park

    Class A office space available for rent in South Portland.

    707 Sable Oaks Dr, South Portland, ME 4106

    View details
    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 22 Active listings in South Portland, ME, we suggest exploring alternatives. Similar 5 Properties for Sales.

    Similar Spaces for Sale in South Portland, ME

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    Mixed-Use Building with Office Suites
    $560,000
    4,370 SF
    Mixed-Use Building with Office Suites

    Multi-level property combines office space and a one-bedroom apartment for diversified commercial and residential use.

    854 Broadway, South Portland, ME 04106

    View details
    Mixed-Use Office and Apartment
    $560,000
    0.23 Acres
    Mixed-Use Office and Apartment

    Mixed-use property with private offices and a 1-bedroom apartment, complemented by an in-building office layout.

    854 Broadway, South Portland, ME 04106

    View details

    South Portland, ME Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in South Portland, ME with 22 listings featured on our commercial real estate exchange. The current inventory includes 208,620 square feet of properties with an estimated lease value of $306 /Mo.

    Estimated lease rates for Office Units in South Portland, ME begin at $9 SF/Yr, with an average of $15 SF/Yr and extend to $24 SF/Yr.
    List
    Map

    Popular Searches in South Portland, ME

    Popular Categories

    Most Searched ZIP Codes in South Portland, ME

    • 04106
    • 04101

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!