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    South Portland, ME Medical Office Space for Lease

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    Portland, ME Scarborough, ME Westbrook, ME Falmouth, ME Yarmouth, ME Gorham, ME Saco, ME Freeport, ME
    Medical Office Suite with Exam Rooms
    Updated: Jun 22
    Medical Office Suite with Exam Rooms

    10 Q St, South Portland, ME 04106

    Contact for pricing
    2,250 sqft
    2,250± SF medical/professional office space currently occupied by Casco Bay EyeCare (available 9/1/2026)
    Built for medical use with a waiting room, staff/records area, and several exam rooms
    Full basement included
    Ample on‑site parking
    Full handicap accessibility
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    Medical Office Condos
    Updated: Jun 4
    Medical Office Condos

    25 Long Creek Drive, South Portland, ME 04106

    Contact for pricing
    6,230 sqft
    Office condo with flexible space from 4,530±SF to 6,230±SF, built in 1993
    Includes 1,700±SF daylight basement space for administrative or professional uses
    Main‑level lease rate of $15/SF NNN; lower‑level lease rate of $14/SF NNN
    Convenient access near Western Avenue and Maine Mall, with easy access to I‑95 and I‑295
    Ample on‑site parking for patients, clients, and staff
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    Office
    Office

    244 Western Ave, South Portland, ME 04106

    Contact for pricing
    15,250 sqft 2.61 AC lot

    Medical Office Space · 15,250 SF

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    Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 3 Active listings in South Portland, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    First-Floor Medical Office Space
    First-Floor Medical Office Space

    500 Route 1, Yarmouth, ME 04096

    $20 SF/Yr
    2,000 sqft

    First-floor office space with natural light and frontage suited to dental or medical practice use.

    View details
    Medical Office Space on Campus
    Medical Office Space on Campus

    21 Whitehall Road, Rochester, NH 03867

    $22.50 SF/Yr

    Medical office space for lease on Frisbie Memorial Hospital campus.

    View details
    Rochester Office/Medical Building For Lease
    Rochester Office/Medical Building For Lease

    13 Health Care Drive, Rochester, NH 03867

    $22.75 SF/Yr

    15,696± SF office/medical building available for lease.

    View details
    Ground-Floor Medical Office Space
    Ground-Floor Medical Office Space

    45 Forest Falls Dr, Yarmouth, ME 04096

    Contact for pricing
    2,400 sqft 1.60 AC lot

    Class A professional suite with shared paved parking, an open layout, reception area, kitchenette, and two private accessible bathrooms.

    View details

    Similar Spaces for Sale in South Portland, ME

    Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

    Medical Outpatient Portfolio For Sale
    Medical Outpatient Portfolio For Sale

    25 Long Creek Drive, South Portland, ME 04106

    Contact for pricing
    4,952 sqft

    Two-property medical portfolio fully leased to Straine Dental Management.

    View details
    South Portland Medical Investment Opportunity
    South Portland Medical Investment Opportunity

    254 Western Ave, South Portland, ME

    Contact for pricing
    7,424 sqft 0.88 AC lot

    Long-term NNN investment with a strong healthcare tenant.

    View details
    Professional Condo Near Maine Mall
    Professional Condo Near Maine Mall

    25B Long Creek Drive, South Portland, ME 04106

    Contact for pricing
    4,530 sqft

    Office space ideal for medical, dental, wellness, or clinical services.

    View details

    South Portland, ME Medical Office Space Lease Rates & Market Statistics

    Explore 3 Medical Office Space listings for lease in South Portland, ME on Realmo, a commercial real estate exchange covering the South Portland area. The current inventory totals 23,730 square feet of properties.

    South Portland accounts for 43% of the 7 medical office space listings currently available across Cumberland County, where nearby markets include Yarmouth and Portland. Medical Office Space is one of the more limited space types in South Portland, with just 3 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (6 listings) elsewhere in the South Portland market.

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