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    South Portland, ME Medical Office Space for Lease

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    Portland, ME Bangor, ME Lewiston, ME
    Class A Office/Medical Building
    $13 SF/Yr
    4,646 SF

    Class A Office/Medical Building

    175 Running Hill Road, South Portland, ME

    Class A office/medical building with suites available for lease.

    • Class A office/medical building with suites available, ranging from 4,646 to 8,542± SF.
    • Central location with easy access to Maine Turnpike/I‑95 and I‑295.
    • Conveniently located near Portland International Jetport, hotels, and restaurants.
    • Professionally managed property situated on 13.09± acres.
    • Ample paved parking available.
    Updated: Jul 29, 2025
    View details
    South Portland Retail/Office Opportunity
    Contact for pricing
    11,890 SF

    South Portland Retail/Office Opportunity

    264 Gorham Rd, South Portland, ME

    Modern, adaptable space in high-traffic Maine Mall area.

    • Prime location in the Maine Mall retail trade area with high visibility.
    • Easy access from I‑95 and I‑295.
    • Newer construction (built in 2019).
    • Adaptable space suitable for retail or traditional office uses.
    • Large pylon sign on Gorham Road.
    Updated: Sep 23, 2025
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    Updated Medical Spa Space Available
    $20 SF/Yr
    4,200 SF

    Updated Medical Spa Space Available

    Recently updated medical spa, salon, or medical space for lease.

    198 Maine Mall Rd, South Portland, ME 4106
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    Office
    Contact for pricing
    15,250 SF

    Office

    Medical Office Space · 15,250 SF

    244 Western Ave, South Portland, ME 4106
    View details
    Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 4 Active listings in South Portland, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Bayside Office Space For Lease
    $15 SF/Yr
    33,074 SF

    Bayside Office Space For Lease

    Up to 33,074 SF of office space available for lease.

    165 Lancaster St, Portland, ME
    View details
    Retail/Office Space on Marginal Way
    $38 SF/Yr
    3,522 SF

    Retail/Office Space on Marginal Way

    Retail/office space in a mixed-use building with high visibility.

    191 Marginal Way, Portland, ME
    View details
    Scarborough Office or Medical Space
    $16 SF/Yr
    3,000 SF

    Scarborough Office or Medical Space

    High-quality office/medical space with ample parking near major routes.

    23 Spring St, Scarborough, ME
    View details
    Medical Office Space Available
    $12 SF/Yr
    1,200 SF

    Medical Office Space Available

    Medical office or spa space near Maine Medical Center Scarborough.

    6 Science Park Rd, Scarborough, ME 4074
    View details

    Explore Similar Spaces for Sale in South Portland, ME

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    South Portland Medical Investment Opportunity
    $4,327,286
    7,424 SF

    South Portland Medical Investment Opportunity

    Long-term NNN investment with a strong healthcare tenant.

    254 Western Ave, South Portland, ME
    View details
    Professional Condo Near Maine Mall
    $925,000
    4,530 SF

    Professional Condo Near Maine Mall

    Office space ideal for medical, dental, wellness, or clinical services.

    25B Long Creek Drive, South Portland, ME 4106
    View details
    Medical Outpatient Portfolio For Sale
    $1,154,664
    4,952 SF

    Medical Outpatient Portfolio For Sale

    Two-property medical portfolio fully leased to Straine Dental Management.

    25 Long Creek Drive, South Portland, ME 4106
    View details
    Medical Office Space For Sale
    $3,800,000
    19,188 SF

    Medical Office Space For Sale

    19,188 SF medical office space on 2.61 acres.

    244 Western Ave, South Portland, ME 4106
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Highway 72 Corner Lot
    $6,500/Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
    View details
    Prime Commercial Lot For Rent
    $7,500/Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    Winter Park Mixed-Use Opportunity
    $8,500/Mo
    23,056 SF

    Winter Park Mixed-Use Opportunity

    Double commercial lot in Winter Park, FL, for lease.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details

    South Portland, ME Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in South Portland, ME with 4 listings featured on our commercial real estate exchange. The current inventory includes 8,846 square feet of properties with an estimated lease value of $33 SF/Yr.

    Estimated lease rates for Medical Office Space in South Portland, ME begin at $13 SF/Yr, with an average of $16 SF/Yr and extend to $20 SF/Yr.
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