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    South Portland, ME Medical Office Space for Lease

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    Portland, ME Cape Elizabeth, ME Scarborough, ME
    Class A Medical Building Space
    $25 SF/Yr
    3,099 SF
    Class A Medical Building Space

    100 Foden Road, South Portland, ME 4106

    Class A medical building with convenient highway access and ample parking.
    • Convenient location with direct access to Maine Turnpike, I‑95, and I‑295
    • High‑capacity surface parking lot with 260 spaces
    • Class A, 3‑story medical building
    • Building & Monument Signage Opportunities available
    • Campus‑like setting
    Updated: May 26
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    Class A Office/Medical Building
    $13 SF/Yr
    4,646 SF
    Class A Office/Medical Building

    175 Running Hill Road, South Portland, ME

    Class A office/medical building with suites available for lease.
    • Class A office/medical building with suites available, ranging from 4,646 to 8,542± SF.
    • Central location with easy access to Maine Turnpike/I‑95 and I‑295.
    • Conveniently located near Portland International Jetport, hotels, and restaurants.
    • Professionally managed property situated on 13.09± acres.
    • Ample paved parking available.
    Updated: Jul 29, 2025
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    Updated Medical Spa Space Available
    $20 SF/Yr
    4,200 SF
    Updated Medical Spa Space Available

    Recently updated medical spa, salon, or medical space for lease.

    198 Maine Mall Rd, South Portland, ME 4106

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    Office
    $26 SF/Yr
    15,250 SF
    Office

    Medical Office Space · 15,250 SF

    244 Western Ave, South Portland, ME 4106

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    Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 4 Active listings in South Portland, ME, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 3 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Bayside Office Space For Lease
    $12 SF/Yr
    33,074 SF
    Bayside Office Space For Lease

    Up to 33,074 SF of office space available for lease.

    165 Lancaster St, Portland, ME

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    Retail/Office Space on Marginal Way
    $38 SF/Yr
    3,522 SF
    Retail/Office Space on Marginal Way

    Retail/office space in a mixed-use building with high visibility.

    191 Marginal Way, Portland, ME

    View details
    Medical Office Space Available
    $12 SF/Yr
    1,200 SF
    Medical Office Space Available

    Medical office or spa space near Maine Medical Center Scarborough.

    6 Science Park Rd, Scarborough, ME 4074

    View details
    Class A Office/Medical Suite
    $14 SF/Yr
    Class A Office/Medical Suite

    Office and medical suite across from Maine Medical Center campus.

    71 US Route One, Scarborough, ME 4074

    View details

    Similar Spaces for Sale in South Portland, ME

    Consider Similar Space for Sale. We found 3 Spaces matching your search parameters.

    South Portland Medical Investment Opportunity
    $4,327,286
    7,424 SF
    South Portland Medical Investment Opportunity

    Long-term NNN investment with a strong healthcare tenant.

    254 Western Ave, South Portland, ME

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    Medical Outpatient Portfolio For Sale
    $1,154,664
    4,952 SF
    Medical Outpatient Portfolio For Sale

    Two-property medical portfolio fully leased to Straine Dental Management.

    25 Long Creek Drive, South Portland, ME 4106

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    Professional Condo Near Maine Mall
    $925,000
    4,530 SF
    Professional Condo Near Maine Mall

    Office space ideal for medical, dental, wellness, or clinical services.

    25B Long Creek Drive, South Portland, ME 4106

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Pad Site for Lease
    Contact for pricing
    Prime Pad Site for Lease

    Highly visible 1.74 acre pad site in Belmont, NH.

    9 Old State Rd, Belmont, NH 3220

    View details
    Prime Land in Upper St Clair
    $50,000 SF/Yr
    Prime Land in Upper St Clair

    Commercial land for lease in Upper St Clair, PA.

    2585 Maple Lane, Upper St Clair, PA 15241

    View details
    Beaumont Centre Outparcel Opportunity
    Contact for pricing
    Beaumont Centre Outparcel Opportunity

    Outparcel opportunity in established shopping center for ground lease.

    3199 Beaumont Centre Circle, Lexington, KY 40513

    View details
    Prime Lexington Outlot Opportunity
    Contact for pricing
    Prime Lexington Outlot Opportunity

    Outlot for ground lease or build-to-suit in South Lexington.

    3330 Partner Place, Lexington, KY 40503

    View details

    South Portland, ME Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in South Portland, ME with 4 listings featured on our commercial real estate exchange. The current inventory includes 27,195 square feet of properties with an estimated lease value of $84 SF/Yr.

    Estimated lease rates for Medical Office Space in South Portland, ME begin at $13 SF/Yr, with an average of $21 SF/Yr and extend to $26 SF/Yr.
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