Advertise
    South Portland, ME
    For Sale
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Property Types
    1
    • Retail
    • Office
    • Residential Income
    • Restaurants
    • Industrial
    • Mixed-Use
    • Hospitality
    • Health Care
    • Sports & Entertainment
    • Land
    • Agricultural
    • Specialty
    Price
    Price
    $
    $

    South Portland, ME Medical Office Space for Sale

    Notify Me
    List
    Map
    Portland, ME Falmouth, ME Cape Elizabeth, ME
    South Portland Medical Investment Opportunity
    $4,327,286
    7,424 SF
    South Portland Medical Investment Opportunity

    254 Western Ave, South Portland, ME

    Long-term NNN investment with a strong healthcare tenant.
    • Best‑in‑class Tenant: Paradigm Oral Health, a large and growing DSO with 75+ locations.
    • BlackRock Subsidiary: Majority interest acquired by BlackRock, indicating financial strength and stability.
    • ±14.9 Year NNN Investment: Enjoy long‑term passive income.
    • 3% Annual Rental Increases: Growing cash flow and hedge against inflation.
    • Healthcare Real Estate: Recession and e‑commerce resistant investment.
    Updated: Oct 29, 2025
    View details
    Medical Outpatient Portfolio For Sale
    $1,154,664
    4,952 SF
    Medical Outpatient Portfolio For Sale

    25 Long Creek Drive, South Portland, ME 4106

    Two-property medical portfolio fully leased to Straine Dental Management.
    • Fully leased to Straine Dental Management, a nationally expanding DSO with a strong operational performance and proven patient base.
    • Brand‑new corporate‑guaranteed net leases with over 8.4 years of remaining term.
    • Enjoy predictable income growth with 2% annual rental escalations, providing a natural inflation hedge.
    • Net lease structure offers a passive investment approach with minimal landlord responsibilities.
    • Offered free and clear of existing debt.
    Updated: Feb 19
    View details
    Professional Condo Near Maine Mall
    $925,000
    4,530 SF
    Professional Condo Near Maine Mall

    Office space ideal for medical, dental, wellness, or clinical services.

    25B Long Creek Drive, South Portland, ME 4106

    View details
    Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 3 Active listings in South Portland, ME, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 2 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Ground-Floor Commercial Condo with Road Frontage
    $159,000
    441 SF
    Ground-Floor Commercial Condo with Road Frontage

    Single condo unit in a 2022 mixed-use building with direct York Street frontage and shared restroom access.

    298 York Street, York, ME 03909

    View details
    3-Unit Mixed-Use Building
    $449,000
    3,076 SF
    3-Unit Mixed-Use Building

    Mixed-use three-unit structure with income from residential and a flexible first-floor commercial space in Biddeford.

    38 Jefferson Street, Biddeford, ME 04005

    View details
    Single-Story Medical Office Condo
    $250,000
    1,088 SF
    Single-Story Medical Office Condo

    Medical office condo with a built-out suite, including a waiting room, exam room, and private office.

    2 Medical Center Unit 3, Biddeford, ME 4005

    View details
    Mixed-Use Office Condo with Road Frontage
    $159,000
    442 SF
    Mixed-Use Office Condo with Road Frontage

    Bright, internet-ready commercial condo with direct road frontage and ADA accessibility for office, medical, or retail use.

    298 York Street, York, ME 3909

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Land in Cook's Corner
    $550,000
    1.67 Acres
    Prime Land in Cook's Corner

    Two lots in Brunswick's Cook's Corner, high visibility, development potential.

    Farley Road lot: #11&12, Brunswick, ME 04011

    View details
    Approved Medical Office Land
    $850,000
    Approved Medical Office Land

    Land approved for a 10,000 sq ft medical office.

    28 Lumber St, Hopkinton, MA 1748

    View details
    6.79 Acres on Merrow Road
    $700,000
    996 SF
    6.79 Acres on Merrow Road

    Commercial land with ranch home in technology campus zone.

    248 Merrow Rd, Tolland, CT 6084

    View details
    Norwich Commercial Parcel For Sale
    $101,000
    Norwich Commercial Parcel For Sale

    Multi-use commercial land parcel in a convenient Norwich location.

    171 Otrobando Ave, Norwich, CT 6360

    View details

    Off-Market Properties in South Portland, ME

    Consider similar Off-Market properties in South Portland, ME. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    25 Long Creek Dr
    Medical Office Space
    4,532 SF
    Value Estimation by Request

    25 Long Creek Dr, South Portland, ME 04106

    View details
    25 Long Creek Dr
    Medical Office Space
    16,150 SF
    Value Estimation by Request

    25 Long Creek Dr, South Portland, ME 04106

    View details

    South Portland, ME Medical Office Space Investment Opportunities Market Analysis

    Explore 5 medical office space for sale in South Portland, ME, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 16,906 square feet of properties for sale, with an estimated market value of $6,406,950.

    Sale prices for medical spaces in South Portland, ME start at $925,000, averaging $2,135,650, and reaching up to $4,327,286 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    List
    Map

    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 28
    Medical Office Space 7
    Office buildings 5

    Demographics Overview

    Population 27K
    Population Growth (5Y) +4.4%
    Median Household Income $83,744
    College Educated 33.5%

    High-Yield Neighborhoods for Investment

    Identify South Portland submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    04106 $1M

    Taxes & Financing

    Tax Rate (average for all types) 1.41%
    Property Tax per SF $23.17 per SF
    Tax Rate vs County Average 0.10 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Cumberland County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in Cumberland County

    Retail

    Property Size Breakdown

    The majority of commercial real estate listings in South Portland fall within the 100,000+ square foot range.

    Need Help?

    Reach out if you need assistance with Realmo tools or have questions about your listings

    Contact Us

    Popular Searches in South Portland, ME

    Popular Categories

    Most Searched ZIP Codes in South Portland, ME

    • 04106

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!