Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent / SF / Yr
    $
    $
    Rent / Mo
    $
    $
    Size
    Property size / sq.ft.

    Meet Realmo: The Largest Hub
    of Commercial Real     Estate in the US

    Over 1 million active listings and over 150 million property profiles

    South Portland, ME Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Portland, ME Bangor, ME Lewiston, ME
    54 results
    Restaurant/Retail Space For Sublease
    $15 SF/Yr
    2,647 SF

    Restaurant/Retail Space For Sublease

    185 Cottage Rd., South Portland, ME

    2,647± SF restaurant/retail space available for sublease.

    • High‑traffic location next to popular establishments and near Willard Beach
    • Includes existing restaurant FF&E and walk‑in cooler
    • 2,647± SF restaurant/retail space available for sublease
    • 20± off‑street parking spaces
    • Recently renovated bar and seating area
    Updated: Nov 12, 2025
    View details
    Retail Space in Cornerbrook Plaza
    $7 SF/Yr
    12,808 SF

    Retail Space in Cornerbrook Plaza

    343 Gorham Rd, South Portland, ME

    High-performing retail center with flexible space and excellent accessibility.

    • High‑performing retail center in the heart of the Maine Mall area.
    • Excellent visibility and accessibility with convenient access to I‑95 and I‑295.
    • 12,000± SF available with a flexible layout.
    • Can accommodate a wide range of uses (fitness, indoor playgrounds, escape rooms, recreational concepts, and specialty retail).
    • Strong mix of national and regional tenants including Panera Bread, Talbots, U.S. Cellular, and Massage Envy.
    Updated: Sep 18, 2025
    View details
    Freestanding Building at Cash Corner
    $27 SF/Yr
    1,440 SF

    Freestanding Building at Cash Corner

    Freestanding building in high-traffic area with parking and yard space.

    1422 Broadway, South Portland, ME
    View details
    Office Space in John Roberts
    $15 SF/Yr
    10,000 SF

    Office Space in John Roberts

    Class A office space available for rent in South Portland.

    9 Donald B Dean Dr, South Portland, ME
    View details
    Class A Office/Medical Building
    $13 SF/Yr
    4,646 SF

    Class A Office/Medical Building

    Class A office/medical building with suites available for lease.

    175 Running Hill Road, South Portland, ME
    View details
    Industrial Space with LED Lighting
    $8 SF/Yr
    28,800 SF

    Industrial Space with LED Lighting

    28,800+/- sq ft industrial space for lease.

    155 Rumery St, South Portland, ME
    View details
    Class-A Office Suite For Lease
    $16 SF/Yr
    5,121 SF

    Class-A Office Suite For Lease

    Full-floor office suite in South Portland's Maine Mall area.

    30 Long Creek Dr, South Portland, ME
    View details
    South Portland Office Space Available
    $16 SF/Yr
    6,321 SF

    South Portland Office Space Available

    Office space for lease near Maine Mall and Portland Jetport.

    311 Darling Ave, South Portland, ME
    View details
    Retail Space Near Maine Mall
    $23 SF/Yr
    1,054 SF

    Retail Space Near Maine Mall

    Retail space with high visibility and ample parking available for lease.

    29 Western Ave, South Portland, ME
    View details
    South Portland Industrial Flex Space
    $2,350/Mo
    1,875 SF

    South Portland Industrial Flex Space

    Flexible industrial space in South Portland, minutes from I-295.

    130 Thadeus St, South Portland, ME
    View details
    Class A Office Space Available
    Contact for pricing
    1,323 SF

    Class A Office Space Available

    Class A office building with ample parking and professional landscaping.

    778 Main Street, South Portland, ME 4106
    View details
    South Portland Retail/Office Opportunity
    Contact for pricing
    11,890 SF

    South Portland Retail/Office Opportunity

    Modern, adaptable space in high-traffic Maine Mall area.

    264 Gorham Rd, South Portland, ME
    View details
    Industrial Building Near Maine Mall
    $15 SF/Yr
    5,700 SF

    Industrial Building Near Maine Mall

    5,700± SF industrial building with office space for lease.

    2092 Broadway, South Portland, ME
    View details
    South Portland Industrial/Flex Space
    $7 SF/Yr
    2,400 SF

    South Portland Industrial/Flex Space

    2,400± SF industrial/flex space for lease in South Portland.

    1 Runway Rd, South Portland, ME 4106
    View details
    Updated Medical Spa Space Available
    $20 SF/Yr
    4,200 SF

    Updated Medical Spa Space Available

    Recently updated medical spa, salon, or medical space for lease.

    198 Maine Mall Rd, South Portland, ME 4106
    View details
    Class A Office Sublease Available
    $15 SF/Yr
    7,599 SF

    Class A Office Sublease Available

    7,599±SF Class A office space for sublease in South Portland.

    500 Southborough Dr, South Portland, ME
    View details
    Freestanding Restaurant/Retail Building in Maine
    Contact for pricing
    6,250 SF

    Freestanding Restaurant/Retail Building in Maine

    6,250 SF restaurant/retail building in Maine Mall trade area.

    465 Maine Mall Rd, South Portland, ME 4106
    View details
    Maine Mall Retail Space Available
    Contact for pricing
    4,768 SF

    Maine Mall Retail Space Available

    Retail space near Maine Mall, suitable for various businesses.

    50 Maine Mall Rd, South Portland, ME 4106
    View details
    Industrial Facility with Modern Office
    Contact for pricing
    10,654 SF

    Industrial Facility with Modern Office

    Well-maintained industrial and office space near I-95 and Jetport.

    76 Darling Ave, South Portland, ME 4106
    View details
    Retail/Office Space For Lease
    $24 SF/Yr
    1,700 SF

    Retail/Office Space For Lease

    Retail/office space in high-traffic South Portland location.

    209 Western Ave, South Portland, ME
    View details
    South Portland Office Space Available
    Contact for pricing
    2,601 SF

    South Portland Office Space Available

    Class A office space for lease near I-95 and I-295.

    324 Cummings Rd, South Portland, ME
    View details
    Corner Office Suite For Rent
    $14 SF/Yr
    4,040 SF

    Corner Office Suite For Rent

    4,040± SF office suite with ample free parking.

    202 Gannett Dr, South Portland, ME
    View details
    Class A Office Suite Available
    $13 SF/Yr
    3,765 SF

    Class A Office Suite Available

    3,765 SF office suite for lease in South Portland.

    82 Running Hill Road, South Portland, ME 4106
    View details
    South Portland Office Space Available
    $10 SF/Yr
    1,812 SF

    South Portland Office Space Available

    Office space for lease in landmark South Portland building.

    100 Brickhill Avenue, South Portland, ME
    View details

    South Portland, ME Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in South Portland, ME with 54 listings featured on our commercial real estate exchange. The current inventory includes 339,444 square feet of properties with an estimated lease value of $501 /Mo.

    Estimated lease rates for Commercial real estate in South Portland, ME begin at $7 SF/Yr, with an average of $16 SF/Yr and extend to $28 SF/Yr.
    List
    Map

    Browse Commercial real estate for Lease Near South Portland, ME

    Popular Searches in South Portland, ME

    Popular Categories

    Most Searched ZIP Codes in South Portland, ME

    • 04106
    • 04101

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!