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    South Portland, ME Office Spaces for Sale

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    Portland, ME Falmouth, ME Cape Elizabeth, ME
    7 results
    Mixed-Use Property in South Portland
    $560,000
    0.23 Acres
    Mixed-Use Property in South Portland

    854 Broadway, South Portland, ME 04106

    Mixed-use property with office spaces and apartment in South Portland.
    • Mixed‑use property in a highly visible location on a popular commuter street.
    • Immaculate 1‑bedroom apartment on the 3rd floor featuring 2 egresses, cherry cabinets, and granite counters.
    • Two first‑floor office spaces with separate entries and beautiful hardwood floors.
    • Four individual offices on the second floor.
    • Detached 1‑car garage leased year‑round.
    Updated: Apr 15
    View details
    Mixed-Use Property on Broadway
    $560,000
    4,370 SF
    Mixed-Use Property on Broadway

    854 Broadway, South Portland, ME 04106

    Highly visible mixed-use property in South Portland, Maine.
    • Mixed‑use property in a highly visible location on a popular commuter street.
    • Immaculate 1‑bedroom apartment on the 3rd floor with cherry cabinets and granite counters.
    • Two first‑floor office spaces with separate entries and hardwood floors.
    • Four individual offices on the second floor.
    • Detached 1‑car garage leased year‑round.
    Updated: Oct 30, 2025
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    South Portland Medical Investment Opportunity
    $4,327,286
    7,424 SF
    South Portland Medical Investment Opportunity

    Long-term NNN investment with a strong healthcare tenant.

    254 Western Ave, South Portland, ME

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    Professional Condo Near Maine Mall
    $925,000
    4,530 SF
    Professional Condo Near Maine Mall

    Office space ideal for medical, dental, wellness, or clinical services.

    25B Long Creek Drive, South Portland, ME 4106

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    Medical Outpatient Portfolio For Sale
    $1,154,664
    4,952 SF
    Medical Outpatient Portfolio For Sale

    Two-property medical portfolio fully leased to Straine Dental Management.

    25 Long Creek Drive, South Portland, ME 4106

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    Office Space Near Maine Mall
    $3,800,000
    2,495 SF
    Office Space Near Maine Mall

    2,495 SF mixed-use/office space near Maine Mall.

    244 Western Ave, South Portland, ME 4106

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    Medical Office Space For Sale
    $3,800,000
    19,188 SF
    Medical Office Space For Sale

    19,188 SF medical office space on 2.61 acres.

    244 Western Ave, South Portland, ME 4106

    View details
    Based on your search, we've compiled 167 Potential Opportunities for your consideration. Besides 7 Active listings in South Portland, ME, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 152 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Portland Mixed-Use Income Property
    $875,000
    3,948 SF
    Portland Mixed-Use Income Property

    Well-maintained mixed-use property with retail and residential units.

    777 Forest Avenue, Portland, ME 04103

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    Portland Flex Space For Sale
    $750,000
    2,764 SF
    Portland Flex Space For Sale

    Flex space available for sale in Portland, Maine.

    429 Deering Avenue, Portland, ME 4103

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    Class A Office Building For Sale
    $4,595,000
    1,000 SF
    Class A Office Building For Sale

    Class A office building in a rapidly developing commercial corridor.

    202 Larrabee Road, Westbrook, ME 4092

    View details
    Westbrook Industrial Distribution/Headquarters Opportunity
    $8,750,000
    61,120 SF
    Westbrook Industrial Distribution/Headquarters Opportunity

    61,000+ SF turnkey industrial building near Portland Jetport.

    41 Eisenhower Dr, Westbrook, ME 4092

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Waterfront Land with Harbor Views
    $999,000
    4,791 SF
    Waterfront Land with Harbor Views

    Waterfront land with dock, boathouse, and utilities in place.

    22 Boathouse Way, Portland, ME 4108

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    Falmouth Land with Approved Plans
    $395,000
    20,037 SF
    Falmouth Land with Approved Plans

    Cleared lot with approved plans for mixed-use development.

    6-8 Bluebird Trail, Falmouth, ME 4105

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    Windham Commercial Land For Sale
    $1,800,000
    6,000 SF
    Windham Commercial Land For Sale

    Three lots totaling over 16 acres on Roosevelt Trail.

    30, 32, 34 Roosevelt Trail, Windham, ME 04062

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    3.2 Acres on Route 1
    $895,000
    139,392.00 Acres
    3.2 Acres on Route 1

    3.2 acres on Route 1 in Biddeford, Maine.

    532 Elm Street, US Route 1, Biddeford, ME 04005

    View details

    Off-Market Properties in South Portland, ME

    Consider similar Off-Market properties in South Portland, ME. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    13 Ocean St

    13 Ocean St

    OFFICE BUILDING • 3,729 SF
    Value Estimation
    $725,000
    13 Ocean St, South Portland, ME 04106-2888
    View details
    324 Gannett Dr

    324 Gannett Dr

    OFFICE BUILDING • 26,118 SF
    Value Estimation
    $4,540,000
    324 Gannett Dr, South Portland, ME 04106-3270
    View details
    884 Broadway

    884 Broadway

    OFFICE BUILDING • 3,862 SF
    Value Estimation
    $500,000
    884 Broadway, South Portland, ME 04106-4371
    View details
    72 Ocean St Ste, Unit 105

    72 Ocean St Ste, Unit 105

    CONDOMINIUM OFFICES • 1,620 SF
    Value Estimation by Request
    72 Ocean St Ste, South Portland, ME 04106-2840
    View details
    160 Western Ave

    160 Western Ave

    OFFICE BUILDING • 11,025 SF
    Value Estimation
    $2,950,000
    160 Western Ave, South Portland, ME 04106-2414
    View details
    210 Western Ave, Unit C

    210 Western Ave, Unit C

    CONDOMINIUM OFFICES • 3,300 SF
    Value Estimation
    $525,000
    210 Western Ave, South Portland, ME 04106-2424
    View details
    1006 Broadway

    1006 Broadway

    OFFICE BUILDING • 1,280 SF
    Value Estimation by Request
    1006 Broadway, South Portland, ME 04106-4205
    View details
    100 Main St

    100 Main St

    OFFICE BUILDING • 2,400 SF
    Value Estimation
    $2,000,000
    100 Main St, South Portland, ME 04106-2620
    View details
    345 Cottage Rd

    345 Cottage Rd

    OFFICE BUILDING • 1,612 SF
    Value Estimation by Request
    345 Cottage Rd, South Portland, ME 04106-3919
    View details
    138 Ocean St

    138 Ocean St

    OFFICE BUILDING • 3,407 SF
    Value Estimation
    $690,000
    138 Ocean St, South Portland, ME 04106-3652
    View details
    429 Preble St, Unit 1

    429 Preble St, Unit 1

    CONDOMINIUM OFFICES • 400 SF
    Value Estimation by Request
    429 Preble St, South Portland, ME 04106-3034
    View details
    373 Broadway

    373 Broadway

    OFFICE BUILDING • 3,786 SF
    Value Estimation
    $845,000
    373 Broadway, South Portland, ME 04106-2952
    View details
    75 Dartmouth St

    75 Dartmouth St

    OFFICE BUILDING • 5,086 SF
    Value Estimation
    $700,000
    75 Dartmouth St, South Portland, ME 04106-6211
    View details
    210 Western Ave, Unit A2

    210 Western Ave, Unit A2

    CONDOMINIUM OFFICES • 1,650 SF
    Value Estimation by Request
    210 Western Ave, South Portland, ME 04106-2424
    View details
    14 Gary L Maietta Pkwy

    14 Gary L Maietta Pkwy

    OFFICE BUILDING • 1,820 SF
    Value Estimation by Request
    14 Gary L Maietta Pkwy, South Portland, ME 04106-7816
    View details
    39 Wallace Ave

    39 Wallace Ave

    OFFICE BUILDING • 18,740 SF
    Value Estimation
    $2,155,000
    39 Wallace Ave, South Portland, ME 04106-6143
    View details
    241 Running Hl Rd

    241 Running Hl Rd

    OFFICE BUILDING • 6,257 SF
    Value Estimation
    $1,840,000
    241 Running Hl Rd, South Portland, ME 04106-3220
    View details

    South Portland, ME Office Spaces Investment Opportunities Market Analysis

    Explore 159 office spaces for sale in South Portland, ME, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 42,959 square feet of properties for sale, with an estimated market value of $14,566,950.

    Sale prices for office spaces in South Portland, ME start at $560,000, averaging $2,427,825, and reaching up to $4,327,286 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Office Units 25
    Medical Office Space 6
    Office buildings 5

    Property Size Breakdown

    The majority of commercial real estate listings in South Portland fall within the 100,000+ square foot range.

    Demographics Overview

    Population 27K
    Population Growth (5Y) +4.4%
    Median Household Income $83,744
    College Educated 33.5%

    High-Yield Neighborhoods for Strategic Investment

    Identify South Portland submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    04106 $1.8M

    Taxes & Financing

    Tax Rate (average for all types) 1.41%
    Property Tax per SF $23.17 per sq ft
    Tax Rate vs County Average 0.10 pp below county avg
    Average Loan-to-Value 65.0%

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