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    San Diego, CA Office Spaces for Lease

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    Found 558 office space listings for lease in San Diego, CA, averaging $21/SF/YR. Use lease type data to compare options faster.
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    Office Building for Lease
    Office Building for Lease

    9925 Pacific Heights Blvd., San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    696–1,160 people  174,000 sqft  Built 2026

    Office building offered for lease at 9925 Pacific Heights Blvd., with approximately 174,000 square feet.

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    Law Firm Office Suite
    Law Firm Office Suite

    600 B St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    5–8 people  1,273 sqft
    3 private offices  1 meeting room

    Contiguous office suites with reception, three private offices, a conference room, and break area.

    Reception  Break area
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    Class A Office Building with Conference Center
    Class A Office Building with Conference Center

    750 B St, San Diego, CA 92101

    Full service Class A Core-Columbia
    Contact for pricing
    22–37 people  1 space  5,634 sqft  34-story

    Downtown San Diego Class A high-rise with a 12th-floor sky conference center and tenant amenities including EV charging and 24/7 security.

    Valet parking  EV charging stations  24/7 security  Sky Conference Center
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    Class A High-Rise Office Building
    Class A High-Rise Office Building

    750 B St, San Diego, CA 92101

    Full service Class A Core-Columbia
    Contact for pricing
    8–14 people  1 space  2,206 sqft  34-story

    Class A office tower with floor-to-ceiling windows, EV charging, 24/7 security, and a 32-person conference center.

    Valet parking  EV charging stations  24/7 security  Sky Conference Center
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    Serviced Office Suite in Downtown Tower
    Serviced Office Suite in Downtown Tower

    501 W. Broadway, San Diego, CA 92101

    Coworking Gaslamp
    Contact for pricing
    396–660 people  99,113 sqft  Built 2026  21-story

    Serviced office suite with arched entry, atrium lobby, and marble finishes in a 21-story downtown high-rise.

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    Office Units with Private Offices
    Office Units with Private Offices

    3323 Carmel Mountain Rd, San Diego, CA 92121

    Torrey Preserve
    Contact for pricing
    13–21 people  3,250 sqft

    Office units with open office and private offices, plus restroom and utility/stairwell; available Feb 1, 2027.

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    Office Suite with Built-In Amenities
    Office Suite with Built-In Amenities

    7676 Hazard Center Dr, San Diego, CA 92108

    Full service Mission Valley East
    Contact for pricing
    10–16 people  1 space  2,533 sqft

    Office suite offering 24-hour access, conferencing facilities, and on-site convenience retail and fitness options.

    24 Hour Access  Bus Line  Conferencing Facility  Convenience Store
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    Second-Floor Creative Event Space
    Second-Floor Creative Event Space

    3451-3465 El Cajon Blvd, San Diego, CA 92104

    Gross Corridor
    Contact for pricing
    19–32 people  1 space  4,909 sqft

    Recently renovated creative office and event space on the second floor with 20-foot ceilings.

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    Science District Office and Lab Campus
    Science District Office and Lab Campus

    10581 Roselle St., San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    22–36 people  5,528 sqft  Multi-tenant

    Four clustered campus provides flexible office and lab space within a life sciences science district.

    The Craft Taco  New English Brewing  The Coffee Cart  Conferencing & Event Spaces
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    Standalone Flex Creative R&D Building
    Standalone Flex Creative R&D Building

    9800 Campus Point Dr, San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    96,500 sqft

    Standalone flex/creative/R&D building offers a mix of office and flex/industrial space with secure, controlled-access campus setting.

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    Flexible Office and Lab Space
    Flexible Office and Lab Space

    11555 Sorrento Valley Rd, San Diego, CA 92121

    Torrey Pines
    Contact for pricing
    14–24 people  3,740 sqft

    Office units within the SOVA Science District campus with conferencing, outdoor collaboration areas, and fitness amenities.

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    Office Suite with Conference Room
    Office Suite with Conference Room

    600 B St, San Diego, CA 92101

    Core-Columbia
    Contact for pricing
    7–11 people  1,790 sqft
    3 private offices  1 meeting room

    Suite includes three private window-lined offices and a conference room.

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    La Jolla Executive Office Space
    La Jolla Executive Office Space

    4225 Executive Sq, La Jolla, CA 92037

    Contact for pricing
    17–28 people  4,343 sqft

    Executive office space available for lease in La Jolla, CA.

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    Medical Office Space with 24/7 Access
    Medical Office Space with 24/7 Access

    2131 3rd Ave, San Diego, CA 92101

    Park West
    Contact for pricing
    1,905 sqft

    Medical office suite in a new development featuring 24/7 controlled access and advanced security.

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    Office Building for Lease
    Office Building for Lease

    4909 Murphy Canyon Rd, San Diego, CA 92123

    Kearny Mesa
    Contact for pricing
    20–33 people  1 space  5,000 sqft

    Office building available for lease at 4909 Murphy Canyon Rd in San Diego.

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    Creative Office Space with Amenities
    Creative Office Space with Amenities

    10065 Barnes Canyon Rd, San Diego, CA 92121

    Class A Sorrento Valley
    Contact for pricing
    71–119 people  17,939 sqft

    A 17,939-square-foot creative workspace within a WiredScore Platinum campus offering fitness, recreation, and dining amenities.

    Indoor/outdoor fitness center  Amenity Park  Sport courts & fields  Dining options
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    Creative Office Suite with Shower
    Creative Office Suite with Shower

    11021 Via Frontera, San Diego, CA 92127

    Rancho Bernardo
    Contact for pricing
    46–76 people  11,539 sqft

    Creative office suite offering nine private offices, a large conference room, and a shower.

    Private offices  Conference room  Shower
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    Life Sciences Office and Lab Space
    Life Sciences Office and Lab Space

    10581 Roselle St., San Diego, CA 92121

    Sorrento Valley
    Contact for pricing
    22–36 people  5,541 sqft  Multi-tenant

    Flexible office and lab spaces within a multi-cluster science district campus in San Diego.

    The Craft Taco  New English Brewing  The Coffee Cart  Conferencing & Event Spaces
    View details
    Corner Medical Office Suite
    Corner Medical Office Suite

    11230 Sorrento Valley Road, San Diego, CA 92121

    Torrey Pines
    Contact for pricing
    15–25 people  3 spaces  3,889 sqft

    Corner suite features glass-lined reception, double-door entry, and multiple private offices with conference rooms.

    Furnished  Outdoor picnic area  Showers and locker rooms
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    Creative Space with Ocean Views
    Creative Space with Ocean Views

    3344 North Torrey Pines Court, Suite 110, La Jolla, CA 92037

    Contact for pricing
    36–60 people  9,090 sqft

    Tastefully designed creative space with ocean views available for sublease.

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    Ground-Floor Office Suite
    Ground-Floor Office Suite

    750 B St, San Diego, CA 92101

    Full service Class A Core-Columbia
    Contact for pricing
    26–44 people  1 space  6,653 sqft  34-story

    Ground-floor former bank space with traditional finishes in a Class A downtown office building.

    Expansive floor-to-ceiling windows  Valet parking  EV charging stations  24/7 security
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    Office Suite with Operable Windows
    Office Suite with Operable Windows

    7777 Fay Ave, La Jolla, CA 92037

    Contact for pricing
    10–16 people  2,548 sqft

    Suite includes nine offices, conference room, reception area, kitchen, storage, balconies, and operable windows.

    Conference room  Reception  Kitchen  Storage
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    Office Space Available For Rent
    Office Space Available For Rent

    2851 S Camino Del Rio, San Diego, CA 92116

    Mission Valley East
    Contact for pricing
    10–16 people  2,509 sqft

    Office space available for lease in San Diego, CA.

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    Move-In Ready Retail or Office
    Move-In Ready Retail or Office

    7606 Girard Ave, La Jolla, CA 92037

    Triple net (NNN)
    Contact for pricing
    786 sqft
    25,000 VPD

    Move-in ready space on Girard Ave with strong visibility near a major La Jolla intersection.

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