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San Diego, CA Office Spaces for Lease

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Found 558 office space listings for lease in San Diego, CA, averaging $21/SF/YR. Use lease type data to compare options faster.
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Rancho Bernardo Office Space Available
Rancho Bernardo Office Space Available

10805-10815 Rancho Bernardo Rd, San Diego, CA 92127

Black Mountain Ranch
Contact for pricing
132–220 people  33,054 sqft

Available office space in Rancho Bernardo, San Diego.

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Sorrento Mesa Office Space
Sorrento Mesa Office Space

5405 Morehouse Dr, San Diego, CA 92121

Sorrento Valley
Contact for pricing
24–40 people  6,126 sqft

Office space available for rent in Sorrento Mesa.

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Sorrento Valley Road Office Space
Sorrento Valley Road Office Space

10665 Sorrento Valley Road, San Diego, CA 92121

Sorrento Valley
Contact for pricing
152–254 people  38,208 sqft

Office space available for rent in Sorrento Valley, San Diego.

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La Jolla First Floor Office
La Jolla First Floor Office

San Diego, CA

Full service Little Italy
Contact for pricing
7–11 people  7 spaces  1,782 sqft  3.45 acres

First floor office space available for rent in La Jolla.

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Office Suite with Private Offices
Office Suite with Private Offices

101 W Broadway, San Diego, CA 92101

Horton Plaza
Contact for pricing
9–15 people  2,290 sqft
3 private offices

Second-generation office space featuring three private offices along the window line and an open workstation area.

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Office Space Available For Rent
Office Space Available For Rent

4939 Directors Place, San Diego, CA 92121

Sorrento Valley
Contact for pricing
248–413 people  62,082 sqft

62,082 square foot office space available for rent.

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Second-Floor Office Suite
Second-Floor Office Suite

1621 Grand Ave, San Diego, CA 92109

Mission Bay
Contact for pricing

Second-floor office space offered as one suite or combined into a larger 3,000 SF option, with off-street parking.

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Office Space Near San Diego Airport
Office Space Near San Diego Airport

4990 North Harbor Drive, San Diego, CA 92106

Roseville / Fleet Ridge
Contact for pricing
7–11 people  1,754 sqft

Office space for rent with immediate airport and I-5 access.

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Class A Office Building
Class A Office Building

701 B St, San Diego, CA 92101

Core-Columbia
Contact for pricing
94–157 people  23,620 sqft

24-story Class A office building with bay views.

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San Diego Office Space Available
San Diego Office Space Available

4250 Pacific Highway, San Diego, CA 92110

Midway District
Contact for pricing
257–428 people  64,277 sqft

Office space available for lease in San Diego, CA.

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Downtown San Diego Office Space
Downtown San Diego Office Space

610 W Ash St, San Diego, CA 92101

Little Italy
Contact for pricing
244–407 people  61,062 sqft

61062 SF office space available for lease.

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Office Suite with Large Patio
Office Suite with Large Patio

16707 Via Del Campo Ct, San Diego, CA 92127

Triple net (NNN) Rancho Bernardo
Contact for pricing
108–180 people  1 space  27,046 sqft

3rd-floor office suite offers a large patio with valley views and 10-foot ceilings.

Patio
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Fully Furnished Electronics Lab Office
Fully Furnished Electronics Lab Office

12121 Scripps Summit Dr, San Diego, CA 92131

Miramar Ranch North
Contact for pricing
57–95 people  1 space  14,362 sqft

Office space is fully furnished and set up for small electronics lab use with plug-and-play functionality.

Furnished  Small electronics lab
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La Jolla Medical Office Space
La Jolla Medical Office Space

5726 La Jolla Blvd, La Jolla, CA

Triple net (NNN)
Contact for pricing
1,500 sqft  0.52 acres

Turn-key medical office in La Jolla's Bird Rock community.

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Office/Medical Space for Lease
Office/Medical Space for Lease

5106 Federal Blvd., #201, San Diego, CA 92105

Oak Park
$21 SF/Yr
Built 2026

Office and medical space with updated finishes and free parking.

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Office Space Available For Rent
Office Space Available For Rent

10240 Flanders Court, San Diego, CA 92121

Sorrento Valley
Contact for pricing
128–214 people  32,236 sqft

Office space available for lease in San Diego, CA.

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Office Flex Building
Office Flex Building

7473 Lusk Boulevard, San Diego, CA 92121

Sorrento Valley
Contact for pricing
44,006 sqft

Flex space offering 34 offices, 15 conference rooms, and two labs within a 190-cube setup.

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Office Space Available For Rent
Office Space Available For Rent

11455 El Camino Real, San Diego, CA 92130

Torrey Preserve
Contact for pricing
60–100 people  15,084 sqft

Office space available for lease in San Diego, CA.

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Office Space with Canyon Views
Office Space with Canyon Views

9444 Waples St., San Diego, CA 92121

Sorrento Valley
Contact for pricing
109–182 people  8 spaces  27,379 sqft  Built 2026

Office space featuring private offices, open area, and canyon views.

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Sorrento Valley Office Space
Sorrento Valley Office Space

4115 Sorrento Valley Blvd, San Diego, CA

Sorrento Valley
Contact for pricing
24–40 people  1 space  6,000 sqft  2.72 acres

6,000 SF office space available for rent.

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Class A Office Space
Class A Office Space

13520 Evening Creek Dr N, San Diego, CA 92128

Class A Sabre Springs
Contact for pricing
10–17 people  2,689 sqft
Public transit

State-of-the-art Class A office with outdoor meeting areas, on-site management, and EV charging.

4.0/1,000 SF parking  Fitness center  Shower and locker facilities  Outdoor meeting areas
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Office Space Available For Rent
Office Space Available For Rent

10935 Vista Sorrento Parkway, San Diego, CA 92130

Torrey Pines
Contact for pricing
260–434 people  65,123 sqft

Office building with 65,123 square feet available for rent.

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Prestigious Office Space in San Diego
Prestigious Office Space in San Diego

5050 Murphy Canyon Rd., San Diego, CA 92123

Kearny Mesa
Contact for pricing

Exceptional leasing opportunity in vibrant Kearny Mesa district.

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Office Space with I-8 Signage
Office Space with I-8 Signage

2820 Camino Del Rio S |, San Diego, CA 92108

Mission Valley East
Contact for pricing
188–313 people  2 spaces  47,000 sqft  Built 1982

Office property available for rent with prominent Interstate signage.

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