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Stand Alone Medical Office Building

4101 Main St Suite E & F Hilton Head Island, SC 29926

4101 Main St Suite E & F, Hilton Head Island, SC, 29926

$1,348,000

For Sale

$1,348,000

Stand-alone medical building on Hilton Head Island, ready for occupancy.

Property Size3,600 SF

Price / SF$374.44

AddedJan 27

Days on Market169

Last RefreshJul 8 at 4:46 pm

Property Features for 4101 Main St Suite E & F

General Information

Standard status: Active
Size: 3,600 SF
Property subtype: Medical & Office Building

Building Details

Year Built: 2001

Listing office Charter I Commercial

Listing date Jan 27, 2026

Source Naiglobal

Displayed information is deemed reliable but is not guaranteed and should be independently verified.

All listing content including descriptions, pricing, images are the copyrighted material of Charter I Commercial

Investment Insights

Based on property information with market context.

This stand-alone medical office building is located on Main Street on the north end of Hilton Head Island, just off Highway 278. The property offers convenient access to Hilton Head Hospital, the surrounding professional area, and nearby Bluffton. The ground-floor layout includes multiple exam rooms, a waiting area, and private offices. Plumbing is in place for additional exam or treatment rooms. With a size of 3600 square feet, this recently vacated building is ready for immediate tenant improvements or occupancy. It presents an ideal setting for medical or wellness users seeking a convenient and professional island location.

Key Highlights

Stand‑alone medical building on Hilton Head Island.
Prime location on Main Street, north end of Hilton Head, with easy access to Highway 278.
Proximity to Hilton Head Hospital and surrounding professional area.

Local Financial Insights For Healthcare Medical

Simulate Cap Rate and NOI

NOI Build-Up

Component	$	$/SF
Gross rent	$108.0k	$30.00
− Vacancy	−$11.3k	−$3.15
EGI	$96.7k	$26.85
− OpEx	−$38.7k	−$10.74
NOI	$58.0k	$16.11

3,600 SF · lease $30.00/SF/yr · vacancy 10.50% · expense 40.00%

Alternative Uses

Best Use

Healthcare Medical

$828.5K

$725.0K – $966.6K (±1% cap)

NOI $57,996 @ 7.0% cap · market cap 4.30%

Second Best

Office B

$708.2K

$619.7K – $826.2K (±1% cap)

NOI $49,572 @ 7.0% cap · market cap 3.68%

Theoretical Best

Office A

$1.09M

$950.4K – $1.27M (±1% cap)

NOI $76,032 @ 7.0% cap · market cap 5.64%

Zoning and permitted uses should be independently verified with local authorities.

Property Analytics

Property Profile Location Intelligence

Current Use by Public Records

Discover Specific Chiropractic Alternative Medicine Practice Tracee Spencer Hair Hair Salon Movement Mortgage Loan Service Dr. Hannah Bannon Physician Matthew Mastrorocco, DMD Dental Office

Suggested Use

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For sale
Medical Office Space
SC
Hilton Head Island
29926
4101 Main St Suites E & F

What type of property is this?

Medical Office Space - Stand-alone medical building on Hilton Head Island, ready for occupancy.

Where is this medical office space located?

The property is located at 4101 Main St Suite E & F Hilton Head Island, SC.

What is the asking price?

The asking price for this property is $1,348,000.

What are key features of this property?

This property features: Stand‑alone medical building on Hilton Head Island.; Prime location on Main Street, north end of Hilton Head, with easy access to Highway 278.; Proximity to Hilton Head Hospital and surrounding professional area.