Medical Space

Boerne, TX Medical Office Space for Lease

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Retail and Office Space on Main Street
Updated: Jun 1
Retail and Office Space on Main Street

101-1109 S Main St, Boerne, TX 78006

$3,000/Mo
4,575 sqft
Versatile commercial space on highly visible S Main Street with strong signage opportunities
Flexible layout suited for a variety of customer‑facing uses
Prominent street frontage for businesses seeking high exposure
Suitable for professional office, wine tasting room, medical or wellness office, boutique retail, or specialty business
Convenient access for customers and clients
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Boerne Retail/Office Space For Rent
Updated: Nov 25, 2025
Boerne Retail/Office Space For Rent

1100 N. Main, Boerne, TX 78006

Contact for pricing
Great exposure and access
Ample Parking
Suitable for medical/office service and traditional retail
Monument Sign available
Tilt Wall Construction informs about durability
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Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 2 Active listings in Boerne, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office or Retail Suite
Medical Office or Retail Suite

2-1036 E Borgfeld Dr, San Antonio, TX 78260

$4,000/Mo
1,200 sqft 0.65 AC lot

Approximately 1,500 sq-ft suite is available within a multi-tenant building, suited for medical office or retail use.

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Dental Office and End Cap Retail
Dental Office and End Cap Retail

23522 Wilderness Oak, San Antonio, TX 78258

Contact for pricing
1,400 sqft

Two 2nd-generation suites are available: 1,400 SF dental space and 1,300 SF end cap retail space.

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Medical Office Space
Medical Office Space

8230 N Loop 1604 W, San Antonio, TX 78249

Contact for pricing
5,243 sqft

Class A medical office building near restaurants, retailers, and a Baptist emergency hospital.

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Class A Medical Office Building
Class A Medical Office Building

8230 N Loop 1604 W, San Antonio, TX 78249

Contact for pricing
1,468 sqft

Class A medical office building near UTSA and an adjacent Baptist emergency hospital.

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Similar Spaces for Sale in Boerne, TX

Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

Single-Story Office Building
Single-Story Office Building

124 E Bandera Rd, Boerne, TX 78006

Contact for pricing
5,400 sqft

Configured as four office condominium units with an established medical-management occupant.

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Finished Office Unit
Finished Office Unit

5 Coughran Unit 304, Boerne, TX 78006

Contact for pricing
1,504 sqft

Office unit with planned owner-completed interior improvements and convenient highway access.

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Boerne Office Building For Sale
Boerne Office Building For Sale

27511 Interstate 10, Building 6, Boerne, TX 78006

Contact for pricing
4,868 sqft 2.31 AC lot

Turn-key office space in high-traffic area near I-10.

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Boerne Medical Outpatient Building
Boerne Medical Outpatient Building

112 HERFF RD, Boerne, TX 78006

Contact for pricing
52,410 sqft

Class A medical building in Boerne, Texas, for sale.

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Boerne, TX Medical Office Space Lease Rates & Market Statistics

Explore 2 Medical Office Space listings for lease in Boerne, TX on Realmo, a commercial real estate exchange covering the Boerne area. The current inventory totals 4,575 square feet of properties.

Medical Office Space lease rates in Boerne range from $7.87 SF/Yr at the entry level to $7.87 SF/Yr at the top of the market, averaging $7.87 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $7.87 SF/Yr, the local average runs 68% below Texas's state average of $24.31 SF/Yr.

Boerne accounts for 100% of the 2 medical office space listings currently available across Kendall County. Medical Office Space is one of the more limited space types in Boerne, with just 2 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (22 listings) and Office buildings (3 listings) elsewhere in the Boerne market.

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