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    Durham County, NC Medical Office Space for Lease

    10 results
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    Versatile Office/Medical Space Available
    $3,000 / Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke St, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
    View details
    Prime Medical Office Space Available
    Pending
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    2609 N Duke St Unit Bldg 300, Durham, NC 27704

    Versatile medical/office space in Durham's thriving North Duke corridor.

    • Prime medical/office space in a highly sought‑after location on Durham's North Duke Street corridor.
    • Excellent visibility and easy access to major roads and highways.
    • Dedicated parking with ample spaces for clients and staff.
    • Versatile space ideal for medical, dental, or general office use.
    • Includes reception area, private offices, conference rooms, and ADA‑compliant restrooms.
    Updated: Jul 30, 2025
    View details
    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N Roxboro St, Durham, NC 27704
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    Durham Medical/Office Building for Lease
    $23 SF/Yr
    4,769 SF

    Durham Medical/Office Building for Lease

    Freestanding 4,769 SF building suitable for medical or office use.

    110 E Carver St, Durham, NC 27704
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    Class A Office Space
    $23 SF/Yr
    79,440 SF

    Class A Office Space

    Class A office space for lease in North Durham.

    4321 Medical Park Dr, Durham, NC 27704
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    Office/Medical Building Near Southpoint Mall
    $26 SF/Yr
    18,395 SF

    Office/Medical Building Near Southpoint Mall

    Single-story office/medical building near Southpoint Mall available for lease.

    5501 Fortunes Ridge Dr, Durham, NC 27713
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    Medical Office Space in Durham
    $23 SF/Yr
    5,986 SF

    Medical Office Space in Durham

    Dental specialist office space for lease near Duke University/Hospital.

    1212 Broad St, Durham, NC 27705
    View details
    Madison Centre Executive Suites
    $26 SF/Yr
    9,992 SF

    Madison Centre Executive Suites

    Durham Office Space, 1,000 SF Available

    1804 Martin Luther King Jr Pkwy, Durham, NC 27707
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    Durham Medical Office Suite for Lease/Sale
    Contact for pricing
    3,037 SF

    Durham Medical Office Suite for Lease/Sale

    Prime Durham medical office space available.

    249 Nc Highway 54, Durham, NC 27713
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    Durham Medical Office Condos for Lease
    Contact for pricing
    41,558 SF

    Durham Medical Office Condos for Lease

    Modern medical suites, North Durham, NC

    4020 Roxboro St, Durham, NC 27704
    View details
    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 10 Active listings in Durham County, NC, we suggest exploring alternatives. Similar 8 Properties for Sales.

    Explore Similar Spaces for Sale in Durham County, NC

    Consider Similar Space for Sale. We found 8 Spaces in Nearby Locations matching your search parameters.

    Professional Office Condo Near Duke
    $385,000
    1,954 SF

    Professional Office Condo Near Duke

    Office condo in Croasdaile Office Park, convenient location.

    3200 Croasdaile Dr, Durham, NC 27705
    View details
    Colonial Square Office/Medical Building
    $3,499,000
    21,532 SF

    Colonial Square Office/Medical Building

    Multi-functional commercial building in Durham's Independence Park.

    4400 Ben Franklin Blvd, Durham, NC 27704
    View details
    Durham Office Near Highway 85
    Contact for pricing
    1,600 SF

    Durham Office Near Highway 85

    Office property close to Highway 85, Duke, and RTP.

    3219 Guess Rd, Durham, NC 27705
    View details
    Hayti District Office Complex
    $8,000,000
    9,000 SF

    Hayti District Office Complex

    Prime Durham location, 9,000 sq ft, vacant.

    601 Fayetteville St, Durham, NC 27701
    View details
    Durham Medical Office Condo
    $850,000
    3,037 SF

    Durham Medical Office Condo

    Prime Medical Space, 3,037 SF, $850K

    249 Nc Highway 54, Durham, NC 27713
    View details
    Morrisville Office Building - Class A
    Contact for pricing
    35,350 SF

    Morrisville Office Building - Class A

    35,350 SF Office, Prime Location, Vacant

    703 Slater Rd, Morrisville, NC 27560
    View details
    Southpoint Medical Office Investment
    $2,995,000
    8,986 SF

    Southpoint Medical Office Investment

    Durham, NC Medical Office Building - High Occupancy

    249 Nc Hwy 54- –, Durham, NC 27713
    View details
    Durham Medical Office Condos
    Contact for pricing
    41,588 SF

    Durham Medical Office Condos

    Three Class A condos, 2024 renovation

    4020 Roxboro St, Durham, NC 27704
    View details

    Durham County, NC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Durham County, NC with 18 listings featured on our commercial real estate exchange. The current inventory includes 5,475,579,120 square feet of properties with an estimated lease value of $175 SF/Yr.

    Estimated lease rates for Medical Office Space in Durham County, NC begin at $15 SF/Yr, with an average of $21 SF/Yr and extend to $26 SF/Yr.
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    Browse Medical Office Space for Lease Near Durham, NC

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