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Durham County, NC Medical Office Space for Sale

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Charlotte, NC Fayetteville, NC Wilmington, NC

$3,499,000

21,532 SF

Colonial Square Office/Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

Multi-functional commercial building in Durham's Independence Park.

Significant income generation from leased area: $227,739 in 2024.
Large, multi‑functional commercial building with 21,532 total square feet.
Located in a sought‑after office/medical park in northern Durham County.
Flexible space suitable for various professional uses (medical, office, education, law).
Features include an elevator, ample storage, and a loading dock.

Updated: Aug 7, 2025

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25,317 SF

Medical Office & Wellness Center

3017 Pickett Rd, Durham, NC 27705

Medical office and wellness center in high-traffic Durham location.

Rare medical office building with attached fitness/medspa.
Prime re‑positioning opportunity for sale or lease.
Located in a high‑traffic area (approx. 4,200 vehicles daily).
Recently vacated, ready for immediate occupancy/renovation.
Versatile spaces suitable for a variety of medical and wellness services.

Updated: Mar 13

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$750,000

1,600 SF

Durham Office Near Highway 85

Office property close to Highway 85, Duke, and RTP.

3219 Guess, Durham, NC 27705

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41,588 SF

Renovated Medical Office Condos

Newly renovated medical office condos for sale in Durham, NC.

4020 N Roxboro St, Durham, NC 27704

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Based on your search, we've compiled 17 Potential Opportunities for your consideration. Besides 4 Active listings in Durham County, NC, we suggest exploring several alternatives: similar 9 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$1,375,000

2.29 Acres

Cary Parkway Land For Sale

Land available along SW Cary Parkway suitable for various commercial uses.

1016 Kilarney Ridge Loop, Cary, NC 27511

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Jones Dairy Road Land Parcel

Land approved for 49,000 SF medical development.

416 Jones Dairy Road, Wake Forest, NC 27587

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$1,390,000

High Growth Area Land Opportunity

Land suitable for medical offices, daycare, senior living, multi-family.

1200 Granite Falls, Rolesville, NC 27587

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$100,000

0.51 Acres

Cleared Commercial Lots in Oxford

Two commercial lots in downtown Oxford, suitable for various businesses.

209 Broad Street, Oxford, NC 27565

Value Estimation by Request

249 Nc Highway 54, Durham, NC 27713

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Durham County, NC Medical Office Space Investment Opportunities Market Analysis

Explore 13 medical office space for sale in Durham County, NC, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 23,132 square feet of properties for sale, with an estimated market value of $4,249,000.

Sale prices for medical spaces in Durham County, NC start at $750,000, averaging $2,124,500, and reaching up to $3,499,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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