Durham County, NC Medical Office Space for Sale: Buy Medical Spaces Near You

Updated: Aug 7, 2025

Colonial Square Office/Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft · 2.10 AC lot

Significant income generation from leased area: $227,739 in 2024.
Large, multi‑functional commercial building with 21,532 total square feet.
Located in a sought‑after office/medical park in northern Durham County.
Flexible space suitable for various professional uses (medical, office, education, law).
Features include an elevator, ample storage, and a loading dock.

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Updated: Jun 25

Renovated Mixed-Use Restaurant and Offices

2022 Chapel Hill Rd., Durham, NC 27707

$1,700,000

Historic Davis Baking Company building, completely renovated in 2017 into a mixed‑use property
Full‑service restaurant space with a huge kitchen, plus additional cafe space
Rooftop dining patio connected to the dining room via stairs
Second‑floor office space included, with an additional ±1,000 SF unit used as a salon and chiropractic office
Layout could be divided into two separate restaurant concepts with shared large kitchen

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Two-Story Office and Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft

Flexible office and medical facility with elevator, ample storage, and a loading dock, including existing leased area.

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Two-Story Office Building

3621 Lyckan Parkway, Durham, NC 27707

Contact for pricing

12,000 sqft

Two-story, partial-shell office building with infrastructure in place for customized office or medical build-outs.

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Durham Office Near Highway 85

3219 Guess, Durham, NC 27705

$750,000

1,600 sqft

Office property close to Highway 85, Duke, and RTP.

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Medical Office & Wellness Center

3017 Pickett Rd, Durham, NC 27705

Contact for pricing

25,317 sqft

Medical office and wellness center in high-traffic Durham location.

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Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 6 Active listings in Durham County, NC, we suggest exploring several alternatives: similar 9 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Creedmoor Land Near I-85

1495 Concord Church Road, Creedmoor, NC 27522

$369,900

1.05 AC lot

1.0462 acre commercial lot near I-85 in Creedmoor, NC.

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Jones Dairy Road Land Parcel

416 Jones Dairy Road, Wake Forest, NC 27587

Contact for pricing

Land approved for 49,000 SF medical development.

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High Growth Area Land Opportunity

1200 Granite Falls, Rolesville, NC 27587

$1,390,000

Land suitable for medical offices, daycare, senior living, multi-family.

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Commercial Lot in Oxford, NC

College Street, Oxford, NC 27565

$150,000

0.65 AC lot

Commercial lot near Granville Medical Center, ready to build.

Value Estimation by Request

3,037 sqft

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Durham County, NC Medical Office Space Market Trends and Statistics

Explore 15 medical office space for sale in Durham County, NC, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 44,664 square feet of properties for sale, with an estimated market value of $7,748,000.

Sale prices for medical spaces in Durham County, NC start at $750,000, averaging $2,582,666, and reaching up to $3,499,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.