Add Listing
    For Lease
    • For Sale
    • For Lease
    • Sold
    • Property Lookup
    • Brokers
    Back to Search
    The Largest CRE Database in the US with Over 1 Million Listings

    4321 Medical Park Dr Durham, NC 27704

    View on Map
    Claim this Listing
    Loading data...
    Loading data...
    Loading data...
    For Lease
    $23 SF/Yr $152,260/Mo (calc)

    Class A office space for lease in North Durham.

    Type:Office
    Property size:
    79,440 SF
    Added:
    Nov 26, 2025
    Days on Market:
    156
    Last Refresh:
    Apr 5 at 9:25 pm

    Property Features for 4321 Medical Park Dr

    General Information

    Standard status
    Active
    Size
    79,440 SF
    Property subtype
    Office

    Building Details

    Year Built
    2001

    Spaces For Lease

    at 4321 Medical Park Dr Contact us

    We can help!

    Listing Contact
    Brian Farmer
    Brian Farmer

    Listing agent Brian Farmer License #NC #183406

    Listing office Lee & Associates - Raleigh Durham

    Listing date Nov 26, 2025

    Source Lee-associates

    Displayed information is deemed reliable but is not guaranteed and should be independently verified.

    All listing content including descriptions, pricing, images are the copyrighted material of Lee & Associates - Raleigh Durham

    Overview

    Class A Office Space

    Available December 1, 2025, this Class A office space is located at 4321 Medical Park Drive in North Durham's Independence Park, a medical hub across from Duke Regional Hospital. The 79,202 square foot, two-story medical and office building features attractive concrete, steel, and glass construction and was built in 2001. Suites can be combined for up to 27,735 square feet. The building includes a gorgeous atrium with a circular staircase, a freight elevator, and a backup generator. Dock loading is available at the rear of the building. The property offers high ceilings, upgraded finishes, and plentiful parking at a ratio of 4.8 spaces per 1,000 square feet. The location is near various medical and health-related occupants, as well as retail and restaurants. Downtown Durham is 4 miles away, and Duke University is 5 miles away.
    Property Profile Insight Report Location Intelligence

    Current Use by Public Records

    Regional Dermatology of Durham ... Medical Clinic Dr. Elizabeth H. ... Physician Durham Dermatology Associates Physician Dr. Amy D. ... Physician Julie Dodge, PA-C Physician

    Suggested Use

    Restaurant Real Estate Agency Law Firm Building Supply Spa & Massage Center Dental Office Big Box & Wholesale Store Auto Repair Shop Hair Salon Nail Salon

    Zoning and permitted uses should be independently verified with local authorities.

    Similar Places Nearby

    • Durham Animal Hospital — 4306 N Roxboro St, Durham, NC 27704

    Location Insight

    • Map
    • Local Demand
    City
    Durham
    County
    Durham
    State
    North Carolina
    Longitude
    -78.8941
    Latitude
    36.049

    Nearby Similar for Lease

    • $1,500/Mo

      Durham Office Condo For Lease

      Recently remodeled office condo with easy access and great location.
      3201 Yorktown Ave., Durham, NC 27713
      View Details
    • $45,045 SF/Yr

      Durham Office Space For Lease

      Flexible office unit with ample parking and recent upgrades.
      1906 Carolina 54, Durham, NC 27713
      View Details
    • Contact for pricing

      NC, Durham - Spaces Mangum Street

      555 Mangum St, Unit 100, Durham, NC 27701
      View Details
    • Contact for pricing

      NC, Durham - 3511 Shannon Road

      3511 Shannon Rd, Durham, NC 27707
      View Details
    • $3,950,000 SF/Yr

      Versatile Building Available for Lease/Sale

      Adaptable building suitable for restaurant, fitness, or office use.
      211 Rigsbee Ave, Durham, North Carolina 27701
      View Details
    • Contact for pricing

      RTP Imperial

      4819 Emperor Blvd, Unit 400, Durham, NC 27703
      View Details
    • $23 SF/Yr

      Durham Medical/Office Building for Lease

      Freestanding 4,769 SF building suitable for medical or office use.
      110 E. Carver Street, Durham, NC 27704
      View Details
    • $2,400/Mo

      Professional Office Condos For Lease

      Office condos for lease near Duke University Medical Center.
      2741 Campus Walk Ave, Building 400, Durham, NC 27705
      View Details
    • $27 SF/Yr

      Durham Office and Retail Space

      Office and retail suites available for lease in Durham.
      404 Hunt Street, Durham, North Carolina 27701
      View Details
    • $3,000/Mo

      Retail Space on N Duke

      Retail space available for rent on N Duke Street.
      3925 N Duke Street 121, Durham, NC 27704
      View Details
    • $30 SF/Yr

      Plug and Play Lab Space

      Move-in ready lab and office space in Durham, NC.
      4025 Stirrup Creek Drive, Durham, NC 27703
      View Details
    • $33 SF/Yr

      Historic Brick Building in Durham

      Historic 91,168 SF brick building in Durham's Warehouse District.
      333 Liggett Street, Durham, North Carolina 27701
      View Details

    FAQs

    What type of property is this?
    Medical Office Space - Class A office space for lease in North Durham.
    Where is this medical office space located?
    The property is located at 4321 Medical Park Dr Durham, NC.
    What is the lease rate?
    The lease rate is $23 SF/Yr.
    What are key features of this property?
    This property features: Class A office space in Independence Park, a thriving medical hub across from Duke Regional Hospital.; Ability to combine suites for up to 29,098 RSF.; Plentiful parking onsite (4.8 per 1,000 SF).
    (919) 576-2503
    We can help!
    Listing Contact
    Brian Farmer
    Brian Farmer
    Real Estate License ID: NC #183406
    Learn More
    Request Owner's contact information
    Message sent successfully
    Error
    If you are the owner or broker of this property and would like to edit or remove this listing please send a message to web site administrator.
    Message sent successfully
    Error
    Email to Your Friends
    Link copied to clipboard
    Separate multiple addresses with a comma
    Message sent successfully
    Error

    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

    More about this property
    Thanks! Your message was sent.
    Error! Your message wasn't sent.
    Please enter your name
    Please enter email
    Please enter the email in the correct format
    Please enter phone
    Please enter the number in the correct format
    Please enter message
    Thank You

    You are Unsubscribed From Notifications

    Thank You for Inquiry

    4321 Medical Park Dr, Durham, NC 27704

    letter with green check mark
    Check your email

    We sent you the

    agent's contact details. yellow underline

    Can't find it?
    Please check your junk/spam folder.
    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!