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    Durham County, NC Office Spaces for Lease

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    51 properties
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    NC, Durham - 3511 Shannon Road
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    RTP Meridian
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    Private Office Suite Space
    Updated: Jun 29
    Private Office Suite Space

    3201 Yorktown Avenue, Durham, NC 27713

    $350/Mo
    907 sqft $4.63 SF/Yr
    Built in 1988
    Private office rooms with shared common area
    24‑hour access
    WiFi and utilities included
    Convenient location near RTP, Downtown, and highways
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    NC, Durham - Spaces Mangum Street
    Updated: Feb 19
    NC, Durham - Spaces Mangum Street

    555 Mangum St, Unit 100, Durham, NC 27701

    $129-$54,775/Mo
    11-2,612 sqft
    Make a home for yourself and your team in a private office, fully serviced and flexible, with everything included
    Grow in a modern workplace with the added advantage of a benefits program offering exclusive discounts and bespoke procurement support
    Find your own private desk in a beautifully designed shared workspace with 24/7 access, a personal locker, and an inviting reception team
    Virtual offices allow you to establish a presence at any Spaces location worldwide with mail handling, a virtual call assistant, and on‑demand access
    Spaces' meeting rooms have everything you need from audiovisual equipment, whiteboards, and Wi‑Fi to food and beverage services
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    CG-Zoned Commercial Space
    CG-Zoned Commercial Space

    2810 Hillsborough Road, Durham, NC 27705

    $18 SF/Yr
    2,978 sqft $4,467/Mo

    High-visibility commercial suite on Hillsborough Road with Commercial General zoning for a broad range of uses.

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    RTP Imperial
    RTP Imperial

    4819 Emperor Blvd, Unit 400, Durham, NC 27703

    $129-$13,893/Mo
    11-1,965 sqft

    Flexible workspace in RTP Imperial. Book a tour & get info

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    Flexible Office Suite on Highway 54
    Flexible Office Suite on Highway 54

    1906 Carolina 54, Durham, NC 27713

    $45,045 SF/Yr
    2,145 sqft $8,051,793/Mo

    First-floor office suite with eight private offices, updated interiors, and ample parking on a high-traffic corridor.

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    Roxboro Road Professional Office Space
    Roxboro Road Professional Office Space

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704

    $20.50 SF/Yr
    2,408 sqft $4,113/Mo

    Office space ideal for professional services and medical offices.

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    Prime Medical Office Space Available
    Prime Medical Office Space Available

    2609 N Duke Street, Durham, NC 27704

    $18 SF/Yr
    2,312 sqft $3,468/Mo

    Versatile medical/office space in Durham's thriving North Duke corridor.

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    First Floor Office Unit For Lease
    First Floor Office Unit For Lease

    100-a-1906 E Nc Highway 54, Durham, NC 27713

    $45,045 SF/Yr
    2,145 sqft $8,051,793/Mo

    Flexible office unit with ample parking and high traffic count.

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    Office Condo Near I-85
    Office Condo Near I-85

    1816 Front St, Durham, NC 27705

    $18.75 SF/Yr
    3,000 sqft $4,687/Mo

    Office condo for rent near I-85 in Durham.

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    Luxury Mixed-Use Development Near Duke
    Luxury Mixed-Use Development Near Duke

    2812 & 2816 Erwin Rd |, Durham, NC 27705

    $25 SF/Yr
    118,000 sqft $245,833/Mo

    Class A mixed-use development near Duke University and hospitals.

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    Office Space in Durham
    Office Space in Durham

    324 Blackwell Street, Durham, NC 27701

    $29.95 SF/Yr
    9,778 sqft $24,404/Mo

    Office space available for lease in Durham, North Carolina.

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    Downtown Durham Office Space
    Downtown Durham Office Space

    614 West Main Street, Durham, NC 27701

    $38 SF/Yr
    20,126 sqft $63,732/Mo

    Office space in the heart of Downtown Durham's West Village.

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    Office Space in Durham
    Office Space in Durham

    700 West Main Street, Durham, NC 27701

    $30 SF/Yr
    7,943 sqft $19,857/Mo

    7943 SF office space available for lease.

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    Office Space Near American Tobacco
    Office Space Near American Tobacco

    302 East Pettigrew Street, Durham, NC 27701

    $36.50 SF/Yr
    15,998 sqft $48,660/Mo

    Office space for rent adjacent to Durham's historic district.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2510 Meridian Parkway, Durham, NC 27713

    $27 SF/Yr
    51,566 sqft $116,023/Mo

    Office space for rent with easy access to nearby amenities.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2605 Meridian Parkway, Durham, NC 27713

    $28 SF/Yr
    49,387 sqft $115,236/Mo

    Prime location with easy access to major transportation routes.

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    Durham Office Space For Rent
    Durham Office Space For Rent

    2525 Meridian Parkway, Durham, NC 27713

    $28.50 SF/Yr
    59,039 sqft $140,217/Mo

    Office space available in a prime Durham location.

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    Downtown Durham Office Space Available
    Downtown Durham Office Space Available

    433 W. Main Street, Durham, NC 27701

    Contact for pricing
    16,692 sqft

    Office spaces for lease in the heart of downtown Durham.

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    High-Visibility Office Building
    High-Visibility Office Building

    3917 University Dr, Durham, NC 27707

    Contact for pricing

    Prime office location with walkable amenities and major-route access for teams seeking convenience and customer-friendly visibility.

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    Downtown Durham Office Space
    Downtown Durham Office Space

    212 West Main Street, Durham, NC 27701

    Contact for pricing
    41,000 sqft

    Full floor office space in downtown Durham's iconic tower.

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    Durham Lab Space for Lease
    Durham Lab Space for Lease

    4505 Emperor Blvd, Durham, NC 27703

    Contact for pricing
    1,476 sqft

    Lab space available for lease in Durham, North Carolina.

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    Downtown Durham Office Space
    Downtown Durham Office Space

    411 West Chapel Hill Street, Durham, NC 27701

    Contact for pricing
    47,477 sqft

    Centrally located office space in historic Durham tower.

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    Durham County, NC Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Durham County, NC with 51 listings featured on our commercial real estate exchange. The current inventory includes 433,585 square feet of properties with an estimated lease value of $4,041,130.

    Estimated lease rates for Office Spaces in Durham County, NC begin at $4 SF/Yr, with an average of $161,645 and extend to $3,950,000.
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