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    Durham County, NC Office Buildings for Sale

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    Charlotte, NC Fayetteville, NC Wilmington, NC
    12 results
    Colonial Square Office/Medical Building
    $3,499,000
    21,532 SF
    Colonial Square Office/Medical Building

    4400 Ben Franklin Boulevard, Durham, NC 27704

    Multi-functional commercial building in Durham's Independence Park.
    • Significant income generation from leased area: $227,739 in 2024.
    • Large, multi‑functional commercial building with 21,532 total square feet.
    • Located in a sought‑after office/medical park in northern Durham County.
    • Flexible space suitable for various professional uses (medical, office, education, law).
    • Features include an elevator, ample storage, and a loading dock.
    Updated: Aug 7, 2025
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    Downtown Durham Redevelopment Opportunity
    $1,000,000
    Downtown Durham Redevelopment Opportunity

    113 West Main Street, Durham, NC 27701

    Mixed-use redevelopment opportunity in vibrant Downtown Durham on Main Street.
    • Mixed‑use redevelopment opportunity in Downtown Durham.
    • Situated directly on Main Street offering high visibility and foot traffic.
    • Central Business District zoning allows for a wide range of uses including residential, retail, office, and hospitality.
    • Spacious structure ideal for a variety of redevelopment concepts.
    • Walkable to restaurants, shops, entertainment venues, and public transit.
    Updated: Mar 7
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    Renovated Office Buildings For Sale
    $2,375,100
    5,220 SF
    Renovated Office Buildings For Sale

    Two renovated office buildings ideal for owner-user or investment.

    2117 Guess Road, Durham, NC 27705

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    Imperial Center Office Building For Sale
    Contact for pricing
    105,410 SF
    Imperial Center Office Building For Sale

    Four-story office building in Imperial Center Business Park with modern amenities.

    4819 Emperor Blvd., Durham, NC 27703

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    Class A Office Building, Durham
    Contact for pricing
    111,689 SF
    Class A Office Building, Durham

    Four-story Class A office building in Imperial Center Business Park.

    4309 Emperor Blvd., Durham, NC 27703

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    Imperial Center Office Building For Sale
    Contact for pricing
    81,145 SF
    Imperial Center Office Building For Sale

    Three-story office building in Imperial Center Business Park with walkable amenities.

    4307 Emperor Boulevard, Durham, NC 27703

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    Imperial Center Office Building For Sale
    Contact for pricing
    75,563 SF
    Imperial Center Office Building For Sale

    Three-story office building in Imperial Center Business Park.

    1101 Slater Road, Durham, NC 27703

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    Landmark Class-A Office Tower
    Contact for pricing
    264,598 SF
    Landmark Class-A Office Tower

    Iconic 11-story office building with prime location and amenities.

    4820 Emperor Boulevard, Durham, NC 27703

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    Versatile Income-Producing Asset in Durham
    $5,500,000
    34,433 SF
    Versatile Income-Producing Asset in Durham

    Multi-tenant building in a growing submarket with redevelopment potential.

    1020 South Miami Blvd, Durham, NC, USA, Durham, NC 27703

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    Turnkey Commercial Buildings in Durham
    Contact for pricing
    Turnkey Commercial Buildings in Durham

    Freestanding commercial buildings perfect for owner-user office or redevelopment.

    2117 Guess Rd, Durham, NC 27705

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    Class A Office Campus Redevelopment
    Contact for pricing
    151,376 SF
    Class A Office Campus Redevelopment

    Two-building Class A office campus with modern indoor/outdoor workspaces.

    2222 & 2224 NC 54, Durham, NC 27713

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    Southpoint Professional Center Office Space
    $2,995,000
    8,986 SF
    Southpoint Professional Center Office Space

    Office space in Durham, close to Chapel Hill and RTP.

    249 E Nc Hwy 54- Suite 100, Durham, NC 27713

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    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 12 Active listings in Durham County, NC, we suggest exploring several alternatives: similar 60 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Chapel Hill Land For Sale
    Contact for pricing
    1,819 SF
    Chapel Hill Land For Sale

    Corner lot available in Chapel Hill, North Carolina.

    307 N Columbia Street, Chapel Hill, NC 27516

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    Apex, NC Land Assemblage
    $607,240
    3.20 Acres
    Apex, NC Land Assemblage

    3.196 acres of commercial land for sale in Apex, NC.

    7529 Creekbird Road, Apex, NC 27523

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    Apex, NC Land Assemblage
    $2,053,800
    11.41 Acres
    Apex, NC Land Assemblage

    11.41 acres of land for development in Apex, NC.

    3212 US 64 Highway, Apex, NC 27523

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    Prime Downtown Apex Land Opportunity
    $425,000
    0.35 Acres
    Prime Downtown Apex Land Opportunity

    Rare .35 acre property in Historic Apex's Small Town Character District.

    212 Hunter Street, Apex, NC 27502

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    Off-Market Properties in Durham County, NC

    Consider similar Off-Market properties in Durham County, NC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    3608 University Dr
    OFFICE BUILDING
    13,698 SF Lot: 0.86 Acres
    Estimated value
    $2,955,000

    3608 University Dr, Durham, NC 27707-6260

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    2222 Nc Hwy 54
    OFFICE BUILDING
    154,972 SF Lot: 14.99 Acres
    Estimated value
    $9,385,000

    2222 Nc Hwy 54, Durham, NC 27713-5222

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    1912 Nc Hwy 54
    OFFICE BUILDING
    8,876 SF Lot: 0.66 Acres
    Estimated value
    $1,160,000

    1912 Nc Hwy 54, Durham, NC 27713-2235

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    2513 Nc Hwy 54
    OFFICE BUILDING
    4,032 SF Lot: 0.40 Acres
    Value Estimation by Request

    2513 Nc Hwy 54, Durham, NC 27713-2697

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    3211 Shannon Rd
    OFFICE BUILDING
    140,522 SF Lot: 6.38 Acres

    3211 Shannon Rd, Durham, NC 27707-6322

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    2733 Campus Walk Ave
    OFFICE BUILDING
    5,376 SF Lot: 0.85 Acres
    Estimated value
    $1,295,000

    2733 Campus Walk Ave, Durham, NC 27705

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    4117 Roxboro St
    OFFICE BUILDING
    51,910 SF Lot: 2.53 Acres
    Value Estimation by Request

    4117 Roxboro St, Durham, NC 27704-2121

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    4101 Roxboro St
    OFFICE BUILDING
    55,920 SF Lot: 3.82 Acres
    Value Estimation by Request

    4101 Roxboro St, Durham, NC 27704-2121

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    1011 Lamond Ave
    PROFESSIONAL BUILDING
    2,145 SF Lot: 0.34 Acres
    Estimated value
    $1,180,000

    1011 Lamond Ave, Durham, NC 27701-2020

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    612 Gary St
    OFFICE BUILDING
    2,080 SF Lot: 0.12 Acres
    Value Estimation by Request

    612 Gary St, Durham, NC 27703-2202

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    1622 Nc Hwy 54
    PROFESSIONAL BUILDING
    6,876 SF Lot: 0.34 Acres
    Estimated value
    $965,000

    1622 Nc Hwy 54, Durham, NC 27713-2100

    View details
    4000 Sancar Way
    OFFICE BUILDING
    77,675 SF Lot: 4.55 Acres
    Estimated value
    $5,425,000

    4000 Sancar Way, Durham, NC 27709-1103

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    Durham County, NC Office Buildings Investment Opportunities Market Analysis

    Explore 72 office buildings for sale in Durham County, NC, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 70,171 square feet of properties for sale, with an estimated market value of $14,369,100.

    Sale prices for office properties in Durham County, NC start at $2,375,100, averaging $3,592,275, and reaching up to $5,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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