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    Durham, NC Medical Office Space for Lease

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    Chapel Hill, NC Raleigh, NC Cary, NC
    9 results
    Durham Medical/Office Building for Lease
    $23 SF/Yr
    4,769 SF

    Durham Medical/Office Building for Lease

    110 E. Carver Street, Durham, NC 27704

    Freestanding 4,769 SF building suitable for medical or office use.

    • Ideally situated near Duke Regional Hospital and I‑85 in north Durham.
    • Versatile ±4,769 SF building, formerly a medical office and surgery center, suitable for medical or professional office use.
    • Customizable space with landlord offering quick and cost‑effective reconfigurations.
    • Features a reception area, spacious waiting room, multiple exam rooms with sinks, private offices, and surgical rooms.
    • Convenient amenities including 18 on‑site parking spaces, prominent monument signage, and a backup generator.
    Updated: Nov 21, 2025
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    Prime Medical Office Space Available
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    2609 N Duke Street, Durham, NC 27704

    Versatile medical/office space in Durham's thriving North Duke corridor.

    • Prime medical/office space in a highly sought‑after location on Durham's North Duke Street corridor.
    • Excellent visibility and easy access to major roads and highways.
    • Dedicated parking with ample spaces for clients and staff.
    • Versatile space ideal for medical, dental, or general office use.
    • Includes reception area, private offices, conference rooms, and ADA‑compliant restrooms.
    Updated: Dec 4, 2024
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    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N. Roxboro Street, Suite 140, Durham, NC 27704
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    Class A Office Space
    $23 SF/Yr
    79,440 SF

    Class A Office Space

    Class A office space for lease in North Durham.

    4321 Medical Park Dr, Durham, NC 27704
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    Office/Medical Building Near Southpoint Mall
    $26 SF/Yr
    18,395 SF

    Office/Medical Building Near Southpoint Mall

    Single-story office/medical building near Southpoint Mall available for lease.

    5501 Fortunes Ridge Drive, Durham, NC 27713
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    Medical Office Space in Durham
    Contact for pricing
    5,986 SF

    Medical Office Space in Durham

    Dental specialist office space for lease near Duke University/Hospital.

    1212 Broad Street, Suite B, Durham, NC 27705
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    Medical Office Space Sublease
    Contact for pricing
    1,504 SF

    Medical Office Space Sublease

    Medical office space available for sublease.

    5015 Southpark Dr, Durham, NC 27713
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    Move-in Ready Office Suite
    $21 SF/Yr
    1,000 SF

    Move-in Ready Office Suite

    First-floor office suite in a high-demand Durham location.

    1804 Martin Luther King Jr Pkwy, Durham, NC 27707
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    Medical Office Space For Lease
    Contact for pricing

    Medical Office Space For Lease

    Second generation medical office space available for lease.

    4020 N Roxboro St, Durham, NC 27704
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    Based on your search, we've compiled 21 Potential Opportunities for your consideration. Besides 9 Active listings in Durham, NC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office/Medical Space Near UNC Rex
    $24 SF/Yr
    5,468 SF

    Office/Medical Space Near UNC Rex

    Office/medical space for lease, walking distance to UNC Rex.

    2501 Atrium Drive, Raleigh, NC 27607
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    Blue Ridge Road Office Space
    Contact for pricing
    5,432 SF

    Blue Ridge Road Office Space

    Medical or general office space for lease near UNC Rex.

    3126 Blue Ridge Road, Raleigh, NC 27612
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    Retail, Medical, or Office Space
    Contact for pricing

    Retail, Medical, or Office Space

    First floor end unit suitable for retail, medical, or office.

    1200 Gathering Park Cir, Cary, NC 27519
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    Class A Medical Office Building
    $30 SF/Yr
    36,000 SF

    Class A Medical Office Building

    Three-story medical office building with variety of medical tenants.

    7560 Carpenter Fire Station Rd, Cary, NC 27519
    View details

    Similar Spaces for Sale in Durham, NC

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    Colonial Square Office/Medical Building
    $3,499,000
    21,532 SF
    Colonial Square Office/Medical Building

    Multi-functional commercial building in Durham's Independence Park.

    4400 Ben Franklin Boulevard, Durham, NC 27704

    View details
    Medical Office & Wellness Center
    Contact for pricing
    25,317 SF
    Medical Office & Wellness Center

    Medical office and wellness center in high-traffic Durham location.

    3017 Pickett Rd, Durham, NC 27705

    View details
    Durham Office Near Highway 85
    $750,000
    1,600 SF
    Durham Office Near Highway 85

    Office property close to Highway 85, Duke, and RTP.

    3219 Guess, Durham, NC 27705

    View details
    Renovated Medical Office Condos
    Contact for pricing
    41,588 SF
    Renovated Medical Office Condos

    Newly renovated medical office condos for sale in Durham, NC.

    4020 N Roxboro St, Durham, NC 27704

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Lot For Rent
    $7,500/Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
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    Corner Lot on Highway 72
    $5,000/Mo
    1,875 SF

    Corner Lot on Highway 72

    1.7 acre corner lot zoned for commercial, medical, residential.

    30472 Highway 72, Madison, AL 35756
    View details
    WINTER PARK Land Lease Opportunity
    $8,500/Mo
    23,056 SF

    WINTER PARK Land Lease Opportunity

    Commercial land lease opportunity in Winter Park, Florida.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details

    Durham, NC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Durham, NC with 9 listings featured on our commercial real estate exchange. The current inventory includes 108,324 square feet of properties with an estimated lease value of $132 SF/Yr.

    Estimated lease rates for Medical Office Space in Durham, NC begin at $18 SF/Yr, with an average of $22 SF/Yr and extend to $26 SF/Yr.
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    Most Searched ZIP Codes in Durham, NC

    • 27704
    • 27713
    • 27705
    • 27707

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