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    Durham County, NC Mixed-use Properties for Lease

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    Charlotte, NC Raleigh, NC Greensboro, NC
    Luxury Mixed-Use Development Near Duke
    $25 SF/Yr
    118,000 SF
    Luxury Mixed-Use Development Near Duke

    2812 & 2816 Erwin Rd |, Durham, NC 27705

    Class A mixed-use development near Duke University and hospitals.
    • Walking distance to Duke University Hospital, Duke University, Durham VA Hospital, and Lenox Baker Children’s Hospital
    • Class A mixed‑use development with luxury apartments, offices, and retail
    • Convenient to US 15‑501 and NC 147/Durham Freeway
    • Ample surface and structured parking available
    • Property adjoins a 141‑key AC Hotel by Marriott
    Updated: Sep 25, 2025
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    Mixed-Use Development Opportunity in Durham
    Contact for pricing
    71,652 SF
    Mixed-Use Development Opportunity in Durham

    3214 Hillsborough Road, Durham, NC 27705

    Mixed-use development site with retail, restaurant, and residential potential.
    • Class‑A mixed‑use development featuring retail, restaurants, and residential dwellings.
    • Located one mile from Duke University Main Campus & Hospital.
    • 12 AC total property size.
    • 71,652 SF of Retail space.
    • Best‑in‑class retail and restaurant opportunities.
    Updated: Mar 6
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    Erwin Road Mixed-Use Retail Space
    Contact for pricing
    118,000 SF
    Erwin Road Mixed-Use Retail Space

    Class A retail space in mixed-use development near Duke University.

    2812 & 2816 Erwin Rd |, Durham, NC 27705

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    Downtown Durham Mixed-Use Asset
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    Downtown Durham Mixed-Use Asset

    Mixed-use property in the heart of Downtown Durham.

    601 West Main Street, Durham, NC 27701

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    Mixed-Use Redevelopment Opportunity
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    Mixed-Use Redevelopment Opportunity

    Mixed-use redevelopment with main street setting.

    University Dr & Shannon Rd, Durham, NC 27707, USA, Durham, NC 27707

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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 5 Active listings in Durham County, NC, we suggest exploring alternatives. Similar 9 Properties for Sales.

    Similar Spaces for Sale in Durham County, NC

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Downtown Durham Redevelopment Opportunity
    $1,000,000
    Downtown Durham Redevelopment Opportunity

    Mixed-use redevelopment opportunity in vibrant Downtown Durham on Main Street.

    113 West Main Street, Durham, NC 27701

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    Downtown Durham Multifamily Development Opportunity
    Contact for pricing
    8,721 SF
    Downtown Durham Multifamily Development Opportunity

    Entitled mixed-use site with 201 residential units and commercial space.

    6 Grace Ln, Durham, NC 27701

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    Downtown Durham Mixed-Use Property
    $830,000
    2,386 SF
    Downtown Durham Mixed-Use Property

    Historic building with modern upgrades, suitable for multiple uses.

    114 E Main St, Durham, NC 27701

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    Downtown Durham Mixed-Use Property
    $1,400,000
    4,500 SF
    Downtown Durham Mixed-Use Property

    Mixed-use property in Downtown Durham with office and residential spaces.

    116 East Main Street, Durham, NC 27701

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    Durham Automotive/Retail Opportunity
    $650,000
    2,640 SF
    Durham Automotive/Retail Opportunity

    Vacant property in Durham with high visibility and strong potential.

    901 E Trinity Ave, Durham, NC 27704

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    Multi-Purpose Building on 2.24 Acres
    $799,900
    1.27 Acres
    Multi-Purpose Building on 2.24 Acres

    Well-maintained multi-purpose building on 2.24 acres with lease in place.

    315 Southerland St, Durham, NC 27703

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    Downtown Durham Mixed-Use Property
    $1,400,000
    4,500 SF
    Downtown Durham Mixed-Use Property

    Mixed-use property in Downtown Durham with office and residential spaces.

    116 E Main, Durham, NC 27701

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    Retail and Office Development Site
    Contact for pricing
    Retail and Office Development Site

    Approved site for 33,000 SF retail and office development.

    5802 & 5904 S Miami Blvd |, Durham, NC 27560

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    Durham Mixed-Use Asset Near Duke
    Contact for pricing
    105,055 SF
    Durham Mixed-Use Asset Near Duke

    Mixed-use asset near Duke University with multifamily, retail, office.

    2816 Erwin Rd, Durham, NC 27705

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Land in Jarrettsville Corridor
    Contact for pricing
    Prime Land in Jarrettsville Corridor

    1.55 acre parcel in Jarrettsville's business corridor.

    1753, Jarrettsville, MD 21084

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    Harrisburg Redevelopment Site For Rent
    Contact for pricing
    11,000 SF
    Harrisburg Redevelopment Site For Rent

    5.85-acre redevelopment site approved for 92 residential units.

    2150 Herr Street, Harrisburg, PA 17103

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    Atlanta Land for Lease
    $1,850/Mo
    Atlanta Land for Lease

    3-acre commercial land available for lease in Atlanta, GA.

    1057 Constitution Road SW, Atlanta, GA 30315

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    Prime Commercial Acres For Lease
    $6,000/Mo
    Prime Commercial Acres For Lease

    4.12 acres of commercial land for lease in Rainsville, AL.

    4.12 Acres Al Highway 35, Rainsville, AL 35986

    View details

    Durham County, NC Mixed-use properties Leasing Opportunities Market Analysis

    Explore Mixed-use properties leasing options in Durham County, NC with 5 listings featured on our commercial real estate exchange. The current inventory includes 118,000 square feet of properties with an estimated lease value of $25 SF/Yr.

    Estimated lease rates for Mixed-use properties in Durham County, NC begin at $25 SF/Yr, with an average of $25 SF/Yr and extend to $25 SF/Yr.
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