Durham County, NC Office Spaces for Sale

List

Map

Charlotte, NC Fayetteville, NC Wilmington, NC Durham, NC Raleigh, NC Greensboro, NC Jacksonville, NC Asheville, NC

42 properties

Sort:

Updated: Jun 10, 2025

Two-Story Office and Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft

Wight Mansion: two‑story office/medical building in Colonial Square at Independence Park (northern Durham County).
Total size of 21,532 SF: 9,135 SF above grade plus 4,405 SF below grade, with 5,300 SF currently leased.
Includes an elevator, ample storage, and a loading dock to support office, medical, or other professional uses.
Built in 1997.
Guest facilities: 3.

View details

This listing looks promising.

Here's a quick look at some key insights for

4400 Ben Franklin Boulevard, Durham, NC 27704

View Property Analytics

Est. Cap Rate

9.2%
Above avg (5.9%)
Est. NOI

$321K
Annual
Mortgage

$150K
Jul 2016
Property Type

Office Building
Built 1916

View Property Analytics

Updated: Apr 9

Durham Commercial Land Opportunity

3421 N Duke Street, Durham, NC 27704

$1,300,000

2,386 sqft 0.61 AC lot

Two adjacent properties (3413 & 3421 N Duke St) sold together, offering a larger footprint.
Prime location on the growing N Duke Street corridor with strong visibility.
Excellent potential for investors, small business owners, or future development.
Spacious lots provide flexibility for various uses (office, service‑based business, redevelopment).
Conveniently located minutes from downtown Durham, Duke University, and major highways.

View details

Craftsman Live-Work Bungalow

1814 Chapel Hill Road, Durham, NC 27707

$496,000

1,922 sqft 0.30 AC lot

1930s bungalow with office-institutional live-work potential, fireplace parlor, separate dining, and an unfinished walk-out basement.

View details

Industrial Flex Property with Fenced Yard

1015 Ellis Road, Durham, NC 27703

$1,385,000

4,940 sqft 0.74 AC lot

Three-building industrial flex site includes multiple garage bays, a converted office, and a fully fenced yard for outdoor operations.

View details

Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center

Historic Neoclassical Office Building

102 East Main Street, Durham, NC 27701

$3,200,000

8,782 sqft

Renovated 1920 bank building with terrazzo floors, marble columns, and high-ceiling office space in downtown Durham.

View details

Historic Office Building with Porch

830 N. Mangum St., Durham, NC 27701

$649,000

3,300 sqft 0.48 AC lot

Historic structure on a large lot with flexible zoning and ample parking, suited for an office conversion or renovation.

View details

Renovated Historic Mixed-Use Building

319 E Chapel Hill St, Durham, NC 27701

$5,025,000

12,000 sqft

1914 building fully modernized in 2019 with added third floor and roof deck plus plentiful nearby parking.

View details

Colonial Square Office/Medical Building

4400 Ben Franklin Boulevard, Durham, NC 27704

$3,499,000

21,532 sqft 2.10 AC lot

Multi-functional commercial building in Durham's Independence Park.

View details

Leased First-Floor Office Condominium

5003 Southpark Drive, Durham, NC 27713

$389,000

1,386 sqft

First-floor office condominium in Southpark Professional Center, currently leased through July 2029 with tenant option to renew.

View details

Industrial Flex with Laydown Yard

1101 E Cornwallis, Durham, NC 27713

$1,500,000

6,831 sqft 1.40 AC lot

Leased industrial flex with heated warehouse, office, and concrete laydown yard on about 1.4 acres.

View details

Renovated Office Buildings For Sale

2117 Guess Road, Durham, NC 27705

$2,375,100

5,220 sqft 0.72 AC lot

Two renovated office buildings ideal for owner-user or investment.

View details

Office Condominium with ADA Features

3101 Guess Road #H, Durham, NC 27705

$159,500

1,400 sqft

Well-maintained office condo with ADA bathroom and an equipped breakroom, suited for service use.

View details

Live-Work Craftsman Bungalow

1814 Chapel Hill, Durham, NC 27707

$498,000

1,922 sqft

Craftsman-style home with office-ready interiors, a fireplace front parlor, and flexible outdoor parking behind a detached garage.

View details

Modern Office Space Available

101-103 W Main St, Durham, NC

$1,171,000

7,306 sqft 0.20 AC lot

7,306 SF office space, currently leased until 2026.

View details

Live-Work Property with Ground-Level ADU

804 Madison Street, Durham, NC 27701

$895,000

2,450 sqft

Flexible downtown live-work residence with a ground-level ADU and zoning flexibility for office or rental uses.

View details

Class-A Office Building with Retail

110 Corcoran Street, Durham, NC 27701

Contact for pricing

130,195 sqft

A Class-A downtown office complex with ground-floor retail and extensive on-site amenity space.

View details

Two-Story Office Building

3621 Lyckan Parkway, Durham, NC 27707

Contact for pricing

12,000 sqft

Two-story, partial-shell office building with infrastructure in place for customized office or medical build-outs.

View details

Historic Downtown Durham Corner Building

125 E Parrish, Durham, NC 27701

$1,360,000

3,775 sqft

Fully leased retail and office space in Durham's City Center.

View details

Imperial Center Office Building For Sale

4307 Emperor Boulevard, Durham, NC 27703

Contact for pricing

81,145 sqft

Three-story office building in Imperial Center Business Park with walkable amenities.

View details

Imperial Center Office Building For Sale

4819 Emperor Blvd., Durham, NC 27703

Contact for pricing

105,410 sqft

Four-story office building in Imperial Center Business Park with modern amenities.

View details

Durham Warehouse and Office Space

1000 Parliament Court, Suite 200, Durham, NC 27703

Contact for pricing

32,320 sqft

Warehouse and office space available near Raleigh-Durham International Airport.

View details

Class A Office Building, Durham

4309 Emperor Blvd., Durham, NC 27703

Contact for pricing

111,689 sqft

Four-story Class A office building in Imperial Center Business Park.

View details

Landmark Class-A Office Tower

4820 Emperor Boulevard, Durham, NC 27703

Contact for pricing

264,598 sqft

Iconic 11-story office building with prime location and amenities.

View details

Renovated Mixed-Use Restaurant and Offices

2022 Chapel Hill Rd., Durham, NC 27707

$1,700,000

A 2017 renovated mixed-use building with full-service restaurant space, a rooftop dining patio, and second-floor office use.

View details

Durham County, NC Office Spaces Market Trends and Statistics

Explore 72 office spaces for sale in Durham County, NC, showcased through 42 active listings on our real estate platform. These investment opportunities span a total of 132,255 square feet of properties for sale, with an estimated market value of $39,145,600.

Sale prices for office spaces in Durham County, NC start at $159,500, averaging $1,779,345, and reaching up to $6,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

List

Map