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    Durham County, NC Office Spaces for Sale

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    Charlotte, NC Fayetteville, NC Wilmington, NC
    39 results
    Durham Commercial Land Opportunity
    $1,300,000
    2,386 SF
    Durham Commercial Land Opportunity

    3421 N Duke Street, Durham, NC 27704

    Two adjacent properties for sale in Durham's growing corridor.
    • Two adjacent properties (3413 & 3421 N Duke St) sold together, offering a larger footprint.
    • Prime location on the growing N Duke Street corridor with strong visibility.
    • Excellent potential for investors, small business owners, or future development.
    • Spacious lots provide flexibility for various uses (office, service‑based business, redevelopment).
    • Conveniently located minutes from downtown Durham, Duke University, and major highways.
    Updated: Apr 9
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    Colonial Square Office/Medical Building
    $3,499,000
    21,532 SF
    Colonial Square Office/Medical Building

    4400 Ben Franklin Boulevard, Durham, NC 27704

    Multi-functional commercial building in Durham's Independence Park.
    • Significant income generation from leased area: $227,739 in 2024.
    • Large, multi‑functional commercial building with 21,532 total square feet.
    • Located in a sought‑after office/medical park in northern Durham County.
    • Flexible space suitable for various professional uses (medical, office, education, law).
    • Features include an elevator, ample storage, and a loading dock.
    Updated: Aug 7, 2025
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    Downtown Durham Redevelopment Opportunity
    $1,000,000
    Downtown Durham Redevelopment Opportunity

    Mixed-use redevelopment opportunity in vibrant Downtown Durham on Main Street.

    113 West Main Street, Durham, NC 27701

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    Renovated Office Buildings For Sale
    $2,375,100
    5,220 SF
    Renovated Office Buildings For Sale

    Two renovated office buildings ideal for owner-user or investment.

    2117 Guess Road, Durham, NC 27705

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    Imperial Center Office Building For Sale
    Contact for pricing
    105,410 SF
    Imperial Center Office Building For Sale

    Four-story office building in Imperial Center Business Park with modern amenities.

    4819 Emperor Blvd., Durham, NC 27703

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    Class A Office Building, Durham
    Contact for pricing
    111,689 SF
    Class A Office Building, Durham

    Four-story Class A office building in Imperial Center Business Park.

    4309 Emperor Blvd., Durham, NC 27703

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    Imperial Center Office Building For Sale
    Contact for pricing
    81,145 SF
    Imperial Center Office Building For Sale

    Three-story office building in Imperial Center Business Park with walkable amenities.

    4307 Emperor Boulevard, Durham, NC 27703

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    Imperial Center Office Building For Sale
    Contact for pricing
    75,563 SF
    Imperial Center Office Building For Sale

    Three-story office building in Imperial Center Business Park.

    1101 Slater Road, Durham, NC 27703

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    COMMERCIAL - Durham, NC
    $435,000
    1,386 SF
    COMMERCIAL - Durham, NC

    Office Units · 1,386 SF

    5003 Southpark Drive, Durham, NC 27713

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    Durham Warehouse and Office Space
    Contact for pricing
    32,320 SF
    Durham Warehouse and Office Space

    Warehouse and office space available near Raleigh-Durham International Airport.

    1000 Parliament Court, Suite 200, Durham, NC 27703

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    Landmark Class-A Office Tower
    Contact for pricing
    264,598 SF
    Landmark Class-A Office Tower

    Iconic 11-story office building with prime location and amenities.

    4820 Emperor Boulevard, Durham, NC 27703

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    Golden Belt Campus Office Space
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    Golden Belt Campus Office Space

    Restored historic textile mill in downtown Durham.

    807 E Main St & 800 Taylor St, Durham, NC 27701

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    Refurbished Office Space Available
    Contact for pricing
    32,950 SF
    Refurbished Office Space Available

    Office suites available near Research Triangle Park and Raleigh-Durham Airport.

    3020 S. Miami Blvd, Durham, NC 27703

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    Downtown Durham Mixed-Use Property
    $1,400,000
    4,500 SF
    Downtown Durham Mixed-Use Property

    Mixed-use property in Downtown Durham with office and residential spaces.

    116 East Main Street, Durham, NC 27701

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    Versatile Income-Producing Asset in Durham
    $5,500,000
    34,433 SF
    Versatile Income-Producing Asset in Durham

    Multi-tenant building in a growing submarket with redevelopment potential.

    1020 South Miami Blvd, Durham, NC, USA, Durham, NC 27703

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    RTP Light Industrial Property
    $550,000
    2,133 SF
    RTP Light Industrial Property

    Light industrial property in RTP with office and storage space.

    2528 South Alston Avenue, Durham, NC 27713

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    Turnkey Commercial Buildings in Durham
    Contact for pricing
    Turnkey Commercial Buildings in Durham

    Freestanding commercial buildings perfect for owner-user office or redevelopment.

    2117 Guess Rd, Durham, NC 27705

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    Durham Office Condominium For Sale
    $249,000
    1,183 SF
    Durham Office Condominium For Sale

    Office condominium in Durham, convenient location, suitable for investors.

    3201 Yorktown, Durham, NC 27713

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    Durham Office Condominium For Sale
    $165,000
    831 SF
    Durham Office Condominium For Sale

    Office condominium in Durham, close to RTP and downtown.

    3201 Yorktown, Durham, NC 27713

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    Medical Office & Wellness Center
    Contact for pricing
    25,317 SF
    Medical Office & Wellness Center

    Medical office and wellness center in high-traffic Durham location.

    3017 Pickett Rd, Durham, NC 27705

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    Historic Downtown Durham Corner Building
    $1,360,000
    3,775 SF
    Historic Downtown Durham Corner Building

    Fully leased retail and office space in Durham's City Center.

    125 E Parrish, Durham, NC 27701

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    Downtown Durham Mixed-Use Property
    $1,400,000
    4,500 SF
    Downtown Durham Mixed-Use Property

    Mixed-use property in Downtown Durham with office and residential spaces.

    116 E Main, Durham, NC 27701

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    Durham Office Near Highway 85
    $750,000
    1,600 SF
    Durham Office Near Highway 85

    Office property close to Highway 85, Duke, and RTP.

    3219 Guess, Durham, NC 27705

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    Class A Office Campus Redevelopment
    Contact for pricing
    151,376 SF
    Class A Office Campus Redevelopment

    Two-building Class A office campus with modern indoor/outdoor workspaces.

    2222 & 2224 NC 54, Durham, NC 27713

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    Durham County, NC Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in Durham County, NC, showcased through 39 active listings on our real estate platform. These investment opportunities span a total of 109,261 square feet of properties for sale, with an estimated market value of $30,878,100.

    Sale prices for office spaces in Durham County, NC start at $165,000, averaging $1,816,358, and reaching up to $6,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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